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         Hemophilia:     more books (100)
  1. Orthopedic Surgery in Patients with Hemophilia by P.M. Mannucci, 2008-07-01
  2. Haemophilia: Proceedings of the IX Congress of the World Federation of Haemophilia, Istanbul, 20-22 August, 1974 (International congress series) by World Federation of Hemophilia, 1975
  3. Raising a Child with Hemophilia: A Practical Buide for Parents by by Laureen a Kelley, 1999-01-01
  5. Handbook on hemophilia and other bleeding disorders by dr syed numan, 2010-01-08
  6. Cell Genesys obtains results from preclinical hemophilia gene therapy studies.(Brief Article): An article from: BIOTECH Patent News
  7. "The Gift Of Experience": Excerpts from conversations with 21 Men With hemophilia and their caregivers (Volume 1) by Laura Gray, Christine Chamberlain, 2010-04-24
  8. Pooling Blood: A journey of two girls with hemophilia and their parents' struggle to keep them alive by Cheryl Nineff D'Ambrosio, 2010-02-22
  9. Joshua The Knight of the Red Snake (What is Hemophilia?) by Laureen A. Kelley, 2001
  10. Living With Hemophilia by Peter Jones, 1974-06
  11. The Gift of Experience: Conversations About Hemophilia by Laura Gray, Christine Chamberlain, 2008-04-16
  12. Curtis & Jerry on Mount Omega (Adventures with Hemophilia) by Celynd Scaglione, 2006
  13. Minutes of the patients. Hemophilia. / Protokol vedeniya bolnykh. Gemofiliya. by unknown, 2006
  14. Gale Encyclopedia of Medicine: Hemophilia by Jennifer F. Wilson MS, 2002-01-01

61. How To Deal With Hemophilia
If a person has hemophilia, his blood doesn t clot as it should. What does that mean? Find out in this article for kids.
KidsHealth Kids Kids' Health Problems Blood
Hemophilia (say: hee-muh- fih -lee-uh) is a genetic disorder in which a person's blood does not clot properly. "Hemo" means blood and "philia" means a tendency toward. A person who has hemophilia has a tendency to bleed excessively. Think of the last time you had a cut or scrape. When the bleeding stops on its own, you're seeing clotting in action. A Bit About Blood
If your blood is clotting normally, your body naturally protects itself. Platelets , which are "sticky cells," go to where the bleeding occurs and cover the hole, plugging it up. This is the first step in the clotting process. When the platelets plug the hole, they release chemicals that attract more sticky platelets and also activate various clotting factors, which are proteins in the blood. These proteins mix with the platelets to form fibers, which make the clot stronger and stop the bleeding. Our bodies have 12 clotting factors that work together to make fibrinogen (say: fy- brih -nuh-jun), the substance that makes the fibers. Trouble begins if the body is missing one of these factors.

62. Matt Klimshuk's Home Page
Information on von Willebrand's Disease and links to von Willebrand's and hemophilia sites.
"Information is Power" Providing Information on von Willebrand's Disease Go To Personal Information What Is Von Willebrand's Disease? Von Willebrand's Disease (vWD) is not a disease at all, but the most common genetic disorder in the world (classic hemophilia is more well known due to its connection with the royal families of Europe). In fact, vWD is times more common than classic hemophilia! It was discovered by a Finnish doctor in the 1920s, who named it after himself and called it a disease. Later, Dr. von Willebrand discovered in truth that the illness was linked to a missing blood factor, which assists with the clotting of blood. He named the factor after himself as well - von Willebrand's Factor (vWF). The disorder is not sex linked (autosomal), meaning that both men and women can have it, but some can be carriers only and not manifest any of the symptoms. VWD occurs when the body makes either inferior vWF or none at all. Other blood factors can be short-changed as well. Generally, vWD is divided into three types: Type I (mild), Type II (Medium) and Type III (severe). The lower the type, the less the symptoms will occur and the less strenuous they will be. What Are the Symptoms?

63. Hemophilia
For guys with a rare bleeding disorder called hemophilia, minor cuts and bruises can be a big deal. The good news is that it s a lot easier to control now

Teens Blood Disorders
If you ride a skateboard or play a sport, you probably know about bruises and banged-up knees and elbows. But for guys with a rare bleeding disorder called hemophilia (pronounced: hee-muh- fih -lee-uh), minor cuts and bruises can be a big deal. What Is Hemophilia?
Hemophilia is a disease that prevents a person's blood from clotting properly, which means that the person bleeds more than a person without hemophilia does. It's a genetic disorder, which means it's the result of a change in genes that's either inherited (passed on from parent to child) or that happens during development in the womb. "Hemo" means blood and "philia" means a tendency toward. A person who has hemophilia has a tendency to bleed excessively. Hemophilia affects mostly boys, although it's very rare: Only about one in every 8,000 boys is born with hemophilia. The disease can affect people of any race or nationality. For most people, when they get a cut, the body naturally protects itself. Sticky cells in the blood called platelets go to where the bleeding is and plug up the hole. This is the first step in the clotting process. When the platelets plug the hole, they release chemicals that attract more sticky platelets and also activate various proteins in the blood known as

64. Blood Diagnostics, Inc. - Index
Wholesale distributor of plasma derived pharmaceuticals, including IVIG, hemophilia fators VII, VIII IX, albumins and hyperimmunes and injectables.
window.location.replace('../index.htm') Purity Delivered Introducing Rho phylac a new RhIg product from one of the most trusted names in plasma derived therapies. To learn more about Rho phylac visit this link. click here Visit the ASHP web site for information about the ASHP Midyear Clinical Meeting and Exhibit as well as important information regarding the practice of pharmacy in hospitals and Health Systems. For important Medicare Reimbursement changes Click here To assist you in addressing these issues we have included CMS Sample letters Sample A Sample B Sample C For the latest CMS Information release Click here Let Us Engineer Your Supply Chain Solution! BDI Logistics serves as an extension of your organization to provide you with a seamless and efficient supply chain solution. Learn more about BDI Logistics Intramed Plus is a provider of innovative and cost effective home infusion therapy VISION: To offer hope to all people with HIV / AIDS and other chronic illness.

65. Copernicus Theraputics - Home
Developing human gene therapy products for cystic fibrosis and hemophilia B and DNA vaccinations. The company creates proprietary PLASmin Complexes which are efficient nonviral vectors and REPLIsome vectors which allow replication of non-viral vectors.
Copernicus Therapeutics, Inc. is a privately-held company developing products for human gene therapy and vaccination. Copernicus was established in 1997 based on technologies discovered at Case Western Reserve University that provide the foundation for the use of DNA as drugs.
Copernicus is not involved in gene discovery or the linkage of genetic defects to disease. Copernicus' business focuses on using its technologies to make and sell gene therapy products to treat, cure or prevent human diseases - products that work.
Copernicus Therapeutics, Inc. presented data at the American Society of Gene Therapy meeting showing that their compacted DNA formulation can effectively transfect non-dividing human cells, solving the problem of restricted access of plasmid DNA to the nucleus. more
Copernicus has developed three technology platforms that provide unique opportunities to develop novel therapeutics. These platforms have separate therapeutic applications but, when combined, can result in synergistic advantages. more
Copernicus' technologies present opportunities for products in many important markets. The Company's delivery technologies solve many of the problems that have hindered gene therapy, with a market projected to be worth $12 billion by 2007.

66. Great Lakes Hemophilia Foundation Wisconsin Von Willebrand Disease Bleeding Diso
Education Services of the Great Lakes hemophilia Foundation Wisconsin von Willebrands Disease Bleeding Disorders.



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68. Hardin MD : Hemophilia
From the University of Iowa, the *best* lists of Internet sources in hemophilia.
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69. THE MERCK MANUAL, Sec. 11, Ch. 131, Hemostasis And Coagulation
hemophilia may result from gene mutations point mutations involving a About 50% of cases of severe hemophilia A result from a major inversion of a

70. THE MERCK MANUAL, Sec. 11, Ch. 131, Hemostasis And Coagulation Disorders
Information for doctors from this online textbook.
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This Publication Is Searchable The Merck Manual of Diagnosis and Therapy Section 11. Hematology And Oncology Chapter 131. Hemostasis And Coagulation Disorders Topics [General] Hemostasis Hereditary Coagulation Disorders Acquired Coagulation Disorders
Hereditary Coagulation Disorders
Common forms of hereditary bleeding disorders caused by clotting factor deficiencies of factor VIII, IX, or XI. Hemophilia A (factor VIII deficiency), which affects about 80% of hemophiliacs, and hemophilia B (factor IX deficiency) have identical clinical manifestations, screening test abnormalities, and X-linked genetic transmission. Specific factor assays are required to distinguish the two.
Hemophilia may result from gene mutations: point mutations involving a single nucleotide, deletions of all or parts of the gene, and mutations affecting gene regulation. About 50% of cases of severe hemophilia A result from a major inversion of a section of the tip of the long arm of the X chromosome. Because factor VIII and factor IX genes are located on the X chromosome, hemophilia affects males almost exclusively. Daughters of hemophiliacs will be obligatory carriers, but sons will be normal. Each son of a carrier has a 50% chance of being a hemophiliac, and each daughter has a 50% chance of being a carrier. (See also Ch. 286.

71. Hemophilia, Heredity Blood Disorders, NCBDDD, CDC
The National Center on Birth Defects and Developmental Disabilities promotes child development, prevents birth defects and developmental disabilities,
NCBDDD Home Hereditary Blood Disorders About CDC Activities Health care Bleeding disorders Clotting disorders ... Contact Us
Thank you for visiting the CDC-NCBDDD Web site. In order to contact the National Center on Birth Defects and Developmental Disabilities, please click here Hemophilia Hemophilia is an inherited bleeding disorder that affects 18,000 persons (primarily males) in the United States. The disorder results from deficiencies in blood clotting factors and can lead to spontaneous internal bleeding and bleeding following injuries or surgery. These bleeding episodes can cause severe joint damage, neurological damage, damage to other organ systems involved in the hemorrhage, and, in rare cases, death. Treating the bleeding episodes involves the prompt and proper use of clotting factor concentrates. von Willebrand disease The most common bleeding disorder is von Willebrand disease (vWD), which is found in approximately 1-2% of the U.S. population. VWD results from a deficiency or defect in the body's ability to make von Willebrand factor, a protein that helps blood clot. Although VWD occurs in men and women equally, women are more likely to notice the symptoms because of heavy or abnormal bleeding during their menstrual periods and after childbirth.

72. MSN Encarta - Hemophilia
hemophilia, hereditary blood disease involving the inability of blood to clot, or coagulate, leading to hemorrhage, or bleeding.

73. Hemophilia- MMWR Reports On HIV/AIDS - CDC-NCHSTP-Divisions Of HIV/AIDS Preventi
CDC Division of HIV/AIDS Prevention - HIV/AIDS Related MMWRs from 1993-Present
National Center for HIV, STD and TB Prevention
Divisions of HIV/AIDS Prevention MMWRs By Subject Home Index Search ... Subscribe
MMWRs on HIV/AIDS and Hemophilia
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  • HIV transmission between two adolescent brothers with hemophilia. 1993 Dec 17;42(49):948-51.
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  • HIV Infection in Two Brothers Receiving Intravenous Therapy for Hemophilia April 10, 1992 / 41(14);228-231
  • Perspectives in Disease Prevention and Health Promotion Safety of Therapeutic Products Used for Hemophilia Patients July 29, 1988 / 37(29);441-444,449-450
  • HIV Infection and Pregnancies in Sexual Partners of HIV- Seropositive Hemophilic Men United States September 11, 1987 / 36(35);593-5

74. Hemophilia Resource Network
Clinical care pathways and administrative services to hematologists managing hospitalized persons with hemophilia.

75. Hemophilia, What Is..., NHLBI DCI
hemophilia is a rare inherited bleeding disorder. The blood does not clot normally. Persons with hemophilia may bleed for a longer time following an injury

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Blood Diseases Hemophilia : What Is ...
What Is ...
Other Names Causes Diagnosis ... Links
What Is Hemophilia?
Hemophilia (heem-a-FILL-ee-ah) is a rare inherited bleeding disorder. The blood does not clot normally. Persons with hemophilia may bleed for a longer time following an injury or accident than others. They also may bleed internally, especially in the joints (knees, ankles, and elbows). Babies born with hemophilia are missing or have a low level of a protein needed for normal blood clotting or blood coagulation. The protein is called a clotting factor. About 18,000 persons in the U.S. have hemophilia. About 400 babies are born each year with the disorder. Hemophilia usually occurs only in males (with very rare exceptions). A person with hemophilia has a problem with certain proteins in the blood, called clotting factors, which help blood clot. Hemophilia can be due to:
  • A low level of one of the clotting factors
    A clotting factor that is completely missing.
When clotting factors are missing, or your body does not have enough of these factors, it can take a long time for your blood to clot after an injury or accident.
What Is Clotting?

76. Hemophilia Foundation Of Nevada: Serving The Bleeding Disorders Community Of Nev
A nonprofit consumer advocacy and service organization founded in 1990 to help meet the vast education and support needs of the bleeding disorders community in Nevada.
preloadRollover("images/scrolling/scroll_sm_up.gif", "scroll_sm_up"); preloadRollover("images/scrolling/scroll_sm_down.gif", "scroll_sm_down"); var n=14; NEWSLINE HOMEPAGE What's New with the HFNV H.F.N.V. About H.F.N.V. Our Services HFNV Forum HEMOPHILIA What is Hemophilia? Treatment VON WILLEBRAND About von Willebrand Treatment Resources HOW TO HELP How Can You Help? H.T.C. LAS VEGAS About Us EVENT CALENDAR Event Calendar EVENT PHOTOS Past Event Photos ORGANIZATION LINKS Bleeding Disorders Resources CORPORATE LINKS Home Health Care Manufacturers BOARD OF DIRECTORS Executive Committee and Board Members EXECUTIVE DIRECTOR Executive Directors Page Welcome to the H.F.N.V. Web Site
The HFNV would like to welcome Ramona Alicea as the new President of the Board of Directors. The next time you see her at an event, please give the warmest of welcomes. When you get a chance we added a new feature to the site check out the HFNV Forum Also stay tuned for the details of our upcoming newsletters. Keep your eyes open, you could be famous!!! Any persons with HFNV event pictures, or anyone who would like to write about an event and have it printed in our newsletter is welcome to do so. Please e-mail any input or pictures to Ian Corona at:

77. Choice Source Therapeutics
Provide hemophilia care for patients.
About Us Services Contacts Resources About Us Services Contacts Resources ... Español

78. Inheritance Of Hemophilia
hemophilia is a sex linked trait in humans, inherited in the same way white eye color in Drosophila. Males are hemizygous, receiving their only X chromosome

X-linked Inheritance: Hemophilia
Hemophilia is a sex linked trait in humans, inherited in the same way white eye color in Drosophila. Males are hemizygous, receiving their only X chromosome from their mother. Females are heterozygous, inheriting X chromosomes from both parents. If a female has a defective gene on one of her two X chromosomes, she will be protected from its effects by the normal gene on her second X chromosome. If a male has a mutant X and a normal Y chromosome, he will be affected by a X-linked disease.
A son, whose mother has two normal alleles, will not be affected by hemophilia even if the father has the disease and the defective gene. A daughter of the same parents will be a heterozygous carrier.
A heterozygous carrier mother and a normal father pass the gene for hemophilia on to possibly one- half of their children. Half the daughters will be carriers and half the sons will be hemophilic. The rest of the siblings will be normal. Daughters, as long as one parent is genotypically normal, can only be carriers. The normal gene on the second X chromosome counteracts the defect and the daughters do not suffer from the trait. If a son receives the defective gene from his mother, he will be hemophilic because the Y chromosome can not counteract the defective gene located on his X chromosome.
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79. Welcome To Hemophilia Options Home Page
hemophilia Options is a speicialty care pharmacy offering therapies for patients with bleeding disorders. Services include pharmacy, nursing care,
click here!
Who We Are
Hemophilia Options is a specialty care pharmacy offering therapies for patients with bleeding disorders. Services include pharmacy, nursing care, home medical supplies and equipment, and reimbursement services.
Centers of Excellence
  • Experienced nursing teams trained in bleeding disorder and pediatric proficiencies 24-hour pharmacy/nursing services for rapid response to patient needs Providing a wide selection of factor and factor-related products Continuous Infusion Protocols Patient Care Coordination for product needs, medical equipment, physical therapy, dental care, education and training
Hemophilia Options works closely with physicians and caregivers to deliver the appropriate level of service and support. Working in cooperation with physicians, insurance companies, and other healthcare professionals, we implement personal treatment plans designed to meet the special needs of each patient. Some patients become independent very quickly with their therapy, others need on-going support. To assure consistency and quality of care, Hemophilia Options assigns a Patient Care Coordinator to each patient. The patient is also supported by a clinical pharmacist and a nursing team. This individual approach is cost-effective, and helps to ensure that each patient receives and administers the proper medication for the best possible results.
Therapies for Patients with Bleeding Disorders
Hemophilia Options service for pediatric and adult factor programs are on the leading edge of industry standards in approach to new therapies, products and service.

80. Hemophilia - Medical Information On Treatment Options, And Links To Other Sites.
Information on hemophilia, diagnosis, symptoms, treatment issues, and patient information.
Haemophilia or hemophilia is the name of any of several hereditary genetic illnesses that impair the body's ability to control bleeding. Genetic deficiencies (or, very rarely, an autoimmune disorder) cause lowered plasma clotting factor activity so as to compromise blood-clotting; when a blood vessel is injured, a scab will not form and the vessel can continue to bleed excessively for a very long period of time. The bleeding can be external, if the skin is broken by a scrape, cut or abrasion, or it can be internal, into muscles, joints or hollow organs. Causes Haemophilia is generally caused by a mutation affecting the genes encoding one of the clotting factors. The genes for the most common form, Haemophilia A , are located on the X chromosome, so haemophilia is usually a sex-linked trait. Women have two X-chromosomes, whereas men have one X and one Y chromosome. Since the mutations causing the disease are recessive, a woman carrying the defect on one of her X-chromosomes will not be affected by it, as the equivalent allele on her other chromosome would express itself to produce the necessary clotting factors. However the Y-chromosome in men has no gene for factors VIII or IX. If the gene responsible for blood clotting on a man's X-chromosome is deficient there is no equivalent on the Y-chromosome, so the deficient gene is not masked by the dominant allele and he will develop the illness. Since a man receives his single X-chromosome from his mother, the son of a healthy woman silently carrying the deficient gene will have a 50% chance of inheriting that gene from her and with it the disease. In contrast, for a woman to inherit the disease, she must receive two deficient X-chromosomes, one from her mother and the other from her father (who must therefore be a haemophiliac himself). Hence haemophilia is far more common among men than women. However, haemophiliac daughters are more common than they once were, as improved treatment for haemophilia means that more men survive to adulthood and become parents. Adult women with haemophilia menstruate periodically, so they must take clotting factor to survive.

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