21. Three New Familial Hemiplegic Migraine Mutants Affect P/Q-type Three New Familial hemiplegic migraine Mutants Affect P/Qtype Ca2+ Channel Kinetics* Richard L. Kraus, Martina J. Sinnegger http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

22. Familial Hemiplegic Migraine Information Diseases Database Familial hemiplegic migraine, Disease Database Information. http://www.diseasesdatabase.com/ddb4693.htm

Diseases Database Index Sponsors Contact ... Previous Page Familial hemiplegic migraine information Search Familial hemiplegic migraine may cause or feature (Follow link for list.) may be allelic with (Follow link for list.) belong(s) to the category of (Follow link for list.) No UMLS definitions. Familial hemiplegic migraine: specific web sites Send Familial hemiplegic migraine to medical search engines (JavaScript enabled browsers only.) If your browser has no JavaScript you can still use these: Search using Internet medical databases Search using Internet search engines (non-specialist) We subscribe to the HONcode principles of the Health On the Net Foundation Valid XHTML 1.0 Served 2005-09-09 07:07:15 View metadata Last major update 2005-09-03. The medical information here is presented for education, background reading and general interest. The Diseases Database is not a diagnostic or clinical decision-making tool. Please consult your own licensed physician regarding diagnosis and treatment of any medical condition! Content is not asserted complete or error free, please see also our

23. What Is Hemiplegic Migraine? From All Info About Headaches And Migraine Disease In order to discuss hemiplegic migraine, we have to understand that Migraine canpresent in a variety of ways. hemiplegic migraine is a rare form of http://headaches.allinfoabout.com/articles/hemiplegic.htm

All Info About Headaches and Migraine Disease All info about Site Title All Info About advertise with us contacting us Select Your Language Deutsch Español Francais Italiano ... Portuguese Topics Fundamentals Articles FAQ Doctors ... Migraine Disease Home Shop For Books With Amazon What Is Hemiplegic Migraine? In order to discuss Hemiplegic Migraine, we have to understand that Migraine attacks are episodic manifestations of a genetic neurological disease. Migraine can present in a variety of ways. Hemiplegic Migraine is a rare form of Migraine, made more confusing by there being two variations: Familial Hemiplegic Migraine (FHM) and Sporadic Hemiplegic Migraine (SHM). Both FHM and SHM often begin in childhood and cease during adult years. Diagnosing FHM and SHM can be difficult as the symptoms are also indicative of vascular disease. and can be thought to be stroke, epilepsy, or other conditions. A full neurological work up and careful review of medical history and symptoms are necessary to rule out other causes and confirm a diagnosis of FHM or SHM. Family medical history is especially helpful in diagnosing FHM. FHM and SHM share the same symptoms, which will vary among different Migraineurs. The difference between the two is that FHM can be traced back in the family history and has been linked to mutations of specific genes on chromosomes 1 and 19. SHM is FHM without the familial connection and that particular genetic mutation.

24. All Info About Chronic Pain, Headache. Glossary: Sporadic Hemiplegic Migraine Glossary Sporadic hemiplegic migraine. All Info About Chronic Pain, Headache, For people who suffer from chronic pain, headaches, or Migraine disease http://headaches.allinfoabout.com/glossary/gloss-hemi-mig-spor.htm

All Info About Chronic Pain, Headache, and Migraine All info about Site Title All Info About advertise with us contacting us Select Your Language Deutsch Español Francais Italiano ... Portuguese Topics Fundamentals Articles FAQ Doctors ... Migraine Disease Home Shop For Books With Amazon Sporadic Hemiplegic Migraine : Migraine with aura including motor weakness but no first-or second-degree relative has Migraine with aura including motor weakness. International Headache Society diagnostic criteria: A. At least 2 attacks fulfilling criteria B and C. B. Aura consisting of fully reversible motor weakness and at least one of the following: 1. fully reversible visual symptoms including positive features (e.g., flickering lights, spots or lines) and/or negative features, (i.e., loss of vision) 2. Fully reversible sensory symptoms including positive features (i.e., pins and needles) and/or negative features (i.e., numbness) 3. fully reversible

25. EMedicine - Migraine Variants Article By Gretchen L Birbeck, MD Alternating hemiplegic migraine (primarily in childhood) A gene has beenidentified for familial hemiplegic migraine on chromosome band 19p13. http://www.emedicine.com/NEURO/topic219.htm

26. EMedicine - Childhood Migraine Variants : Article By Wendy G Mitchell, MD hemiplegic migraine (usually an autosomal dominant disorder) may present in early hemiplegic migraine may present in early childhood. Basilar migraine http://www.emedicine.com/neuro/topic494.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Neurology Pediatric Neurology Childhood Migraine Variants Last Updated: February 24, 2005 Rate this Article Email to a Colleague Synonyms and related keywords: abdominal migraine, acute confusional migraine, basilar migraine, benign paroxysmal vertigo of childhood, cyclic vomiting of childhood, hemiplegic migraine, migraine, migraine aura without headache, ophthalmoplegic migraine, vascular headache AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Wendy G Mitchell, MD , Program Director, Professor, Department of Pediatrics, Division of Neurology, Children's Hospital Los Angeles, University of Southern California Wendy G Mitchell, MD, is a member of the following medical societies: American Academy of Neurology American Academy of Pediatrics American Epilepsy Society , and Child Neurology Society Editor(s): James J Riviello, Jr, MD

27. Treatment Of Sporadic Hemiplegic Migraine With The Calcium-Channel Blocker Verap Treatment of Sporadic hemiplegic migraine with the CalciumChannel Blocker Verapamil. http://www.headachedrugs.com/archives/hemiplegic.html

Home About Dr. Robbins Archived Articles Headache Books ... Back to List Title: Author: Date: Source: Treatment of Sporadic Hemiplegic Migraine with the Calcium-Channel Blocker Verapamil Yu W. Horowitz SH Posted: June 2003 Neurology Key questions: Does neuronal calcium channel dysfunction underlie hemiplegic migraine, and is calcium channel blocker therapy effective? Method: The authors describe 4 patients with sporadic hemiplegic migraine (SHM) who were responsive only to oral or intravenous verapamil – not to other common migraine therapies. The authors had previously reported a successful response to intravenous verapamil in familial hemiplegic migraine (FHM); this study confirms the efficacy of this agent. Conclusions: If new genetic studies have revealed de novo mutation of CACN1A1 in patients with SHM, then it may be part of the spectrum of FHM syndrome. Neuronal calcium channel dysfunction may underlie the pathogenesis of both forms of hemiplegic migraine; the calcium-channel blocker verapamil is an effective treatment for both disorders. Home About Dr. Robbins

28. Genes And Migraine hemiplegic migraine The inherited or familial form of hemiplegic migraine isa rare In these families, hemiplegic migraine has an autosomal dominant http://www.headachedrugs.com/archives/genes_migraine.html

Home About Dr. Robbins Archived Articles Headache Books ... Back to List Title: Author: Date: Source: Genes and Migraine Kathy Gardner, MD Spring 1999 issue of ACHE Posted Sept 1999 Many migraineurs have other family members who also suffer with migraine headache. Mom used to have migraine headaches with her menstrual cycle, grandmother once had "sick" headaches, and brother has "sinus" headaches which are less severe but sound strangely similar to migraine if you ask questions about symptoms and triggers. For years scientists have argued whether disorders such as migraine that tend to run in families do so because of shared genes or the shared environment. People often assume that any disorder that occurs in several family members must be genetic. However, families tend to share similar diets, exposures and lifestyles, all of which might be involved in making someone susceptible to a specific disorder. A combination of genetic and environmental factors seems to be the best overall explanation for most common disorders, including migraine. Nevertheless, the fact that you occasionally find large families with many members suffering from migraine suggest a stronger genetic basis for those particular families. As it turns out, a definite inheritance pattern has been found in a few families who suffer with a severe form of migraine called hemiplegic migraine.

29. Botulinum Toxin Type A In The Treatment Of Sporadic Hemiplegic Migraine We report a unique case of a 47 year old woman with hemiplegic migraine responding To our knowledge this is the first case report of hemiplegic migraine http://www.priory.com/psych/Botulinum.htm

Botulinum Toxin Type A in the treatment of sporadic hemiplegic migraine: A case report. Authors and correspondence: Principle author and correspondence: Dr. Ray Goggins, Specialist Registrar in General Adult Psychiatry, Cirencester Memorial Centre, Sheep St, Cirencester, Gloucestershire, GL7 1QR raygoggins@yahoo.co.uk Telephone: +44 (01285) 640933 or +44 (07941) 865178 Fax: ++44 (0117) 9241750 Dr Daniel Rogers, Consultant Neuropsychiatrist, the Burden Centre, Bristol, BS16 1JB Telephone (0117) 9186710 Abstract Recent reports suggest that Botulinum toxin type A may help patients suffering from chronic pain disorders. We report a unique case of a 47 year old woman with hemiplegic migraine responding to botulinum toxin type A injections. There is increasing evidence that botulinum toxin type A may be a useful treatment for severe headaches and migraines. To our knowledge this is the first case report of its successful use in sporadic hemiplegic migraine. Case report A 44 year old woman was referred to a tertiary neuropsychiatric centre by her GP with disabling headaches. At the age of 41 she developed episodes of severe headache for the first time which gradually increased in severity. There was no family history of migraine. Episodes would start with nausea for 30 to 60 minutes followed by a pain in her forehead which could be right or left sided and occasionally bilateral and which spread gradually to the back of her head and down her neck. She also had mild photophobia, phonophobia and prostration. She often would notice "a cloudy film" over her vision but no classic migrainous visual disturbances. She described headaches as "horrendous" like "a tightening band" around her head. They occurred at any time of the day but often were present when she awakened. Simple analgesics were largely ineffective in reducing the pain.

30. ICHD-II 1.2.4 Familial Hemiplegic Migraine - Migraine Aura Information about migraine with aura for practicing neurologists and patients. http://www.migraine-aura.org/EN/ICHD-II_1.2.4_Familial_Hemiplegic_Migraine.html

Search Sitemap Navigation home ... Table IHS/WHO ICHD-II 1.2.4 About us Contact Readers' feedback Funding We subscribe to the HONcode principles. Verify here. Objectives Help us help Honors nominated for ICHD-II 1.2.3 ICHD-II 1.2.5 1.2.4 Familial hemiplegic migraine (FHM) Description: Migraine with aura including motor weakness and at least one first- or second-degree relative has migraine aura including motor weakness. Diagnostic criteria: A. At least 2 attacks fulfilling criteria B and C B. Aura consisting of fully reversible motor weakness and at least one of the following: fully reversible visual symptoms including positive features (eg, flickering lights, spots or lines) and/or negative features (ie, loss of vision) fully reversible sensory symptoms including positive features (ie, pins and needles) and/or negative features (ie, numbness) fully reversible dysphasic speech disturbance C.

31. ICHD-II 1.2.5 Sporadic Hemiplegic Migraine - Migraine Aura Information about migraine with aura for practicing neurologists and patients. http://www.migraine-aura.org/EN/ICHD-II_1.2.5_Sporadic_hemiplegic_migraine.html

Search Sitemap Navigation home ... Table IHS/WHO ICHD-II 1.2.5 About us Contact Readers' feedback Funding We subscribe to the HONcode principles. Verify here. Objectives Help us help Honors nominated for ICHD-II 1.2.4 ICHD-II 1.2.6 1.2.5 Sporadic hemiplegic migraine Description: Migraine with aura including motor weakness but no first- or second-degree relative has aura including motor weakness. Diagnostic criteria: A. At least 2 attacks fulfilling criteria B and C B. Aura consisting of fully reversible motor weakness and at least one of the following: fully reversible visual symptoms including positive features (eg, flickering lights, spots or lines) and/or negative features (ie, loss of vision) fully reversible sensory symptoms including positive features (ie, pins and needles) and/or negative features (ie, numbness) fully reversible dysphasic speech disturbance C.

32. EEG In Hemiplegic Migraine Varkey B, Varkey L Neurol India Neurol India is an peerreviewed biomedical periodical of Neurological Societyof India. http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2004;volume=52;iss

33. EEG In Hemiplegic Migraine, Varkey B, Varkey L: Neurol India Neurol India is an peerreviewed biomedical periodical of Neurological Societyof India. http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2004;volume=52;iss

34. Familial Hemiplegic Migraine Deciphering migraine mechanisms clues from familial hemiplegic migraine genotypes.Ann Neurology, 2004, 55, 2, 276279. http://www.dizziness-and-balance.com/disorders/central/migraine/familial_hemiple

Timothy C. Hain, MD Please read our Return to Index Search this site Page last modified: November 1, 2004 Familial Hemiplegic Migraine (FHM). This disorder is an autosomal domininant condition characterized by migraine, hemiparesis, and in some families, progressive cerebellar atrophy. FHM1 is associated with a mutation in the a-1 a subunit gene for calcium channels. Four different missence mutations have been identified. Mutations in this subunit have also been identified in one of the episodic ataxias , and in one of the spinocerebellar atrophies (SCA-6). FHM2 is associated with a mutaiton in the ATPase gene. It has recently been suggested that both of these mutations render the brain more susceptible to glutamate release (Moskowitz et al, 2004). FHM1 and FHM2 are characterized by enhanced susceptibility and sustained attacks of visual, somatosensory and aphasic auras as well as by prolonged motor weakness or paralysis. Photophobia, phonophobia, nausea and vomiting are also common symptoms. Motor weakness is uncommon in classic migraine (migraine with aura). References: Moskowitz and others. Deciphering migraine mechanisms: clues from familial hemiplegic migraine genotypes. Ann Neurology, 2004, 55, #2, 276-279.

35. Spinocerebellar Ataxia Familial hemiplegic migraine has also been linked to mutations in the calcium Familial hemiplegic migraine and episodic ataxia type2 are caused by http://www.dizziness-and-balance.com/disorders/central/cerebellar/sca.htm

Spinocerebellar Degenerations Timothy C. Hain, MD Please read our Return to Index Page last modified: August 6, 2005 Figure 1: Sagittal MRI of person with an inherited cerebellar degeneration (of unknown origin). This MRI shows prominent atrophy (shrinkage) of the midline (called the vermis). The main goal of this page is to serve as a repository for recent information about inherited cerebellar degenerations. It is not comprehensive, but we hope that it might be of some use to individuals searching for information about these rare conditions on the web. We highly recommend also using the OMIM database , which can be accessed on the web. A large number of the genetic ataxias can be tested for using contemporary methodology. An example of a lab that does this is Athena Most of the information here concerns inherited conditions, as there is considerable new data derived from researchers using a nearly complete map of the human genome (your tax dollar is doing some good !), and improvements in the technology of molecular biology. It seems quite feasible that within the next decade, we may be able to determine the gene that is damaged in most inherited cerebellar degenerations. As these data become known, it may also be possible to target specific therapies, probably over the next 2 decades. In other words, stay tuned, but we aren't there yet. There are numerous non-genetic causes of cerebellar disease.

36. HealingWell.com Community Forum I don t suffer from hemiplegic migraine myself, but I recently did a little Hi Mary, I too have hemiplegic migraine, there doesn t seem to be a lot of http://www.healingwell.com/community/default.aspx?f=31&m=253234

37. Familial Hemiplegic Migraine Families - HUM-MOLGEN Author, Topic Familial hemiplegic migraine Families. landres unregistered,posted 1105-2002 0831 PM Edit/Delete Message Reply w/Quote http://hum-molgen.org/bb/Forum2/HTML/000116.html

home genetic news bioinformatics biotechnology ... DIAGnostics - Clinical Research (professional requests) Familial Hemiplegic Migraine Families profile register preferences faq ... next oldest topic Author Topic: Familial Hemiplegic Migraine Families landres unregistered posted 11-05-2002 08:31 PM Dear Colleagues: We are currently looking for genes involved in familial hemiplegic migraine (FHM). We are interested in forming collaborations with clinicians/researchers with access to large Mendelian families with FHM. We would prefer to study families with greater than ten affecteds but families with six or more affecteds will be considered. We look forward to hearing from you. Please respond directly to: Lisa Andres, MS CGC Certified Genetic Counselor Xenon Genetics Inc. http://www.xenongenetics.com/ landres@xenongenetics.com IP: 209.139.213.1 All times are ET (US) next newest topic next oldest topic Administrative Options: Close Topic Archive/Move Delete Topic Hop to: Select a Forum or Archive List of Forums: Biotechnical requests and sources DIAGnostics - Clinical Research (professional requests) Ethical, legal and social implications

38. Entrez PubMed Aura in some patients with familial hemiplegic migraine can be stopped by intranasalketamine. Kaube H, Herzog J, Kaufer T, Dichgans M, Diener HC. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

39. Entrez PubMed Genes for familial hemiplegic migraine (FHM) and episodic ataxia type2 (EA-2)have been mapped to chromosome 19p13. We characterized a brain-specific http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8

40. ScienceDaily -- Browse Topics: Health/Conditions_and_Diseases/Neurological_Disor American Council for Headache Education hemiplegic migraine Page List of symptoms Migraine Gene Discovered - Article discusses rare form of hemiplegic http://www.sciencedaily.com/directory/Health/Conditions_and_Diseases/Neurologica

@import "/styles/navbar.css"; @import "/styles/tabStyles.css"; Set home page Bookmark site Add search Latest News ... Email to friend Text Size A A A Front Page ... Migraine : Hemiplegic Subtopics Search Google: Hemiplegic News Books Links ... Study Finds A Mouse Model For Episodic Neurological Disorders (August 5, 2002) full story [ More news about Hemiplegic List Price: Amazon.com's Price: You Save: Prices subject to change. Steps to Follow: The Comprehensive Treatment of Patients with Hemiplegia by: Patricia M. Davies May 15, 2000 List Price: Amazon.com's Price: You Save: Prices subject to change. Right in the Middle: Selective Trunk Activity in the Treatment of Adult Hemiplegia by: Patricia M. Davies July 01, 1990 Shoulder in Hemiplegia by: Rene Cailliet June 01, 1980 [ More books about Hemiplegic American Council for Headache Education Hemiplegic Migraine Page - List of symptoms associated with hemiplegic migraine. Migraine Gene Discovered - Article discusses rare form of hemiplegic migraine linked to gene on chromosome 19. National Headache Foundation - Brief description of the condition. Help build the largest human-edited directory on the web.

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