Home About Services Kate Connick ... Site Map Canine Cushing's Disease Cushing's Disease (hyperadrenocorticism) is a common condition in older dogs, often mistaken for the aging process itself. Dogs gain weight, lose hair, urinate in the house, and make owners begin to prematurely consider euthanasia. Yet Cushing's disease is treatable and that treatment can result in a longer, more comfortable life for the dog and its owner. Thus, it is important for the regular pet owner to learn the basic facts about Cushing's disease. In health: In Cushing's Disease: The feedback loop has gone awry in Cushing's disease for one of three reasons: a pituitary tumor, an adrenal tumor, or veterinary interference. The result is a chronic excess of blood cortisol. In effect, the dog is being poisoned with too much cortisol and cannot rely on its own feedback mechanism to regulate the blood cortisol level. Pituitary Dependant Hyperadrenocorticism: The most common cause of Cushing's disease is a microscopic, benign pituitary tumor (microadenoma) which oversecretes ACTH and ignores the adrenals' response. 50% of pituitary tumors are less than 3mm in diameter. The dog's pituitary keeps cranking out ACTH, causing the adrenals to keep cranking out cortisol, yet the pituitary does not respond to the elevated blood cortisol levels by stopping its release of ACTH. 85% of Cushing's cases are pituitary dependent. Dogs with pituitary dependent hyperadrenocorticism tend to have two very large adrenal glands, as both are constantly working to keep up production of excess cortisol. | |
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