The risk of stomach cancer in patients with gastric or duodenal ulcer disease Authors: Hansson L-E, Nyren O, Hsing AW, Bergstrom R, Joseffson S, et al.
Source: New England Journal of Medicine. 335:242-9. July 25, 1996.
Institutions: Uppsala University and Mora Hospital, Sweden; National Cancer Institute, International Epidemiology Institute and Harvard School of Public Health, USA.
Financial support: National Cancer Institute. Summary Background Helicobacter pylori infection is associated with gastritis, gastric ulcer, duodenal ulcer and gastric cancer. There has been some evidence, however, that although gastric ulcer disease is associated with an increased risk for gastric cancer, this relationship does not hold between duodenal ulcer and gastric cancer. This study was designed to clarify the relationship between gastric ulcer, duodenal ulcer and gastric cancer. Methods In this retrospective cohort study from Sweden, a group of patients with documented gastric or duodenal ulcer disease was selected using hospital discharge data. This group was then analyzed for the subsequent development of gastric cancer. The incidence of cancer was then compared to that of the Swedish population at large. - The cohort was assembled using ICD-7 and ICD-8 hospital discharge diagnosis data from the Swedish national board of health and welfare's Inpatient Register. Each patient is uniquely identified by a national registration number in the Register. Patients were selected if they had a diagnosis of peptic ulcer disease for a hospital discharge between 1965 and 1983. For patients with more than one such discharge, the first one was identified as the index episode.
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