1. Eosinophilia Facts about eosinophilia including what it is, how and when it occurs, symptoms, diagnosis and treatment. http://www.netdoctor.co.uk/diseases/facts/eosinophilia.htm

Search: All NetDoctor Diseases Medicines NetDoctor.co.uk Home News and features News News archive Newsletter Features Encyclopaedia Diseases Examinations Medicines Premium services SMS services StayQuit thediet Health centres ADHD Allergy and asthma Children's health Depression ... All health centres Discussion and support Discussion forums Support groups Services Ask the doctor Find a hospital Search Medline Test yourself Information About NetDoctor Commercial opportunities NetDoctor.com Eosinophilia Written by M Y Karim , lecturer in immunology What are eosinophils? An eosinophil is a type of white blood cell. Eosinophils are produced in the bone marrow and are normally found in the bloodstream and the gut lining. They contain proteins that help the body to fight infection from parasitic organisms, such as worms. But in certain diseases these proteins can damage the body. What is eosinophilia? The term eosinophilia refers to conditions in which abnormally high amounts of eosinophils are found in either the blood or in body tissues. When does eosinophilia occur?

2. Home Page Information and support site for people who ingested LTrytophan in the 1980's and are suffering from EMS. http://www.nemsn.org/

National Eosinophilia-Myalgia Syndrome Network Eosinophilia-Myalgia Syndrome was first recognized in 1989 in New Mexico. Three women sought medical help for a mysterious, undiagnosable condition whose symptoms were marked by debilitating muscle pain and a high Eosinophilia count (a type of white blood cell that is usually found when a toxin or parasitic infection is present). It was eventually discovered that all of the women had one thing in common: they had been taking L-tryptophan, a health food supplement sold as a sleep aid. The tainted product was traced back to Showa Denko Inc, a Japanese company, that had been cutting corners in their purification procedure to reduce their manufacturing costs. Additionally, they were experimenting with genetically engineered bacteria in order to accelerate and increase the efficiency of their production process. As a result, contaminated batches of L-tryptophan were placed on the market. Within three months, 37 people died and over 1500 were permanently disabled from using this product. By early 1990, officers of the Food and Drug Administration (FDA) banned the sale of all over the counter L-tryptophan dietary supplements because it was found to be the common link in the EMS cases. Research was conducted to discover the cause of this illness. By using high performance liquid chromatography, an unidentified impurity, called "peak E" was found in batches of L-T as well as nearly 60 other contaminants. These batches were traced back to one manufacturer, Showa Denko KK (SDKK), one of Japan's largest petrochemical companies.

3. Eosinophilia-Myalgia: Advocacy, Information, Support Advocacy, information, and support for those with eosinophiliaMyalgia (EMS). http://www.swiftsite.com/eosinophilia-myalgia/

EOSINOPHILIA-MYALGIA SYNDROME BRIEF DESCRIPTION OF EMS Eosinophilia-Myalgia Syndrome (EMS) is a rare, multi-systemic, chronic, autoimmune disease caused by ingestion of impure L-tryptophan, an amino acid dietary supplement sold over the counter in the 1980s until removed by the FDA after EMS occurred. Eosinophilia is an elevated level of a type of white blood cell called an eosinophil. Myalgia refers to muscle pain. Many Americans ingested the supplement regularly or occasionally during the 1980s, often upon the advice of a physician, for medical problems including insomnia, chronic pain, and depression; however, an Epidemic of a novel illness, which came to be called Eosinophilia-Myalgia Syndrome, occurred in the second half of 1989 into early 1990 (peaking between July and October 1989). The overwhelming majority of persons who got sick with EMS had ingested contaminated L-Tryptophan eventually traced to one large petrochemical company, Showa Denko K.K., of Japan. Bottle labeling did not indicate the raw product originated in Japan, and nobody in this country, it seems, was told that genetic engineering had been used to manufacture the L-Tryptophan. Mandatory labeling of country of origin on bottles and containers - had it been in place - might have caused many persons to think twice about taking dietary supplements like L-Tryptophan. Although five to ten thousand Americans (and many scores in various other nations) were probably affected, approximately 2,000 Americans were seriously injured, many of whom continue to suffer with a variety of symptoms: chronic pain, cognitive dysfunction, muscle weakness and spasms, among other symptoms. Since about 1996, research has slowed to a near standstill. Fewer studies at any time involve EMS, a toxin-induced and man-caused novel disease on the verge of becoming a mere footnote in medical history: Therefore, I call EMS "The Forgotten Disease" just as the Korean War is often called "The Forgotten War."

4. MedlinePlus Medical Encyclopedia: Simple Pulmonary Eosinophilia (Loeffler's Synd Adam.com defines this disorder, its causes, incidence and risk factors. http://www.nlm.nih.gov/medlineplus/ency/article/000105.htm

@import url(/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Simple pulmonary eosinophilia (Loeffler's syndrome) Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... References Illustrations Lungs Respiratory system Alternative names Return to top Pulmonary infiltrates with eosinophilia; Eosinophilic pneumonia; Loeffler's syndrome Definition Return to top Simple pulmonary eosinophilia is inflammation of the lungs associated with an increase in eosinophils, a type of white blood cell. Causes, incidence, and risk factors Return to top Most cases of simple pulmonary eosinophilia are due to an allergic reaction of some sort, either from a drug, such as sulfonamide, or parasitic infection, such as that caused by the worm Ascaris lumbricoides . Other parasites may also cause the syndrome. Symptoms Return to top General ill feeling malaise Fever Dry cough Chest pain Shortness of breath Wheezing Rapid respiratory rate Rash Note: Symptoms range from none at all to severe. They will usually go away without treatment.

5. Eosinophilia Facts about eosinophilia including what it is, how and when it occurs, symptoms, diagnosis and treatment. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

6. What Is Eosinophilia? A recent bllod test came back with the words ‘eosinophilia confirmed’. Under Range 05 my number was marked 24High. What is eosinophili http://www.netdoctor.co.uk/ate/heartandblood/203623.html

Search: All NetDoctor Diseases Medicines NetDoctor.co.uk Home News and features News News archive Newsletter Features Encyclopaedia Diseases Examinations Medicines Premium services SMS services StayQuit thediet Health centres ADHD Allergy and asthma Children's health Depression ... All health centres Discussion and support Discussion forums Support groups Services Ask the doctor Find a hospital Search Medline Test yourself Information About NetDoctor Commercial opportunities NetDoctor.com What is eosinophilia? Question Answer Thank you for your question. An eosinophilia simply means that there is an increase in the usual number of a certain type of white blood cell in the blood. The eosinophil is distinguished from other white blood cells by the presence within it's membrane of coarse granules which stain orange-red with a special stain used by the hospital laboratory, called Romanowsky stain. Broadly speaking, the function of the eosinophil is to respond to allergy. An eosinophilia is commonly reported in patients who have asthma, hayfever, food sensitivities or parasitic infections such as intestinal worms. It is not usually of any great significance and merely reflects what is going on in the body rather than being a cuase of some illness. Additional causes of eosinophilia include reactions to certain drugs (glucophage does not usually cause eosinophilia), infections such as scarlet fever, tuberculosis and erythema multiforme (characterized by red rashes on the skin), skin diseases such as eczema and pemphigus, Hodgkins disease, ulcerative colitis and medications such as chlorpromazine, digitalis, penicillin and streptomycin.

7. Non Allergic Rhinitis Information about nonallergic types of rhinitis, including infectious rhinitis, hormonal rhinitis, non-allergic rhinitis with eosinophilia syndrome (NARES), certain types of occupational rhinitis, gustatory and drug-induced rhinitis. http://www.jcaai.org/Param/Rhinitis/Complete/non_allergic_rhinitis.htm

13. Nonallergic rhinitis is characterized by sporadic or persistent perennial symptoms of rhinitis that do not result from IgE-mediated immunopathologic events. Examples of nonallergic rhinitis are infectious rhinitis, hormonal rhinitis, vasomotor rhinitis, nonallergic rhinitis with eosinophilia syndrome (NARES), certain types of occupational rhinitis, and gustatory and drug-induced rhinitis. The differential diagnosis of nonallergic rhinitis is extensive. The mechanisms in each are poorly understood. Nonallergic rhinitis with inflammatory cells present in the mucosa can be classified by inflammatory cell type. Nonallergic rhinitis with eosinophilia syndrome (NARES) is characterized by nasal congestion and prominent nasal eosinophilia. (see summary statement #15) The mechanism of the eosinophil infiltration is not known. Eosinophilia is also prominent when nasal polyps are present, but again the mechanism of eosinophil recruitment is not known. Subjects with aspirin sensitivity have nasal eosinophilia. Aspirin and other nonsteroidal antiin-flammatory drugs (NSAIDs) block cyclooxygenase activity, and shunt arachidonic acid to the 5-lipoxygenase pathway that increases production of the potent proinflammatory cysteinyl leukotrienes (LTC , LTD , and LTE Neutrophilic infiltrates usually indicate the presence of bacterial rhinosinusitis, especially when humoral immunodeficiency or ciliary dysmotility are present. LTB

8. Eosinophilia Myalgia Syndrome Support Site National eosinophiliaMyalgia Syndrome Network eosinophilia-Myalgia Syndrome - was first recognized in 1989 in New Mexico. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

9. EMedicine - Eosinophilia : Article By Daniel R Lucey, MD, MPH eosinophilia In this chapter, the term eosinophilia is defined as an increase in peripheral blood eosinophilic leukocytes to more than 450 cells/mL of http://www.emedicine.com/med/topic685.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Hematology Eosinophilia Last Updated: February 19, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: eosinophilic leukocytes, idiopathic hypereosinophilic syndrome, HES, CHINA, Ascaris lumbricoides, AUTHOR INFORMATION Section 1 of 8 Author Information Introduction Clinical Workup ... Bibliography Author: Daniel R Lucey, MD, MPH , Chief, Fellowship Program Director, Department of Internal Medicine, Division of Infectious Diseases, Washington Hospital Center; Professor, Department of Internal Medicine, Uniformed Services University of the Health Sciences Coauthor(s): Palaniandy Kogulan, MD , Fellow, Department of Infectious Diseases, Washington Hospital Center, George Washington University Daniel R Lucey, MD, MPH, is a member of the following medical societies: Alpha Omega Alpha , and American College of Physicians Editor(s): Pradyumma D Phatak, MD

10. EMedicine - Eosinophilia-Myalgia Syndrome Article By Shrilekha eosinophiliaMyalgia Syndrome - In October 1989, the health department in New Mexico was notified of 3 patients with an unexplained acute illness http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

11. EMedicine - Eosinophilia-Myalgia Syndrome : Article By Shrilekha Sairam, MD, MBB eosinophiliaMyalgia Syndrome - In October 1989, the health department in New Mexico was notified of 3 patients with an unexplained acute illness http://www.emedicine.com/med/topic693.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Rheumatology Eosinophilia-Myalgia Syndrome Last Updated: August 2, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: EMS, eosinophilia myalgia syndrome, toxic oil syndrome, TOS, L-tryptophan, tryptophan, polyneuropathy, cardiopulmonary disease, superimposed infection AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Shrilekha Sairam, MD, MBBS , Fellow, Department of Internal Medicine, Division of Rheumatology, University of Texas at Galveston Coauthor(s): Jeffrey R Lisse, MD, FACP , Associate Chief, Professor, Department of Internal Medicine, Section of Rheumatology, University of Arizona School of Medicine Editor(s): Carlos J Lozada, MD , Director of Rheumatology Fellowship Program, Associate Professor, Department of Medicine, Division of Rheumatology and Immunology, Jackson Memorial Medical Center, University of Miami School of Medicine;

12. Eosinophilia-Myalgia Advocacy, Information, Support eosinophiliaMyalgia Advocacy, Information, Support http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

13. Postgraduate Medicine A Practical Workup For Eosinophilia A practical workup for eosinophilia http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

14. IL-13 Is Sufficient For Respiratory Syncytial Virus G IL13 Is Sufficient for Respiratory Syncytial Virus G Glycoprotein-Induced eosinophilia After Respiratory Syncytial Virus Challenge 1 http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

15. Eosinophilia-Myalgia Syndrome Symptoms Blueball eosinophilia (elevated levels of eosinophils, a type of white blood cell; Blueball Myalgia (muscle pain continued while eosinophilia usually http://www.swiftsite.com/eosinophilia-myalgia/symptoms.htm

Symptoms of Eosinophilia-Myalgia Syndrome (EMS) Symptoms of EMS in its Various Stages from Acute to Chronic Please see Bibliography at end of List Symptoms Often Found in the Acute Phase of EMS (early months; onset) Please remember that this list is not meant to be absolutely representative of all cases at this stage. EMS is a diverse disease which manifested in different ways in people. However, certain symptoms tended to appear frequently in the acute stage, though not in all persons. Also, it's possible other symptoms appeared in some persons at this point in the disease not listed here. I am not an expert. Please see references at end. Eosinophilia (elevated levels of eosinophils , a type of white blood cell; sometimes was not tested, so was missed; may be possible that some persons got EMS but did not have eosinophilia) Myalgia (muscle pain) Swelling (edema) of the face or extremities or other areas of the body, such as the arms Weight changes (gain followed by loss; or just loss; or perhaps just gain) Hair loss (scalp and body hair; tended to grow back later though not always a complete return to normal)

16. IL-13 Is Sufficient For Respiratory Syncytial Virus G Your browser does not support frames. Click here to view the unframed reprint. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

17. THE MERCK MANUAL, Sec. 11, Ch. 136, Eosinophilic Disorders eosinophilia. A peripheral blood eosinophil count 350/µL. The development of eosinophilia has features of an immune response a primary challenge with an http://www.merck.com/mrkshared/mmanual/section11/chapter136/136b.jsp

18. Construction And Characterization Of Recombinant Vaccinia Viruses Coexpression of IFN- during vvGs priming results in a trend towards reduced BAL eosinophilia following RSV challenge Lack of IFN- increases http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

19. Eosinophilic Fasciitis & Eosinophilia-Myalgia Syndrome Article describes eosinophilic fasciitis and eosinophiliamyalgia syndrome, their symptoms, diagnoses, and treatments. http://rarediseases.about.com/cs/efandems/a/060202.htm

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20. Construction And Characterization Of Recombinant Vaccinia Viruses and B. S. Graham IL13 Is Sufficient for Respiratory Syncytial Virus G Glycoprotein-Induced eosinophilia After Respiratory Syncytial Virus http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

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