1. Factor V Leiden / Thrombophilia Support Page - Living With Thrombophilia This site contains information for those living with Thrombophilia or factor v leiden. http://www.fvleiden.org/

Home Email Forum Programs Resources ... Search Factor V Leiden Prothrombin 20210 Mutation Activated Protein C Resistance Antithrombin Deficiency and other clotting disorders If you have comments, questions, or want to post something on this web site, please send email to Deborah Okner Smith Why am I doing this? page updated 8/20/2005 links updated 8/27/2005 Factor V Leiden is the most common hereditary blood coagualtion disorder in the United States. It is present 5% of the in the Caucasian population and 1.2% of the African American population. Factor V Leiden increases the risk of venous thrombosis 3-8 fold for heterozygous (one bad gene inherited) and substantially more, 30-140 fold, for homozygous (two bad gene inherited) individuals. The prothrombin 20210 mutation is the second most common inherited clotting abnormality. It is more common than protein S and C deficiency and Antithrombin deficiency combined; 2% of the general population is heterozygous. It is only a mild risk factor for clots, but together with other risk factors (such as oral contraceptives, surgery, trauma, high blood pressure, obesity, smoking, etc) or combined with other clotting disorders (like Factor V Leiden), the risk of clotting increases dramatically. Factor V Leiden can be associated with the following complications: Venous Thrombosis blood clots in veins, such as:

2. Factor V Leiden of factor v leiden, its risks and treatment options. Also discusses the impact of other conditions on this disease....... http://www-admin.med.uiuc.edu/hematology/PtFacV2.htm

University of Illinois - Urbana/Champaign Carle Cancer Center Hematology Resource Page Patient Resources Factor V Leiden Home Factor V Leiden Antiphospholipid Syndrome General Clotting Information ... Protein S deficiency Factor V Leiden is a genetically acquired trait that can result in a thrombophilic (hypercoaguable) state resulting in the phenomenon of activated protein C resistance (APCR) as described below. Associated with factor V Leiden, APCR was first described in 1993; factor V Leiden was subsequently discovered in 1994. Over 95% of patients with APCR have factor V Leiden. Factor V Leiden's overall impact on the coagulation cascade described below. Mechanism of Action of Factor V Leiden: Factor V Leiden is characterized by a phenomenon called APCR where a genetic mutation in the factor V gene causes a change in the factor V protein making it resistant to inactivation by protein C. Epidemiology of Factor V Leiden: Factor V Leiden is seen more commonly in the northern European populations. About 4-7% of the general population is heterozygous (see * below) for factor V Leiden. About 0.06 to 0.25% of the population is homozygous (see * below) for factor V Leiden. The factor V Leiden mutation is relatively uncommon in the native populations of Asia, Africa and North America. In contrast, in Greece and southern Sweden, rates above 10% have been reported.

3. Factor V Leiden / Thrombophilia Support Page - Living With factor v leiden is the most common hereditary blood coagulation disorder in the United States. It is present in 5% of the American population. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

4. Ask Dr. Stephan Moll - Factor V Leiden: Laboratory Tests Q1 Why do some test results for factor v leiden (FVL) come back normal ? Since there continues to be confusion between factor v leiden and factor V http://www.fvleiden.org/ask/31.html

Home Email Forum Programs Resources ... Ask Dr. Stephan Moll These questions have been submitted by folks on the mailing list and answered by Dr. Moll, Director of the Thrombophilia Program at the Carolina Cardiovascular Biology Center, Department of Medicine, Division of Hematology-Oncology , UNC Chapel Hill (North Carolina, USA). Why am I doing this? Click here for a printable version of this question 31. Factor V Leiden: Laboratory tests Last Updated: 2/15/2004 Q : "Why do some test results for factor V Leiden (FVL) come back "normal"? It seems to reason that test results should come back either positive or negative for FVL. Since there continues to be confusion between factor V Leiden and factor V deficiency, is the latter at times tested in place of testing for FVL? Since the test results came back quot;normal" for 2 of my relatives, could they have been tested for factor V deficiency? If not, what is a person to conclude upon discovering their test results are "normal"? A : It is incorrect and confusing terminology to say that the factor V Leiden test was "normal". The wrong test can, indeed, have been performed. The patient needs to ask her/his physician to clarify the issue.

5. Startpagina Factor V Leiden Informatieve site over alles wat met trombose en (erfelijke)stollingsafwijkingen te maken heeft, toegespitst op faktor V Leiden. http://www.factorvleiden.nl/

Startpagina Factor V Leiden Startpagina Factor V Leiden

6. Factor V Leiden of factor v leiden, its risks and treatment options. Also discusses the impact of other conditions on this disease....... http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

7. Factor V Leiden factor v leiden is not a disease, it is the presence of a particular gene that is passed on from your parents. http://www.netdoctor.co.uk/diseases/facts/factorv.htm

Search: All NetDoctor Diseases Medicines NetDoctor.co.uk Home News and features News News archive Newsletter Features Encyclopaedia Diseases Examinations Medicines Premium services SMS services StayQuit thediet Health centres ADHD Allergy and asthma Children's health Depression ... All health centres Discussion and support Discussion forums Support groups Services Ask the doctor Find a hospital Search Medline Test yourself Information About NetDoctor Commercial opportunities NetDoctor.com Factor V Leiden Reviewed by Dr Patrick Davey , cardiologist and Dr Rachel Green , consultant haematologist What is Factor V Leiden? The role of Factor V Leiden is still uncertain. Factor V Leiden is not a disease, it is the presence of a particular gene that is passed on from your parents. Factor V Leiden is a variant of the protein Factor V (5) which is needed for blood clotting. People who have a Factor V deficiency are more likely to bleed badly while people with Factor V Leiden have blood that has an increased tendency to clot. People carrying the Factor V Leiden gene have a five times greater risk of developing a blood clot (thrombosis) than the rest of the population. However, many people with the gene will never suffer from blood clots. In Britain, 5 per cent of the population carry one or more genes for Factor V Leiden, which is far more than the number of people who will actually suffer from thrombosis.

8. Page Not Found Discusses the thrombotic risks of this inherited disorder, also known as factor v leiden. http://www.beckmancoulter.com/Coulter/Techpubs/coagulation/APC.asp

var brname = ""; Products Customer Support Resource Center Contact Us ... Our Company Page Not Found The page you requested was not found. It may have moved, or it may no longer exist. Did you bookmark the page? The URL may have changed. Use the search feature in the upper right corner of this page to relocate the page and replace your bookmark. Did you type the URL into the address/location bar correctly? Check your spelling, capitalization and punctuation and try again. Did a link in the Beckman Coulter website bring you here? If so, please send us your comments . On the comments form, select "Contact the WebMaster" under the column "Non Product Related Questions". If available, please specify the name of the link you clicked, the URL of the page, or how you navigated there. Home Products Customer Support Resource Center ... Printing Instructions

9. Factor V Leiden factor v leiden is not a disease, it is the presence of a particular gene that is passed on from your parents. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

10. Pregnancy, Clotting, And Factor V Leiden An Overview Pregnancy, Clotting, and factor v leiden An Overview http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

11. Factor V Leiden Thrombophilia - Genetics Home Reference What other names do people use for factor v leiden thrombophilia? factor v leiden thrombophilia is an inherited disorder of blood clotting. http://ghr.nlm.nih.gov/condition=factorvleidenthrombophilia

Home What's New Browse Handbook ... Search Factor V Leiden thrombophilia Related Gene(s) Quick links to this topic NIH Publications National Institutes of Health MedlinePlus Health Information Educational resources Information pages Patient support For patients and families Gene Reviews Clinical summary Gene Tests DNA test labs ClinicalTrials.gov Research studies PubMed Recent literature OMIM Genetic disorder catalog References Factor V Leiden thrombophilia On this page: What is factor V Leiden thrombophilia? How common is factor V Leiden thrombophilia? ... help with understanding factor V Leiden thrombophilia? What is factor V Leiden thrombophilia? Factor V Leiden thrombophilia is an inherited disorder of blood clotting. Factor V Leiden is the name of a specific mutation that results in thrombophilia, or an increased tendency to form abnormal blood clots in blood vessels. People who have the factor V Leiden mutation are at somewhat higher than average risk for a type of clot that forms in veins, such as the deep veins of the legs (deep venous thrombosis), or a clot that travels through the bloodstream and lodges in the lungs (pulmonary embolism). How common is factor V Leiden thrombophilia?

12. Factor V Leiden Syndrome factor v leiden Syndrome http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

13. Factor V Leiden Thrombophilia - References - Genetics Home Reference factor v leiden and the risk for venous thromboembolism in the adult Danish population. Cardiovascular implications of the factor v leiden mutation. http://ghr.nlm.nih.gov/condition=factorvleidenthrombophilia/show/References

Home What's New Browse Handbook ... Search Factor V Leiden thrombophilia Back to condition summary Factor V Leiden thrombophilia References These sources were used to develop the Genetics Home Reference condition summary on factor V Leiden thrombophilia. Gene Review Juul K, Tybjaerg-Hansen A, Schnohr P, Nordestgaard BG. Factor V Leiden and the risk for venous thromboembolism in the adult Danish population. Ann Intern Med. 2004 Mar 2;140(5):330-7. PubMed citation ... PubMed citation Last Comprehensive Review: May 2005 Published: September 6, 2005 Contact NLM Customer Service Lister Hill National Center for Biomedical Communications ... Selection Criteria for Web Links Indicates a page outside Genetics Home Reference.

14. Factor V Leiden Thrombophilia factor v leiden Thrombophilia Hereditary Resistance to Activated Protein C, factor v leiden Mutation Author Jody L Kujovich, MD http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

15. GeneReviews: Factor V Leiden Thrombophilia Your browser does not support HTML frames so you must view factor v leiden Thrombophilia in a slightly less readable form. Please follow this link to do so. http://www.geneclinics.org/profiles/factor-v-leiden/

Your browser does not support HTML frames so you must view Factor V Leiden Thrombophilia in a slightly less readable form. Please follow this link to do so.

16. News - Factor V Leiden And Prothrombin G20210A Mutations Increase factor v leiden and prothrombin G20210A mutations contribute significantly to central venous cathete http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

17. Factor V Leiden Thrombophilia factor v leiden thrombophilia is characterized by a poor anticoagulant response to F5 is the only gene associated with factor v leiden thrombophilia. http://www.geneclinics.org/profiles/factor-v-leiden/details.html

Factor V Leiden Thrombophilia [Hereditary Resistance to Activated Protein C, Factor V Leiden Mutation] Author: Jody L Kujovich, MD About the Author / Author History Initial Posting: 14 May 1999 Last Update 20 May 2004 Summary Disease characteristics. Factor V Leiden thrombophilia is characterized by a poor anticoagulant response to activated protein C (APC) and an increased risk of venous thromboembolism. The term "factor V Leiden" refers to the specific G-to-A substitution at nucleotide 1691 in the gene for factor V that predicts a single amino acid replacement (Arg506Gln) at one of three APC cleavage sites in the factor Va molecule. Factor V Leiden is inactivated at a rate approximately ten times slower than normal factor V and persists longer in the circulation, resulting in increased thrombin generation and a mild hypercoagulable state reflected by elevated levels of prothrombin fragment F1+2 and other activated coagulation markers . Individuals heterozygous for the factor V Leiden mutation have a slightly increased risk for venous thrombosis; homozygous individuals have a much greater thrombotic risk.

18. Factor V Leiden Mutation And The Risks For Thromboembolic Disease factor v leiden Mutation and the Risks for Thromboembolic Disease http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

19. Pregnancy, Clotting, And Factor V Leiden: An Overview Women with factor v leiden (FVL) have a substantially increased risk of A discussion of the merits of screening for factor v leiden in oral http://www.naturalchildbirth.org/natural/resources/prebirth/prebirth35.htm

Pregnancy, Clotting, and Factor V Leiden: An Overview The past 10 years have brought new understanding of and explanations why some women clot on birth control pills and during pregnancy. Research into genetic origins of disease has uncovered many coagulopathies, some of them surprisingly common. The most common is Factor V Leiden, also known as Activated Protein C Resistance, which carries a 3-10 times greater risk of clot when someone has one copy of the gene and 30-140 times greater risk of clotting for someone with two copies. Between 3% and 10% of Caucasian people are heterozygous for Factor V Leiden, and a much smaller percentage are homozygous. In Sweden the rate of heterozygous mutation may be as high as 15% in some areas, while in other parts of the world and among other races only a fraction of a percent of the population may have it. It is thought that the original mutation occurred as much as 20,000-30,000 years ago in a single individual.(1) Women with Factor V Leiden (FVL) have a substantially increased risk of clotting in pregnancy (and on estrogen containing birth control pills or hormone replacement) in the form of DVT (deep vein thrombosis, sometimes

20. MSRGSNet/Genetic Drift/Venous Thrombosis And The Factor V (Leiden) Venous Thrombosis and the Factor V (Leiden) Mutation Introduction Who should be tested? Deep vein thrombosis and pulmonary embolism http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Page 1     1-20 of 97    1  | 2  | 3  | 4  | 5  | Next 20