41. Cushing's Syndrome Age at diagnosis of Cushing s syndrome was 874 (mean 39) years. When Cushing ssyndrome was diagnosed, significant psychiatric illness, http://www.biopsychiatry.com/cushings.htm

Psychiatric aspects of Cushing's syndrome by Kelly WF Diabetes Care Centre, Middlesbrough General Hospital, UK. QJM 1996 Jul; 89(7):543-51 ABSTRACT P CRF LHPA Stress Options ... The Good Drug Guide The Responsible Parent's Guide To Healthy Mood Boosters For All The Family

42. CUSHING'S SYNDROME IN HORSES - Equiworld - Equestrian Information - Horses And P Equiworld (r) provides a wide range of equestrian information, horse links, equinechat, horse sales, riding schools, and lots more horsey information. http://www.equiworld.net/uk/horsecare/veterinary/cushings.htm

CUSHING'S SYNDROME IN HORSES Cushing's Syndrome is well known in humans, cats and especially in dogs. It is also becoming more prevalent in horses, and yet there is little written about identifying it, and caring for horses who suffer from it. It is regarded as incurable in horses, though it is possible that horses can live reasonably happily for a long time whilst suffering from it. CUSHING'S DISEASE IS HYPERADRENOCORTICISM "Cushing's disease" is a term used in human medicine that refers to pituitary dependent hyperadrenocorticism. According to veterinary and human medical experts the disease is characterised by excessively high levels of steroids in the body. Steroids are compounds that circulate naturally in our bodies and our pets' bodies. Two major centres in the body regulate the levels of these steroids. The main centre is a gland in the brain called the pituitary. This gland controls most of the hormones in the body. This disease is called hyperadrenocorticism.; (hyper = too much; adreno = adrenal gland; cort = cortex, the outer layer of the adrenal gland; ism = process). Blood tests often help the diagnosis of Cushing's Syndrome, and they indicate high levels of blood glucose. This would be similar to diabetes, which is very rare in horses, but is sometimes found in horses with Cushing's. SYMPTOMS In dogs and cats There are times when the steroid control in the body becomes deregulated and excess steroids are present. Clinical signs, in dogs, include

43. Cushing's Syndrome Cushing s syndrome results from cortisol excess; Commonest cause is iatrogenic from A biochemical confirmation of the diagnosis of Cushing s syndrome http://www.surgical-tutor.org.uk/system/hnep/cushings.htm

Up Tracheostomy Foreign bodies ENT disorders ... Neck lumps in children Cushing syndrome Cushing's syndrome results from cortisol excess Commonest cause is iatrogenic from the use of exogenous steroid medication Cushing's disease has an incidence of 1 per 100.000 / year Female : male is 5:1 Peak incidence is 30-50 years Aetiology Primary adrenal disease (20%) Adrenal adenoma Adrenal carcinoma Adrenal cortical hyperplasia Secondary adrenal disease Cushing's disease = Due to ACTH secreting pituitary microadenoma (70%) Ectopic ACTH production from a malignancy (10%) Small cell carcinoma of the lung Carcinoid tumours Medullary carcinoma of the thyroid Pseudo-Cushing's syndrome Major depressive illness Alcohol excess Clinical features Symptoms Signs Weight gain Truncal obesity Menstrual irregularity Plethora Hirsuitism in women 'Moon' face Headache Hypertension Thirst Bruising Back pain Striae Muscle weakness Buffalo hump Abdominal pain Acne Lethargy / depression Osteoporosis Investigation The clinical picture often does not allow identification of the cause of Cushing's syndrome Investigations are aimed at: A biochemical confirmation of the diagnosis of Cushing's syndrome Identifying the site of the pathological lesion - adrenal, pituitary, ectopic production

44. Furr Angels! - Understanding Of And Resources For Cushings Disease Cushing s syndrome (~15% of all cases of spontaneous hyperadrenocorticism) occursas the result of a typically benign tumor of the adrenal gland, http://www.furr-angels.com/cushings.htm

home what's mew announcements for you warm fuzzies ... the spotted cat - our products free email account free postcards link to us receive our mewsletter ... cushings and resources diabetes and resources felv (feline leuk) and resources fip and resources first aid kit basics fiv and resources halloween safety heimlich maneuver nutrition and pet food ... back to top of navigational menu Cushing’s disease is also known as hyperadrenalcorticism and is caused by chronic excess levels of hormones, particularly corticosteroids or cortisol. This disease is typically seen in middle and older aged dogs and cats, although it is much less common in cats. Additionally, cats who are diagnosed with Cushing’s, also tend to have concurrent diabetes mellitus. To provide the best possible overview, listed below are the causes, symptoms, methods for diagnosing, current treatments available and resources for additional information and assistance. For more specific information as it pertains to your pet, please consult with your veterinarian.

45. Cushing's Syndrome Cushing s syndrome, also known as hypercortisolism, occurs when a person s tissuesare Cushing s syndrome is fairly rare. For every one million people, http://www.nichd.nih.gov/publications/pubs/cushings.htm

Home Search Sitemap Contact ... Publications Cushing's Syndrome Contents: Who gets it? What are it's symptoms? What causes Cushing's syndrome? How is it diagnosed? ... What about the future? Cushing's Syndrome Cushing's syndrome, also known as hypercortisolism, occurs when a person's tissues are exposed to an excess of the hormone cortisol. When the appropriate amount of cortisol is released by the adrenal glands, it helps regulate blood pressure, energy production, the ability to fight disease, and how the body maintains itself and responds to stress. But too much cortisol can alter the normal function of these processes, resulting in the symptoms of Cushing's syndrome. Who gets it? Cushing's syndrome is fairly rare. For every one million people, 2-5 new cases are diagnosed each year, with about 10 percent of these being children and teenagers. What are its symptoms? Most children and teenagers with Cushing's syndrome will show several of the following: - extreme weight gain - growth retardation - missed periods in teenage girls - excess hair growth - acne - reddish-blue streaks on the skin - high blood pressure - tiredness and weakness - either very early or late puberty Adults with the disease may also have symptoms of extreme weight gain, excess hair growth, high blood pressure, and skin problems. In addition, they may show:

46. Cushing's Support & Research Foundation - About Pedriatic Cushings CSRF, The Cushing s Support and Research Foundation, Cushing s syndrome, How is Cushing s syndrome (CS) in children different than in adults? http://csrf.net/AboutCushings_Pedriatic.htm

CSRF 65 E India Row, Suite 22B Boston, MA 02110 Phone: 617.723.3674 Fax: 617.723.3674 Email: cushinfo@csrf.net Pediatric Cushing's Cushing's syndrome in children By: Meg Keil, MS, CRNP How is Cushing's syndrome (CS) in children different than in adults? CS in children is rare. An estimated 10 to 15 of every million people are affected a year and only about ten percent of these new cases occur in children. For pre-pubertal children, and certainly for toddlers, adrenal tumors (e.g. adenoma, carcinoma, or bilateral hyperplasia) are a more common cause of CS. In older children, pituitary adenomas are a more common cause of CS. Ectopic (a site other than pituitary or adrenal) sources of CS are extremely rare in children. Overall, there is a female to male predominance, which decreases with younger age. There is no single symptom shared by every child with CS. It is common for children with CS to show an increase in rate of weight gain accompanied by a decrease in growth rate (linear height). Figure A shows a growth chart that is typically seen in children with CS. Other problems that may occur in children with CS include: rounded face, reddened

47. EQUINE CUSHINGS DISEASE Cushing s syndrome produces opposite changes in hair coat in the horse and dog . This syndrome in horses is sometimes referred to as Peripheral Cushing s http://www.laminitis.org/cushings.html

EQUINE CUSHING'S DISEASE by Robert A Eustace FRCVS Abstracted from the scrutineered veterinary journal In Practice (1991) Vol 13. No 4 July p 147-148 Hyperadrenocorticism produces the opposite changes in hair coat in the two species. In equines this condition is usually secondary to an adenoma, or hyperplasia, of the pars intermedia of the pituitary gland whereas in the dog the syndrome may be primarily of adrenal origin. In horses there appears to be insufficient DOPamine being released from the hypothalamus. DOPamine inhibits the pars intermedia of the pituitary gland. Therefore when there is less DOPamine there is less inhibition of the pars intermedia which then increases in size. Equine Cushing's cases always develop laminitis if they live long enough. They may become immunosuppressed and subject to a variety of parasitic or infectious agents such as helminthiasis or pneumonia. Many cases show muscle loss and become polydipsic and polyphagic; they may be diabetic. A supra-orbital swelling, due to the deposition of a fat depot, is commonly seen giving the eyes a protuberant appearance. To the trained observer, these cases can be diagnosed on clinical appearance and history alone. The clinical signs include;

48. Cushing's Syndrome. DermNet NZ Authoritative facts about the skin from the New Zealand Dermatological Society. http://dermnetnz.org/systemic/cushings.html

@import url("/common/screen.css"); DermNet NZ Ad Authoritative facts about the skin from the New Zealand Dermatological Society Incorporated Home For patients For doctors ... Site map Search: Home Systemic diseases Cushing's syndrome What is Cushing's syndrome? Cushing's syndrome is a hormonal disorder caused by prolonged exposure to inappropriately high levels of plasma glucocorticoid (also referred to as cortisol) hormones. Glucocorticoid hormones maintain glucose regulation, suppress the immune response and are released as part of the body's response to stress. The production of cortisol from within the cortex of the adrenal glands is regulated by a small gland just below the brain called the pituitary gland. There are several causes of Cushing's syndrome: Adrenocortical hyperplasia (overgrowth of adrenal cortex) secondary to pituitary overproduction of adrenocorticotrophic hormome (ACTH) Non-cancerous pituitary tumours that secrete increased amounts of ACTH Benign or malignant adrenal tumours that release excess glucocorticoids into the blood corticosteroids such as prednisone for blistering diseases, asthma, arthritis and other inflammatory diseases.

49. Cushing's Disease-hyperadrenocorticism Medical Therapy of Canine cushingssyndrome EN Behrend, RJ Kemppainen Cushing s syndrome (GS) can result from excess adrenocorticotropin secretion http://www.thensome.com/cushings.htm

Hyperadrenocorticism-Cushing's Disease Cushing's Disease and Cushing's Syndrome cushing's disease electronic forum's archives cushing's and diabetes cushing's ... caroarenas10@hotmail.com Mitotane has been considered as treatment of choice for canine hyperadrenocorticism. However, this drug has potential severe side effects and, therefore, safer alternatives for treatment of hyperadrenocorticism are needed. Other described medical options (ketoconazole, l-deprenyl, aminoglutethimide) are quite less effective. In some pilot studies, trilostane seemed to be safe and effective for the management of hyperadrenocorticism. However, it is still necessary to know the dosage and the duration of the effect, in order to establish a protocol of use in the management of this disease. Vet Rec 2002 Jun 29;150(26):799-804 : Trilostane treatment of 78 dogs with pituitary-dependent hyperadrenocorticism. Neiger R, Ramsey I, O'Connor J, Hurley KJ, Mooney CT. Department of Veterinary Clinical Sciences, Royal Veterinary College, Hatfield. The efficacy of trilostane in the treatment of canine pituitary-dependent hyperadrenocorticism (PDH) was evaluated in 78 dogs with the condition which were treated for up to three years. The drug appeared to be well tolerated by almost all the dogs, and only two developed clinical signs and biochemical evidence of hypoadrenocorticism. Polyuria and polydipsia completely resolved in 70 per cent of the dogs that had these problems, and skin changes resolved in 62 per cent of the dogs that had skin abnormalities. There was a significant reduction (P

50. Clinical Trial: Cognition, Steroids, And Imaging In Cushings Disease patients with suspected Cushing s syndrome with clinical findings suggestive ofCushing s syndrome and positive screening tests (urinary free cortisol and http://www.clinicaltrials.gov/ct/gui/show/NCT00081341

Home Search Browse Resources ... About Cognition, Steroids, and Imaging in Cushings Disease This study is currently recruiting patients. Verified by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) April 2005 Sponsored by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Information provided by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ClinicalTrials.gov Identifier: Purpose This study investigates the effects of the glucocorticoid hormone cortisol on brain structure and function. Patients with Cushing's disease are studied before and after treatment. Brain imaging and neuropsychologic tests are used to study changes in the hippocampus and thinking and learning functions as well as mood during the period of elevated cortisol. At several intervals after treatment, these are reexamined to study the degree of reversibility of the abnormalities. The contribution of cortisol as well as testosterone and estrogen to dysfunction and recovery is studied. Since elevated cortisol and dysregulation of its secretory system occurs in a significant proportion of the aged and in Alzheimers Disease and Major Depressive Disorder, these studies will help advance knowledge of the role of cortisol in these conditions. Condition Cushing Syndrome MedlinePlus related topics: Adrenal Gland Disorders Study Type: Observational Study Design: Natural History, Longitudinal, Prospective Study

51. Cushings Ectopic ACTH syndrome. This is a rare version of Cushing s that does not fallinto any of the above categories. It can be found in association with cancer http://www.lbah.com/canine/cushings.htm

Cushing's Disease (hyperadrenocorticism) Introduction Anatomy Physiology Cause ... Feline Cushing's Introduction Cushing's Disease (also know as hyperadrenocorticism- Cushing's is easier to pronounce so stick with that word) results when the adrenal glands secrete an excess amount of cortisone. It is the most common endocrinopathy (hormone disease) encountered in older dogs. This disease is the exact opposite of another endocrine problem in dogs called addison's disease (hypoadrenocorticism). This detailed page will emphasize Cushing's disease in dogs, with an explanation of how it differs from cats at the end. This is a complex disease that does not lend itself to a simple explanation or an easy diagnosis. You might want to go to the bathroom before attempting this page! We have a summary page on Cushing's if the explanation on this page is too detailed for your needs. Several medical terms and abbreviations relate directly to Cushing's: cortisol - cortisone produced by the adrenal glands atrophy - decreased size of an organ exogenous cortisone - supplemental cortisone hypertrophy - increased size of an organ HaC - hyperadrenocorticism polyuria - excess urinating CRH - corticotropin releasing hormone polydipsia - excess drinking polyphagia - excess appetite PU/PD - polyuria and polydipsia glucocorticoids mostly cortisol, and a small amount of corticosterone

52. Cushings Introduction Often called simply Cushing s syndrome , hyperadrenocorticism Cushing s Disease is a subset of Cushing s syndrome whereby the excessive http://www.newmanveterinary.com/Cushings.html

Harvey Cushing See Biography Introduction Predilections Breed Associations ... Treatment Introduction: Often called simply " Cushing's Syndrome ", hyperadrenocorticism describes the clinical signs referable to the excessive levels of serum glucocorticoids produced by the adrenal gland Cushing's Disease is a subset of Cushing's Syndrome whereby the excessive production of glucocorticoids by the adrenal gland(s) is specifically due to excessive production of ACTH by the pituitary gland. This is known as Pituitary-Dependent Hyperadrenocorticism (PDH) Autonomous unregulated synthesis of glucocorticoids by the adrenal gland is known as Adrenal-Dependent Hyperadrenocorticism (ADH) The first appreciation for the connection of certain pituitary abnormalities and stomach ulcers (secondary to excessive circulating corticosteroids) was by a fascinating genius and neurosurgeon, Dr. Harvey Cushing (see above T he normal regulation of adrenal gland activity by the pituitary and hypothalamic centers of the central nervous system is shown elsewhere on this website. It is suggested that the reader review that page before proceeding. Predilections (naturally acquired disease) ADH more likely in oldest dogs, on average, though incidences of ADH and PDH occur over the same age range

53. Cushing's Syndrome Information Page: National Institute Of Neurological Disorder Cushing s syndrome information sheet compiled by the National Institute ofNeurological Disorders and Stroke (NINDS). http://www.ninds.nih.gov/disorders/cushings/cushings.htm

Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system More about Cushing's Syndrome Studies with patients Research literature Press releases Search NINDS... (help) Contact Us My Privacy NINDS is part of the National Institutes of Health You are here: Home Disorders Cushing's Syndrome NINDS Cushing's Syndrome Information Page Synonym(s): Hypercortisolism Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Cushing's Syndrome? Is there any treatment? What is the prognosis? What research is being done? ... Organizations What is Cushing's Syndrome? Cushing's syndrome, also called hypercortisolism , is a rare endocrine disorder caused by chronic exposure of the body's tissues to excess levels of cortisol - a hormone naturally produced by the adrenal gland. Exposure to too much cortisol can occur from long-term use of synthetic glucocorticoid hormones to treat inflammatory illnesses. Pituitary adenomas (benign tumors of the pituitary gland) that secrete increased amounts of ACTH ( adrenocorticotropic hormone

54. Cushing S Syndrome Cushing s syndrome is the result of a group of symptoms observed when the body There are quite a few symptoms associated with Cushing s syndrome (also http://www.geocities.com/Petsburgh/2418/cushings.htm

55. Cushing's Disease Index | Wake Forest University Baptist Medical Center Cushing s syndrome. Clinical Uses of CorticotropinReleasing Hormone in theEvaluation of Patients with Cushing s syndrome Surgical Mangement of Cushing s http://www1.wfubmc.edu/neurosurgery/Pituitary Tumors/Cushings Disease Index.htm

Neurosurgery Brain Tumor Ctr of Excellence Cranial Base Epilepsy Center ... Pituitary Tumors Cushing's Disease Index Cushing's Disease Index Pituitary Links: Pituitary Tumor Center General Information / Symptoms Prolactinoma Acromegaly ... Cushing's Disease Links to resources relating to Cushing's disease (ACTH or adreno corticotrophic hormone-secreting pituitary adenomas) Pituitary Network Association (PNA) Homepage (recommended) Gamma Knife for Cushing's Disease (ACTH-sectreting) pituitary adenoma Pituitary Adenoma Information from the Wake Forest University BestHealth Library Pituitary tumor pituitary adenoma Missed menstrual periods (amenorrhea) and pituitary adenomas Male infertility, impotence, and loss of sexual desire and pituitary adenomas Pituitary apoplexy Pituitary insufficiency Acromegaly (growth hormone-secreting pituitary adenoma) Gigantism /Giantism Growth Hormone Cushing's Syndrome Cushing's Disease (ACTH-secreting pituitary adenoma) Cortisol Metyrapone test Dexamethasone suppression test Acute adrenal crisis ... National Institute of Diabetes, Digestive and Kidney Disease of the National Institutes of Health (NIH) Cushing's Syndrome Multiple Endocrine NeoplasiaType 1 More Cushing's Disease Links (ACTH or adrenocorticotropic hormone secreting pituitary adenoma) National Institute of Diabetes, Digestive and Kidney Disease

56. Cushing S Syndrome (hypercortisolism) Conn s syndrome (hypercortisolism) is a condition where the adrenal glands overproduce the mineralocorticoid hormone aldosterone. http://endocrine-disorders.health-cares.net/cushings-syndrome.php

57. SmartPak Equine - Cushing's Syndrome Pharmaceutical treatments for Cushing’s syndrome include pergolide and cyproheptadine . 1 Kellon, E. “Herbal Offers Hope for Cushing’s syndrome. http://www.smartpakequine.com/cushings.aspx

HOME SEARCH OUR SITE EQUINE SUPPLEMENTS HORSE PRODUCTS RIDER GEAR BARN/STABLE SUPPLIES PHARMACY NEW PRODUCTS! BEST SELLERS CLEARANCE WHAT IS A SMARTPAK? HORSE HEALTH CARE TIPS COMPARISON CHARTS TESTIMONIALS SUPPLEMENTS AT RISK TEAM SMARTPAK MY ACCOUNT BARN MANAGERS FREE CATALOGS NEWSLETTER SIGN-UP BUILD YOUR SMARTPAK SHOP FOR SUPPLIES NEED HELP? MY ACCOUNT Cushing's Syndrome While thought to be primarily a disease of older horses, it can also affect horses as young as ten. Symptoms include: A coarse, wavy coat that fails to shed out Excessive thirst (may drink as much as 20 gallons/day) Excessive urination Low energy level/depressed Eye tumors or blindness Compromised immune system Laminitis Increased appetite w/no weight gain Loss of muscle over the topline Blood tests may indicate high blood sugar and high blood fats, anemia, reduced lymphocyte counts, and electrolyte derangements may be appropriate for your horse. Nutrition Antioxidants, like Vitamin C and Vitamin E help with free radical damage Magnesium , chromium, sulfur Omega-3 fatty acids Recently, there has been development of some herbal products, although research on their success rates is limited.

58. Healthopedia.com - Cushing's Syndrome (Hypercortisolism) Cushing s syndrome is a hormonal disorder that occurs when the body tissues areexposed Cushing s disease is the most common type of Cushing s syndrome. http://www.healthopedia.com/cushings-syndrome/

Set Homepage Email Page Favorites Home Health Centers Medical Encyclopedia Medical Symptoms ... Special Topics Related Resources Health Centers Endocrine Disorders Allergic Reaction to a Medication Bruising Depression ... Radiation Therapy Other Topics Stress You are here : Healthopedia.com Medical Encyclopedia Diseases and Conditions Cushing's Syndrome Category : Health Centers Endocrine Disorders Cushing's Syndrome Alternate Names : Hypercortisolism Pictures and Images Attribution Cushing's syndrome is a hormonal disorder that occurs when the body tissues are exposed to high levels of the hormone cortisol. The adrenal glands produce cortisol. Cushing's disease is the most common type of Cushing's syndrome. It is caused by a noncancerous tumor of the pituitary gland. What is going on in the body? Cushing's syndrome occurs when body tissues are exposed to high levels of cortisol for a long time. Cortisol is an important hormone that regulates many body functions, including stress management. A part of the brain known as the hypothalamus sends CRH, a hormone, to the pituitary gland. The pituitary gland then produces another hormone called ACTH. The ACTH then stimulates the adrenal glands to produce cortisol. The hypothalamus and pituitary monitor blood levels of cortisol. They adjust their hormone release as needed. This maintains a normal balance of cortisol. Sometimes the cortisol balance in the body is thrown off. The person may have excess cortisol under the following conditions:

59. 24Dr.com Reference Library - Encyclopaedia - Cushing's Syndrome 24Dr.com is an online interactive information system. This site was developed toenable members of the general public to access medical professionals and http://www.24dr.com/reference/encyclopaedia/cushings.htm

Search for in All of 24Dr.com Contact points Dictionary Encyclopaedia eShop Library News Medicines Information Symptoms Travel Clinic Home Register / Login Dictionary Encyclopaedia Travel clinic Drug database Library Contact points Common symptoms Illustrations Feedback CUSHING'S SYNDROME What is it? Cortisol is a natural substance produced by the adrenal gland. It can also be produced synthetically. What are the symptoms? In women, there may be increased growth of facial and body hair, and menstrual periods may become irregular or stop completely. Exposure to too much cortisol can occur for different reasons such as long-term use of glucocorticoid hormones to treat inflammatory illnesses; pituitary adenomas (benign tumors of the pituitary glands) which secrete increased amounts of adrenocorticotropic hormone (ACTH); ectopic ACTH syndrome (a condition in which ACTH is produced by various types of potentially malignant tumors that occur in different parts of the body); and adrenal tumors (tumors of the adrenal glands). What is the treatment?

60. R: Diagnostic Tests On Patients With Cushing's Syndrome . Cushing s syndromeis a hypertensive disorder associated with oversecretion of cortisol......Diagnostic Tests on Patients with Cushing s syndrome. http://stat.ethz.ch/R-manual/R-patched/library/MASS/html/Cushings.html

R Documentation Diagnostic Tests on Patients with Cushing's Syndrome Description Cushing's syndrome is a hypertensive disorder associated with over-secretion of cortisol by the adrenal gland. The observations are urinary excretion rates of two steroid metabolites. Usage Cushings Format The Cushings data frame has 27 rows and 3 columns: Tetrahydrocortisone urinary excretion rate (mg/24hr) of Tetrahydrocortisone. Pregnanetriol urinary excretion rate (mg/24hr) of Pregnanetriol. Type underlying type of syndrome, coded a (adenoma) , b (bilateral hyperplasia), c (carcinoma) or u for unknown. Source J. Aitchison and I. R. Dunsmore (1975) Statistical Prediction Analysis. References Venables, W. N. and Ripley, B. D. (2002) Modern Applied Statistics with S. Fourth edition. Springer. [Package MASS version 7.2-19 Index]

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