61. Cushing's Syndrome Of The Adrenal: The Obesity Tumor. Award winning site describes all adrenal diseases and tumors. Symptoms, diagnosis,and treatments for Cushing s disease and cortisol secreting tumors. http://www.endocrineweb.com/obesity.html

~ Cushing's Syndrome ~ Note: this page contains information which assumes you have read our introduction to the adrenal gland page . If not, go there first. Remember, the adrenal gland has a center gland (medulla) which produces adrenaline , and an outer gland (the cortex) which produces several hormones such as cortisol an aldosterone. This page is about cortisol overproduction by the adrenal cortex. In 1932, a physician by the name of Harvey Cushing described eight patients with central body obesity, glucose intolerance, hypertension, excess hair growth, osteoporosis, kidney stones, menstrual irregularity, and emotional liability. It is now known that these symptoms are the result of excess production of cortisol by the adrenal glands. Cortisol is a powerful steroid hormone, and excess cortisol has detrimental effects on many cells throughout the body. Although some of these symptoms are common by themselves, the combination of these suggests that a workup for this disease may be in order. Keep in mind that Cushings syndrome is rare, occurring in only about 10 patients per one million population. On the other hand, simple obesity can be associated with some of these symptoms in the absence of an adrenal tumorthis is related to the slightly different mechanism by which normally produced steroids are metabolized by individuals who are obese. Note: The most common cause of excess steroids in the blood and its side effects, however, is long-term use of steroid medications for other disorders.

62. Dog Owner's Guide: Cushing's Disease Article by Norma Bennett Woolf, which includes common drug therapies. http://www.canismajor.com/dog/cushings.html

[Dog Owner's Guide: Cushing's disease (www.canismajor.com/dog/cushings.html)] Home Topics Index Newest ... About Cushing's disease Cushing's disease can trouble older dogs Animal bodies are a marvel of interactions between organs and systems kept in balance by the production of enzymes that aid in metabolic processes and hormones that regulate body functions. When the balance is disturbed by illness, injury, or advancing age, the body goes awry: appetite and water consumption change, organs malfunction, or medication to treat one illness causes another. Such is the case with Cushing's disease, also known as hyperadrenocorticism, the production of excess hormones from the adrenal glands. Cushing's disease usually strikes older dogs with a bucket-full of symptoms that can mimic other diseases. Increased appetite, increased drinking and urination, panting, high blood pressure, bulging abdomen, skin lumps and discoloring, hair loss, muscle weakness, and nervous system disorders can occur with the disease. The adrenal glands are located above the kidneys. The adrenals produce cortin, a complex of steroid hormones that help regulate body weight, mineral balance, the structure of connective tissue, some white blood cell production, and skin health. Adrenal glands are stimulated to produce cortin by adrenocorticotropic hormone (ACTH) from the pituitary gland. Cushing's disease can be triggered by a tumor of the adrenal glands or of the pituitary gland; either one can cause the adrenal glands to run amok and produce an excess of corticosteroids.

63. Cushing's Syndrome/Cushing's Disease And CRH - Neuroendocrine Clinical Center & A key utilization of CRH will be in patients with Cushing s syndrome. CRH Testing Differential Diagnosis of Cushing s syndrome http://pituitary.mgh.harvard.edu/e-f-942.htm

THE CLINICAL CENTER ABOUT US ATTENDING STAFF OUTPATIENT SERVICES INPATIENT CONSULTATION ... SPEAKERS BUREAU CONDITIONS ACROMEGALY AMENORRHEA CUSHINGS SYNDROME GROWTH HORMONE DISORDERS ... SEARCH Clinical Uses of Corticotropin-Releasing Hormone in the Evaluation of Patients with Cushing's Syndrome Beverly M. K. Biller, M.D. Referrals Neuroendocrine Bulletin Archive Guestbook Neurosurgery Home ... Testing Protocol CRH Testing - Differential Diagnosis of Cushing's Syndrome CRH Testing - Bilateral Inferior Petrosal Sinus Sampling CRH Test - Cushing Syndrome versus Pseudo-Cushing's Table 1 : Bilateral inferior petrosal sinus sampling with CRH at the Massachusetts General Hospital References Testing Protocol To perform a CRH test, blood is drawn for baseline ACTH and cortisol levels at -15 and minutes followed by a 1 mg/kg dose of oCRH administered as an IV bolus. Samples for ACTH and cortisol are then drawn at 15, 30, 60, 90 and 120 minutes. The test is well tolerated, with the most common side effects being transient facial flushing occurring in 20% of subjects, and rare dyspnea and hypotension. Normal subjects experience a rapid rise in ACTH and cortisol, with a gradual decline over the subsequent two hours.

64. EMedicine - Cushing Syndrome : Article By Gail Adler, MD, PhD Cushing syndrome Cushing syndrome is caused by prolonged exposure to elevatedlevels of either endogenous or exogenous glucocorticoids. http://www.emedicine.com/med/topic485.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Endocrinology Cushing Syndrome Last Updated: September 26, 2001 Rate this Article Email to a Colleague Synonyms and related keywords: Cushing's syndrome, hypercortisolism, ACTH-independent hypercortisolism, ACTH-dependent hypercortisolism AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Gail Adler, MD, PhD , Assistant Professor, Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School Coauthor(s): Jennifer Lawrence, MD , Consulting Staff, Department of Endocrinology, Valdosta Specialty Clinic, South Georgia Medical Center Gail Adler, MD, PhD, is a member of the following medical societies: Endocrine Society Editor(s): Frederick H Ziel, MD

65. Cushing's Disease Picture of a dog with Cushing s Disease. Welcome to the Cushing’s syndromeInformational Website Testing Laboratory Hints Suggesting Cushing’s syndrome http://www.marvistavet.com/html/body_cushing_s_disease.html

Welcome to the Cushing’s Syndrome Informational Website Table of Contents Symptoms of Cushing’s Syndrome What Exactly IS Cushing’s Syndrome? Testing: Laboratory Hints Suggesting Cushing’s Syndrome Testing: Confirming Cushing’s Syndrome ... Treatment: Adrenal Tumor Treatment: Feline What if there is Concurrent Diabetes Mellitus? We know of two listservs is available for owners of pets with Cushing’s disease. Instructions for subscribing to these lists are available through the following external links: www.io.com/~lolawson/cushings/forum.html groups.yahoo.com/group/caninecushings-autoimmunecare/ SORRY Some of the above linked pages are not yet here but will be soon!

66. Cushing's Syndrome Treatment In Horses Cushing s syndrome treatment and prevention in horses using Recovery eq (nutricol) http://www.recoveryeq.com/cushings_syndrome_pro.htm

Cushing's syndrome treatment and prevention in horses using Recovery eq (nutricol) Cushing's syndrome treatment and prevention in horses using Recovery eq (nutricol) Cushing's Syndrome What is Cushing's syndrome? Symptoms/diagnosis of Cushing's syndrome The etiology of Cushing's syndrome Treatments for Cushing's syndrome ... Equine health options What is Cushing's syndrome? Symptoms/diagnosis of Cushing's syndrome Cushing's syndrome is the term used to define the clinical effects of enhanced glucocorticoid action on the body. While equine Cushing's syndrome has been associated with both the exogenous administration of potent glucocorticoids (e.g. corticosteroids) and with endogenous glucocorticoid substances produced by the pituitary tumour, there are other potential mechanisms that could explain the increased glucocorticoid effect. Increased HSD activity in the cells leads to increased cortisol within the tissues. This increase is believed to give rise to clinical signs of Cushing's syndrome. In an attempt to determine if laminitis associated with obesity can be a manifestation of abnormal HSD activity in the peripheral tissues of affected horses, Dr. Philip Johnson at the University of Missouri at Columbia developed a test for HSD in the tissues of horses. Dr. Johnson then compared the level of HSD in the tissues of the skin and hoof of normal healthy adult horses with the level found in horses with laminitis. He was able to show that HSD could be identified both in the skin and hoof tissues and that the level of HSD was substantially elevated in the tissues of horses with laminitis.

67. The Pituitary Foundation | GP Fact File | 4. Cushing's Disease Sheet No 4 of the GP Fact File produced by The Pituitary Foundation. Also availablein pdf format. http://www.pituitary.org.uk/gp-factfile/4-cushings.htm

Text version Home News Contact Us ... Skip search box SEARCH THIS SITE Advanced search Skip section links GP FACT SHEETS 1. Introduction 2. Non-Functioning Tumour 3. Acromegaly 5. Hyperprolactinaemia ... GP Fact File Index LINKS Skip main links The Endocrine System Pituitary Disorders Resources ... About The Pituitary Foundation Pituitary Foundation Fact Sheet Incidence: New Cases per million per year ACTH ACTH by a pituitary tumour and consequent hypersecretion of cortisol. Other causes are an adrenal tumour or an ectopic tumour secreting ACTH Presenting symptoms psychiatric disturbance (often characterised by amplification of previous personality traits) moon face - particularly filling in of the temporal fossa weight gain - central obesity muscle wasting and proximal myopathy (patients have difficulty standing from a seated position without use of arms) thin skin * - tendency to bruise hirsutism (caused by androgen excess) violaceous striae ACTH levels, tends to protect against this.

68. HON Mother & Child Glossary, Adrenal Gland Disorders: Cushing's Syndrome HON Mother Child Glossary, Adrenal Gland Disorders Cushing s syndrome.Cushing s syndrome is the result of the excessive production of corticosteroids by http://www.hon.ch/Dossier/MotherChild/child_hormones/cushings_syndrome.html

Introduction Reproduction Pregnancy During Pregnancy ... Glossary A-Z Childhood Illness Bacteria Virus Cancer Gastrointestinal ... Mental Health Adrenal Gland Disorders: Cushing's Syndrome Cushing's Syndrome Description Cushing's syndrome is the result of the excessive production of corticosteroids by the adrenal glands. An overproduction of corticotrophin (the hormone that controls the adrenal gland) by the pituitary gland , which stimulates the adrenal glands to produce corticosteroids, may be one cause. In addition, certain lung cancers and other tumours outside the pituitary gland may produce corticotrophins. Other causes include benign or cancerous tumours on the adrenal glands. Symptoms and Signs The most common symptoms may include: Upper body obesity Round face Increased fat around neck Thinning arms and legs Fragile and thin skin Stretch marks on abdomen, thighs, buttocks, arms, and breasts Bone and muscle weakness Severe fatigue High blood pressure High blood sugar Irritability and anxiety Excess hair growth in women Irregular or stopped menstrual cycles in women Reduced sex drive and fertility in men However, each individual may experience symptoms differently.

69. Hardin MD : Cushings Disease From the University of Iowa, the *best* lists of Internet sources in cushings Disease. http://www.lib.uiowa.edu/hardin/md/cushings.html

Cushings Disease A service of the University of Iowa Site Map Diseases Home ... Diseases Search Hardin MD See also: Home Prednisone Skin Diseases Popular Women's Health Dermatology Nursing Pharm Infect Disease Addisons Disease +Pictures Autoimmune Diseases +Pictures Back Pain +Pictures Cancer +Pictures Childrens Diseases +Pictures Circulatory System +Pictures Dizziness +Pictures Diabetes +Pictures Endocrine System Graves Disease +Pictures High Blood Pressure +Pictures Hypothyroidism +Pictures Infectious Diseases +Pictures Lung Cancer +Pictures Medical Pictures Nervous System Diseases +Pictures Ovarian Cysts +Pictures Prednisone +Pictures Psoriasis +Pictures Rheumatoid Arthritis +Pictures Skeletal System Skin Pictures Stretch Marks +Pictures Thyroid Disease +Pictures Womens Health +Pictures Yeast Infection +Pictures Cushings Disease Pictures Karolinska : Cushing syndrome Medical Library, Karolinska Institute, Sweden LookSmart : Cushing's syndrome or hypercortisolism Yahoo : Cushing's syndrome Cushing's disease US Government Cushings Disease Pictures Cushing's photos Cushings.homestead.com

70. CUSHING What causes Cushing s syndrome? Why do I need treatment? How do I know that Ihave Cushing s syndrome? TESTS. What does this involve? http://www.dundee.ac.uk/medther/tayendoweb/cushing.htm

CUSHING'S SYNDROME What is Cushing's syndrome? What is cortisol? How is cortisol produced normally? What causes Cushing's syndrome? ... For further information why not contact What is Cushing's syndrome? This is a clinical disease caused by the excessive level of circulating cortisol hormone. What is cortisol? One of the steroid hormones produced from the adrenal glands. It is essential for the survival of a person. How is cortisol produced normally? The pituitary gland is a small pea size gland situated in a hollow bony pouch, at the base of the brain, at the back of the bridge of the nose. It is the master gland of the endocrine system and controls the functions of the other endocrine glands. The pituitary gland releases a hormone called ACTH which enters the blood circulation and passes to the adrenal glands making these glands release cortisol. The adrenal glands lie just above each of your two kidneys and when stimulated by ACTH release cortisol into the blood. What causes Cushing's syndrome? This can be caused by;

71. UpToDate Clinical Manifestations Of Cushing's Syndrome INTRODUCTION — The symptoms and signs of Cushing s syndrome 1 result directly This topic will review the major manifestations of Cushing s syndrome. http://patients.uptodate.com/topic.asp?file=adrenal/2048

72. Surgical-tutor.org.uk - A Free Online Surgical Resource http://www.surgical-tutor.org.uk/default-home.htm?system/hnep/cushings.htm~right

73. Pets With Diabetes: Cushing's Disease And Diabetes Pets With Diabetes Cushing s and Diabetes. Many dogs have both Cushing s diseaseand diabetes. Special considerations should be taken in diagnosing these http://www.petdiabetes.org/cushings.htm

Cushing's Disease and Diabetes What is Cushing's? Causes Signs Diagnosis ... Resources What is Cushing's Dogs have two adrenal glands, which are are small pea-sized glands located next to the kidneys. The adrenal glands produce several types of hormones that are involved in regulating many of the body's processes including control of blood potassium and sodium concentrations, water metabolism, protein, fat and carbohydrate metabolism, stress response, regulation of blood pressure, and to a small extent sex hormone levels. The outer portion of the adrenal gland is called the cortex and it produces corticosteroids (cortisol and corticosterone) and mineralocorticoids (aldosterone). Cortisol is involved in the metabolism of carbohydrates, fat, and protein. Aldosterone is involved in regulation of mineral and water balance. The inner portion of the adrenal gland is called the medulla and it produces epinepherine, which during a stress response, raises blood glucose levels, blood pressure, and cardiac output. Production of cortisol by the adrenal gland is controlled by the pituitary gland, which is a small gland located at the base of the brain. The pituitary gland produces adrenocorticotropic hormone (ACTH) which stimulates the adrenal cortex to produce corticosteroids (cortisol). Additionally, the hypothalamus, a small structure in the brain, secretes corticotropin-releasing hromone (CRH) which signals the pituitary gland to produce ACTH. When enough cortisol is produced, it in turn goes back to the pituitary and hypothalamus and tells them to stop producing ACTH and CRH. In technical terms this is called a negative feedback system. The hypothalamus produces CRH which tells the pituitary gland to produces ACTH. The ACTH tells the adrenal glands to produce cortisol, which returns back to the hypothalamus and pituitary to turn off CRH and ACTH production.

74. Cushing's Syndrome: Definition And Much More From Answers.com Cushing s syndrome n. A syndrome caused by an increased production of ACTH froma tumor of the adrenal cortex or of the anterior lobe of the. http://www.answers.com/topic/cushing-s-syndrome

showHide_TellMeAbout2('false'); Business Entertainment Games Health ... More... On this page: Dictionary Diagnosis Medical WordNet Wikipedia Mentioned In Or search: - The Web - Images - News - Blogs - Shopping Cushing's syndrome Dictionary Cushing's syndrome n. A syndrome caused by an increased production of ACTH from a tumor of the adrenal cortex or of the anterior lobe of the pituitary gland, or by excessive intake of glucocorticoids. It is characterized by obesity and weakening of the muscles. [After Harvey Williams CUSHING Diagnosis Cushing's Syndrome What is Cushing's syndrome? Cushing's syndrome is an extremely complex hormone condition that involves many areas of the body. Cushing's syndrome is the result of an excess of a hormone called "cortisol" and it's effects on the human body. Ironically one of the most common causes of Cushing's syndrome is the administration of "cortisol-like medications" to patients by doctors for the treatment of various diseases. All the other causes of Cushing's syndrome are the result of excess production of cortisol by the adrenal glands. What causes Cushing's syndrome?

75. Addison's Disease Endocrinology Adrenal Disease cushings Disease. Addison and CushingInternational Federation (ACIF). http//www.nvacp.nl/page.php?main=5. References http://www.fpnotebook.com/END3.htm

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76. Diabetes Mellitus, Type 2, Type 1, And Metabolic Disorders Treatment And Medicat Cushing s syndrome Related Doctor s Views Updates Doctor s Responses aboutCushing s syndrome Pituitary, Cushing s syndrome and Growth hormone http://www.medicinenet.com/cushings_syndrome/

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77. Cushing's Support & Research Foundation CSRF, The Cushing s Support and Research Foundation, Cushing s syndrome, CushingDisease, Cushing s syndrome is an endocrine or hormonal disorder. http://csrf.net/AboutCushings.htm

CSRF 65 E India Row, Suite 22B Boston, MA 02110 Phone: 617.723.3674 Fax: 617.723.3674 Email: cushinfo@csrf.net About Cushing's The Basics Fact Sheet Testing Glossary ... Adrenal Cancer The Basics What is Cushing's Syndrome? Cushing's syndrome is an endocrine or hormonal disorder. It occurs when the adrenal glands release too much of the hormone cortisol into the body for long periods of time. Cortisol is essential to many of the body's cardiovascular and metabolic functions. But perhaps its most important job is to help the body respond to stress. Normally the adrenal gland releases the exact amount necessary to meet our daily needs. However, sometimes the process goes wrong and an excess of cortisol is produced. The malfunction may be caused by: A pituitary tumor, which causes the pituitary gland (at the base of the brain) to stimulate the adrenal glands to secrete high levels of cortisol.

78. Cushing Syndrome Definition - Medical Dictionary Definitions Of Popular Medical Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=2883

79. Syndrome, Cushing Definition - Medical Dictionary Definitions Of Popular Medical Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=7516

80. Lysodren Feline Leukemia and FIV (Feline Aids) syndrome, Feline Infectious Peritonitis (FIP) Lysodren is used for the treatment of Cushing s disease. http://www.cah.com/dr_library/cushlysod.html

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