41. Short Description Of Cell Lines. Pathology: Cri Du Chat Syndrome #123450 Pathology cri du chat syndrome 123450 OMIM record. By selecting the cell line name, you will receive the detailed description of the cell line http://www.biotech.ist.unige.it/cldb/pat170.html

Version Short description of cell lines. Pathology: cri du chat syndrome OMIM record By selecting the cell line name , you will receive the detailed description of the cell line By selecting one of the terms between parentheses, you will receive the list of all relevant cell lines You can search any term of the list by using the 'Find' utility of your browser human, Caucasian lymphocyte GGB C-C95 ... By Beatrice...

42. Cri Du Chat Derived from the skin of an adult female Caucasian with cri du chat syndrome. The cells have a deletion in chromosome 5 and have a finite lifespan; http://www.biotech.ist.unige.it/cldb/cl910.html

Version Complete description of the cell line that you requested. Cri du Chat ( human, Caucasian skin, fibroblast cri du chat syndrome (OMIM record) ECACC 90102533 Morphology: Fibroblast Human Caucasian skin deletion in chromosome 5 Depositor: Obtained from ATCC, USA No restrictions. Patent: None Specified By Depositor Properties: Applications: Chromosome studies Available in the following LABORATORY (ECACC, Salisbury, Wiltshire) McCoy's 5a + 2mM Glutamine + 20% Fetal Bovine Serum (FBS). Split confluent cultures 1:3 i.e. seeding at 5x10,000 cells/cm2 using 0.25% trypsin; 5% CO2; 37C. Cells should not be centrifuged. Passages: 17 Karyotype: 2n = 46, diploid Hazard: CX Derived from the skin of an adult female Caucasian with Cri du Chat syndrome. The cells have a deletion in chromosome 5 and have a finite lifespan; up to 35 population doublings expected. Further information Research council deposit: No Price_code: C Availability in cell line catalogues ATCC CCL 90; Bibliographic references: Cytogenetics 1966;5:137 By Beatrice...

43. Cri Du Chat Syndrome cri du chat syndrome, a rare chromosomal disorder that is apparent at birth, is characterized by a distinctive high, shrill, mewing, kittenlike cry http://www.bchealthguide.org/kbase/nord/nord19.htm

var hwPrint=1;var hwDocHWID="nord19";var hwDocTitle="Cri du Chat Syndrome";var hwRank="1";var hwSectionHWID="nord19-Header";var hwSource="en-caQ2_05";var hwDocType="Nord"; National Organization for Rare Disorders, Inc. Cri du Chat Syndrome Important It is possible that the main title of the report Cri du Chat Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms 5p-Syndrome Cat's Cry Syndrome Chromosome 5p-Syndrome Le Jeune Syndrome Partial Deletion of the Short Arm of Chromosome 5 Syndrome Chromosome 5, Monosomy 5p Disorder Subdivisions None General Discussion Cri du Chat Syndrome, a rare chromosomal disorder that is apparent at birth, is characterized by a distinctive high, shrill, mewing, "kitten-like" cry during infancy. This distinctive cry can become less pronounced during late infancy. Other findings and symptoms may include low birth weight and failure to grow at the expected rate (failure to thrive); distinctive abnormalities of the head and face (craniofacial area) including an unusually small head (microcephaly), widely spaced eyes (ocular hypertelorism), and an unusually small jaw (micrognathia); and mental retardation. Cri du Chat Syndrome is caused by the absence of genetic material (deletion) on the short arm (p) of chromosome 5. Resources March of Dimes Birth Defects Foundation 1275 Mamaroneck Avenue White Plains, NY 10605

44. Cri Du Chat Syndrome cri du chat syndrome, a rare chromosomal disorder that is apparent at birth, is characterized by a distinctive http://webcenter.health.webmd.netscape.com/hw/raising_a_family/nord19.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map Health Topics Symptoms ... For a Complete Report Cri du Chat Syndrome Important It is possible that the main title of the report Cri du Chat Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms 5p-Syndrome Cat's Cry Syndrome Chromosome 5p-Syndrome Le Jeune Syndrome Partial Deletion of the Short Arm of Chromosome 5 Syndrome Chromosome 5, Monosomy 5p Disorder Subdivisions None General Discussion Cri du Chat Syndrome, a rare chromosomal disorder that is apparent at birth, is characterized by a distinctive high, shrill, mewing, "kitten-like" cry during infancy. This distinctive cry can become less pronounced during late infancy. Other findings and symptoms may include low birth weight and failure to grow at the expected rate (failure to thrive); distinctive abnormalities of the head and face (craniofacial area) including an unusually small head (microcephaly), widely spaced eyes (ocular hypertelorism), and an unusually small jaw (micrognathia); and mental retardation. Cri du Chat Syndrome is caused by the absence of genetic material (deletion) on the short arm (p) of chromosome 5.

45. Cri Du Chat Syndrome, Results From Genetic Disorder Tests, Amniocentesis, CVS, T cri du chat syndrome is caused by a deletion of part of chromosome 5. The name is derived from the distinctive sound made when children with this problem http://www.paternityangel.com/Preg_info_zone/Disorders/CriDuChat.htm

Home Timeline Men's Info Personal_ Calendar ... Shopping Calculators... Due Date Calcs Weight Gain Calc Most Popular... Baby's Week-by-Week Development Baby's Development in Pictures Baby Names Database Sexual Relations During Pregnancy ... Becoming Pregnant (How it all happens) Navigation... Cri-Du-Chat Syndrome Introduction Trisomy 21 - Down Syndrome Trisomy 18, Edward Syndrome Trisomy 13, Patau Syndrome ... Turner's Syndrome Cri Du Chat Syndrome Cri Du Chat Syndrome is caused by a deletion of part of chromosome 5. The name is derived from the distinctive sound made when children with this problem are crying ('Cri du Chat' means 'Cat's Cry' when translated from French). This anomaly is very rare and occurs about 1 in 50,000 live births. People with this syndrome tend to share distinctive facial features, have a shortened lifespan and suffer varying levels of mental retardation. The following sites can be useful for people seeking further information or support for Cri-Du-Chat Syndrome: http://www.cridchat.u-net.com/

46. Cri Du Chat Syndrome 5p- Information Diseases Database cri du chat syndrome 5p,Lejeune syndrome,5p partial monosomy syndrome,Cat s cry syndrome, Disease Database Information. http://www.diseasesdatabase.com/ddb29133.htm

Diseases Database Index Sponsors Contact ... Previous Page Cri du chat syndrome 5p- information Search 4 synonyms or equivalents were found. Cri du chat syndrome 5p- aka/or Lejeune syndrome aka/or 5p partial monosomy syndrome aka/or Cat's cry syndrome may cause or feature (Follow link for list.) may be a risk factor for (Follow link for list.) belong(s) to the category of (Follow link for list.) Cri du chat syndrome 5p-: Definition(s) via UMLS Code translations and terms via UMLS Cri du chat syndrome 5p-: specific web sites Send Cri du chat syndrome 5p- to medical search engines (JavaScript enabled browsers only.) If your browser has no JavaScript you can still use these: Search using Internet medical databases Search using Internet search engines (non-specialist) We subscribe to the HONcode principles of the Health On the Net Foundation Valid XHTML 1.0 Served 2005-09-09 01:55:02 View metadata Last major update 2005-09-03. The medical information here is presented for education, background reading and general interest. The Diseases Database is not a diagnostic or clinical decision-making tool. Please consult your own licensed physician regarding diagnosis and treatment of any medical condition!

47. Library Pages 1 To 5 Goldnhar and cri du chat syndromes a contiguous gene deletion syndrome Journal of The improved prognosis in cri du chat syndrome, Mary Esther Carlin, MD. http://www.chromodisorder.org/sytrix/card_list.php3?dbid=78&id=155

48. Cri Du Chat Syndrome - Washington DC cri du chat syndrome Washington Hospital Center is located in Washington DC. http://www.whcenter.org/13247.cfm

cddcodebase = "navtools/topmenu/";cddcodebase367050 = "navtools/topmenu/"; Article Manager Home Back to Health Library Print This Page ... Email to a Friend Cri du chat syndrome Definition: Cri du chat syndrome is a group of symptoms that result from missing a piece of chromosome number 5. The syndrome�s name is based on the infant�s cry, which is high pitched and sounds like a cat. Alternative Names: Chromosome 5p deletion syndrome; 5p minus syndrome; Cat cry syndrome Causes, incidence, and risk factors: The cri du chat syndrome is caused by the deletion of information on chromosome 5. It is likely that multiple genes on chromosome 5 are deleted. One deleted gene, called TERT (telomerase reverse transcriptase) is involved in control of cell growth, and may play a role in how some of the features of cri cu chat develop. The cause of this rare chromosomal deletion is not known, but it is expected that the majority of cases are due to spontaneous loss of a piece of chromosome 5 during development of an egg or sperm. A minority of cases result from one parent carrying a rearrangement of chromosome 5 called a translocation. Between 1 in 20,000 and 1 in 50,000 babies are affected. This disease may account for up to 1% of individuals with severe mental retardation. Infants with cri du chat syndrome commonly have a distinctive cat-like cry. They also have an extensive grouping of abnormalities with severe mental retardation being the most important.

49. Cri Du Chat Syndrome My World, , cri du chat syndrome. Homepage; cri du chat syndrome; Who Owns What Volusia county 3D picture movie Snapdragons Stages of mitosis http://www.schools.manatee.k12.fl.us/181cjh/my_world/cri_du_chat_syndrome.html

My World cri du chat syndrome Homepage cri du chat syndrome Who Owns What Volusia county 3D picture movie Snapdragons ... Compare and contrast virus and Bacteria This genetic disorder only affects 1 out of 100,000 new borns. Catherine Horne Home

50. The Cri Du Chat Syndrome Support Group Translate this page The summary for this Japanese page contains characters that cannot be correctly displayed in this language/character set. http://www.tokyo-med.ac.jp/genet/cdcs/cdcsg.htm

ƒlƒR‚È‚«ÇŒóŒQ(Cri-Du-Chat Syndrome) Žx‰‡ƒOƒ‹[ƒv ƒlƒR‚È‚«ÇŒóŒQ(Cri-Du-Chat Syndrome) Žx‰‡ƒOƒ‹[ƒv‚̃z[ƒ€ƒy[ƒW‚ւ悤‚±‚»i‚±‚̃y[ƒW‚͉p‘‚ÌŽx‰‡’c‘̂̃z[ƒ€ƒy[ƒW‚̃~ƒ‰[ƒTƒCƒg‚Å‚·j Last update 2nd April 1997 ( Added gallery texts, removed dead links. ) Prev update 26th March 1997 ( More 'Help' ) Prev update 16th March 1997 ( More gallery ) Prev update 13th March 1997 ( More 'Help' ) ‚²’ˆÓ - ‚±‚̃y[ƒW‚̃IƒŠƒWƒiƒ‹‚Æ‚È‚Á‚Ä‚¢‚é‰p‘‚Ì URL ‚́CˆÈ‰º‚Ì’Ê‚è‚Å‚· - http://www.cridchat.u-net.com ‚UÎ‚̃lƒR‚È‚«ÇŒóŒQ‚̃Vƒƒ[ƒƒbƒg‚̎ʐ^‚Å‚·D (k¬‚µ‚Ä‚ ‚è‚Ü‚·DƒIƒŠƒWƒiƒ‹‚Í j ƒlƒR‚È‚«ÇŒóŒQ‚Ƃ͂ǂ̂悤‚È‚à‚Ì‚Å‚·‚© ? Cri Du Chat Syndrome (ƒtƒ‰ƒ“ƒXŒê‚Å"ƒlƒR‚̖‚«º" ‚Æ‚¢‚¤ˆÓ–¡‚Å‚·) ‚́C5”ԐõF‘Ì‚É‚ ‚éˆâ“`Žq‚ªŽ¸‚í‚ꂽ‚èCŒë‚Á‚½êŠ‚Ɉړ®‚µ‚Ä‚µ‚Ü‚¤‚±‚Æ‚É‚æ‚è‹N‚±‚éˆâ“`Žq‚Ì•a‹C‚Å‚·D‚±‚Ì•a‹C‚Í1963”N‚Ƀ_ƒEƒ“ÇŒóŒQ‚à”­Œ©‚µ‚½‚±‚Æ‚Å’m‚ç‚ê‚郌ƒWƒ [ƒk‹³Žö‚É‚æ‚菉‚ß‚ÄŒ©o‚³‚ê‚Ü‚µ‚½D”ނ́C‚±‚Ì•a‹C‚Ì‘å•”•ª‚Ì“û—cŽ™‚ª‚ ‚°‚é“Æ“Á‚Ì‚È‚«º‚ðÇŒóŒQ‚Ì–¼‘O‚Æ‚µ‚Ü‚µ‚½D ‚Ù‚©‚É‚¢‚­‚‚©‚Ì–Ú—§‚Á‚½—Տ°Çó‚Í‚ ‚è‚Ü‚·‚ªC‚±‚Ì‚È‚«º‚Í‚±‚̏njóŒQ‚É‹É‚ß‚Ä“Á’¥“I‚Å‚ ‚邽‚߁C‚ӂ‚¤ˆãŽt‚͐õF‘Ì•ªÍ‚ðs‚¤‘O‚É‚±‚̏ó‘Ô‚É‹C•t‚«‚Ü‚·D g‘̏Ǐó‚Æ“¯—l‚ɁCƒlƒR‚È‚«ÇŒóŒQ‚ł́CŽíX‚Ì’ö“x‚̐¸_”­’B‚̏áŠQ‚ª”F‚ß‚ç‚ê‚Ü‚·D’ʏí‚Ì‹³ˆç‚ðŽó‚¯‚Ä‚¢‚éŽq‹Ÿ‚½‚¿‚à­”‚¢‚Ü‚·‚ªC‘å•”•ª‚ÌŽq‹Ÿ‚½‚¿‚É‚Í‚æ‚è“Á•Ê‚È‹³ˆç‚ª•K—v‚Æ‚³‚ê‚Ü‚·D’·Šú“I‚ȃlƒR‚È‚«ÇŒóŒQ‚ÌŽq‹Ÿ‚½‚¿‚ÌŒo‰ß‚͗ǍD‚Å‚·D Žx‰‡ƒOƒ‹[ƒv‚Ì–Ú“I‚͉½‚Å‚·‚©H ‰p‘’†‚́i‚»‚µ‚Ä‚¢‚Ü‚â‘S¢ŠE‚Ì!jŠ³ŽÒ‚³‚ñ‚̉Ƒ°‚â‰îŒì‚ÌŠF‚³‚ñ‚ÉŽx‰‡‚Æ—Fî‚ð•ù‚°‚邱‚ƁD

51. Cri Du Chat Syndrome. Iyer SL, Duraiswamy A, Kher AS, Joshi S, Bharucha BA, Kana J Postgrad Med, Online version this peerreviewed periodical, a publication of the Staff Society of Seth GS Medical College and KEM Hospital, India, http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1996;volume=42;issue=3

52. Cri Du Chat Syndrome... A Parent Support Group for Children with cri du chat syndrome PO Box 268 Lakewood, CA 90714 (888) 9700777 (714) 890-9112 - fax Email fiveminus@aol.com http://www.mnip-net.org/MNIP/factshts.nsf/0/d89237f53acd4c6c85256eb00051f60a?Ope

53. Cri Du Chat Syndrome cri du chat syndrome. Student s name jon homan Grade 10th Category Life_Science.Genetics Expert Aves. would this be labeled as sex linked or under http://www.seps.org/oracle/oracle.archive/Life_Science.Genetics/2003.11/00106964

cri du chat syndrome Student's name: jon homan Grade: 10th Category: Life_Science.Genetics Expert: Aves Follow the link at the end of this message for information about this syndrome. It is caused by a deletion of a part of chromosome number 5 so it would be classified under chromosome structure. It is one of the most common human deletion syndromes. http://www3.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?123450#DESCRIPTION Choose where to go next: Back to the subjects To other messages by this scientist To the general archive If you see an error in our program, please report it so that we can improve the web site.

54. What Is Cri Du Chat Syndrome Cri du Chat (KREE doo SHAH) Syndrome is a chromosomal disorder where the short Although cri du chat syndrome can present medical problems ranging from http://www.thehutchpage.com/aboutcriduchat.htm

What is Cri du Chat Syndrome? Cri du Chat (KREE doo SHAH) Syndrome is a chromosomal disorder where the short arm of the fifth chromosome is lost from the first cell of life. All of our genes are attached to chromosomes. So when a piece of a chromosome is lost, so is a piece of the genetic code that makes us who we are. In approximately 90 percent of cases, including Vincent's, both parents are chromosomally normal and the deletion occurs spontaneously for reasons that geneticists cannot yet explain. The syndrome is rare. Estimates of its occurrence range from one in 30,000 to one in 50,000 live births. Undoubtedly this accounts for the relative paucity of information on Cri du Chat, as compared to more commonly known chromosomal disorders such as Down's Syndrome. Like most chromosomal disorders, Cri du Chat presents an array of developmental challenges intellectual as well as physical. Mental retardation ranges from mild to severe, with most cases falling into the moderate range. Communication is the most significant challenge for persons with this syndrome. Some form of sign language is a must. Physical development is impaired primarily by low muscle tone, which underscores the importance of early intervention in the form of physical therapy. It is considered exceptional for a child with this syndrome to walk before 3 years old. Some people with the syndrome are never able to walk at all.

55. Caremark.com cri du chat syndrome occurs when a piece of chromosomal material is missing from a Dr. Jerome Lejeune first described cri du chat syndrome in 1963. http://www.caremark.com/wps/portal/_s.155/5522/.cmd/ad/.pm/-/.c/1703/.ce/5535/.p

56. Cri Du Chat -- Facts, Info, And Encyclopedia Article cri du chat syndrome, also called deletion 5p syndrome, or 5p minus, Individuals with cri du chat syndrome are often underweight at birth. http://www.absoluteastronomy.com/encyclopedia/c/cr/cri_du_chat.htm

Cri du chat [Categories: Genetic disorders] Cri du chat syndrome , also called deletion 5p syndrome , or 5p minus , is a rare genetic disorder due to a missing portion of (A threadlike body in the cell nucleus that carries the genes in a linear order) chromosome 5. It was first described by Lejeune in 1963. The condition affects an estimated 1 in 20,000 to 50,000 live births. The disorder is found in people of all ethnic backgrounds and is slightly more common in females. Signs and symptoms Its name, meaning cry of the cat in French, is from the distinctive mewing sound made by infants with the disorder. As babies, patients tend to be squirmy with a mewing cry, ascribed to abnormal (Click link for more info and facts about laryngeal) laryngeal development. The cry becomes less distinctive with age. Individuals with cri du chat syndrome are often underweight at birth. The disorder is characterized by severe (Lack of normal development of intellectual capacities) mental retardation and delayed development, distinctive facial features, small head size ( (An abnormally small head and underdeveloped brain) microcephaly ), low birth weight, and weak muscle tone (

57. Ask An Expert: Cri Du Chat Syndrome Question. what are some symptoms of cri du chat syndrome? Answer. Cri du chat (cat cry) or 5p syndrome is a genetic disorder where the person is missing http://www.netwellness.org/question.cfm/29154.htm

NetWellness provides the highest quality health information and education services created and evaluated by faculty of our partner universities. Thursday, September 8, 2005 Home HealthTopics Health Centers Reference Library ... Search this Topic Inherited Disorders and Birth Defects Cri du chat syndrome Question: what are some symptoms of cri du chat syndrome? Answer: Cri du chat (cat cry) or 5p- syndrome is a genetic disorder where the person is missing a small part of the short arm of chromosome number 5. Chromosomes are the structures in all of our cells that carry DNA that instructs the body how to form, function and grow. There are 46 chromosomes in each cell of the body. You inherit half of your chromosomes from your mother and half from your father. On a rare occasion, a piece of a chromosome can break off and be lost at conception – this is usually the case in 5p- syndrome. Babies born with 5p- syndrome may have a high pitched cry, usually are small at birth, have poor muscle tone and a small head (microcephaly). Children with 5p- usually grow slowly. Mental retardation is also seen. While not common, some children will have a congenital heart defect and there can other problems such as a cleft lip and palate or other organ involvement. The website listed below has additional information about 5p- syndrome. For more information: 5p- Society Response by: Anne Matthews, R.N., Ph.D.

58. Growth Study Of Cri Du Chat Syndrome -- Collins And Eaton-Evans 85 (4): 337 -- A We compared the growth of children with cri du chat (5p ) syndrome with the Subjects were recruited through the cri du chat syndrome Support Group. http://adc.bmjjournals.com/cgi/content/full/85/4/337

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Author Keyword(s) Vol Page [Advanced] This Article Abstract Full Text (PDF) Submit a response ... Alert me if a correction is posted Services Email this link to a friend Similar articles in ADC Online Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Collins, M S R Articles by Eaton-Evans, J Related Collections Other Neurology Genetics Nutrition and Metabolism Other Pediatrics Arch Dis Child 337-338 ( October ) Short report Growth study of cri du chat syndrome M S R Collins a , J Eaton-Evans b a North and West Belfast Health and Social Services Trust, Muckamore Abbey Hospital, Antrim, BT41 4SH, UK, b Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine Correspondence to: Mrs Collins Accepted 11 June 2001 Abstract Top Abstract Introduction Methods Results Discussion and conclusions References We compared the growth of children with cri du chat (5p ) syndrome with the 1990 UK growth curves. Most subjects had impaired

59. Developmental And Behavioural Characteristics Of Cri Du Chat Syndrome -- Cornish In terms of a developmental profile, children with cri du chat syndrome were able A neuropsychologicalgenetic profile of atypical cri du chat syndrome http://adc.bmjjournals.com/cgi/content/abstract/archdischild;75/5/448

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Author Keyword(s) Vol Page [Advanced] This Article Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in ADC Online Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Cornish, K. Articles by Pigram, J PAPERS Developmental and behavioural characteristics of cri du chat syndrome KM Cornish and J Pigram Faculty of Medicine, Medical School, University of Nottingham, Queen's Medical Centre. Developmental and behavioural characteristics were assessed in 27 children with cri du chat syndrome using the Society for the Study of Behavioural Phenotypes questionnaire, which gave information on prenatal and perinatal conditions, neurological problems, and developmental and behavioural

60. Disease - Cri Du Chat Syndrome - Hartford, Connecticut Disease cri du chat syndrome - courtesy of Saint Francis Care of Hartford, Connecticut, contemporary medicine with major clinical concentrations in heart http://www.saintfranciscare.com/11766.cfm

@import url(main.css); About Us Health Information Health Focus Todays Breast Health News ... Ways To Help Adam Article Manager Back Back to main Health Information page Disease - Cri du chat syndrome Definition: Cri du chat syndrome is a group of symptoms that result from missing a piece of chromosome Alternative Names: Chromosome 5p deletion syndrome; 5p minus syndrome; Cat cry syndrome Causes And Risk: The cri du chat syndrome is caused by the deletion of information on chromosome 5. It is likely that multiple genes on chromosome 5 are deleted. One deleted gene, called TERT (telomerase reverse transcriptase) is involved in control of cell growth, and may play a role in how some of the features of cri cu chat develop. The cause of this rare chromosomal deletion is not known, but it is expected that the majority of cases are due to spontaneous loss of a piece of chromosome 5 during development of an egg or sperm. A minority of cases result from one parent carrying a rearrangement of chromosome 5 called a translocation. Between 1 in 20,000 and 1 in 50,000 babies are affected. This disease may account for up to 1% of individuals with severe mental retardation. Infants with cri du chat syndrome commonly have a distinctive cat-like cry. They also have an extensive grouping of abnormalities with severe mental retardation being the most important.

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