81. Anemia, Hemolytic, Warm Antibody Warm Antibody hemolytic anemia is an autoimmune disorder characterized by the premature destruction of red blood cells by the body s natural defenses http://www.bchealthguide.org/kbase/nord/nord770.htm

var hwPrint=1;var hwDocHWID="nord770";var hwDocTitle="Anemia, Hemolytic, Warm Antibody";var hwRank="1";var hwSectionHWID="nord770-Header";var hwSource="en-caQ2_05";var hwDocType="Nord"; National Organization for Rare Disorders, Inc. Anemia, Hemolytic, Warm Antibody Important It is possible that the main title of the report Anemia, Hemolytic, Warm Antibody is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Autoimmune Hemolytic Anemia Warm Reacting Antibody Disease Disorder Subdivisions None General Discussion Warm Antibody Hemolytic Anemia is an autoimmune disorder characterized by the premature destruction of red blood cells by the body's natural defenses against invading organisms (antibodies). Normally, the red blood cells have a life span of approximately 120 days before they are removed by the spleen. In an individual affected with Warm Antibody Hemolytic Anemia, the red blood cells are destroyed prematurely and bone marrow production of new cells can no longer compensate for their loss. The severity of the anemia is determined by the time the red blood cells are allowed to survive and by the capacity of the bone marrow to continue new red blood cell production. Immune Hemolytic Anemias are subdivided by the optimal temperature at which the antibodies destroy red blood cells. As their names imply, Warm Antibody Hemolytic Anemia occurs at temperatures of 37 degrees centigrade or higher while Cold Antibody Hemolytic Anemia usually occurs at approximately to 10 degrees.

82. FIRSTConsult - Sdfdsf FIRSTConsult, Autoimmune hemolytic anemia (Medical Condition File). Published for medical students and primary healthcare providers by Elsevier. http://www.firstconsult.com/?action=view_article&id=1010023&type=101&bref=1

83. Microangiopathic Hemolytic Anemia - Wikipedia, The Free Encyclopedia In medicine (hematology) microangiopathic hemolytic anemia (MAHA) is a subgroup of hemolytic anemia (anemia, loss of red blood cells through destruction) http://en.wikipedia.org/wiki/Microangiopathic_hemolytic_anemia

You did it! Over US$240,000 was donated in the 21 day fund drive. Thank you for your generosity! You are still welcome to make a donation or purchase Wikimedia merchandise Microangiopathic hemolytic anemia From Wikipedia, the free encyclopedia. In medicine hematology microangiopathic hemolytic anemia (MAHA) is a subgroup of hemolytic anemia anemia , loss of red blood cells through destruction) caused by factors in the small blood vessels. It is identified by the finding of anaemia and schistocytes ("bite cells") on microscopy of the blood film Automated analysers (the machines that perform routine full blood counts in most hospitals) are generally programmed to flag blood films that display red blood cell fragments or schistocytes The most important causes are: Thrombotic thrombocytopenic purpura (TTP) Hemolytic uremic syndrome (HUS) Disseminated intravascular coagulation (DIC) HELLP syndrome and eclampsia Heparin-induced thrombocytopenia (HIT) Several other rare causes In all causes, the mechanism of MAHA is the formation of a fibrin mesh due to increased activity of the system of coagulation . The red blood cells are physically cut by these protein networks, and the fragments are identical to the schistocytes seen on light microscopy.

84. Hemolysis - Wikipedia, The Free Encyclopedia Hemolysis can be distinguished from other forms of anemia in several ways In severe immunerelated hemolytic anemia, steroid therapy is sometimes http://en.wikipedia.org/wiki/Hemolysis

You did it! Over US$240,000 was donated in the 21 day fund drive. Thank you for your generosity! You are still welcome to make a donation or purchase Wikimedia merchandise Hemolysis From Wikipedia, the free encyclopedia. Hemolysis (alternative spelling haemolysis ) is the excessive breakdown of red blood cells . When this happens, it causes a form of anemia Contents Hemolysis caused during blood collection Hemolytic anemia Symptoms Causes of hemolysis ... edit Hemolysis caused during blood collection Hemolysis is an important factor in medical tests, as a blood sample may become hemolysed with prolonged storage or when complications arise during venipuncture . For example, when a blood sample is collected, hemolysis is rare when the collection is straight forward. On occasions when a patient's veins are uncooperative (such as collapsing under the pull of a vacuum from a syringe or a modern vacuum tube), the problem becomes more prevalent. The red cells in the blood are literally smashed on their way through the needle , often due to excessive suction. This results in a poor sample. Hemolysis may cause interference with the test results for a patient, but this is mostly limited to biochemistry tests. edit Hemolytic anemia Normally, a red blood cell survives 90 to 120 days in circulation: about 1% of human red blood cells break down each day, which matches the production rate. The

85. Autoimmune Hemolytic Anemia - Children's Hospital Boston Flower Autoimmune hemolytic anemia. Programs that treat this condition. Anemia and RBC Disorders. Unfortunately, at this time, we are not able to provide http://www.childrenshospital.org/az/Site797/mainpageS797P0.html

or find by letter: A-F G-L M-R S-Z My Child Has... Home Autoimmune hemolytic anemia Autoimmune hemolytic anemia Programs that treat this condition Anemia and RBC Disorders Autoimmune hemolytic anemia is a condition where the body destroys its red blood cells faster than they can be produced. The condition can be intrinsic caused by a disorder within the red blood cells themselves, or extrinsic prompted by infection, medications, antibodies, or other causes. Treatment for hemolytic anemia may include blood transfusions, corticosteriod medications, intravenous immune globulin, and sometimes removal of the spleen or immunosuppressive therapy. Children's Hospital Boston is the primary pediatric teaching hospital of Harvard Medical School Contact Us Privacy Accessibility Give Now Children's Hospital Boston 300 Longwood Avenue Boston MA 02115

86. Nikon MicroscopyU: Human Pathology Digital Image Gallery - Hemolytic Anemia In instances of mild hemolytic anemia, the patient may be asymptomatic, Some of the most common symptoms of hemolytic anemia include weakness, fatigue, http://www.microscopyu.com/galleries/pathology/hemolyticanemia.html

MicroscopyU Site Map Small World Contest Interactive Tutorials Basic Concepts ... MicroscopyU Home Human Pathology Digital Image Gallery Hemolytic Anemia Red blood cells develop in the bone marrow and, in a typical healthy human, survive in the circulatory system for 100 to 120 days. The premature breakdown of red blood cells, an event that can occur due to a wide range of disorders and conditions, is known as hemolysis . When the bone marrow of an individual is unable to produce enough red blood cells to offset those that are precipitately lost, hemolytic anemia ensues. In instances of mild hemolytic anemia, the patient may be asymptomatic, but in severe cases, one’s life can become endangered. The elderly and people with cardiovascular problems are at greatest risk of death from hemolytic anemia, but overall the mortality rate associated with the disease is quite low. Some of the most common symptoms of hemolytic anemia include weakness, fatigue, darkened urine, pallor, jaundice, shortness of breath, fever, confusion, and rapid heart rate. Though the readily observable symptoms of hemolytic anemia are similar to those of other types of anemias, there are several signs that can aid in a more specific diagnosis. Some key signs of the hemolytic form of the condition are only recognizable with the aid of a microscope. For instance, when blood smear examination reveals red blood cell fragments, an unusually large number of

87. Nikon MicroscopyU: Human Pathology Digital Image Gallery - Hemolytic Anemia cells to offset those that are precipitately lost, hemolytic anemia ensues. In instances of mild hemolytic anemia, the patient may be asymptomatic, http://www.microscopyu.com/galleries/pathology/hemolyticanemialarge.html

Human Pathology Digital Image Gallery Hemolytic Anemia Red blood cells develop in the bone marrow and, in a typical healthy human, survive in the circulatory system for 100 to 120 days. The premature breakdown of red blood cells, an event that can occur due to a wide range of disorders and conditions, is known as hemolysis . When the bone marrow of an individual is unable to produce enough red blood cells to offset those that are precipitately lost, hemolytic anemia ensues. In instances of mild hemolytic anemia, the patient may be asymptomatic, but in severe cases, one’s life can become endangered. The elderly and people with cardiovascular problems are at greatest risk of death from hemolytic anemia, but overall the mortality rate associated with the disease is quite low. Some of the most common symptoms of hemolytic anemia include weakness, fatigue, darkened urine, pallor, jaundice, shortness of breath, fever, confusion, and rapid heart rate. View a larger image of hemolytic anemia.

88. Drug Induced Hemolytic Anemia Numerous cases of druginduced hemolytic anemia have been described in patients We report a case of severe cefotetan-induced hemolytic anemia in a http://www.thedoctorsdoctor.com/pathologists_making_a_difference/hemolytic_anemi

Background Thomas Hirose, M.D. is a board certified pathologist with subspecialty expertise and board certification in Transfusion Medicine. As director of the Blood Bank in several hospitals, it is his job to oversee all transfusion reactions which may occur from the utilization of blood products. In addition, any patient with a bleeding problem usually comes to his attention because of the therapeutic decisions which need to be made regarding the transfusion of blood products. This is how he made a difference for the patient. Recently I received a call from an Internist regarding a 55 year male patient who was severely anemic (hematocrit 18%) and was found to have a positive DAT. The patient was thought to have a small retroperitoneal hemorrhage . The attending physician was reluctant to transfuse any blood and questioned whether he should premedicate this patient with steroids, aspirin and benadryl because there was a positive direct Coombs assay. The patients serologic evaluation revealed a 2+ reaction with anti-IgG Coombs reagent and 4+ anti-C3d. The indirect Coombs assay was negative. This pattern suggested that the patient may have been exposed to a medication (Cefotetan, Volaren, Unisyn etc.) which could induce a positive direct Coombs and could also be associated with red cell hemolysis.

89. UpToDate Approach To The Adult Patient With Hemolytic Anemia INTRODUCTION — hemolytic anemia is anemia due to a shortened survival of circulating red When hemolysis occurs, the degree of anemia is minimized by a http://patients.uptodate.com/topic.asp?file=red_cell/12473

90. UpToDate Clinical Features And Treatment Of Autoimmune Hemolytic Anemia: Warm Ag Autoimmune hemolytic anemia (AIHA) due to warm agglutinins is almost (See Pathogenesis of autoimmune hemolytic anemia Warm agglutinins and drugs ). http://patients.uptodate.com/topic.asp?file=red_cell/13044

91. Zinc Poisoning Zinc Induced hemolytic anemia anemia. How zinc is able to produce hemolysis is not known. Treatment. If an object possibly made of zinc is seen on a http://www.marvistavet.com/html/body_zinc_poisoning.html

Red Blood Cell Destruction In mammals, the red blood cell is basically a small bag of hemoglobin, the protein which binds oxygen in the lungs, carries it and releases it to other tissues. A normal canine red blood cell lives 120 days and dies when it either becomes too stiff to fold itself through the tiny capillaries of the circulation (and it simply bursts trying to do so) or it cannot generate enough energy to keep itself alive. The spleen is responsible for removing old red blood cells. The spleen possesses many tortuous, winding blood vessels where red blood cells may break if they are not supple enough to pass through. The spleen then collects the hemoglobin. Bilirubin, a pigment made from old hemoglobin, is a by-product of this process. Bilirubin is sent to the liver to be “conjugated,” a chemical process enabling the bilirubin to be excreted in bile, a digestive emulsifier secreted by the liver. Bilirubin is responsible for the color of feces. What is Hemolysis?

92. Adult Health Advisor 2004.2: Anemia iron deficiency anemia; hemolytic anemia; vitamin B12 deficiency anemia Jaundice (yellow skin and eyes) may be a symptom of hemolytic anemia. http://www.med.umich.edu/1libr/aha/aha_anemia_crs.htm

Adult Health Topics All Health Topics Find a UMHS Doctor Search Adult Topics Search All Topics This information is approved and/or reviewed by U-M Health System providers but it is not a tool for self-diagnosis or a substitute for medical treatment. You should speak to your physician or make an appointment to be seen if you have questions or concerns about this information or your medical condition. Index Anemia What is anemia? Anemia is a blood disorder that is defined as: having fewer red blood cells than normal, or having less hemoglobin than normal (hemoglobin is the part of red blood cells that carries oxygen). When there are not enough red blood cells or there is too little hemoglobin, the blood is not able to carry enough oxygen to all parts of the body. There are several forms of anemia, such as: iron deficiency anemia hemolytic anemia vitamin B-12 deficiency anemia folic acid deficiency anemia anemia caused by inherited abnormalities of RBCs (for example, sickle cell anemia and thalassemia) anemia caused by chronic (ongoing) disease, such as rheumatoid arthritis.

93. UNTSHC Clinic Digital Library hemolytic anemia (Keyword search) List of documents. MD Consult Homepage Lewis Library subscription ( INFO ). Today in Medicine Table of content http://unthsc-dl.slis.ua.edu/clinical/hematology/anemias/hemolytic/acquired/noni

Clinical Resources by Topic: Hematology Nonimmune Hemolytic Anemia Clinical Resources Emergency Pediatrics Geriatrics Pathology ... Miscellaneous Resources See also: General Hematology Clinical Resources Nonimmune Hemolytic Anemia Patient/Family Resources Harrison's Principles of Internal Medicine 16th Ed.-2005: Table of contents Lewis Library subscription INFO Chapter 52. Anemia and Polycythemia: Table of contents Hematopoiesis and the Physiologic Basis of Red Cell Production: Access document Anemia: Access document Acknowledgment: Access document Further Reading: Access document Chapter 93. Hemolytic Anemias and Acute Blood Loss: Table of contents Introduction: Access document Hemolytic Anemias: Access document Further Reading: Access document Hoffman: Hematology: Basic Principles and Practice 4th Ed.-2005 (MD Consult): Table of contents Lewis Library subscription INFO Part IV - Red Blood Cells: Access document Chapter 40 - Red Blood Cell Membrane Disorders: Access document Introduction: Access document Vertical and Horizontal Interactions of Membrane Proteins and Disorders of Red Blood Cell Shape: Access document Acanthocytosis, Stomatocytosis, and the Bilayer Couple Hypothesis:

94. PharmGKB: Anemia, Hemolytic Alternate Names, Acquired hemolytic anemia; Acquired hemolytic anemias; Anemia, Acquired Hemolytic; Anemia, Hemolytic, Acquired; Anemia, Microangiopathic; http://www.pharmgkb.org/do/serve?objId=PA443343&objCls=Disease

95. BioMed Central | Full Text | Autoimmune Hemolytic Anemia Occurred Prior To Evide Autoimmune hemolytic anemia occurred prior to evident nephropathy in a patient with chronic hepatitis C virus infection case report http://www.biomedcentral.com/1471-2369/4/7

home journals A-Z subject areas advanced search ... Volume 4 Viewing options Abstract Full text PDF Associated material: Pre-publication history PubMed record Related literature: Articles citing this article on Google Scholar Other articles by authors Ohsawa I ... Similar articles (PubMed) Tools: E-mail to a friend Download references Post a comment Key E-mail Corresponding author Case report Autoimmune hemolytic anemia occurred prior to evident nephropathy in a patient with chronic hepatitis C virus infection: case report Isao Ohsawa Yuki Uehara Sumiko Hashimoto Morito Endo Takayuki Fujita and Hiroyuki Ohi Internal medicine II Nihon University School of Medicine, Tokyo, Japan Department of laboratory medicine, Nihon University School of Medicine, Tokyo, Japan Clinical laboratory, Nihon University Itabashi hospital, Tokyo, Japan BMC Nephrology The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2369/4/7 Received Accepted Published Outline Abstract Abstract Background Case presentation Conclusions ... Pre-publication history Background Renal involvement in patients with chronic hepatitis C virus infection has been suggested to be due to a variety of immunological processes. However, the precise mechanism by which the kidneys are damaged in these patients is still unclear.

96. Hemolytic Anemia - YourDictionary.com - American Heritage Dictionary Search Mamma.com for hemolytic anemia . TYPE IN YOUR WORD CLICK GO! Search hemolytic anemia n. Anemia resulting from the lysis of red blood cells, http://www.yourdictionary.com/ahd/h/h0146425.html

Search Mamma.com for "hemolytic anemia" Search: Normal Definitions Short defs (Pronunciation Key) hemolytic anemia n. Anemia resulting from the lysis of red blood cells, as in response to certain toxic or infectious agents and in certain inherited blood disorders. Back to Search Back The American Heritage Dictionary of the English Language, Fourth Edition

97. UCLA Department Of Medicine - Wfsection-Hereditary Hemolytic Anemia UCLA Department of Medicine Homepage provides information of the UCLA Medical Center including Latest News, Proceedings of UCLA Healthcare, Useful Weblink, http://www.med.ucla.edu/modules/wfsection/article.php?articleid=173

98. Differential Diagnosis -- Case 150 Thrombocytopenia, microangiopathic hemolytic anemia, moderately abnormal liver function tests (LFT) and usually mildly abnormal renal function tests are http://path.upmc.edu/cases/case150/diff.html

Differential Diagnosis Renal Failure, Anemia and Thrombocytopenia DIFFERENTIAL DIAGNOSIS: The differential diagnosis of oliguric renal failure, thrombocytopenia and thrombotic microangiopathic hemolytic anemia (MAHA) (evidenced by the red blood cell fragments, increased LDH and decreased haptoglobin) in a post partum setting includes acute fatty liver of pregnancy (AFLP), HELLP syndrome (hemolysis, elevated liver enzymes and low platelets), thrombotic thrombocytopenic purpura / hemolytic uremic syndrome (TTP/HUS), disseminated intravascular coagulation (DIC) and preeclampsia (table 1). Differentiating among these conditions is critical because they respond to different therapeutic modalities and the laboratory is often critical in making these distinctions. Table 1. Laboratory Differential Diagnosis in Pregnancy Associated Thrombotic Microangiopathies* Abnormality HUS/TTP AFLP HELLP DIC Preeclampsia Abnormal PT/PTT N Y N Y Y or N Hemolysis Y Y Y Y Y Thrombocytopenia Y Y Y Y Y Abnormal liver function tests N Y Y N N Abnormal renal function tests Y N N N N *adapted from Fricke et al HELLP syndrome is seen in 5% of patients with preeclamsia; 70% of cases occur antenatally and 30% occur within the first 48 hours post partum. Thrombocytopenia, microangiopathic hemolytic anemia, moderately abnormal liver function tests (LFT) and usually mildly abnormal renal function tests are characteristically present. Antepartum preeclampsia developes most commonly in nulliparous women and is characterized by proteinuria, edema and hypertension. Hemolysis is rare, and mild thrombocytopenia is present in 10-15% of cases. LFTs are minimally affected, and renal failure is rare. This patient did not have hypertension and LFTs were only transiently abnormal, making HELLP syndrome and preeclampsia less likely.

99. Www.cfsan.fda.gov/cgi-bin/bbbglos?anemia=hemolytic Penn State Faculty Research Expertise Database (FRED)Acquired hemolytic anemia, Acquired hemolytic anemias hemolytic anemia, hemolytic anemias. hemolytic anemias, Acquired, Hemolytic Jaundice http://www.cfsan.fda.gov/cgi-bin/bbbglos?anemia=hemolytic

100. Healthopedia.com - Drug-Induced Immune Hemolytic Anemia (Drug-Induced Hemolytic Druginduced immune hemolytic anemia is a condition where the immune system hemolytic anemia brought on by an immune reaction to a drug can be caused by http://www.healthopedia.com/drug-induced-immune-hemolytic-anemia/

Set Homepage Email Page Favorites Home Health Centers Medical Encyclopedia Medical Symptoms ... Special Topics Related Resources Health Centers Blood Disorders and Lymphatic System Immune System Anemia Fatigue ... Blood Transfusion You are here : Healthopedia.com Medical Encyclopedia Diseases and Conditions Drug-Induced Immune Hemolytic Anemia Category : Health Centers Blood Disorders and Lymphatic System Drug-Induced Immune Hemolytic Anemia Alternate Names : Drug-Induced Hemolytic Anemia Attribution Drug-induced immune hemolytic anemia is a condition where the immune system destroys the red blood cells. This takes place in response to medication. The resulting low red blood cell count is known as anemia What is going on in the body? Red blood cells transport oxygen to tissues of the body. In some people, medications can cause the immune system to attack and destroy red blood cells. This is known as hemolysis. What are the causes and risks of the disease? Hemolytic anemia brought on by an immune reaction to a drug can be caused by a number of medications. Examples include many types of antibiotics and certain blood pressure drugs, among others. Next section Author: Adam Brochert, MD

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