101. Gi.ucsf.edu/ALF/info/infohemochrom.html NEJM Hereditary hemochromatosis A New Look at an Old DiseaseReview Article from The New England Journal of Medicine Hereditary hemochromatosis A New Look at an Old Disease. http://gi.ucsf.edu/ALF/info/infohemochrom.html

102. CNN - Hemochromatosis: If You Don't Know What It Is, You Should - July 26, 1999 hemochromatosis is a frequently asymptomatic disorder in which the body absorbs And ironically, it is possible to have both hemochromatosis and anemia, http://www.cnn.com/HEALTH/9907/26/hemochromatosis/

MAIN PAGE WORLD U.S. LOCAL ... daily almanac MULTIMEDIA: video video archive audio multimedia showcase ... more services E-MAIL: Subscribe to one of our news e-mail lists. Enter your address: document.write(' '); Or: Get a free e-mail account E-MAIL DISCUSSION: message boards chat feedback CNN WEB SITES: AsiaNow Svenska Norge Danmark ... Italian FASTER ACCESS: europe japan TIME INC. SITES: Go To ... Time.com People Money Fortune EW CNN NETWORKS: more networks transcripts SITE INFO: help contents search ad info ... jobs WEB SERVICES: health > story page Hemochromatosis: If you don't know what it is, you should July 26, 1999 Web posted at: 5:59 PM EDT (2159 GMT) In this story: What is hemochromatosis? Early detection is key Treatment Pitfalls ... RELATEDS By Kiki Alderon SYMPTOMS AND COMPLICATIONS If you have any of the following conditions, you should be screened for hemochromatosis: an enlarged liver, cirrhosis or cancer of the liver, arthritis, diabetes or heart irregularities. Other symptoms include: weakness and/or fatigue abdominal pain bronzed skin that is not the result of sun exposure decreased libido impotence loss of bone density (WebMD) If, say, 300 Americans had to name the most common genetic disorder in the United States, most of them probably wouldn't guess the correct answer.

103. Iron_enemy S Home Page There is a support group of people who have hemochromatosis, or someone in their family has it. on by the hemochromatosis, who takes over 185 units of http://www.geocities.com/HotSprings/Villa/6540/

I AM VERY HONORED TO HAVE RECEIVED THESE AWARDS Please click on the awards and learn about who gives them and others who have received them. You will read some heart warming stories. WE ALL HAVE CROSSES TO BEAR Thank you for visiting my site. I worked very hard to get it just right, plus this is my first site. The main reason was to get you to read it, for the information may save your life. Please allow time to load, read it, enjoy the graphics, and sign my guestbook on your way out. God Bless. There is a support group of people who have Hemochromatosis, or someone in their family has it. Join the group for support and information. Click below to subscribe to FHHF. Click to subscribe to FHHF YOU ARE VISITOR HEMOCHROMATOSIS Are You Dying From Too Much Iron? Never heard of this disease, HEMOCHROMATOSIS? Neither had I until I was diagnosed with it. It's not a pretty disease if not caught in time. As a matter of fact, it's a KILLER. It's assumed now that my father died, at the age of 68, from it, but the death certificate

104. UpToDate Patient Information: Hemochromatosis INTRODUCTION — hemochromatosis is a condition characterized by excess hemochromatosis is usually inherited and most often affects white people. http://patients.uptodate.com/topic.asp?file=livr_dis/2974

105. Introduction hemochromatosis is a disorder in which iron absorption proceeds at a rate greater hemochromatosis has been shown to be heritable through a variety of http://opbs.okstate.edu/~leach/Bioch5853/Minireviews/Hemochro.doc.html

Hemochromatosis Scott Nicholson Introduction Iron absorption and regulation Iron is generally absorbed through the duodenum after being bound (in the ferrous state) by mucin lining the luminal side of the duodenum. The mucin transfers iron to trans-membrane integrins, and, once in the cell, iron is transferred to mobilferrin, which then transfers the iron to ferritin or to an as-yet unknown protein, which transfers iron to transferrin bound to the extracellular side of the protein and releasing it into the plasma. TfR bound to the corporeal portion of the mucosal cell functions to bind tranferrin from the plasma and bring it into the cell through clathrin-mediated endocytosis, where it may function to regulate iron absorption.(3) When the iron-bound transferrin enters the bloodstream, it is reabsorbed mainly by hepatocytes and erythroblasts, again by transferrin receptor. TfR is itself regulated by a MHC type 1-like protein which forms a stable complex with the intracellular portion of TfR and beta2-microglobulin(4), effectively decreasing its affinity for iron-bound transferrin, thereby inhibiting absorption of bound transferrin and maintaining iron homeostasis (2,5) ( fig. 1

106. Hemosiderosis / Hemochromatosis a CHORUS notecard document about hemosiderosis / hemochromatosis. http://chorus.rad.mcw.edu/doc/00184.html

CHORUS Collaborative Hypertext of Radiology Liver and biliary system About CHORUS Search Feedback hemosiderosis / hemochromatosis iron deposition due to abnormal metabolism or iron overload abnormal iron metabolism alcoholic cirrhosis multiple blood transfusions (e.g., Hb SS, thalassemia Findings: osteoporosis chondrocalcinosis (CPPD) arthropathy resembles CPPD arthropathy distinctive feature: BEAK-like osteophytes at MCP jts mottled increased density of liver spleen Definitions: hemosiderosis: hemosiderin deposition within cells hemochromatosis: hemosiderin within cells AND interstitium Charles E. Kahn, Jr., MD - 2 February 1995 Last updated 26 May 2004 Related CHORUS documents: hepatoma chondrocalcinosis dense liver on CT Wilson disease ... Thorotrast Search for related articles: AJR American Journal of Roentgenology PubMed : index to biomedical literature ... Medical College of Wisconsin

107. Virtual Hospital: Aging Begins At 30: 1998: Hemochromatosis The weekly newspaper columns of Ian Maclean Smith, MD, on a variety of consumer health topics. It is dedicated to promoting good health in later life by http://www.vh.org/adult/patient/internalmedicine/aba30/1998/hemochromatosis.html

Aging Begins at 30 Hemochromatosis: Poorly Named, But Easily Treated Ian Maclean Smith, M.D. Emeritus Professor Department of Internal Medicine University of Iowa Hospitals and Clinics Creation Date: August 1998 Last Revision Date: August 1998 Peer Review Status: Internally Peer Reviewed My friend told me I diagnosed his hemochromatosis at age 55 almost 20 years ago. Since then he has been bled 500 ccs, 210 times. The blood removed for iron overload now amounts to twice his bodyweight! In this blood pigment disease, misnamed before its cause was known, there is an increase in gut iron absorption. The excess is deposited in the liver, heart, pancreas, and skin. If untreated the skin gets reddish brown colored and the pancreatic islets, that make insulin, fail so it is called bronze diabetes. Normally the body absorbs a milligram of iron daily. Men excrete the same amount, but menstruating women excrete 1.5 mg. In hemochromatosis 4 mg or more is absorbed daily. Hemochromatosis is a hereditary disease. The causative gene in over 80% is HPE. The frequency is 5% of the population but one in ten are carriers with one such gene. About one in 3,000 get the disease. It is a recessive hereditary disease and requires two genes. Its clinical expression is 5 to 10 times as frequent in men as in women whose menstrual and pregnancy bleeding is natural treatment. It takes time to appear and 70% develop the disease in their 40s or 50s. I noted a minor anemia in my friend at his annual check and found he had a raised serum iron and a high saturation of transferrin, a protein that moves iron from the gut to the bone marrow. In hemachromatosis, iron increases 75-fold in the liver and pancreas, 15-fold in the heart, and 5-fold in the spleen, kidney, and skin. A liver biopsy showed lots of iron and confirmed his diagnosis.

108. Hemochromatosis CHC Wausau Hospital s Medical Library and Patient Education Center provides research services and healthcare information to physicians, http://www.chclibrary.org/micromed/00050600.html

Main Search Index Definition Description Causes ... Resources Hemochromatosis Definition Hemochromatosis is an inherited blood disorder that causes the body to retain excessive amounts of iron. This iron overload can lead to serious health consequences, most notably cirrhosis of the liver. Description Hemochromatosis causes excess iron storage in several organs of the body including the liver, pancreas, endocrine glands, heart, skin, and intestinal lining. The buildup of iron in these organs can lead to serious complications, including heart failure , liver cancer, andcirrhosis of the liver. It is estimated that about 5% of cirrhosis cases are caused by hereditary hemochromatosis. Idiopathic pulmonary hemosiderosis, a disorder afflicting children and young adults, is a similar overload disorder characterized by abnormal accumulation of hemosiderin. Hemosiderin is a protein found in most tissues, especially the liver. It is produced by digestion of hematin, an iron-related substance. Hereditary hemochromatosis is passed by an autosomal recessive trait on the genes. (Scientists have recently identified the precise gene.) Because of its hereditary nature, as many as 25% of the siblings of hemochromatosis patients will also develop the disorder.

109. Old World Aviaries: Hemochromatosis: A Metabolic Disease Of Softbills hemochromatosis is probably the leading cause of death of mynas and toucans in The same therapy used in humans, where hemochromatosis also occurs, http://www.oldworldaviaries.com/text/styles/Hemochromatosis.html

Old World Aviaries Hemochromatosis: A metabolic disease of softbills by Darrel K. Styles, DVM Hill Country Aviaries, L.L.C. One of the biggest challenges of keeping and maintaining a large softbill collection or just a single pet is the problem of the iron storage disease known as hemochromatosis. This disease affects a wide range of species including mynahs, toucans, tanagers, birds-of-paradise, and many others. It is not a disease we see in parrots, finches, or canaries. Hemochromatosis is probably the leading cause of death of mynas and toucans in captivity, and collections of birds-of-paradise have been decimated by this malady. The cause is unknown, but the effect is a massive uptake and storage of iron in the liver. This excessive storage leads to hepatomegaly or liver enlargement. Consequently, some degree of liver dysfunction is observed. However, the most remarkable aspect of the pathology of the disease is liver enlargement. This enlargement leads to ascites or fluid exuded into the air sacs. This fluid in combination with an oversized liver results in dyspnea, or difficulty in breathing. The clinical presentation of these birds is often a myna or toucan with a swollen abdominal area accompanied by open-mouthed breathing. I have seen this problem displayed so severely in mynahs that if you changed their position from upright to lateral, the birds began to drown in their own fluids, which were leaking from the air sacs into the lung. Large quantities of fluid may be taken from a small bird.

110. Hemochromatosis Overview of hemochromatosis (iron overload), a common genetic disease. Related Tests Transferrin saturation, Ferritin. Can also develop as a complication http://www.labtestsonline.org/understanding/conditions/hemochrom.html

TESTS Test not listed? A/G Ratio ACE ACT ACTH AFB Culture AFP Maternal AFP Tumor Marker Albumin Aldolase Aldosterone Allergies ALP Alpha-1 Antitrypsin ALT Ammonia Amylase ANA Antibody Tests Antiglobulin, Direct Antiglobulin, Indirect Antiphospholipids Antithrombin Apo A Apo B ApoE Genotyping aPTT AST Autoantibodies Bicarbonate Bilirubin Blood Culture Blood Gases Blood Smear BMP BNP Bone Markers BRCA BUN C-peptide CA-125 CA 15-3 CA 19-9 Calcitonin Calcium Cardiac Biomarkers Cardiac Risk Cardiolipin Antibodies Catecholamines CBC CCP C. diff CEA Celiac Disease Tests CF Gene Mutation Chemistry Panels Chlamydia Chloride Cholesterol CK CK-MB CMP CMV Coagulation Factors Complement Levels Cortisol Creatinine Creatinine Clearance CRP CRP, high-sensitivity

111. Diagnosis And Management Of Hemochromatosis. Firstdegree relatives of a confirmed case of hemochromatosis Early diagnosis of hereditary hemochromatosis (HH) prevents organ damage and dysfunction http://www.guideline.gov/summary/summary.aspx?ss=15&doc_id=3448&nbr=2674

112. Liver Information: Hemochromatosis USC Liver Transplant Surgery Program and Center for Liver Disease specializes in the surgical and medical management of the following disease entities http://www.surgery.usc.edu/divisions/hep/livernewsletter-hemochromatosis.html

Hemochromatosis Hemochromatosis, a disease of excess iron storage, is caused by multiple factors including hematological abnormalities requiring transfusion support such as thalassemia or chronic hemolytic anemia, excessive dietary exposure or in association with chronic liver disease such as viral hepatitis or alcoholic liver disease. A distinct subset of iron storage disease, referred to as hereditary hemochromatosis (HH), exists within families, especially those with Northern European ancestry of Nordic or Celtic origin. Estimated carrier rates of 6 to 8% have been reported in this population, making this the most common hereditary disorder in this group. This high carrier rate coupled with ease of preventive treatment by phlebotomy makes this an ideal disease to screen for in this high-risk population. Clinically, hemochromatosis only presents after significant injury to the target organs, which include the parathyroid, heart, pancreas, liver and pituitary gland. Common symptoms include fatigue, weakness, arthritis and impotence associated with physical findings of congestive heart failure, hepatomegaly, bronze skin and hypogonadism along with cryptogenic "silent" cirrhosis. Patients now rarely present with these so-called "late" findings and most often are detected by increased iron stores as evidenced by increase in transferrin saturation, total iron binding capacity and serum ferritin levels. Previously, the so-called "gold standard" for hemochromatosis was measurement of iron concentration in a liver biopsy sample, which has the added advantage of assessing severity of hepatic injury.

113. The Immune System In Hemochromatosis - More Than Meets The Eye? Hereditary haemochromatosis (HH) is a disease characterised by excessive absorbance and storage of iron in the body, which results from a mutation in HFE, http://www.medicalnewstoday.com/medicalnews.php?newsid=27271

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