121. Proteome Systems - Proteomics Technology And Discovery Specializes in interpretation of 2dimensional gels, and developing point-of-care diagnostics in the areas of cystic fibrosis, cancer, infectious disease and aging. Includes alpha-amylase test, and research programs, with contacts in USA, Japan and headquarters in Sydney, Australia. http://www.proteomesystems.com/

Home Contact Us var hcenter=(((window.screen.availWidth-640)/2)-23); var vcenter=(window.screen.availHeight-490)/2; Log On Online Catalogue Search: Advanced Search var baseHREF = "http://www.proteomesystems.com/inc/106/Menu/"; CORPORATE  TECHNOLOGY DISCOVERY DIAGNOSTICS ... INVESTORS Welcome to Proteome Systems US Government Grant funds PXL “scavenger drugs” to treat radiation damage Proteome Systems (PXL) and its partners today announced they have been awarded a National Institute of Health (NIH) grant to develop its “scavenger compounds” to treat radiation exposure caused by terrorist attacks or industry accidents. The US$20 million grant has been awarded to a consortium consisting of Proteome Systems, Medical College of Wisconsin, Henry Ford Health Systems in Detroit, and the University of Toronto. The consortium will together develop Proteome’s proprietary therapeutic compounds for the treatment of radiation damage.... Two significant developments for Proteome Systems' Technology business Multifunctional electrophoresis systems Proteome Systems has created a unique set of integrated 2-D electrophoresis systems designed from the ground up by pioneers in the field. Our system combines pre-fractionation technology, the multi-compartment electrolyser (MCE), with isoelectric focusing (IEF), SDS-PAGE and semi-dry electro-blotting. Take a closer look...

122. Cystic Fibrosis The Human Genome Project website by The Wellcome Trust. http://www.wellcome.ac.uk/en/genome/genesandbody/hg06f006.html

Cystic fibrosis 30/7/03. By RT Cystic fibrosis is a relatively common inherited disorder involving the accumulation of thick mucus in the lungs and pancreatic ducts. This causes breathing difficulties, chronic respiratory infections and problems with digestion. Although there is no cure for the disease, appropriate clinical management in the form of physiotherapy, antibiotic treatment and a supplemented diet allows most patients to live well into their 30s. Genetics Cystic fibrosis is a single gene disorder caused by a malfunctioning gene on chromosome 7. It is a recessive disease , which means that both copies of the gene must be defective. It has the highest incidence of any recessive disease in Caucasian populations (approximately 1 in 2000) but it is less common in other population groups (1 in 15 000 in Africans, and 1 in 30 000 in Asians). The disease gene is named CFTR, which stands for cystic fibrosis transmembrane conductance regulator. The normal product of this gene is a chloride channel, a protein whose function is to export chloride ions from the cell. The CFTR protein also helps to regulate the import of sodium ions. Its overall effect is to prevent the accumulation of salt (sodium chloride) inside mucus-producing cells, which is necessary to produce mucus of the correct consistency.

123. Clayton Bates CF Support Site - Home For family, friends, and other supporters to find out about the disease and offer support for Clayton. http://www.claytonbates.org

@import "raised.css"; Skip Navigation Clayton Bates Cystic Fibrosis Support Site Menu Home News CF Data Family ... Guestbook Change Styles Default Alternative 1 Introduction My son has Cystic Fibrosis. He is 5 years old. He was born on July 6, 2000. Clayton was diagnosed with Cystic Fibrosis at 18 months old. So far, he has had 4 hospital stays and 1 surgery. His favorite things: Colors = Green and Blue Food = Pizza, ,Chicken Nuggets, and lots of Ketchup Toys = anything "Little People", "Bob the Builder", and "XBOX" Animals = frogs and tigers This site is for family, friends, and other supporters to find out about CF and offer support for Clayton. Latest Guestbook Entry Visitors since February 1, 2005 This site is a member of WebRing. To browse visit Here

124. Cystic Fibrosis - DrGreene.com Learn about this genetic condition, how it is diagnosed, and what treatment is necessary to prolong life. http://www.drgreene.com/21_1064.html

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125. We'll Find A Cure // This Time Around Supports fans with cystic fibrosis. Lyrics, fun, links and campaigns. http://www.fallenstars.com/hmh/

Java Applet list of Hanson fans with cystic fibrosis Please take a moment to let it load. No applet? Click here Enter Site Best viewed with Microsoft Internet Explorer. To my cousin Rae-Anne, my best friend Felicity and everyone touched by CF, this page is for you. FastCounter by LinkExchange HTP Magazine. House Of Hope Central i'll admit it ... i love hanson.

126. CF Advantage The mutation that causes deadly cystic fibrosis has survived for 52,000 years perhaps because it offers protection against diarrhea. By Josie Clausiusz http://wsrv.clas.virginia.edu/~rjh9u/cysfib.html

Hidden Benefits Josie Clausiusz The mutation that causes deadly cystic fibrosis has survived for 52,000 years - perhaps because it offers protection against diarrhea. When humans left the Near East and invaded Europe around 40,000 years ago, they took with them bone and stone tools for hunting and engraving, early art in the form of beads and pendants, and social skills that were probably superior to those of Europe's resident Neanderthals. It now seems they also took with them a mutant gene: the gene for the deadly disease cystic fibrosis. So robust is this gene that it spread all over Europe; cystic fibrosis is now the most common fatal genetic disorder among Caucasians. How could the disease have been passed from generation to generation for so long, when until the advent of modern medicine it generally killed people before they could have children? Recent experiments on mice offer an answer. They suggest that the 5 percent of all Caucasians who carry just one copy of the cystic fibrosis gene - and thus don't suffer from the disease - are protected against another deadly scourge: diarrhea. The gene for cystic fibrosis was discovered in 1989. It codes for a protein that forms channels in cell membranes, especially the cells lining the intestines and airways. Normally these channels funnel chloride ions out of a cell, thus making its surroundings saltier; that in turn draws water out of the cell by osmosis. In the lungs this fluid washes away bacteria and other unwanted debris. In the intestines it does the same and also brings digestive enzymes into contact with food. In sweat glands chloride channels have an additional function; they recycle salt out of the glands and back into the skin before it can be lost to the outside world.

127. GeneCare Medical Genetics Center - Patient Information On Cystic Fibrosis Testin UW Pediatrics cystic fibrosis CenterThe University of Wisconsin cystic fibrosis Center is dedicated to providing state of the art care to patients with cystic fibrosis. http://www.genecare.com/cf.html

Cystic Fibrosis Testing What is Cystic Fibrosis? CF begins in infancy or early childhood, and may include pneumonia, breathing problems, lung damage, intestinal problems, and poor growth. While CF treatment has improved, death may occur in early childhood or as a young adult. The average lifespan is about 31 years. Cystic fibrosis (CF) is an inherited disorder which occurs in about 1 in 2,500 live births. CF occurs more often in Caucasian and Jewish individuals than in other ethnic groups. How is CF Inherited? CF is inherited as a recessive genetic disorder. Recessive means the effect of the CF gene is only seen when a baby inherits a CF gene from both parents. Parents of a CF baby carry one CF gene and one normal gene and are unaffected CF carriers. When both parents carry a CF gene, they have a 1 in 4 (25%) chance of having a baby with CF with each pregnancy; a 2 in 4 (50%) chance the baby will carry the CF gene, but not have CF; and a 1 in 4 (25%) chance the baby will not carry the gene. Why Screen for CF?

128. Cystic Fibrosis Foundation - Special People Salutes Cochran for her support of the cystic fibrosis Foundation. (April 2001) http://www.cff.org/special_people/index.cfm?ID=55

129. Cystic Fibrosis - Pulmonologychannel Information on cystic fibrosis. http://www.pulmonologychannel.com/cf/

Home Search SiteMap Contact Us ... Physician Board CYSTIC FIBROSIS Overview Symptoms Diagnosis Treatment ... Additional Information CONDITIONS Anemia ARDS Asthma Bronchitis ... Solitary Pulmonary Nodule Tuberculosis DIAGNOSTIC TESTS CT Scan MRI Scan RESOURCES Anatomy Clinical Trials Glossary Links ... What Is a Pulmonologist? ABOUT US Healthcommunities.com Pressroom Testimonials Overview Cystic fibrosis (CF) is the most common fatal, inherited disease in the United States (see Incidence ). CF causes the body to produce abnormally thick and sticky mucus in several different parts of the body, most prominently in the lungs and other parts of the respiratory system. It also affects the pancreas, leading to serious digestive problems. CF alters the mucus secretions of the body’s epithelial cells. Epithelial cells make up the outside layer of tissue that lines every open surface of the body, inside and out, including the various tunnels and cavities in the lungs, urinary tract, liver, and reproductive tract. In patients with CF, the mucus that the epithelial cells secrete is much thicker and stickier than normal. It clogs the airways of the lungs, blocking the flow of air and making the tissue vulnerable to continual lung infections. It blocks the flow of pancreatic juices in the pancreas, impeding digestion and the absorption of fats and fat-soluble vitamins, leading to nutrition deficiencies and intestinal complications. CF is a genetic disease resulting from the inheritance of a defective autosomal recessive gene (see

130. National Cystic Fibrosis Awareness National cystic fibrosis Awareness Committee The National cystic fibrosis Awareness Committee (NCFAC) exists to serve as an instrument for advancing the http://www.cfawareness.org/

131. BioSpace News: Cystic Fibrosis News on new developments with cystic fibrosis. Kept in an easy to use format with upto-date links. http://www.biospace.com/news_rxtarget.cfm?RxTargetID=63

132. Jenta Industries Is A Non-profit Idaho Corporation. As a way to deal with the loss of her daughter to cystic fibrosis, Carolyn Haning started making stuffed puppies and to date, has donated over 40,000 of the little cuddly pets to children who are hospitalized or suffer from abuse and neglect. http://lovepuppy.wildwebwest.com

HOME OUR STORY PHOTO GALLERY ORDER A LOVE PUPPY ... CONTACT US Welcome to the "Love Puppy" Program. Jenta Industries is a non-profit Idaho Corporation that provides "Love Puppies" to children who are hospitalized or are subject to trauma, abuse or neglect. We have over 350 hospitals on our permanent "Love Puppy" program who receive regular shipments of these cuddly stuffed pups, free of charge, to give away to their young patients. We have also donated "Love Puppies" to several nursing homes, homes for abused children, and homes for handicapped kids, as well as to several agencies that deal with child abuse and neglect. The area law enforcement officers carry our puppies in their patrol cars to comfort children who have been victims of car accidents or domestic disputes. Our primary contributors are the families of children who receive the puppies. They have always been very generous with their gifts. We also sell some of the puppies to help offset costs of manufacturing. They sell for $10 and we can make three puppies for the kids, for every one that we sell. We have every color imaginable, so we can fill those special orders for Christmas too. If you are interested in purchasing a "Love Puppy", please

133. Healthfinder® - Cystic Fibrosis Carefully selected government and nonprofit health information on cystic fibrosis. http://www.healthfinder.gov/Scripts/SearchContext.asp?topic=216

134. Cystic Fibrosis Find out what cystic fibrosis is, the symptoms and the causes. http://www.mamashealth.com/cfibrosis.asp

Mamashealth.com Home Lung Diseases and Illnesses ARDS Asbestosis Asthma Black Lung Disease ... Tuberculosis Links Email Mama What is Cystic Fibrosis? Cystic fibrosis is a chronic, non contatious, fatal genetic disorder that affects over 30,000 Americans. It is the most common inherited disease affecting children and young adults. This disease is marked by chronic infections, clogged airways, and digestive and reproductive problems. Cystic fibrosis affects tissues that produce mucus secretions, such as the airway, the gastrointestinal tract, the ducts of the pancreas, the bile ducts of the liver and the male urogenital tract. Cystic fibrosis affects the body's epithelial cells. Epithelial cells make up the lining of the lungs pancreas liver digestive tract and reproductive system, and are also found in the sweat glands and sinuses. In cystic fibrosis patients, the mucus is very thick. Mucus usually protects tissues from harm, but abnormally thick mucus obstructs the ducts and airways, causing damage to the tissues. It affects different tissues different ways. In the lungs the thick mucus clogs the respiratory system and allows bacteria to grow in it. The thick mucus also impairs the pancreas by preventing enzymes from reaching the intestines to digest food. The bile ducts in the liver may be affected, causing biliary cirrhosis in a small percentage of patients. Salt absorption in the sweat ducts is also impaired, and CF patients produce extremely salty sweat.

135. Cystic Fibrosis -- Topic Overview What is cystic fibrosis? cystic fibrosis (CF) is a chronic and progressive disease usually diagnosed http://my.webmd.com/hw/cystic_fibrosis/hw188550.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... Credits Cystic Fibrosis Topic Overview What is cystic fibrosis? Cystic fibrosis (CF) is a chronic and progressive disease usually diagnosed in childhood that causes mucus to become thick, dry, and sticky. The mucus builds up and clogs passages in many of the body's organs, but primarily the lungs and the pancreas . In the lungs, the mucus can lead to serious breathing problems and lung disease. In the pancreas, the mucus can lead to malnutrition and problems with growth and development. People with CF have an average life expectancy of about 32 years, although new treatments offer hope for longer and healthier lives. To back to the top Cystic Fibrosis: Topic Overview Previous Next Search the Help Last updated: August 20, 2003

136. Tests And Indications Information about a test for seven common inherited diseases in the Ashkenazi Jewish population TaySachs disease, Canavan disease, cystic fibrosis, Gaucher disease, Bloom syndrome, familial dysautonomia and Fanconi anemia. http://cfar-www.med.nyu.edu/genetics/lab/ashkenazi_screen.html

NYU Medical Center Home NYU School of Medicine Home Research Home Administration ... Calendars Tests and Indications Cystic Fibrosis Cystic fibrosis is the most common genetic disorder among Caucasians (1:29) and is less common among other ethnic groups (see table below). The American College of Medical Genetics (ACMG) recommends that CF screening be offered to couples considering starting a family and recommends the mutation panel listed below for all ethnicities. The detection rate differs with ethnic origin and is shown along with after testing residual risk estimates in the table below. Mutations Analyzed: 621+1G->T 1717-1G->A 711+1G->T 1898+1G->A 3849+10kbC->T 2789+5G->A 3120+1G->A This test distinguishes the F508C, I507V, and I506V polymorphisms and the poly T allele is reported where clinically significant. Sensitivity and Estimated Carrier Risk: Estimated Carrier Risk Ethnic Group Detection Rate Before Test After Test Ashkenazi Jewish ~1 in 930 European Caucasian ~1 in 140 African American ~1 in 207 Hispanic American ~1 in 105 Asian American ND ND Ashkenazi Jewish Genetic Disease Screening A video entitled: "The Importance of Genetic Screening for Ashkenazi Jewish People" is available on our website and may be shared with your patients.

137. Breathing Room: The Art Of Living With Cystic Fibrosis Guidance about the art of living with cystic fibrosis. http://www.thebreathingroom.org

Home News and Info Looking Glass Caregiver Stories ... Contact Join our newsletter list! Enter your email address: Breathing Room has lots in store for the new year. If you would like to share your personal stories, news items or poetry with us, please contact: us at: info@thebreathingroom.org. Also, please visit cfmessageboard.com to connect with members of the CF community online. Breathing Room facilitates candid and open communication between adults with Cystic Fibrosis, supports the development of a community of adults with CF and provides education and insight for families, caregivers, and medical professionals who impact our lives. to donate to Breathing Room Technology by Facing the Limit Statistics. Numbers. Data. They swim in my head like a school of fish, confusing me and forcing me to face the ultimate question – how much time do I have? A Thousand Cranes My twin daughters with cystc fibrosis Haunted by their impending death. Crossing a turbulent river trying to reach the other side, Two choices: drown or reach the other shore. Personal stories wanted Breathing Room wants to hear from you!. We will be posting revolving themes several times during the year, and want to hear your thoughts and experiences. For guidelines, please check

138. Cfnetwork Creates a platform for scientists involved in fundamental CF research, for the more than 160 genetic diagnostic laboratories, for CF associations of http://www.cfnetwork.be/

European Thematic Network for Cystic Fibrosis The European Cystic Fibrosis Thematic Network was a project approved under the th framework program from the European Union. At the moment the CF network is running without financial support of the EU. The network works in close collaboration with Unit 1 of EuroGentest Since 1996, European External Quality Assessment (EQA) schemes have been set up for genetic testing of cystic fibrosis with the support of the EU (Biomed (1996 - 1999 BMH4-CT96-0462), EMQN (1998 - 2001 SMT4-CT98-7515) and the European CF network (2000 - 2004 QLK3-CT99-0241)). Since 2004 the CF EQA schemes are partially supported by companies. Six purified DNA samples harbouring homozygous or heterozygous CFTR mutations are sent annually to approximately 250 laboratories with the request to test for the presence of CFTR mutations, using their routine protocols. Since 1999, the scope of the scheme has been broadened. It includes the entire analytical process, from DNA sample receipt up to the written report with the final interpretation of the data as it is normally being sent to the clinician who requested for the genetic test. To ensure anonymity during the whole procedure, an identification number is assigned to each participant by the scheme organizer.

139. Cystic Fibrosis Disease Profile Images of all 24 human chromosomes and different genes that have been mapped to them. Free wall poster available from Web site. http://www.ornl.gov/sci/techresources/Human_Genome/posters/chromosome/cf.shtml

Human Genome Project Information Genomics:GTL Microbial Genome Program home The U.S. Department of Energy Biological and Environmental Research program funds this site. Genetic Disease Profile: Cystic Fibrosis For more about the gene that causes cystic fibrosis, see the CFTR Gene Profile . The following was taken from NIH Publication No. 95-3650 Cystic Fibrosis Timeline Middle Ages - In medieval folklore, infants with salty skin, a symptom of cystic fibrosis, are considered "bewitched" because they routinely die an early death. - Fanconi refers to the previously nameless condition as "cystic fibrosis with bronchiectasis." - Andersen of Columbia University develops the first comprehensive description of cystic fibrosis symptoms. - Lowe establishes that cystic fibrosis is a recessive genetic disorder. - After observing excessive dehydration of cystic fibrosis patients during a New York City heat wave, di Sant' Agnese of Columbia University formally reports to the American Pediatric Society that CF patients secrete excessive amounts of salt in their sweat. This observation leads to development of the sweat test as a diagnostic standard for cystic fibrosis.

140. Cystic Fibrosis Medicine Provides a place to search various databases for cystic fibrosis articles, links to other CF sites, a message forum and a wide variety of information on management of the disease. http://www.cfprescriber.com/

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