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         Extrapontine Myelinolysis:     more detail
  1. Methylphenidate Treatment of Neuropsychiatric Symptoms of Central and Extrapontine Myelinolysis(*).: An article from: Journal of Studies on Alcohol by Denise Bridgeford, David B. Arciniegas, et all 2000-09-01

41. Neurology -- Sign In Page
Lateral pontine and extrapontine myelinolysis associated with Extrapontinemyelinolysis with involvement of the hippocampus in three children with
http://www.neurology.org/cgi/content/full/64/3/574
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Hypernatremia from a hunger strike as a cause of osmotic myelinolysis
van der Helm-van Mil et al. Neurology.
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42. Neurosurgery - October 1998, Volume 43, Issue 4
extrapontine myelinolysis and Behavioral Change after Transsphenoidal PituitarySurgery Case Report. Masahiko Tosaka, MD; Hideaki Kohga, MD
http://www.neurosurgery-online.com/pt/re/neurosurg/toc.00006123-199810000-00000.

43. Transplantation - Fulltext: Volume 61(4) February 27, 1996 P 658-661 CENTRAL PON
1B) posttransplant and had evidence of extrapontine myelinolysis (EPM) only on Pontine and extrapontine myelinolysis following liver transplantation
http://www.transplantjournal.com/pt/re/transplantation/fulltext.00007890-1996022
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References (17) View full size inline images Transplantation Volume 61(4) 27 February 1996 pp 658-661
CENTRAL PONTINE MYELINOLYSIS AND CYCLOSPORINE NEUROTOXICITY FOLLOWING LIVER TRANSPLANTATION
Fryer, Jonathan P. ; Fortier, Marielle V. ; Metrakos, Peter ; Verran, Deborah J. ; Asfar, Sami K. ; Pelz, David M. ; Wall, William J. ; Grant, David R. ; Ghent, Cameron N. Multiorgan Transplant Service and Department of Radiology, University Hospital, University of Western Ontario, London, Ontario, Canada Multiorgan Transplant Service. Department of Radiology. Address correspondence to Dr. Jonathan P. Fryer, Department of Surgery, Northwestern University, 303 East Superior, Suite 532, Chicago, IL 60611. Received 7 June 1995. Accepted 5 September 1995. Article Outline Figures/Tables
Abstract TOP
In a recent series of 44 liver transplants we identified both extrapontine myelinolysis (EPM)-characteristic of cyclocosporine neurotoxicity-and central pontine myelinolysis (CPM) in 5 recipients posttransplant. An additional 2 recipients had EPM only posttransplant. MRIs performed in 4 asymptomatic recipients were normal. Large perioperative shifts in serum sodium, hypomagnesemia, and high cyclosporine levels may play a role in the development of these lesions, although the evidence from this study is inconclusive. In addition to supportive care, dilantin was started in patients who had seizures; aggressive magnesium replacement was initiated for hypomagnesemia, and cyclosporine levels were reduced in all patients. All patients demonstrated a slow steady recovery and all but 2 are home at the time of writing. CPM may be more prevalent than previously appreciated following liver transplantation, although its prognosis may not be as dismal.

44. Transplantation - Abstract: Volume 61(4) February 27, 1996 P 658-661 CENTRAL PON
CENTRAL PONTINE MYELINOLYSIS AND CYCLOSPORINE NEUROTOXICITY FOLLOWING LIVER we identified both extrapontine myelinolysis (EPM)characteristic of
http://www.transplantjournal.com/pt/re/transplantation/abstract.00007890-1996022
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CENTRAL PONTINE MYELINOLYSIS AND CYCLOSPORINE NEUROTOXICITY FOLLOWING LIVER TRANSPLANTATION.
Transplantation. 61(4):658-661, February 27, 1996.
Fryer, Jonathan P. 1,2; Fortier, Marielle V. 3; Metrakos, Peter 1; Verran, Deborah J. 1; Asfar, Sami K. 1; Pelz, David M. 2; Wall, William J. 1; Grant, David R. 1; Ghent, Cameron N. 1 Abstract:
In a recent series of 44 liver transplants we identified both extrapontine myelinolysis (EPM)-characteristic of cyclocosporine neurotoxicity-and central pontine myelinolysis (CPM) in 5 recipients posttransplant. An additional 2 recipients had EPM only posttransplant. MRIs performed in 4 asymptomatic recipients were normal. Large perioperative shifts in serum sodium, hypomagnesemia, and high cyclosporine levels may play a role in the development of these lesions, although the evidence from this study is inconclusive. In addition to supportive care, dilantin was started in patients who had seizures; aggressive magnesium replacement was initiated for hypomagnesemia, and cyclosporine levels were reduced in all patients. All patients demonstrated a slow steady recovery and all but 2 are home at the time of writing. CPM may be more prevalent than previously appreciated following liver transplantation, although its prognosis may not be as dismal.
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45. Hyatrogenic Extrapontine Myelinolysis In Central Diabetes Insipidus: Are Cyclosp
Hyatrogenic extrapontine myelinolysis in Central Diabetes Insipidus Are Cyclosporineand 1Desamino-8-D-Arginine Vasopressin Harmful in Association?
http://jcem.endojournals.org/cgi/content/full/82/6/1749

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Special Articles
Hyatrogenic Extrapontine Myelinolysis in Central Diabetes Insipidus: Are Cyclosporine and 1-Desamino-8- D -Arginine Vasopressin Harmful in Association?
Mohamad Maghnie Eugenio Genovese Stefan Lundin Federico Bonetti and Departments of Pediatrics (M.M., F.B., M.A.), Radiology (E.G.), University of Pavia, IRCCS Policlinico S. Matteo, Pavia, Italy; Department of Clinical Pharmacology (S.L.), Lund University Hospital, Lund, Sweden Address all correspondence and requests for reprints to: Mohamad Maghnie, Department of Pediatrics, University of Pavia, IRCCS Policlinico S.Matteo, 27100 Pavia. Italy. E-mail
Introduction Top
Introduction
DDAVP kinetics
Differential diagnosis and...

46. Clinical Neuropharmacology - UserLogin
CPM) or, rarely, other cerebral regions (extrapontine myelinolysis; EPM) (1) . Medlej R. Tamraz J. extrapontine myelinolysis treatment with TRH.
http://www.clinicalneuropharm.com/pt/re/clnneupharm/fulltext.00002826-200003000-
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47. Current Opinion In Neurology - Abstract: Volume 13(6) December 2000 P 691-697 Os
Osmotic demyelination disorders central pontine and extrapontine myelinolysis.Current Opinion in Neurology. 13(6)691697, December 2000.
http://www.co-neurology.com/pt/re/coneuro/abstract.00019052-200012000-00014.htm
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Current Opinion in Neurology. 13(6):691-697, December 2000.
Brown, William D. Abstract:
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48. Current Opinion In Neurology - UserLogin
Abbreviations CT computed tomography EPM extrapontine myelinolysis CPM central Clinical features of central pontine and extrapontine myelinolysis TOP
http://www.co-neurology.com/pt/re/coneuro/fulltext.00019052-200012000-00014.htm
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49. World J Gastroenterol
None of the patients showed extrapontine myelinolysis. central pontine andextrapontine myelinolysis. Acta Neurobiol Exp 2001; 61 141144
http://www.wjgnet.com/1007-9327/10/2540.asp

50. Artículo 34: Movimientos Anormales En Un Caso De Mielinólisis Extrapontina. Re
Translate this page Illowsky BP, Laureno R. Pontine and extrapontine myelinolysis a neurologic Wright DG, Laureno R, Victor M. Pontine and extrapontine myelinolysis.
http://www.infodoctor.org/neuro/Art34.htm
Principal Mapa Presentación Artículos ... Novedades Movimientos anormales en un caso
de Mielinólisis Extrapontina.
Revisión de la literatura - Abnormal movements in a case of
extrapontine myelinolysis.
Review of the literature -
D. Ezpeleta, C. de Andrés*, S. Giménez-Roldán*.
Servicio de Neurología, Hospital General Universitario Gregorio Marañón, Madrid. Publicado en 1998 en Revista de Neurología
MEDLINE
Resumen. Summary Introduction and clinical case. We present a case of extra-pontine myelinolysis caused by acute hypernatraemia in which a complex picture of late onset extrapyramidal features, choreodystonia and parkinsonism developed. Repeated physical examinations, neurophysiological and neuroimaging studies using magnetic resonance all indicated an extra-pontine site of the lesions, which symmetrically affected the striate and to a lesser extent both thalami. We review the relevant literature available and analyze the cases described as having abnormal movements associated with a myelinolytic syndrome. Conclusions.

51. Current Opinion In Critical Care - UserLogin
Osmotic demyelination central pontine myelinolysis and extrapontine myelinolysisTOP. Hyponatremia is a common complication of patients with liver disease
http://www.co-criticalcare.com/pt/re/cocritcare/fulltext.00075198-199904000-0000
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52. Current Opinion In Critical Care - Abstract: Volume 5(2) April 1999 P 112 Neurol
These complications include polyneuropathy, central and extrapontine myelinolysis,seizures, and central nervous system tumors.
http://www.co-criticalcare.com/pt/re/cocritcare/abstract.00075198-199904000-0000
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Current Opinion in Critical Care. 5(2):112, April 1999.
Chang, Cherylee W.J. MD Abstract:
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53. Instituto Nacional De Salud
Translate this page Extrapontine osmotic myelinolysis is a rare nervous system complication. Central pontine and extrapontine myelinolysis the osmotic demyelination
http://www.ins.gov.co/biomedica/ver_articulo.php?id_articulo=41

54. UCSF - Neuroradiology Interesting Case: December, 2001
patchy and asymmetric lesions); extrapontine myelinolysis (requires anappropriate clinical context; often associated with central pontine myelinolysis)
http://www.neurorad.ucsf.edu/previouscases/12012001.html
Excerpted from:
Thieme Publishing's

"Teaching Atlas of Brain Imaging"
UCSF Attendings
Nancy J. Fischbein MD
William Dillon MD , and A. James Barkovich MD
167 cases, over 1000 figures at $139.00.
Interesting Cases
Clinical Presentation
Six months prior to presentation, this 13 year old girl developed fatigue and weight loss. She then presented with a generalized seizure and lapsed into coma for three days. Upon awakening, she was disoriented and inappropriate. An MR scan was obtained. Fig A Fig B Fig C Fig D
Pearls
  • Reversibility of T2-prolonging lesions has been documented, suggesting that they represent areas of edema and possibly microinfarction.
  • The so-called lupus anticoagulant (an antiphospholipid antibody) has a high association with cerebrovascular accidents and venous sinus thrombosis.
    Pitfalls
  • No specific imaging finding is diagnostic of neuropsychiatric lupus.
  • Imaging findings do not necessarily correlate with severity of clinical manifestations.
    Radiologic Findings
    An axial proton density-weighted image (Fig. A ) and a coronal FLAIR image (Fig.
  • 55. [Dysphagia] CPM
    extrapontine myelinolysis symmetrically affects thalamocapsular regions, neostriatum,and other territories. Myelinolysis usually results from the rapid
    http://list.dysphagia.com/dysphagia/2002-July/msg00370.html
    Date Prev Date Next [Chronological] [Thread] ... [Top]
    [Dysphagia] CPM
    • Subject [Dysphagia] CPM From eripley@yahoo.com (Irene Campbell-Taylor) Date: Wed, 31 Jul 2002 09:30:51 -0700 (PDT)
    http://health.yahoo.com

    56. Early Diagnosis Of Central Pontine Myelinolysis With Diffusion-Weighted Imaging
    There was no evidence for extrapontine myelinolysis. Wright DG, Laureno R,Victor M. Pontine and extrapontine myelinolysis.
    http://www.ajnr.org/cgi/content/full/25/2/210
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    This Article Abstract Figures Only Full Text (PDF) ... Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager PubMed PubMed Citation Articles by Ruzek, K. A. Articles by Miller, G. M. American Journal of Neuroradiology 25:210-213, February 2004
    American Society of Neuroradiology
    Case Report
    BRAIN
    Early Diagnosis of Central Pontine Myelinolysis with Diffusion-Weighted Imaging
    Kimberly A. Ruzek a Norbert G. Campeau a and Gary M. Miller a a From the Mayo Clinic, Department of Radiology, Rochester, Minnesota Address correspondence to Norbert G. Campeau, MD, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905
    Abstract TOP
    Abstract
    Introduction
    Case Report
    Discussion Conclusion References Summary: Central pontine myelinolysis (CPM) occurs in the setting of rapidly corrected hyponatremia, especially in chronically debilitated patients. Conventional CT and MR imaging findings

    57. Resolving MR Features In Osmotic Myelinolysis (central Pontine And Extrapontine
    features in osmotic myelinolysis (central pontine and extrapontine myelinolysis) myelinolysis) and in other locations (extrapontine myelinolysis).
    http://www.ajnr.org/cgi/content/abstract/14/1/163
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    ARTICLES
    Resolving MR features in osmotic myelinolysis (central pontine and extrapontine myelinolysis)
    VB Ho, CR Fitz, CC Yoder and CA Geyer
    Department of Radiology, Walter Reed Army Medical Center, Washington, DC 20307-5001. Osmotic myelinolysis is a distinctive clinical syndrome with characteristic MR features in the central pons (central pontine myelinolysis) and in other locations (extrapontine myelinolysis). We describe the resolving MR features in an adolescent who has experienced complete neurologic recovery. Regions of involvement manifested increased T2 signal intensity. The extrapontine involvement was noted to resolve earlier with interim-increased T1-weighted signal. The mechanism for the variable

    58. Accessing Article
    Menger H, Jorg J. Outcome of central pontine and extrapontine myelinolysis.J Neurol 1999; 246 700–705. Article PubMed ChemPort
    http://www.nature.com/bmt/journal/vaop/ncurrent/full/1705115a.html
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    59. Log In Problems
    Central pontine and extrapontine myelinolysis associated with type 2 diabeticpatient with hypokalemia. Diabetes Res Clin Pract. 2005;687580.
    http://www.medscape.com/viewarticle/505496_print
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    60. Log In Problems
    in the splenium were first described in Italian red wine drinkers but havebeen documented in cases of malnutrition and extrapontine myelinolysis.
    http://www.medscape.com/viewarticle/505496_3
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