21. GLOMERULAR DISEASES Most glomerular diseases are capable of producing similar clinical findings. Today the use of renal biopsy allows glomerular diseases to be described as http://umed.med.utah.edu/ms2/renal/Word files/n) Glomerular Diseases.htm

GLOMERULAR DISEASES Wayne A. Border, M.D. Most glomerular diseases are capable of producing similar clinical findings. Historically, patients who had the acute onset of hematuria, proteinuria and renal failure were said to have the nephritic syndrome or glomerulonephritis. Patients who had a more insidious onset in which proteinuria leading to hypoalbuminemia and edema was the principal finding were said to have nephrosis or the nephrotic syndrome or glomerulopathy. Today the use of renal biopsy allows glomerular diseases to be described as distinct entities defined by a combination of associated functional, histologic, immunologic and etiologic factors. For each glomerular disease there is a body of knowledge about pathogenesis, natural history, prognosis and response to treatment. Clinical Manifestations of Glomerular Injury Red and white cells and cellular casts in the urine, proteinuria, and renal failure are three principal findings in glomerulonephritis. Abnormalities in urinalysis and proteinuria are present in most cases but the severity of proteinuria and renal failure varies from patient to patient as well as with the type of glomerulonephritis. Cellular casts only arise within renal tubules and can be found in either glomerulonephritis or interstitial nephritis.

22. Renal Endothelin-1 And Endothelin Receptor Type B Expression In Your browser does not support frames. Click here to view the unframed reprint. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

23. Glomerular Diseases Questions glomerular diseases. CASE 1. A 37 year old bank clerk consulted his physician one Wednesday on account of ankle swelling and puffy eyes. http://umed.med.utah.edu/ms2/renal/Small group questions/glomerular disease ques

GLOMERULAR DISEASES CASE 1 A 37 year old bank clerk consulted his physician one Wednesday on account of ankle swelling and puffy eyes. He had put on 20-30 lbs over the preceding few weeks. He was started on a diuretic and admission was arranged for early the following week but on Sunday night he was admitted as an emergency because of nocturnal dyspnea. Spun deposit - numerous oval fat bodies, granular and hyaline casts, some with fatty inclusions. Occ RBCs and RTECS (renal tubular epithelial cells). Labs: Na 132, K 3.l, Cl 92, HCO 31 mEq/L, BUN 34, creatinine 2.l mg/100 ml. Fasting glucose 68 mg/100 ml, albumin l.2 g/dl ANA negative. CH50 75 units (normal complement levels). Urine protein 18 g/24 h. Creatinine clearance 62 ml/min. I.V.P. Both kidneys are large, but no abnormalities were seen. A renal biopsy was performed and, based on the results, prednisone 60 mg on alternate days was administered, together with an increased dose of diuretics. One month later, his edema had subsided appreciably: creatinine clearance was 68 ml/min and 24 h protein excretion was 11 g/day. Glycosuria was now present and plasma K had fallen to 2.4 mEq/L.

24. Glomerular Diseases glomerular diseases Updated January 21, 2005 glomerular diseases National Institute of Diabetes and Digestive and Kidney Diseases http://www.noah-health.org/en/kidver/kidney/specific/glomerular.html

Skip navigation About NOAH Help English Spanish Both Advanced NOAH Kidney and Liver Change text size: Glomerular Diseases Updated: January 21, 2005 Alport Syndrome (Hereditary Nephritis) NOAH Page Asymptomatic Proteinuria and Hematuria Syndrome Merck Manual, 2nd Home Edition Glomerular Diseases National Institute of Diabetes and Digestive and Kidney Diseases Glomerulonephritis Kidney Foundation of Canada (also in French Glomerulonephritis Methodist Health Care System, Houston TX (also in Spanish Glomerulonephritis University of Maryland Medicine Glomerulonephritis Mayo Clinic Ischemic Nephropathy Mayo Clinic Post-Infectious Glomerulonephritis Mayo Clinic Analgesic Nephropathy Analgesic Nephropathy University of Virginia Health System (also in Spanish Analgesic Nephropathy (Pain Killers and the Kidneys) National Institute of Diabetes and Digestive and Kidney Diseases Immunoglobulin A (IgA) Nephropathy Immunoglobulin A (IgA) Nephropathy University of Virginia Health System (also in Spanish IgA Nephropathy National Institute of Diabetes and Digestive and Kidney Diseases IgA Nephropathy Kidney Foundation IgA Nephropathy (Berger's Disease) Mayo Clinic Researched by NOAH Contributing Editor: NOAH Team NOAH Kidney and Liver Kidney Diseases Specific Disease > Glomerular Diseases Health Topics Index A to Z Page of the Month Advanced Search ... Feedback

25. Search Result For "Glomerular Disease" NOAH pages containing Glomerular Disease . Displaying 15 of 680. glomerular diseases Alport Syndrome (Hereditary Nephritis); Asymptomatic Proteinuria and http://www.noah-health.org/search/results.php?lang=1&keyword=Glomerular Disease&

26. Hereditary Glomerular Diseases Glomerular involvement is minimal early in the disease, but progresses to scarring and fibrosis. At some point in the course of renal destruction, http://www.uhmc.sunysb.edu/internalmed/nephro/webpages/Part_J.htm

Hereditary Glomerular Diseases Dr. C. Stewart Hereditary Nephritis (Alport’s syndrome) Clinical Features A genetic disease characterized by the onset of hematuria in early childhood and later progression to renal failure, predominantely in males, accompanied by the development of sensorineural (high frequency) hearing loss. A typical male patient presents with the onset of persistent gross or microscopic hematuria, sometimes exacerbated by upper respiratory illness, before the age of six. After years of recurrent or persistent hematuria, renal insufficiency is noted to occur, usually in the third or forth decade of life, occasionally before the age of twenty. Nephrotic syndrome may occurs in 30 – 40% of patients. Hearing loss is variable, ranging from complete deafness to (more frequently) a high-frequency loss detected by audiometric exam. Associated abnormalities may include megalocornea, lenticlonus, spherophakia, myopia, retinitis pigmentosa, and macrothrombocytopenia. In females, the disorder is usually mild, with only microscopic hematuria, and does not typically progress to renal failure. In one series, 74% of patients were less than six years of age at presentation.

27. MyDNA.com - Glomerular Diseases myDNA is a consumer focused health, genetics, and genomics information provider offering disease condition information, health wellness tips, http://www.mydna.com/health/kidney/glomerular/

@import url(http://www.mydna.com/plone.css); @import url(http://www.mydna.com/ploneCustom.css); myDNA.com Search Yellow Pages News ... Diets Search For In Entire Site Articles News Images Advanced Search Home Health Center ... Kidney Disorders Glomerular Diseases Page Tools Print This Page E-Mail This Page Add to Favorites Genetics Genetics Envirogenomics Nutrigenomics Pharmacogenomics Health Allergy Asthma Brain Tumors Breast Cancer Cervical Cancer Colorectal Cancer Dental Health Diabetes Digestive Disorders Headache Heart Disease Influenza Kidney Disorders News Top Tens Dialysis Glomerular Diseases Overview Tools Medications Diagnostic Tests

28. MyDNA.com - Other Glomerular Diseases myDNA is a consumer focused health, genetics, and genomics information provider offering disease condition information, health wellness tips, http://www.mydna.com/health/kidney/glomerular/overview/othergd.html

@import url(http://www.mydna.com/plone.css); @import url(http://www.mydna.com/ploneCustom.css); myDNA.com Search Yellow Pages News ... Diets Search For In Entire Site Articles News Images Advanced Search Home Health Center ... Overview Other Glomerular Diseases Page Tools Print This Page E-Mail This Page Add to Favorites Genetics Genetics Envirogenomics Nutrigenomics Pharmacogenomics Health Allergy Asthma Brain Tumors Breast Cancer Cervical Cancer Colorectal Cancer Dental Health Diabetes Digestive Disorders Headache Heart Disease Influenza Kidney Disorders News Top Tens Dialysis Glomerular Diseases Overview Tools Medications Diagnostic Tests

29. Glomerular Diseases glomerular diseases include many conditions with a variety of genetic and environmental How do glomerular diseases interfere with kidney function? http://www.clevelandclinic.org/health/health-info/docs/1200/1204.asp?index=5993&

30. Glomerular Diseases The Kidney Urology Foundation of America is a national, notfor-profit organization dedicated to helping people avoid the debilitating effects of kidney http://www.kidneyurology.org/Patient_Resources/PaR_Lib_Glomerular.htm

WHAT YOU SHOULD KNOW ABOUT GLOMERULAR DISEASES About Us Patient Resources Professional Resources Support Us ... Corporate Sponsors WHAT ARE THE GLOMERULI AND WHAT DO THEY DO? The glomeruli are clusters of blood vessels inside the kidney that help to clean waste and extra water from your body. The glomeruli are attached to small fluid-collecting tubes called tubules . Together, the glomeruli-and-tubules form nephrons. Each kidney has about 1 million nephrons. In healthy nephrons, the glomeruli filter out wastes and extra water, and keep blood cells and protein in the body. HOW DO GLOMERULAR DISEASES HURT YOUR KIDNEYS? Glomerular diseases damage the glomeruli, letting protein and red blood cells leak out of your body. Sometimes a glomerular disease makes it hard for your body to clean out wastes, so the wastes begin to build up in the blood. Also, the diseases make it hard for your body to get rid of extra water, meaning that fluids may begin to collect in the face, hands, feet, or ankles and cause swelling. WHAT ARE SIGNS OF GLOMERULAR DISEASE?

31. Diabetes Monitor - Glomerular Diseases How do glomerular diseases interfere with kidney function? glomerular diseases include many conditions with a variety of genetic and environmental http://www.diabetesmonitor.com/b283.htm

glomerular diseases People with diabetes may develop kidney disease. One of the more common kidney problems in diabetes is sometimes called "diabetic glomerulosclerosis" and is discussed below On this page: What are the kidneys and what do they do? How do glomerular diseases interfere with kidney function? What are the symptoms of glomerular disease? How is glomerular disease diagnosed? ... For More Information M any diseases affect kidney function by attacking the glomeruli, the tiny units within the kidney where blood is cleaned. Glomerular diseases include many conditions with a variety of genetic and environmental causes, but they fall into two major categories: Glomerulonephritis (gloh-MAIR-yoo-loh-neh-FRY-tis) describes the inflammation of the membrane tissue in the kidney that serves as a filter, separating wastes and extra fluid from the blood. Glomerulosclerosis (gloh-MAIR-yoo-loh-skleh-ROH-sis) describes the scarring or hardening of the tiny blood vessels within the kidney. Although glomerulonephritis and glomerulosclerosis have different causes, they can both lead to end-stage renal disease (ESRD). Top What are the kidneys and what do they do?

32. Glomerular Diseases - Swedish Medical Center, Seattle, Washington glomerular diseases Swedish Medical Center, Seattle, Washington. http://www.swedish.org/15053.cfm

PDF Version Search Send-to-Friend Health Library Home Glomerular diseases Adapted from the National Institutes of Health by HealthGate Editorial Staff Many diseases affect kidney function by attacking the tiny units within the kidney where blood is cleaned. Glomerular diseases include many conditions with a variety of genetic and environmental causes, but they fall into two major categories: Glomerulonephritis (gloh-MAIR-yoo-loh-neh-FRY-tis) describes the inflammation of the membrane tissue in the kidney that serves as a filter, separating wastes and extra fluid from the blood. Glomerulosclerosis (gloh-MAIR-yoo-loh-skleh-ROH-sis) describes the scarring or hardening of the tiny blood vessels within the kidney. Although glomerulonephritis and glomerulosclerosis have different causes, they can both lead to end-stage renal disease (ESRD). What are the kidneys and what do they do? The two kidneys are bean-shaped organs located near the middle of the back, just below the rib cage to the left and right of the spine. Each about the size of a fist, these organs act as sophisticated filters for the body. They process about 400 quarts of blood a day to sift out about 2 quarts of waste products and extra water that eventually leave the body as urine. Blood enters the kidneys through arteries that branch inside the kidneys into tiny clusters of looping blood vessels. Each cluster is called a

33. UpToDate Glomerular Diseases Due To Nonamyloid Fibrillar Deposits glomerular diseases due to nonamyloid fibrillar deposits. Burton D Rose, MD Gerald B Appel, MD. UpToDate performs a continuous review of over 330 journals http://patients.uptodate.com/topic.asp?file=glomrdis/8926

34. Kidney & Urologic Diseases Discussion: Glomerular Diseases glomerular diseases include many conditions with a variety of genetic and environmental Click here for more information about glomerular diseases. http://aaaaq.com/kidney_urologic/2005/02/glomerular-diseases.html

@import url("http://www.blogger.com/css/blog_controls.css"); @import url("http://www.blogger.com/dyn-css/authorization.css?blogID=10952186"); @import url(http://www.blogger.com/css/navbar/main.css); @import url(http://www.blogger.com/css/navbar/4.css); BlogThis! Your two kidneys are vital organs that perform many functions to keep your blood clean and chemically balanced. Understanding how your kidneys work can help you to keep them healthy. This site allows you to share information with others who have a similar condition. Digestive Diseases Discussion - High Blood Pressure Discussion - Saturday, February 19, 2005 Glomerular Diseases Many diseases affect kidney function by attacking the glomeruli, the tiny units within the kidney where blood is cleaned. Glomerular diseases include many conditions with a variety of genetic and environmental causes, but they fall into two major categories: Glomerulonephritis (gloh-MAIR-yoo-loh-neh-FRY-tis) describes the inflammation of the membrane tissue in the kidney that serves as a filter, separating wastes and extra fluid from the blood. Glomerulosclerosis (gloh-MAIR-yoo-loh-skleh-ROH-sis) describes the scarring or hardening of the tiny blood vessels within the kidney.

35. Glomerular Diseases Glomerular kidney disease. Causes, detection and treatment. http://aaaaq.com/kidney_urologic/glomerular_diseases/

@import url("http://www.blogger.com/css/blog_controls.css"); @import url("http://www.blogger.com/dyn-css/authorization.css?blogID=10953027"); @import url(http://www.blogger.com/css/navbar/main.css); @import url(http://www.blogger.com/css/navbar/4.css); BlogThis! Glomerular Diseases Many diseases affect kidney function by attacking the glomeruli, the tiny units within the kidney where blood is cleaned. Glomerular diseases include many conditions with a variety of genetic and environmental causes, but they fall into two major categories: Glomerulonephritis (gloh-MAIR-yoo-loh-neh-FRY-tis) describes the inflammation of the membrane tissue in the kidney that serves as a filter, separating wastes and extra fluid from the blood. Thursday, March 02, 2006 About Glomerular Diseases This site contains information from government publications about glomerular diseases that have been reformatted and reorganized. There are numerous links to the original documents. The goal is to make the information easier to find and to allow the sharing of information between users. This is a very big undertaking and you can help me help others. Please add your comments or questions to any topic that concerns you. If you know of additional resources please include links to them.

36. Glomerular Diseases Sometimes a glomerular disease also interferes with the clearance of waste products by A number of different diseases can result in glomerular disease. http://healthgate.partners.org/browsing/browseContent.asp?fileName=21108.xml&tit

37. Center For Glomerular Diseases At Columbia University Cyclosporine Treatment of glomerular diseases. Ann Rev Med. Appel Gerald B. Guest Editor Treatment of glomerular diseases Seminars in Nephrology Vol. http://www.cumc.columbia.edu/dept/nephrology/glomerularcenter/diabetes.html

DIABETES MELLITUS A double blind randomized placebo trial with aminoguanidine, an advanced glycosulation end product blocker, in Type I diabetics found less proteinuria and retinopathy but was short of statistical significance in preventing doubling of the serum creatinine. (Abst Amer Soc Neprol , Bolton K., Appel GB, et al for the Action I Investigator Group- The Effect of Advanced Glycosylation End Product Inhibition in Patients with Diabetic Nephropathy. Submitted for publication). A current study evaluates the efficay of a new advanced glycosylation space end product blocker in preventing the progression of Type II diabetic nephropathy. Rosenstock J, Appel GB. Diabetic Nephropathy in Principles of Diabetes Mellitus ( Kluwer ) editor L. Poretsky. (accepted for publication 2002.) Other recent studies and publications supported in part by the Center for Glomerular Diseases: Klein M, Radhakrishnan J, Appel GB. Cyclosporine Treatment of Glomerular Diseases. Ann Rev Med. 50: 1-15, 1999. Matalon A, Radhakrishnan J, Appel GB, Valeri A. HIV and the Kidney: Management Challenges. Resident and Staff Physician 47:44-50, 2000.

38. Center For Glomerular Diseases At Columbia University Clinical trials are underway to study most major glomerular diseases including focal glomerulosclerosis, diabetic nephropathy, membranous nephropathy, http://www.cumc.columbia.edu/dept/nephrology/glomerularcenter/overview.html

The Center for Glomerular Diseases at Columbia University was organized to foster the advancement and study of glomerular diseases of the kidney. It is a collaborative effort of members of the Divisions of Nephrology and Renal Pathology at Columbia University and is based at the Presbyterian Division of the New York Presbyterian Hospital. Through the Center members collaborate in clinical and laboratory research, in clinical studies designed to treat glomerular kidney diseases, and educational activities. Currently over 1800 renal biopsies are processed annually by the Renal Pathology Division. This provides a large resource for defining new diseases of the kidney and studying the relationships between renal histopathology and the clinical features, course, and outcome of the patients. Basic research in the development of the glomerular filters has been a priority of the research laboratories in the Renal Division at Columbia University. Clinical trials are underway to study most major glomerular diseases including focal glomerulosclerosis, diabetic nephropathy, membranous nephropathy, IgA nephropathy, and many patterns of lupus nephritis. Educational activities include the publication of many scientific articles each year. Annually the Renal Pathology Department and Renal Division conduct a four day course dealing with Renal Biopsy and Medical Diseases of the Kidney.

39. Glomerular Diseases - National Institutes Of Health (NIH) glomerular diseases Health Information from National Institutes of Health (NIH) http://health.nih.gov/result.asp/1058/14

Home Health Information Kidney and Urinary System Glomerular Diseases Resources NIDDK Clinical Trials MedlinePlus NIH Institute and Center Resources National Institute of Diabetes and Digestive and Kidney Diseases NIDDK Directory of Kidney and Other Urologic Diseases Organizations Glomerular Diseases ... Your Urinary System and How It Works Related Topics: Kidney Diseases (General) Kidney and Urinary System Up to Top Look up "Glomerular Diseases" in: MedlinePlus - health resources from US government agencies and other credible organizations Clinical Trials Database - research studies in which you can participate This page was last reviewed on Thursday, July 28, 2005. Career Opportunities Visitor Information FOIA Employee Information ... Search National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892 Department of Health and Human Services

40. Glomerular Diseases - New Jersey glomerular diseases New Jersey - courtesy of Somerset Medical of Somerville, New Jersey. http://www.somersetmedicalcenter.com/13390.cfm

Community Advisor Search Send to a friend Home  Conditions and Concerns Glomerular diseases Adapted from the National Institutes of Health by HealthGate Editorial Staff Many diseases affect kidney function by attacking the tiny units within the kidney where blood is cleaned. Glomerular diseases include many conditions with a variety of genetic and environmental causes, but they fall into two major categories: Glomerulonephritis (gloh-MAIR-yoo-loh-neh-FRY-tis) describes the inflammation of the membrane tissue in the kidney that serves as a filter, separating wastes and extra fluid from the blood. Glomerulosclerosis (gloh-MAIR-yoo-loh-skleh-ROH-sis) describes the scarring or hardening of the tiny blood vessels within the kidney. Although glomerulonephritis and glomerulosclerosis have different causes, they can both lead to end-stage renal disease (ESRD). What are the kidneys and what do they do? The two kidneys are bean-shaped organs located near the middle of the back, just below the rib cage to the left and right of the spine. Each about the size of a fist, these organs act as sophisticated filters for the body. They process about 400 quarts of blood a day to sift out about 2 quarts of waste products and extra water that eventually leave the body as urine. Blood enters the kidneys through arteries that branch inside the kidneys into tiny clusters of looping blood vessels. Each cluster is called a

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