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         Hemiplegic Migraine:     more detail
  1. Channelopathy: Cystic Fibrosis, Autosomal Dominant Polycystic Kidney, Brugada Syndrome, Familial Hemiplegic Migraine

61. Internet Scientific Publications, LLC.
Familial hemiplegic migraine, A Case Report Of Attack Associated Findings Transcranial Doppler sonography in familial hemiplegic migraine.
http://www.ispub.com/ostia/index.php?xmlPrinter=true&xmlFilePath=journals/ijn/vo

62. GeneReviews: Familial Hemiplegic Migraine
Migraine hemiplegic migraine aura consisting of hemiplegia and/or hemiparesis a chromosomal abnormality has been confirmed in familial hemiplegic migraine.
http://www.genetests.org/query?dz=fhm

63. The Health Library — Nervous System And Brain
Genes and MigraineACHE MigraineMedlinePlus. Familial hemiplegic migraine.hemiplegic migraineACHE Familial hemiplegic migraineGeneReviews
http://healthlibrary.stanford.edu/resources/internet/bodysystems/neuro_headache.
Diseases and Disorders Use these links to jump directly to your topic of interest in Nervous System and Brain: Signs and Symptoms: Pain Neurologic Manifestations Language Disorders Perceptual Disorders Central Nervous System: Brain Diseases Brain Injury Infections Malformations ... Tumors Other Diseases and Disorders: Autoimmune Nervous System Diseases Autonomic Nervous System Diseases Cranial Nerve Disorders Degenerative Nervous System Diseases ... Sleep Disorders Other Topics: General Nervous System and Brain Anatomy Diagnostic Procedures Neural Transplantation Headache and Migraine (Jump to: General Information Headache and Migraine in Children Headache in Seniors Headache Treatment ... Organizations Types of Headache: Cervicogenic Cluster Exercise-Related Hemicrania Continua ... Tension Organizations American Council for Headache Information (ACHE) National Headache Foundation (NHF) General Information Headache: Hope Through Research:NINDS Causes and Diagnosis of Headaches:UpToDate Patient Information Headaches, Self-Care Flowchart:American Academy of Family Physicians Headache Pain:National Pain Foundation ... Headache:MedlinePlus Headache and Migraine in Children Kids Get Headaches Too:ACHE Headaches in Children and Adolescents:American Academy of Family Physicians Headache in Adolescents:ACHE Recognizing Headache in Students:ACHE ... Headache in Kids: A Guide for Parents:ACHE Headache in Seniors Headaches in Older People:Postgraduate Medicine Headache and the Mature Adult:ACHE Headache Treatment, General

64. The Bioline EPrints Archive - EEG In Hemiplegic Migraine
EEG in hemiplegic migraine. Varkey, B and Varkey, L (2004) EEG in hemiplegicmigraine. Neurology India 52(1)134. Full text available as
http://bioline.utsc.utoronto.ca/archive/00001213/
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EEG in hemiplegic migraine
Varkey, B and Varkey, L EEG in hemiplegic migraine Neurology India Full text available as:
PDF
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Abstract
no abstract Item Type: Journal (Paginated) Keywords: Subjects: Medicine Neurology ID Code: Deposited By: Jairam, Jennifer Deposited On: 26 May 2004 Alternative Locations: http://www.bioline.org.br/request?ni04048 http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2004;volume=52;issue=1;spage=134;epage=134;aulast=Varkey Repository Contact Information © 2005 Bioline International

65. Blackwell Synergy - Cookie Absent
Familial hemiplegic migraine and episodic ataxia type2 are caused by Familial hemiplegic migraine type 2 is linked to 0.9Mb region on chromosome 1q23.
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1743-5013.2005.20311.x
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66. Familial Hemiplegic Migraine
(FHM) A type of migraine with aura with particular family history.
http://www.aboutmigraines.com/reference/headache-glossary/definitions.asp?171-fa

67. 602481 MIGRAINE, FAMILIAL HEMIPLEGIC, 2; FHM2
A history of migraine or hemiplegic migraine was found in several family members.Linkage to chromosome 1q21q23 was found. Marconi et al.
http://srs.sanger.ac.uk/srsbin/cgi-bin/wgetz?[omim-ID:602481] -e

68. *182340 ATPase, Na+/K+ TRANSPORTING, ALPHA-2 POLYPEPTIDE; ATP1A2
In a family with familial hemiplegic migraine2 (602481), De Fusco et al. (2003)identified a heterozygous 2763T-C mutation in the ATP1A2 gene, resulting in
http://srs.sanger.ac.uk/srsbin/cgi-bin/wgetz?[omim-ID:182340] -e

69. Familial Hemiplegic Migraines Familial Hemiplegic Migraines Are
To be termed a familial hemiplegic migraine, the sufferer must have A familialhemiplegic migraine is ususally inherited from the mother and the
http://www.cem.msu.edu/~cem181h/projects/97/migrane/familia.htm
Familial hemiplegic migraines Familial hemiplegic migraines are associated with severe headache pain and a gradual onset of unilateral weakness or heaviness. To be termed a familial hemiplegic migraine, the sufferer must have symptoms of hemiparesis or a pins and needles feeling on one side or limb of the body. This type of migraine could completely resolve in minutes or last several hours, but the hemiparises will last hours or days beyond the headache itself. It is also very typical that the hemiparesis may being evfen before the headache attack. A complicated hemiplegic attack also occurs, where the weakness may last up to two weeks or may never resolve entirely. A familial hemiplegic migraine is ususally inherited from the mother and the affected side of the body in most instances is associated with dysphasia and other cortical symtoms. Becuase of ischaemic changes in the cerebrum and brainstem, deaths due to familial hemiplegic migraines have been recorded. Back to Main Page

70. The Migraine Gene Overview The Familial Hemiplegic Migraine, FHM
The familial hemiplegic migraine, FHM, a subtype of migraine with aura, The familial hemiplegic migraine is the result of a missense mutation in the
http://www.cem.msu.edu/~cem181h/projects/97/migrane/genetics.htm
The Migraine Gene Overview The familial hemiplegic migraine, FHM, a subtype of migraine with aura, has been mapped to chromosome 19p13.
    Diagram of the gene where chromosome 19p13 is found
Brain-secifif P/Q-type calcium-channel alpha -subunit gene, CACNA1A is identified in the responsible region of 47 exons covering 300 kb. The familial hemiplegic migraine is the result of a missense mutation in the alpha subunit. In the sequencing of all the exons and their corresponding surroundings, a polymorphic variation is revealed, including a (CA) n -repeat and a (CAG) n -repeat in the 3' untranslated region. In the familial hemiplegic migraine, four missense mutations were discovered in conserved functional domains and one of the mutations has occurred in two different unrelated families of hemiplegic migraines. FHM is a rare autosomal dominant subtype migraine with aura and is associated within some families with progressive cerebellar atrophy and ictal hemiparesis. The cerebellar atrophy was found in FHM is linked to the chromosome 19p13. The region that contains chromosome 19p13 FHM locus is also involved with migraines with or without auras. This adds to the hypothesis that FHM is part of the migraine spectrum involving biological mechanisms and similar genetic factors. Mutations In FHM, several synonymous nucleotide substitutions and polymorphisms were identified by their occurrence in lack of cosegregation with the disease and in unaffected controls. The

71. ATP1A2 - Sodium/potassium-transporting ATPase Alpha-2 Chain Precursor
Familial hemiplegic migraine, a rare Mendelian form of MA, can be caused by The shared hemiplegic migraine phenotype of mutations in ATP1A2 and CACNA1A
http://www.pdg.cnb.uam.es/UniPub/iHOP/gg/86601.html
Novel mutations in the Na+, K+-ATPase pump gene associated with familial hemiplegic migraine and benign familial infantile convulsions Abstract-9990634
Here we show that mutations in the gene that encodes the alpha2 subunit of the Na+/K+ pump are associated with familial hemiplegic migraine type 2 ( ) linked to chromosome 1q23 (OMIM 602481). Abstract-9658968
The mechanism by which activates the promoter is discussed. Abstract-7631237
The Na,K-ATPase gene ( ) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene ( ) on mouse chromosome Abstract-8336549
MAIN OUTCOME MEASURES: Presence of mutations in and Abstract-10211378
No mutations in and in probands with common types of migraine Abstract-10211378
The predicted polypeptide is 1029 amino acids and shares 82 and 79.8% identity, respectively, with human and Abstract-9511557
In this family, all available affected family members with FHM, benign familial infantile convulsions , or both, carry the mutation.

72. Migraine
hemiplegic migraine Patients with hemiplegic migraine have temporary paralysison one side of the body, a condition known as hemiplegia.
http://www.healthywomen.org/content.cfm?L1=3&L2=54

73. Untitled Document
genetic mutation responsible for the very rare familial hemiplegic migraine, channels appears to be responsible for familial hemiplegic migraine.
http://www.nym.org/healthinfo/docs/097/doc97causes.html
WHAT CAUSES MIGRAINE HEADACHES?
Until recently, the general theory on the migraine process rested solely on the idea that abnormalities of blood vessel (vascular) systems in the head were responsible for migraines. Now, however, experts tend to believe that migraine starts with an underlying central nervous system disorder, which, when triggered by various stimuli, sets off a chain of neurologic and biochemical events, some of which subsequently affect the brain's vascular system. No experimental model fully explains the migraine process.
There is certainly a strong genetic component in migraine with or without auras. Researchers have located a single genetic mutation responsible for the very rare familial hemiplegic migraine, but a number of genes are likely to be involved in the great majority of migraine cases. A number of chemicals, structures, nerve pathways, and other players involved in the process are under investigation.
General Theories to Explain Migraine
Central Nervous Disorder.

74. WCVB-TV Health Center Forums
hemiplegic migraines. i started having symptoms 3 months ago. it I have beendiagnosed with familal hemiplegic migraines. I have
http://wcvb-tvhealth.ip2m.com/forum/index.cfm?fuseaction=forum.viewThread&thread

75. Vascular Headache Of Migraine Type
hemiplegic migraine. Definition Vascular headache featured by motor phenomena which Return to hemiplegic migraine, Return to hemiplegic migraine
http://medlib.med.utah.edu/pain_center/education/outlines/headache/vascular.html
Vascular Headache of Migraine Type Headache Classification Quickmenu Vascular Muscle-contraction Combined Nasal vasomotor reaction Delusional, hypochondriacal Nonmigrainous vascular Traction Cranial inflammation
  • Migraine with aura (Classic migraine)
  • Migraine without aura (Common) migraine
  • "Cluster" headache
  • "Hemiplegic" and "ophthalmoplegic" migraine ...
  • "Lower half" headache
  • Migraine with aura (Classic migraine)
  • Definition
    Recurrent attacks of headache, widely varied in intensity, frequency and duration. Attacks are commonly unilateral in onset, associated with anorexia, and, sometimes, nausea and vomiting. Headaches are preceded by sharply defined transient visual and other sensory or motor prodromes or both.
  • Cause
    Etiology unknown. Appears to be related to disordered brain physiology. Up to 70% of patients have a positive family history for headache. Frequently, the headache is an abnormal response to stress. The aura may be secondary to cerebral vasospasm; the head pain may be a result of activation of the trigeminovascular system.
  • Age of onset
    usually starts during childhood or teenage years, up to 40 years of age.
  • 76. Health/Conditions And Diseases/Neurological Disorders/Headaches/Migraine/Hemiple
    American Council for Headache Education hemiplegic migraine Page List of symptomsassociated with hemiplegic migraine. url www.achenet.org/kids/hemi.php
    http://www.thedoctorslounge.net/dir/Health/Conditions_and_Diseases/Neurological_
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  • American Council for Headache Education Hemiplegic Migraine Page List of symptoms associated with hemiplegic migraine. url: www.achenet.org/kids/hemi.php Migraine Gene Discovered Article discusses rare form of hemiplegic migraine linked to gene on chromosome 19. url: www.pnl.gov/er_news/12_96/migraine.htm National Headache Foundation Brief description of the condition. url: www.headaches.org/consumer/topicsheets/hemiplegic.... mozilla.org url: mozilla.org/
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    77. The Neuroscientist -- Sign In Page
    The clinical spectrum of familial hemiplegic migraine associated with Mapping of a second locus for familial hemiplegic migraine to 1q21q23 and
    http://nro.sagepub.com/cgi/content/refs/11/4/373

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    Migraine: New Molecular Mechanisms
    Pietrobon Neuroscientist.
    This Article Abstract Full Text (PDF) References ... Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Reprints and Permissions PubMed PubMed Citation Articles by Pietrobon, D. To view this item, select one of the options below: Sign In User Name Sign in without cookies.
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    78. Current Opinion In Neurology - UserLogin
    The locations of the mutations that cause familial hemiplegic migraine (squares) Familial hemiplegic migraine and episodic ataxia Type2 are caused by
    http://www.co-neurology.com/pt/re/coneuro/fulltext.00019052-199802000-00001.htm
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    79. Health Report - 12/1/1997: Genes And Migraines
    We call it familial hemiplegic migraine. So like all other migraines you havethe headache but on top of that you have the onesided paresis.
    http://www.abc.net.au/rn/talks/8.30/helthrpt/stories/s360.htm

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    Genes and Migraines
    Broadcast Monday 1 December 1997
    with Summary:
    A research team in the Netherlands has discovered a genetic defect associated with migraine in some people with a very severe
    form of these disabling headaches Transcript: Norman Swan: A research team in The Netherlands has discovered a genetic defect associated with migraine in some people with a very severe form of these disabling headaches. The finding could offer a new avenue to better anti migraine drugs. Here's The Health Report's correspondent in the Low Countries, Ann Blair-Gould. Ann Blair-Gould: Between 10% and 12% of the population of most countries suffers from migraines, and the statistics show that it tends to occur in families although migraines are not inherited in the simple predictable manner; and that it occurs much more often in women, about 2-and-a-half-times more often than in men. So when I recently read that scientists at Leiden University here in The Netherlands had come up with a new model of how we think migraines come about, I went off to see what I could find out. I spoke there to Professor Rune Frants, who is originally from Finland, and who is head of the Department of Human Genetics at Leiden. I asked him first what we've known about what causes migraines up till now. Rune Frants: Biochemically, something with serotonin.

    80. Case Vignettes In Neurology
    Migraine (familial hemiplegic migraine) Other causes of headache include cluster hemiplegic migraine neurological examination, imaging study if focal
    http://medocs.ucdavis.edu/neu/420/cases/cases99/CASE6.HTM
    Case Index PATIENT CASE STUDIES Case 6 2/15 Patient
    Case discussion
    The mother and sister in addition have a history of recurrent attacks of weakness of the right side of the body involving the face, arm and leg. These episodes of weakness last several hours and are invariably associated with a stereotypical headache.
    General and neurological examination was normal.
  • Summarize the Case in 1-2 sentences. This is a 28 yr-old female with recurrent, frequent hemicranial throbbing headaches with nausea and a family history of similar headaches with hemiparesis. Headaches are hormonally related and examination is normal.
  • Discuss lesion localization on the basis of the physical examination. 5th cranial nerve, vascular
  • Discuss underlying pathogenesis on the basis of clinical course. Recurrent, episodic suggests vascular; also suggests channelopathy
  • Indicate one likely clinical diagnosis. List (or classify) alternative diagnoses. Migraine (familial hemiplegic migraine) Other causes of headache include cluster headaches, tension headaches, raised intracranial pressure, inflammation of meninges/blood vessels.
    Cluster headaches occur as unilateral headaches occurring in clusters for example occurring daily for 30 minutes for a period of 6 weeks every year and are associated with tearing of one eye and running nose on the side of the headache Tension headaches occur as nonthrobbing headaches occurring intermittently associated with tightness in muscles (e.g. of neck) without nausea, precipitated by stress, with tenderness (pain on palpation) of muscles.
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