81. Treatment Of Primary Headache: Acute Migraine Treatment. Standards Of Care For H ischemic or structural heart disease, cerebrovascular disease, peripheralvascular disease, and basilar or hemiplegic migraine. http://www.guideline.gov/summary/summary.aspx?view_id=1&doc_id=6579

82. GEMdatabase - Selected Title TITLE, Familial hemiplegic migraine CONDITIONS, Migraine, Hemiplegic.SUBJECTS. AVAILABILITY, Hard Copy Online Outof-Print http://www.gemdatabase.org/GEMDatabase/TitleDetailsOne.asp?TitleID=885

83. Centre For Medical Systems Biology Familial hemiplegic migraine and Episodic Ataxia type2 are caused by mutationsin the Ca++ channel gene CACNL1A4. Cell 1996;87543-552. http://www.cmsb.nl/research/central_nervous_system_domain/migraine.php

Friday, September 9 th Home Research Central Nervous System... Alzheimer's Disease ... Depression Migraine Metabolic and Vascular... Immunity Domain Events Links ... News Centre for Medical Systems Biology Niels Bohrweg 2 P.O. Box 9504 2300 RA Leiden The Netherlands Telephone +31 (0) 71 5274422 Fax +31 (0) 71 5275714 E-mail info@cmsb.nl Suggestions regarding the website - webmaster@cmsb.nl Last modified 2005/03/30 16:55:10 CEST Printer friendly page CMSB Research Program Migraine Migraine is a hereditary chronic multifactorial neurological disorder that affects 12% of the general population (2 million patients in the Netherlands). The disease is characterized by recurring attacks of severe, disabling headaches that also cause nausea, vomiting and, and in one third of the patients are accompanied by neurological aura symptoms (migraine with aura; MA). On average, patients suffer 2 attacks a month, each lasting 1 – 3 days. Approximately 10% of the migraine patients (200,000 Dutch patients) are affected almost weekly. Although considered an episodic disorder, recent neuroimaging work by us clearly shows that patients with severe migraine are at risk for significant brain damage. ... 2004; 41: 701-710. (IF: 13.8)

84. : The AMEDEO Literature Guide Alternating hemiplegia of childhood or familial hemiplegic migraine? Deciphering migraine mechanisms Clues from familial hemiplegic migraine genotypes. http://www.amedeo.com/medicine/mig/annneuro.htm

Home HIV Medicine FAQ Unsubscribe ... Flying Publisher Migraine Free Subscription Articles published in Ann Neurol Retrieve available abstracts of 6 articles: HTML format Single Articles June 2004 SWOBODA KJ , Kanavakis E, Xaidara A, Johnson JE, et al Alternating hemiplegia of childhood or familial hemiplegic migraine?: A novel ATP1A2 mutation. Ann Neurol 2004;55:884-7. PubMed Related articles Abstract available February 2004 MOSKOWITZ MA , Bolay H, Dalkara T Deciphering migraine mechanisms: Clues from familial hemiplegic migraine genotypes. Ann Neurol 2004;55:276-280. PubMed Related articles Abstract available January 2004 BURSTEIN R, Collins B, Jakubowski M Defeating migraine pain with triptans: A race against the development of cutaneous allodynia. Ann Neurol 2004; 55: 19-26. PubMed Related articles Abstract available BURSTEIN R , Jakubowski M Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization. Ann Neurol 2004;55:27-36. PubMed Related articles Abstract available September 2003 VANMOLKOT KR, Kors EE, Hottenga JJ, Terwindt GM, Haan J, Hoefnagels WA et al

85. : The AMEDEO Literature Guide Familial hemiplegic migraine More than just a headache. Severe hemiplegicmigraine attack precipitated by fentanyl sedation for esophagogastroscopy. http://www.amedeo.com/medicine/mig/neurol.htm

Home HIV Medicine FAQ Unsubscribe ... Flying Publisher Migraine Free Subscription Articles published in Neurology Retrieve available abstracts of 103 articles: HTML format Single Articles August 2005 DRUMMOND PD Effect of tryptophan depletion on symptoms of motion sickness in migraineurs. Neurology 2005;65:620-2. PubMed Related articles Abstract available LYNGBERG AC , Rasmussen BK, Jorgensen T, Jensen R, et al Prognosis of migraine and tension-type headache: a population-based follow-up study. Neurology 2005;65:580-5. PubMed Related articles Abstract available BREY RL Both migraine and motion sickness may be due to low brain levels of serotonin. Neurology 2005;65:E9-10. PubMed Related articles Abstract available June 2005 TOTAH AR Migraine and other headaches: associations with Rose angina and coronary heart disease. Neurology 2005;64:1989. PubMed Related articles May 2005 WAEBER C , Moskowitz MA Migraine as an inflammatory disorder. Neurology 2005;64. PubMed Related articles RAMADAN NM Targeting therapy for migraine: what to treat? Neurology 2005;64.

86. Publications Familial hemiplegic migraine involvement of a calcium neuronal channel. Involvement of a Ca2+ channel gene in familial hemiplegic migraine and migraine http://www.humgen.nl/lab-frants/migraine/Publications.htm

Dutch Migraine Genetic Research Group (DMGRG) Key publications before 1999 Lesnik Oberstein SA, van den Boom R, van Buchem MA, van Houwelingen HC, Bakker E, Vollebregt E, Ferrari MD, Breuning MH, Haan J. Cerebral microbleeds in CADASIL. Neurology. 2001 Sep 25;57(6):1066-70. Ophoff RA, DeYoung J, Service SK, Joosse M, Caffo NA, Sandkuijl LA, Terwindt GM, Haan J, van den Maagdenberg AM, Jen J, Baloh RW, Barilla-LaBarca ML, Saccone NL, Atkinson JP, Ferrari MD, Freimer NB, Frants RR. Hereditary vascular retinopathy, cerebroretinal vasculopathy, and hereditary endotheliopathy with retinopathy, nephropathy, and stroke map to a single locus on chromosome 3p21.1-p21.3. Am J Hum Genet. 2001 Aug;69(2):447-53. Diener HC, Tfelt-Hansen P, de Beukelaar F, Ferrari MD, Olesen J, Dahlof C, Mathew N. The efficacy and safety of sc Alniditan vs. sc Sumatriptan in the acute treatment of migraina randomized, double-blind, placebo-controlled trial. Cephalalgia. 2001 Jul;21(6):672-9. Kors EE, Terwindt GM, Vermeulen FL, Fitzsimons RB, Jardine PE, Heywood P, Love S, van den Maagdenberg AM, Haan J, Frants RR, Ferrari MD. Delayed cerebral edema and fatal coma after minor head traumrole of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine.

87. UniProtKB/Swiss-Prot Entry P50993 [AT1A2_HUMAN] Sodium/potassium-transporting AT DISEASE Defects in ATP1A2 are the cause of familial hemiplegic migraine 2 (FHM2) Familial hemiplegic migraine is a rare, severe, autosomal dominant http://www.expasy.org/uniprot/P50993

ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot Search Swiss-Prot/TrEMBL Swiss-Prot/TrEMBL (full text) PROSITE SWISS-2DPAGE ENZYME NEWT Taxonomy HAMAP families ExPASy web site for The ExPASy Server requires Javascript to be fully functional. You may not see all the information available for this page (More information) UniProtKB/Swiss-Prot entry Entry info Name and origin References Comments ... Tools Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents Entry information Entry name Primary accession number Secondary accession numbers Entered in Swiss-Prot in Release 34, October 1996 Sequence was last modified in Release 34, October 1996 Annotations were last modified in Release 48, September 2005 Name and origin of the protein Protein name Sodium/potassium-transporting ATPase alpha-2 chain [Precursor] Synonyms EC Sodium pump 2 Na+/K+ ATPase 2 Gene name Name: Synonyms: From Homo sapiens (Human) TaxID Taxonomy ... References NUCLEOTIDE SEQUENCE. PubMed=2477373 [ NCBI ExPASy EBI Israel ... Shull M.M.

88. Hemiplegic Migraine hemiplegic migraine. This response submitted by Lawana on 10/7/96. I recentlymet a lady who was diagnosed with hemiplegic migraines. http://neuro-www.mgh.harvard.edu/neurowebforum/HeadacheArticles/HemiplegicMigrai

Hemiplegic Migraine This response submitted by Lawana on 10/7/96. Author's Email: beard@hiwaay.net I have migraines with aura as well as numbness and pain on the left side of my body. I also sometimes have severe pain in the left side of my face where the nerve goes through the cannel in the jaw (trigeminal neuralgia). I've been diagnosed with everything from MS to fibromyalgia as well as classic migraines. I had to go off the depakote (for the migraines) because it was causing my hair to fall out. Because of pain and etc. I can't do the things I want to do for my family. I recently met a lady who was diagnosed with hemiplegic migraines. Could someone explain a little more about this and where to get more information and help. Previous Article Return to Main Article Article complete. Click HERE to return to the Neurology Web-Forum Menu.

89. A Population-based Study Of Familial Hemiplegic Migraine Suggests Revised Diagno Familial hemiplegic migraine (FHM) is a rare autosomal dominantly inheritedsubtype of migraine Familial hemiplegic migraine More than just a headache http://brain.oxfordjournals.org/cgi/content/abstract/125/6/1379

JOURNAL HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Full Text FREE Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed ... Cited by other online articles Search for citing articles in: ISI Web of Science (18) Request Permissions PubMed PubMed Citation Articles by Thomsen, L. L. Articles by Russell, M. B. Brain, Vol. 125, No. 6, 1379-1391, June 2002 Guarantors of Brain A population-based study of familial hemiplegic migraine suggests revised diagnostic criteria L. L. Thomsen M. K. Eriksen S. F. Roemer I. Andersen J. Olesen and M. B. Russell Copenhagen Headache Center, Department of Neurology, Glostrup Hospital and Department of Neurology, Gentofte Hospital, University of Copenhagen, Denmark Correspondence: Lise Lykke Thomsen, The Danish Headache Center, University of Copenhagen, Department of Neurology, Glostrup Hospital, Ndr. Ringvej 57, 2600 Glostrup, Denmark E-mail: Familial hemiplegic migraine (FHM) is a rare autosomal dominantly inherited subtype of migraine with aura. The clinical characteristics

90. Single-fiber EMG In Familial Hemiplegic Migraine -- Terwindt Et Al. 63 (10): 194 Twelve familial hemiplegic migraine (FHM) patients (6 with the I1811L mutationin CACNA1A, 3 with M731T mutation in ATP1A2, and 3 without known mutations) http://www.neurology.org/cgi/content/abstract/63/10/1942

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Figures Only Full Text Full Text (PDF) ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Terwindt, G. M. Articles by van Dijk, J. G. Related Collections EMG All Genetics Migraine NEUROLOGY 2004;63:1942-1943 American Academy of Neurology Brief Communications Single-fiber EMG in familial hemiplegic migraine G. M. Terwindt, MD, PhD E. E. Kors, MD A. A. Vein, MD, PhD M. D. Ferrari, MD, PhD and J. G. van Dijk, MD, PhD From the Department of Neurology and Clinical Neurophysiology, Leiden University Medical Center, The Netherlands. Address correspondence and reprint requests to Dr. Gisela M. Terwindt, Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands; e-mail: Twelve familial hemiplegic migraine (FHM) patients (6 with the I1811L mutation in CACNA1A, 3 with M731T mutation in ATP1A2

91. Variability Of Familial Hemiplegic Migraine With Novel A1A2 Na+/K+-ATPase Varian A1A2 Na+/K+ATPase mutations cause familial hemiplegic migraine type 2 (FHM2).The authors identified three putative A1A2 mutations (D718N, R763H, http://www.neurology.org/cgi/content/abstract/62/10/1857

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Figures Only Full Text Full Text (PDF) ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Jurkat-Rott, K. Articles by Dichgans, M. Related Collections All Cerebrovascular disease/Stroke Infarction All Genetics Migraine NEUROLOGY 2004;62:1857-1861 American Academy of Neurology Brief Communications Variability of familial hemiplegic migraine with novel A1A2 Na /K -ATPase variants K. Jurkat-Rott, MD T. Freilinger, MD J. P. Dreier, MD J. Herzog, MD G. C. Petzold, MD P. Montagna, MD T. Gasser, MD F. Lehmann-Horn, MD and M. Dichgans, MD A1A2 Na /K -ATPase mutations cause familial hemiplegic migraine type 2 (FHM2). The authors identified three putative A1A2 mutations (D718N, R763H, P979L) and three that await validation (P796R, E902K, X1021R). Ten to 20% of FHM cases may be FHM2. A1A2 mutations

92. Study Posting (1512) -- Trial #55941, Migraine (Pediatric), Norfolk, VA Children and adolescents who suffer from Basilar/hemiplegic migraine Headachestypically experience occasional moderate to severe headaches, http://www.centerwatch.com/patient/studies/stu55941.html

Trial Information Summary: A Double-Blind, Dose Comparison Study of an Investigational Drug in Pediatric Subjects Between the Ages of 6 and 18 years with Basilar/Hemiplegic Migraine Headaches We are currently conducting a research study for children and adolescents with Basilar/Hemiplegic Migraine Headaches. Children and adolescents who suffer from Basilar/Hemiplegic Migraine Headaches typically experience occasional moderate to severe headaches, pounding in nature, often accompanied by nausea or vomiting and discomfort caused by light or sound. In addition to these symptoms they will typically experience two or more of the following symptoms: vertigo, double vision, decreased hearing, numbness, and altered level of consciousness. In between their headaches these youngsters are usually symptom free and healthy. If this describes your adolescent, he or she may be eligible for this research study. To be eligible to participate, your adolescent must: Be 6-18 years of age and weigh at least 55 pounds Have an average of at least 4 migraines-days per month during the previous 3 months prior to screening Be in good health and willing to take the study medication as directed by the study doctor All study related clinic visits, testing, and study medications are provided at no cost.

93. Human Genome News, January 1998; 9(1-2) A subset of migraines, called hemiplegic migraine, is often preceded by an aura.hemiplegic migraine has also been associated with another disease called http://www.ornl.gov/sci/techresources/Human_Genome/publicat/hgn/v9n1/01carran.sh

Human Genome Project Information Genomics:GTL Microbial Genome Program home ... go to current issue Human Genome News Archive Edition Sponsored by the U.S. Department of Energy Human Genome Program Human Genome News, January 1998; 9:(1-2) Genome Resources Help Scientists Explore Life-Environment Interactions Most current tests for human exposure to environmental mutagens are only indicators of genetic damage and cannot predict adverse outcomes for individuals. In the following article, Anthony V. Carrano [Lawrence Livermore National Laboratory (LLNL)] explains that the future of genetic toxicology and mutation research lies in studying genes and individual genetic variation to reveal risk factors that make some people more susceptible to disease. The basic topic addressed by scientists who explore these issues, he notes, is the nature and consequence of genetic change or variation, with the ultimate purpose of predicting or preventing disease. This article is excerpted from a talk by Carrano at the Human Genome Project session at the 1997 Society of Toxicology meeting in Cincinnati, Ohio. Other speakers were J. Craig Venter (The Institute for Genomic Research), Henry Wagner (Johns Hopkins University), and Richard Woychik (now at Case Western Reserve University). The first 6 years of the Human Genome Project are behind us, and now resources can be applied to functional genomic studies, the genomics of the future. Functional genomics will be facilitated by completing the entire human genome sequence as soon as possible and, along the way, sequencing a significant portion of the mouse and other model-organism genomes. We want to determine all transcript structures and gene-expression patterns in the human genome; ultimately, we want to understand the phenotypes resulting from mutations in every one of the open reading frames. Many groups have begun working in this area even before the genome project is completed, and much work reported at recent genome meetings is pointed toward functional genomics.

94. P428 : Familial Hemiplegic Migraine (FHM): Mutational Analysis Of The FHM2 Gene Background Familial hemiplegic migraine (FHM), a rare autosomal dominant subtypeof migraine with aura, is genetically heterogeneous FHM1 is associated http://www.thieme.de/abstracts/aktneu/abstracts2003/daten/p428.html

Familial hemiplegic migraine (FHM): Mutational analysis of the FHM2 gene ATP1A2 in German families Freilinger T Herzog J Jurkat-Rott K Lehmann-Horn F Gasser T Dichgans M Background: Familial hemiplegic migraine (FHM), a rare autosomal dominant subtype of migraine with aura, is genetically heterogeneous: FHM1 is associated with missense mutations of the CACNA1A gene on chromosome 19p13. The gene for FHM2, ATP1A2 on chromosome 1q23, has recently been cloned, with only two different mutations described so far (De Fusco et al. 2003). Objective: To screen for mutations within the ATP1A2 gene in German FHM families. Methods: Results: Genetic analysis confirmed the known genetic heterogeneity of FHM. All families compatible with linkage to chromosome 1q23 were included in a mutational analysis of the ATP1A2 gene. We identified a novel mutation in the ATP1A2 gene which cosegregates with the disease status and was not detected on 100 control chromosomes. The mutation is located in a highly conserved region of the ATP1A2 gene in close proximity to one of the two previously reported mutations. Conclusions: Our results confirm ATP1A2 as a second gene for FHM by expanding the spectrum of mutations. Mutational screening of ATP1A2 in additional FHM families is underway. Functional analysis of cells expressing the mutant gene product may contribute to a better understanding of the pathophysiological mechanisms underlying FHM and thus to targeted treatment.

95. A Case Of Hemiplegic Migraine In Childhood: Transient Unilateral Hyperperfusion We report on a patient with hemiplegic migraine, in whom MR imaging revealed Since she had a recurrent attack of hemiplegic migraine 10 months after her http://www.ajnr.org/cgi/content/full/22/9/1795

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Abstract Figures Only Full Text (PDF) ... Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager PubMed PubMed Citation Articles by Masuzaki, M. Articles by Mitsudome, A. American Journal of Neuroradiology 22:1795-1797 (October 2001) American Society of Neuroradiology ARTICLE A Case of Hemiplegic Migraine in Childhood: Transient Unilateral Hyperperfusion Revealed by Perfusion MR Imaging and MR Angiography Mayumi Masuzaki a Hidetsuna Utsunomiya a Sawa Yasumoto a and Akihisa Mitsudome a a From the Departments of Pediatrics (M.M., S.Y., A.M.) and Radiology (H.U.), Fukuoka University School of Medicine, Fukuoka, Japan. Abstract TOP Abstract Introduction Case Report Discussion References Summary: We report on an 8-year-old girl with a typical attack of hemiplegic migraine, in whom MR angiography and perfusion

96. Japanese Cases Of Familial Hemiplegic Migraine With Cerebellar Ataxia Carrying A Keywords familial hemiplegic migraine; P/Q type Ca channel; Familial hemiplegicmigraine (FHM) is an autosomal dominantly inherited disorder http://jnnp.bmjjournals.com/cgi/content/extract/72/5/676-a

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Author Keyword(s) Vol Page [Advanced] This Article Full Text Full Text (PDF) Submit a response ... Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Takahashi, T Articles by Tsuji, S Related Collections Genetics Migraine Journal of Neurology Neurosurgery and Psychiatry LETTER Japanese cases of familial hemiplegic migraine with cerebellar ataxia carrying a T666M mutation in the CACNA1A gene T Takahashi S Igarashi T Kimura I Hozumi I Kawachi O Onodera H Takano M Saito and S Tsuji Department of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi, Niigata 951-8585, Japan Correspondence to: Professor Tsuji;

97. Migraine Associated Vertigo Familial hemiplegic migraine has been linked to mutations in the calcium channel Familial hemiplegic migraine and episodic ataxia type2 are caused by http://www.tchain.com/otoneurology/disorders/central/migraine/mav.html

Migraine Associated Vertigo (MAV) Adapted from lecture handout given for the seminar "Recent advances in the treatment of Dizziness", American Academy of Neurology, 1997 and "Migraine Vs Meniere's", at the American Academy of Otolaryngology meeting, 1999-2001. Last edited: 2/2003 Please read our Education Index Search this site Timothy C. Hain, MD , Chicago IL. Dizziness and headache are individually very common human conditions and their combination is also a common symptom complex. Diagnostically, one must determine whether the dizziness and headaches are independent or related to each other, and in particular, whether they are a manifestation of migraine. Here we will review the association between vertigo and migraine. This subject has also been recently reviewed by Reploeg and Goebel (2002) as well as Radke et al (2002). Epidemiology Nearly 13% of the adult population of the United States has migraine. There is a male-female distribution difference. At all ages, about 5% of men have migraine (Stewart, 1994; Lipton et al, 2002). Women of childbearing age have a much higher prevalence, jumping up to roughly 10% at the onset of menstruation, and increasing to nearly 30% at the peak age of 35 years. At menopause, rates of migraine abruptly decline in women back to roughly 10%. The prevalence of Migraine is far higher than that of Meniere's disease , which occurs in only 0.2% of the US population (Wladislavosky-Waserman et al, 1984). In a small study of persons with Menieres disease, the prevalence of Migraine was about 50%, compared with a figure of about 25% in the non-Meniere's population (Radke et al, 2002). Other studies have shown different results however. There have also been recent studies showing that there is a higher frequency of

98. The Familial Hemiplegic Migraine Mutation R192Q Reduces G-protein-mediated Inhib Familial hemiplegic migraine is associated with at least 13 different missense Gating Deficiency in a Familial hemiplegic migraine Type 1 Mutant http://jp.physoc.org/cgi/content/abstract/546/2/337

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: Physiology in Press First published online on November 22, 2002. This Article Full Text Full Text (PDF) All Versions of this Article: most recent Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Cited by other online articles PubMed PubMed Citation Articles by Melliti, K. Articles by Seabrook, G. R. J Physiol pp. DOI: 10.1113/jphysiol.2002.026716 The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca V 2.1) calcium channels expressed in human embryonic kidney cells Karim Melliti, Manfred Grabner* and Guy R. Seabrook Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK and *Department of Biochemical Pharmacology, University of Innsbruck, A-6020 Innsbruck, Austria Familial hemiplegic migraine is associated with at least 13 different missense mutations in the 1A Ca channel subunit. Some of these mutations have been shown to affect the biophysical properties of

99. The Familial Hemiplegic Migraine Mutation R192Q Reduces G-protein-mediated Inhib Familial hemiplegic migraine is associated with at least 13 different missense Familial hemiplegic migraine and episodic ataxia type2 are caused by http://jp.physoc.org/cgi/content/full/546/2/337

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: Physiology in Press First published online on November 22, 2002. This Article Abstract Full Text (PDF) All Versions of this Article: most recent Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Cited by other online articles PubMed PubMed Citation Articles by Melliti, K. Articles by Seabrook, G. R. J Physiol pp. DOI: 10.1113/jphysiol.2002.026716 The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca V 2.1) calcium channels expressed in human embryonic kidney cells Karim Melliti, Manfred Grabner* and Guy R. Seabrook Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK and *Department of Biochemical Pharmacology, University of Innsbruck, A-6020 Innsbruck, Austria ABSTRACT Top Abstract Introduction Methods Results Discussion References Familial hemiplegic migraine is associated with at least 13 different missense mutations in the 1A Ca channel subunit. Some of these mutations have been shown to affect the biophysical properties of

100. Pharmacologic Management Of Acute Attacks Of Migraine And Prevention Of Migraine or 4) the presence of uncommon migraine conditions, including hemiplegicmigraine, migraine with prolonged aura, or migrainous infarction. http://www.guideline.gov/summary/summary.aspx?ss=15&doc_id=3592&nbr=2818

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