1. Birth Disorder Information Directory - CO-CZ Crow Fukase Syndrome (PEP Syndrome, POEMS Syndrome, Shimpo s Syndrome, crowfukase syndrome. Cryptophthalmos-Syndactyly Syndrome (Fraser Syndrome) http://www.bdid.com/defectco.htm

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2. The Crow-Fukase Syndrome A Study Of 102 Cases In Japan The crowfukase syndrome a study of 102 cases in Japan http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

3. Crow-Fukase Syndrome-immunoadsorption Plasmapheresis Effectively crowfukase syndrome-immunoadsorption plasmapheresis effectively lowers elevated interleukin-6 concentration http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

4. POEMS Syndrome crowfukase syndrome; PEP Syndrome; Polyneuropathy-organomegaly-endocrinopathy-Mprotein-skin lesions; Shimpo syndrome; Takatsuki syndrome http://webcenter.health.webmd.netscape.com/hw/brain_nervous_system/nord789.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map Health Topics Symptoms ... For a Complete Report POEMS Syndrome Important It is possible that the main title of the report POEMS Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Crow-Fukase Syndrome PEP Syndrome Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions Shimpo syndrome Takatsuki syndrome Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions Disorder Subdivisions None General Discussion POEMS syndrome is an extremely rare multisystem disorder. POEMS is an acronym that stands for (P)olyneuropathy, disease affecting many nerves; (O)rganomegaly, abnormal enlargement of an organ; (E)ndocrinoapthy, disease affecting certain hormone-producing glands that help to regulate the rate of growth, sexual development, and certain metabolic functions (endocrine system); (M)onoclonal gammopathy or M proteins; and (S)kin defects. Common symptoms include progressive weakness of the nerves in the arms and legs, an abnormally enlarged liver and/or spleen (hepatosplenomegaly), abnormally darkening of the skin (hyperpigmentation) and excessive hair growth (hypertrichosis). Endocrine abnormalities such as failure of the ovaries and testes (gonads) to function properly (primary gonadal failure) and diabetes mellitus type I may be present. Specific endocrine abnormalities associated with POEMS syndrome vary from case to case.

5. Webkatalog 1. Mayo Clinic Rochester Information about POEMS syndrome, what it is, symptoms, diagnosis, treatment and who gets it. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

6. Crow-Fukase Syndrome - General Practice Notebook crowfukase syndrome. POEMS is an acronym for. polyneuropathy. slow onset ofmixed motor and sensory polyneuropathy; peripheral nerve demyelination with http://www.gpnotebook.co.uk/cache/-1046872034.htm

Crow-Fukase syndrome POEMS is an acronym for: polyneuropathy: slow onset of mixed motor and sensory polyneuropathy peripheral nerve demyelination with some axonal degeneration organomegaly: hepatosplenomegaly endocrinopathy: gynaecomastia secondary amenorrhoea diabetes mellitus hypothyroidism monoclonal protein skin changes: hyperpigmentation hypertrichosis skin thickening The underlying pathology is usually an osteosclerotic myeloma. Radiographic surveys often reveal a single osteosclerotic lesion in the spine or proximal long bones. Click here for more information...

7. Arch Dermatol Abstract The Skin Changes In The Crow-Fukase The skin changes in the CrowFukase (POEMS) syndrome. A case report. W. B. Shelley and E. D. Shelley http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

8. The Crow-Fukase Syndrome: A Study Of 102 Cases In Japan -- Nakanishi Et Al. 34 ( Clinical manifestations of 102 cases with the Crow Fukase syndrome (the syndromeof polyneuropathy, anasarca, skin changes, endocrinopathy, dysglobulinemia http://www.neurology.org/cgi/content/abstract/34/6/712

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Nakanishi, T. Articles by Ozaki, Y. ARTICLES The Crow-Fukase syndrome: a study of 102 cases in Japan T Nakanishi, I Sobue, Y Toyokura, H Nishitani, Y Kuroiwa, E Satoyoshi, T Tsubaki, A Igata and Y Ozaki Clinical manifestations of 102 cases with the Crow- Fukase syndrome (the syndrome of polyneuropathy, anasarca, skin changes, endocrinopathy, dysglobulinemia, and organomegaly), with or without myeloma, were reviewed. Fifty-six cases with myeloma consisted of 31 with osteosclerotic, 17 with mixed osteosclerotic and osteolytic, and 8 with osteolytic. Forty-six cases without myeloma consisted of 2 with extramedullary plasmacytoma, 33 with M

9. IngentaConnect Crow-Fukase (POEMS) Syndrome A S L Nerve Biopsy Keywords axon; Crow; Fukase syndrome; demyelinating diseases; neurofilaments; POEMS syndrome http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

10. Neurology -- Table Of Contents (June 1 1984, 34, [6]) I Sobue, Y Toyokura, H Nishitani, Y Kuroiwa, E Satoyoshi, T Tsubaki, A Igata,and Y Ozaki The crowfukase syndrome a study of 102 cases in Japan http://www.neurology.org/content/vol34/issue6/

HOME HELP FEEDBACK SUBSCRIPTIONS ... SEARCH TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: Receive this page by email each issue: [Sign up for eTOCs] Contents: June 1 1984, Volume 34, Issue 6 [Index by Author] Other Issues: ARTICLES CORRESPONDENCE Find articles in this issue containing these words: [Search ALL Issues] To see an article , click its [Full Text] link. To review many abstracts , check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time , click its [Abstract] link. ARTICLES: RP Lesser, CE Pippenger, H Luders, and DS Dinner High-dose monotherapy in treatment of intractable seizures Neurology 1984 34: 707-711. [Abstract] T Nakanishi, I Sobue, Y Toyokura, H Nishitani, Y Kuroiwa, E Satoyoshi, T Tsubaki, A Igata, and Y Ozaki The Crow-Fukase syndrome: a study of 102 cases in Japan Neurology 1984 34: 712-720. [Abstract] KB Digre, MW Varner, and JJ Corbett Pseudotumor cerebri and pregnancy Neurology 1984 34: 721-729. [Abstract] C Gilles, JM Brucher, P Khoubesserian, and JJ Vanderhaeghen

11. POEMS Syndrome Treatment Options At Mayo Clinic Treatment of POEMS Syndrome at Mayo Clinic (Synonyms crowfukase syndrome, PEP syndrome, Shimpo syndrome and Takatsuki syndrome) http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

12. Entrez PubMed crowfukase syndrome is a disease of plasma cell dyscrasia. The diagnosiswas crow-fukase syndrome based on these clinical features. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

13. POEMS Syndrome Synonyms. crowfukase syndrome. PEP Syndrome. Polyneuropathy-organomegaly-endocrinopa. .. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

14. Entrez PubMed A 51year-old woman was diagnosed as crow-fukase syndrome on July 1997, presentingwith lymph node s http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

15. EMedicine - POEMS Syndrome Article By Wingfield Rehmus, MD, MPH POEMS syndrome first was described by Crow in 1956 and then by Fukase in 1968. The syndrome was termed crowfukase syndrome (by which it is http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

16. Internet Scientific Publications, LLC. crowfukase syndrome is a rare multisystem disorder characterized by The apparent source of VEGF overproduction in crow-fukase syndrome has not yet been http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijeicm/vol7n2/crow.xml

17. EMedicine - POEMS Syndrome Article Excerpt By Wingfield Rehmus POEMS syndrome first was described by Crow in 1956 and then by Fukase in 1968. The syndrome was termed crowfukase syndrome (by which it is http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

18. EMedicine - POEMS Syndrome : Article By Wingfield Rehmus, MD, MPH Synonyms and related keywords crowfukase syndrome, Takatsuki syndrome, PEP, The syndrome was termed crow-fukase syndrome (by which it is known in http://www.emedicine.com/derm/topic771.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Dermatology Internal Medicine POEMS Syndrome Last Updated: July 10, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: Crow-Fukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma cell dyscrasia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Wingfield Rehmus, MD, MPH , Co-Director of Clinical Trials, Clinical Instructor, Department of Dermatology, Stanford University Medical Center Coauthor(s): Alexa Boer Kimball, MD, MPH , Director of Clinical Trials, Department of Dermatology, Brigham and Women's Hospital, Harvard University School of Medicine Wingfield Rehmus, MD, MPH, is a member of the following medical societies: American Academy of Dermatology Editor(s): Neil Shear, MD

19. POEMS Syndrome - Quest Diagnostics Patient Health Library Synonyms. crowfukase syndrome. PEP Syndrome. Polyneuropathy-organomegaly-endocrinopa. .. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

20. EMedicine - POEMS Syndrome : Article Excerpt By: Wingfield Rehmus, MD, MPH Synonyms, Key Words, and Related Terms crowfukase syndrome, The syndromewas termed crow-fukase syndrome (by which it is known in Japan) by Nakanishi http://www.emedicine.com/derm/byname/poems-syndrome.htm

(advertisement) Excerpt from POEMS Syndrome Synonyms, Key Words, and Related Terms: Crow-Fukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma cell dyscrasia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes Please click here to view the full topic text: POEMS Syndrome Background: Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare multisystemic disease that occurs in the setting of a plasma cell dyscrasia. The pathophysiologic link between the constellation of symptoms and the underlying disease is not well understood, but the link may be related to changes in the levels of a cytokine or a growth factor. POEMS syndrome first was described by Crow in 1956 and then by Fukase in 1968. The syndrome was termed Crow-Fukase syndrome (by which it is known in Japan) by Nakanishi in a study of 102 cases in Japan. In 1980, the acronym POEMS was coined by Bardwick et al based on the 5 main features of the disease, namely, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. No specific case definition for POEMS exists; however, most authors agree that patients with POEMS syndrome should have 3 or more of the 5 features. The pathophysiology of the disease is not known; however, elevated levels of cytokines and growth factors have been implicated. The polyneuropathy associated with POEMS syndrome is a bilateral symmetric disturbance. It involves both motor and sensory nerves, begins distally, and has a progressive proximal spread. Associated cranial or autonomic nerves are not involved. Both demyelination and axonal degeneration are noted.

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