1. The Diabetes Insipidus Foundation, Inc. Provides information on the different forms of diabetes insipidus. Includes an email support group, articles, brochures, FAQs, and other information. http://www.diabetesinsipidus.org/

Dif 2nd Annual Conference - Don't Miss It! Aug. 6 - 7, Sheraton Inner Harbor - Baltimore, MD, USA more info Welcome to the Water World of Diabetes Insipidus: "A DiFferent Diabetes!" What is Diabetes Insipidus? diabainein: Greek, "to pass through" insipidus: Latin, "having no flavor" Also known as "water diabetes," it is often mistaken for diabetes mellitus/sugar diabetes. It is a rare disease, not widely diagnosed, in which the kidneys produce abnormally large volumes of dilute urine. DiF's website includes information on all four forms of Diabetes Insipidus, as well as articles, brochures, stories, FAQ's, networking, Research Opportunities, a Professional Section including the Water Deprivation Protocol , and a section for Pets. Please go to the Table of Contents for a detailed listing of the site. There are four (4) fundamentally different types of Diabetes Insipidus (DI). Each has a different cause and must be treated in a different way. These four forms are: Neurogenic , also known as central hypothalamic, pituitary

2. MedlinePlus Medical Encyclopedia: Diabetes Insipidus Article from Medline Plus includes information on this illness such as causes,incidences, risk factors, with links to central DI, Nephrogenic DI, http://www.nlm.nih.gov/medlineplus/ency/article/000377.htm

@import url(/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Diabetes insipidus Contents of this page: Illustrations Definition Causes, incidence, and risk factors Symptoms ... Calling your health care provider Illustrations Endocrine glands Definition Return to top Diabetes insipidus is caused by the inability of the kidneys to conserve water, which leads to frequent urination and pronounced thirst. Causes, incidence, and risk factors Return to top Diabetes insipidus (DI) is an uncommon condition that occurs when the kidneys are unable to conserve water as they perform their function of filtering blood. The amount of water conserved is controlled by antidiuretic hormone ( ADH ), also called vasopressin. ADH is a hormone produced in a region of the brain called the hypothalamus. It is then stored and released from the pituitary gland, a small gland at the base of the brain. DI caused by a lack of ADH is called central diabetes insipidus. When DI is caused by failure of the kidneys to respond to ADH, the condition is called nephrogenic diabetes insipidus. The major symptoms of diabetes insipidus are excessive urination and extreme thirst. The sensation of thirst stimulates patients to drink large amounts of water to compensate for water lost in the urine. Central diabetes insipidus is caused by damage to the hypothalamus or pituitary gland as a result of surgery, infection, tumor, or head injury. Although rare, central DI is more common than nephrogenic DI.

3. Nephrogenic Diabetes Insipidus Foundation NDI Information & Resources The NDI Foundation was formed to support education, research, treatment, and cure for nephrogenic diabetes insipidus. Includes nutrition guidelines and articles. http://www.ndif.org/

The Nephrogenic Diabetes Insipidus Foundation is dedicated to informing and helping the NDI community. About the NDI Foundation Journal Articles Researcher Directory Global Conferences Questionnaires Foundation News Researcher Profiles Terminology Medical Alert Cards Frequently Asked Questions Nutrition Guidelines How Can I Help? TABLE of CONTENTS INFORMATION REQUEST Research Participation Opportunity Nephrogenic Diabetes Insipidus Foundation Main Street P.O. Box 1390 Eastsound, WA 98245 (voice) 888-376-6343 (fax) 888-376-6356 e-mail: info@ndif.org Last updated July 26, 2005 You are visitor: 414099 Site developed by: orcas net, inc NDI foundation, nephrogenic, diabetes, insipidus, kidney disorder, urination, thirst, nephrogenic diabetes insipidus, NDI foundation, nephrogenic, diabetes, insipidus, kidney disorder, urination, thirst, nephrogenic diabetes insipidus

4. Pets With Diabetes: Diabetes Insipidus Symptoms, diagnosis, treatment, personal accounts, and references. http://www.petdiabetes.org/diabetes_insipidus.htm

Diabetes Insipidus Diabetes Insipidus Types Signs ... References What is Diabetes Insipidus? Diabetes insipidus (DI) is a disorder of water balance. The animal is unable to concentrate urine, so the urine volume is very high and the urine is dilute. "Insipid" means tasteless referring to the dilute urine. This disease is rare in both dogs and cats. The condition is usually permanent, and the prognosis is good. Without treatment, dehydration leads to stupor, coma, and death. This is a completely different disease from Diabetes Mellitus (DM), a disorder of sugar metabolism involving the hormone insulin. We include the information here because people are often looking for resources and we had some owners of pets with DM who also have experience with DI. Types of diabetes insipidus Central Diabetes Insipidus - caused when the pituitary gland does not secrete enough antidiuretic hormone (ADH) [also called vasopressin]. This type of DI may be the caused by a congenital defect, trauma, a tumor on the pituitary gland, or unknown causes. Nephrogenic Diabetes Insipidus - caused when the kidneys do not respond to the ADH that is produced by the pituitary gland. This type of DI may be caused by a congenital defect, drugs, or caused by other metabolic disorders

5. DIABETES INSIPIDUS Printable and easy to understand fact sheet that covers the basics of this disorder. http://www.rxmed.com/b.main/b1.illness/b1.1.illnesses/DIABETES INSIPIDUS.htm

General Illness Information Common Name: Diabetes Insipidus Medical Term: Description: A rare disorder, resulting in excessive thirst and excessive passage of very dilute urine, due to a hormone deficiency in the pituitary gland, which is situated at the base of the brain. Diabetes Insipidus results from a decreased production of antidiuretic hormone ( vasopressin) , the hormone that normally prevents the kidney from producing too much urine. Antidiuretic hormone is produced in the hypothalamus, then stored and released in the blood stream by the posterior pituitary. Diabetes insipidus may also occur with normal levels of antidiuretic hormone, when the kidneys do not respond normally to the hormone. This condition is called nephrogenic diabetes insipidus. Causes: Diabetes Insipidus may have several causes which are as follows: Tumor of the pituitary gland;

6. The Facts About Diabetes Insipidus Article that details what DI is, how it affects you, symptoms, prevention, diagnosis, and treatments with many reference links for the newly diagnosed. http://www.histio.org/association/library/diabetes.shtml

Current Time Thursday, 08-Sep-2005 22:02:16 EDT The Facts About Diabetes Insipidus Histiocytosis Association of America Information about the Histiocytosis Association of America Histiocytosis Association of America Board of Trustees Histiocytosis Association of America Contact Information Scheduled Events Information Request Form Patient Survey Getting Involved with the Histiocytosis Association Website Lounges Live Chat Online Library Histiocyte Society What is diabetes insipidus? Some patients with Langerhans cell histiocytosis (LCH) develop loss of control of water balance through a deficiency or lack of a hormone, vasopressin. The disorder is called "diabetes insipidus." Areas in the middle of the brain secrete this antidiuretic hormone that is then stored in the pituitary gland. In most cases, the portion of the brain that secretes this hormone or the pituitary, which stores the antidiuretic hormone, has been damaged by the presence of histiocytes. The hormone is necessary to maintain a proper water balance within the body's cells and blood. How does diabetes insipidus affect the body?

7. Disorder-Specific Survival Kit Nephrogenic Diabetes Insipidus Includes information about the cause, diagnosis, and management of NDI and other types of diabetes insipidus. http://depts.washington.edu/transmet/The process/ndi.htm

Disorder-Specific Survival Kit: Nephrogenic Diabetes Insipidus Information about NDI The cause of NDI Other types of diabetes insipidus Management of NDI ... Selected Medical and Scientific References Information about NDI Nephrogenic diabetes insipidus (NDI) is a disorder characterized by an inability of the kidneys to remove water from the urine. The main symptoms of NDI are excessive thirst (polydipsia) and excretion of large amounts of watery urine (polyuria). Individuals with NDI must drink large amounts of water to compensate for the loss of water in the urine. As a result, a person with NDI must urinate more frequently than usual. The Cause of NDI NDI is caused by an inability of a water-saving hormone to work properly in the kidneys. A hormone is a natural chemical made by the body that works in a different part of the body than where it was made. The hormone involved in NDI is called antidiuretic hormone (ADH), also known as vasopressin. Making ADH is one of the mechanisms which help keep water balance normal in the body. Usually, ADH allows the kidneys to save water that would otherwise be lost in the urine. The kidneys are the organs that make urine and help control the balance of water, salt, and other natural substances in the body. ADH is made by the pituitary gland, a small organ at the base of the brain that makes many different hormones. ADH is released into the blood stream where it travels to the kidneys. The amount of ADH made by the pituitary gland depends on the body's water needs. The more water the body needs, the greater the amount of ADH made by the pituitary gland. Only when there is plenty of water does the pituitary gland make less ADH.

8. Thomas Jefferson University Hospital - Diabetes Insipidus Provides a fact sheet on this hormone disorder. Includes causes, treatments and diagnosis. http://content.jeffersonhospital.org/Content.asp?PageID=P00404

9. GeneReviews: Nephrogenic Diabetes Insipidus Includes detailed statistics, summary of the illness, clinical descriptions, diagnosis, management, genetic counseling, and resources. http://www.geneclinics.org/profiles/ndi/

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10. Diabetes Insipidus:  The Other Diabetes Susan ThorpeVargas, Ph.D., explains the types of diabetes insipidus, how the kidney functions, symptoms, diagnosis, treatment, and living with a dog with DI. http://www.mirage-samoyeds.com/diabetes2.htm

Back to Health Home Back to Endocrine Diabetes Insipidus: The Other Diabetes By Susan Thorpe-Vargas, Ph.D. A disease that many people have never heard of may be indirectly causing canine deaths. Not only is the disease dangerous in itself, but the primary symptoms include a behavior that could be perceived, or misinterpreted by owners, trainers and veterinarians, as purposefully destructive, and which figures prominently in the statistics of animals turned over to dog pounds and to veterinarians for euthanasia. The behavior we are referring to is the need for frequent urination. Seldom do owners and veterinarians search for potential medical problems that might contribute to house soiling behaviors. And, if they do, seldom are those searches for medical causes of inappropriate elimination practices complete. At least a quarter of all dogs euthanized or turned into shelters are given up because of behavior related issues. Near the top of the list of reasons for euthanasia and being turned into shelters is house soiling. Therefore, whenever an inappropriate elimination behavior develops, look first for an underlying medical condition before starting training or behavior modification exercises. While diabetes insipidus (DI) is less common than its better-known form, diabetes mellitus, it is probably an under-reported disease as it shares symptoms with other more common diseases including diabetes mellitus. The disease can also go unnoticed if the dog has a constant supply of water and has access to an outdoor run or a doggy door so that his excessive elimination needs do not require human intervention. Nonetheless, the disease is dangerous, and severe dehydration can occur very rapidly (4-6 hours). Leaving a DI dog unattended without water for several hours or overnight may result in severe hyperosmolality, coma, and death.

11. MedlinePlus Diabetes Insipidus diabetes insipidus http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

12. MedlinePlus: Diabetes Insipidus How to Find the Hidden Sodium (Nephrogenic diabetes insipidus Foundation).Specific Conditions; Four Types of diabetes insipidus (DI) (diabetes insipidus http://www.nlm.nih.gov/medlineplus/diabetesinsipidus.html

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Other health topics: A B C D ... List of All Topics Diabetes Insipidus Contents of this page: From the NIH Overviews Diagnosis/Symptoms Nutrition ... Children Search MEDLINE/PubMed for recent research articles on Diabetes Insipidus You may also be interested in these MedlinePlus related pages: Pituitary Disorders Endocrine System (Hormones) Metabolic Problems From the National Institutes of Health Diabetes Insipidus (National Kidney and Urologic Diseases Information Clearinghouse) Overviews Diabetes Insipidus (American Academy of Family Physicians) Also available in: Spanish What Is Diabetes Insipidus? (Diabetes Insipidus Foundation) Diagnosis/Symptoms Polyuria and Polydipsia (Diabetes Insipidus Foundation) Symptoms of Diabetes Insipidus (Diabetes Insipidus Foundation) Tests Used to Diagnose Diabetes Insipidus (Diabetes Insipidus Foundation) Nutrition Cutting Out the Salt, Finding the Flavor of Life (Diabetes Insipidus Foundation) Label Reading Tips...How to Find the Hidden Sodium

13. MedlinePlus Medical Encyclopedia Diabetes Insipidus diabetes insipidus is caused by the inability of the kidneys to conserve water, which leads to frequent urination and pronounced thirst. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

14. About Lithium NDI Visit the The diabetes insipidus Foundation, Inc. at our new web address Thanks for visiting us at the diabetes insipidus Foundation, Inc. http://diabetesinsipidus.maxinter.net/

Visit the The Diabetes Insipidus Foundation, Inc. at our new web address: http://www.diabetesinsipidus.org. Please wait 15 seconds and you will automatically go to our new location. Remember to update your bookmark when you arrive. Thanks for visiting us at the Diabetes Insipidus Foundation, Inc. We thank Omega Communications, Inc., Charlie Cocuzza, Pete Cousin, and Cliff Perdion for all their help and for providing internet access, our website and email gratis.

15. The Diabetes Insipidus Foundation, Inc. Welcome to the Water World of diabetes insipidus "A DiFferent Diabetes!" What is diabetes insipidus? http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

16. Diabetes Insipidus Familydoctor.org Information about diabetes insipidus from the American Academy of Family Physicians. http://familydoctor.org/048.xml

Advanced Search familydoctor.org Home Conditions A to Z Diabetes Diabetes Insipidus What is diabetes insipidus? What causes diabetes insipidus? How do you test for diabetes insipidus? How is diabetes insipidus treated? ... How can I learn more? Diabetes Insipidus Printer-friendly version Email this article What is diabetes insipidus? Despite the similar names, diabetes insipidus is not related to diabetes mellitus (which is sometimes called sugar diabetes). Some people with diabetes insipidus have kidneys that don't concentrate urine very well (meaning their urine is more diluted). They have to urinate very often. They might wake up 2 or 3 times in the night to urinate. People with diabetes insipidus are thirsty all the time. They often want to drink liquids every hour. Return to top What causes diabetes insipidus? Two things cause diabetes insipidus. In some people, a part of the brain (called the hypothalamus) doesn't make enough antidiuretic hormone (called ADH), which your body needs to work right. In other people, the kidneys don't work with this hormone the way they should. Most people with diabetes insipidus get it after an injury to the head or after brain surgery. Some people with diabetes insipidus have a brain tumor. Sometimes it runs in families. Some medicines, like lithium, can also cause it. About 25% of the time, doctors can't find any reason for it. Return to top How do you test for diabetes insipidus?

17. PUPD And Diabetes Insipidus - WSAVA 2002 Conference presentation by Richard W. Nelson, DVM, on distinguishing diabetes insipidus from other conditions that cause excessive thirst and urination. http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2002&PID=2556

18. Diabetes Insipidus Familydoctor.org Information about diabetes insipidus from the American Academy of Family Physicians. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

19. Diabetes Insipidus Familydoctor.org Despite the similar names, diabetes insipidus is not related to diabetes Some people with diabetes insipidus have kidneys that don t concentrate urine http://familydoctor.org/048.xml?printxml

20. Tigger's Diabetes Insipidus Story Personal account of this dog's diagnosis and treatment. http://brindleweb.com/pets/tigdi.html

Tigger's Diabetes Insipidus Story written by brindle Tigger has always seemed like he needed to drink and pee a lot. I was worried about this right from "Day One" when we brought him home from the SPCA and noticed how much he drank. I mentioned to the vet on his very first vet visit about 3 days after we got him - but the vet said not to worry, it was just because of the hot weather. I was still uneasy though. It made him very hard to housetrain and really tried our patience during those first few weeks. He needed to go out almost every 15 minutes or so!! And he just guzzled water. But we learned to sort of manage it so that was that. It was definitely a whole change of lifestyle because no matter what I was doing, I was thinking, "When was Tigger out last? Did I just see him head towards the door? Did I hear him drink any water lately?" However, I got really worried when he starting having "accidents" IN HIS SLEEP. ie, he would not get up, whimper or anything at all, just leave a wet puddle behind afterwards. This worried me since I had read about other dogs having Urinary Tract Infections and having similar symptoms. After it happened about 3 times, we took him to the vet. He said there was no infection. So he got us to do "water deprivation tests" where we didn't give Tig any water for 10 hours or so and then get a urine sample. (We did it over night so it wasn't so hard on him, it just meant I would cut off his water earlier in the evening). Anyway, after doing these tests it seemed that no matter how little water Tigger drank, his urine was still about the same concentration (quite dilute). That meant that Tigger

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