21. Cowden Syndrome Detailed information on cowden syndrome, including causes of the disorder. http://www.healthsystem.virginia.edu/uvahealth/adult_breast/cowden.cfm

[ Skip Navigation ] Health System Home For Health Answers Healthcare Professionals ... Advanced Search Health System Search Search for Information People UVa Home Health System News Health System Events (all) Health System Publications ... Making a Gift Topics All About Cancer Blood Disorders Bone Disorders Breast Health Cancer Cardiovascular Disease Dermatology Diabetes Digestive Disorders Endocrinology Environmental Medicine Eye Care Glossary Gynecological Health Infectious Diseases Kidney Disease Men's Health Mental Health Nervous System Disorders Non-Trauma Emergency Oral Health Orthopaedics Otolaryngology Pathology Pediatrics, General Health Prostate Health Radiology Respiratory Disorders Skin Cancer Surgical Care Urology Women's Health UVa Health Topics A to Z FIND A DOCTOR Benign Breast Conditions Breast Cancer: Medical Oncology Breast Cancer: Radiation Oncology ... WHY CHOOSE UVA Search This Site Cowden Syndrome The risk for breast cancer is increased with Cowden syndrome, a rare autosomal dominant disorder that is also associated with a number of specific noncancerous features. Cowden syndrome is associated with the following characteristics: multiple hamartomatous lesions (benign, or noncancerous,tumors of normal organ tissue) of the skin and other organs, usually present by the late 20s

22. Síndrome De Cowden (Cowden Syndrome) Translate this page El riesgo de cáncer del seno es mayor en el síndrome de Cowden, un trastornoautosómico dominante poco común que S­ndrome de Cowden (cowden syndrome) http://www.healthsystem.virginia.edu/UVAHealth/adult_breast_sp/cowden.cfm

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23. Cowden Syndrome The risk for breast cancer is increased with cowden syndrome, a rare autosomal cowden syndrome is associated with the following characteristics http://medicalcenter.osu.edu/patientcare/healthinformation/otherhealthtopics/Bre

Skip Navigation home about us referring ... Cowden Syndrome Cowden Syndrome The risk for breast cancer is increased with Cowden syndrome, a rare autosomal dominant disorder that is also associated with a number of specific noncancerous features. Cowden syndrome is associated with the following characteristics: macrocephaly (increased head size) increased risk of breast cancer, with an average age of onset ranging from 38 to 46 years increased risk of thyroid cancer increased risk of endometrial cancer Additional features can include noncancerous thyroid lesions, hamartomatous intestinal polyps, lipomas (benign fatty tumors), fibromas, uterine fibroids, and fibrocystic disease of the breast. Some individuals who have inherited a germline PTEN mutation never develop cancer because they never get the second mutation necessary to knock out the function of the gene and start the process of tumor formation. This can make the cancer appear to skip generations in a family, when, in reality, the mutation is present. Persons with a mutation, regardless of whether they develop cancer, however, have a 50/50 chance to pass the mutation on to the next generation. It is also important to remember that the PTEN gene is not located on the sex chromosomes. Therefore, mutations can be inherited from the mother or the father's side of the family.

24. Cowden Syndrome - Mountain View Bay Area Sunnyvale Cupertino Palo Alto Standford cowden syndrome El Camino Hospital is located in the heart of Silicon Valleyat Mountain View, California ,serving Mountain View Bay Area Sunnyvale http://www.elcaminohospital.org/11264.cfm

@import url(default.css); @import url(module.css); Home Hospital News Find A Doctor Health Information A-Z ... Back to Search Cowden Syndrome The risk for breast cancer is increased with Cowden syndrome, a rare autosomal dominant disorder that is also associated with a number of specific noncancerous features. Cowden syndrome is associated with the following characteristics: multiple hamartomatous lesions (benign, or noncancerous, tumors of normal organ tissue) of the skin and other organs, usually present by the late 20s macrocephaly (increased head size) increased risk of breast cancer, with an average age of onset ranging from 38 to 46 years increased risk of thyroid cancer increased risk of endometrial cancer Additional features can include noncancerous thyroid lesions, hamartomatous intestinal polyps, lipomas (benign fatty tumors), fibromas, uterine fibroids, and fibrocystic disease of the breast. Cowden syndrome is caused by mutations in a gene on chromosome 10 known as PTEN. About 80 percent of people whose symptoms meet the criteria for a diagnosis of Cowden syndrome will have a PTEN mutation. Mutations in PTEN confer a 25 percent to 50 percent lifetime risk for breast cancer, about a 10 percent risk of thyroid cancer, and potentially up to a 5 percent to 10 percent risk of endometrial cancer, although this risk is still being evaluated. Some individuals who have inherited a germline PTEN mutation never develop cancer because they never get the second mutation necessary to knock out the function of the gene and start the process of tumor formation. This can make the cancer appear to skip generations in a family, when, in reality, the mutation is present. Persons with a mutation, regardless of whether they develop cancer, however, have a 50/50 chance to pass the mutation on to the next generation.

25. Sindrome De Cowden (Breast Health - Cowden Syndrome) - Mountain View Bay Area Su Sindrome de Cowden (Breast Health cowden syndrome) - El Camino Hospital islocated in the heart of Silicon Valley at Mountain View, California ,serving http://www.elcaminohospital.org/14197.cfm

@import url(default.css); @import url(module.css); Home Hospital News Find A Doctor Health Information A-Z ... Back to Search Sindrome de Cowden (Breast Health - Cowden Syndrome) macrocefalia (tamano aumentado de la cabeza) mayor riesgo de cancer del seno, con una edad promedio de aparicion de 38 a 46 anos mayor riesgo de cancer de tiroides mayor riesgo de cancer endometrial Se pueden incluir caracteristicas adicionales como lesiones tiroideas no cancerosas, polipos intestinales hamartomatosos, lipomas (tumores adiposos benignos), fibromas, miomas uterinos y enfermedad fibroquistica del seno. Algunos individuos que han heredado una mutacion germinal PTEN jamas desarrollan cancer porque nunca se produce la segunda mutacion necesaria para destruir la funcion del gen e iniciar el proceso de formacion del tumor. Esto puede simular que el cancer saltea generaciones en una familia, cuando, en realidad, la mutacion esta presente. Sin embargo, las personas con una mutacion, sin tener en cuenta si desarrollan cancer o no, tienen un 50 por ciento de probabilidades de transmitir la mutacion a la generacion siguiente. Ademas, es importante recordar que el gen PTEN no se localiza en los cromosomas sexuales. Por lo tanto, las mutaciones se pueden heredar de parte de la familia materna o paterna.

26. PTEN Gene Of Cowden Syndrome Found In Autism Inherited gene mutations in the PTEN gene are seen in cowden syndrome, a poorlyrecognized disorder that increases a person’s risk of developing cancers of http://www.rxpgnews.com/psychiatry/learning-disabilities/autism/article_1014.sht

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27. PTEN Gene Of Cowden Syndrome Found In Autism PTEN gene of cowden syndrome found in Autism By Ohio State University Apr 8,2005, 0136. A gene that is changed in many forms of cancer has also been found http://www.rxpgnews.com/psychiatry/learning-disabilities/autism/printer_1014.sht

From rxpgnews.com Autism PTEN gene of Cowden Syndrome found in Autism By Ohio State University Apr 8, 2005, 01:36 A gene that is changed in many forms of cancer has also been found to show similar changes in some forms of autism, according to preliminary research. The gene, known as PTEN, was found to be changed, or mutated, in three of 18 people with larger than normal heads and autism spectrum disorder. Autism spectrum disorder includes classical autism, Rett syndrome and other conditions. The study was led by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital (OSU CCC-James) and Richard J. Solove Research Institute and at Children’s Mercy Hospitals and Clinics, Kansas City, Mo. Inherited gene mutations in the PTEN gene are seen in Cowden syndrome, a poorly recognized disorder that increases a person’s risk of developing cancers of the breast, thyroid and uterus. PTEN mutations are also found in several non-inherited (i.e., spontaneous) cancers, including thyroid and endometrial cancers and some brain tumors. The findings, published in the April Journal of Medical Genetics, raise the possibility that some people with autism and large heads may have an increased risk of cancer.

28. Genetics & Cancer - Cowden Syndrome cowden syndrome is a rare autosomal dominant disorder that is also associated with a cowden syndrome is associated with the following characteristics http://ymghealthinfo.org/content.asp?pageid=P07171

29. Cancer Center Health Information, Genetics Cancer cowden syndrome cowden syndrome isassociated with the following characteristics http://www.rush.edu/rumc/page-1098987397359.html

Bone Marrow Transplant Gynecologic Oncology Myeloid Disease Cancer Center Cancer Programs Prostate Cancer Study Glioblastoma Multiforme Study Hematology/Oncology Trials Cowden Syndrome The risk for breast cancer is increased with Cowden syndrome, a rare autosomal dominant disorder that is also associated with a number of specific noncancerous features. Cowden syndrome is associated with the following characteristics: multiple hamartomatous lesions (benign, or noncancerous, tumors of normal organ tissue) of the skin and other organs, usually present by the late 20s macrocephaly (increased head size) increased risk of breast cancer, with an average age of onset ranging from 38 to 46 years increased risk of thyroid cancer increased risk of endometrial cancer Additional features can include noncancerous thyroid lesions, hamartomatous intestinal polyps, lipomas (benign fatty tumors), fibromas, uterine fibroids, and fibrocystic disease of the breast. Cowden syndrome is caused by mutations in a gene on chromosome 10 known as PTEN. About 80 percent of people whose symptoms meet the criteria for a diagnosis of Cowden syndrome will have a PTEN mutation. Mutations in PTEN confer a 25 percent to 50 percent lifetime risk for breast cancer, about a 10 percent risk of thyroid cancer, and potentially up to a 5 percent to 10 percent risk of endometrial cancer, although this risk is still being evaluated. Some individuals who have inherited a germline PTEN mutation never develop cancer because they never get the second mutation necessary to knock out the function of the gene and start the process of tumor formation. This can make the cancer appear to skip generations in a family, when, in reality, the mutation is present. Persons with a mutation, regardless of whether they develop cancer, however, have a 50/50 chance to pass the mutation on to the next generation.

30. Frankford Hospitals - Cowden Syndrome Detailed information on cowden syndrome, including causes of the disorder.A consumer web site for Frankford Hospitals, a community hospital system in http://www.frankfordhospitals.org/healthinfo/adult/breast/cowden.html

Topic Home Page Topic Index Cowden Syndrome The risk for breast cancer is increased with Cowden syndrome, a rare autosomal dominant disorder that is also associated with a number of specific noncancerous features. Cowden syndrome is associated with the following characteristics: multiple hamartomatous lesions (benign, or noncancerous, tumors of normal organ tissue) of the skin and other organs, usually present by the late 20s macrocephaly (increased head size) increased risk of breast cancer, with an average age of onset ranging from 38 to 46 years increased risk of thyroid cancer increased risk of endometrial cancer Additional features can include noncancerous thyroid lesions, hamartomatous intestinal polyps, lipomas (benign fatty tumors), fibromas, uterine fibroids, and fibrocystic disease of the breast. Cowden syndrome is caused by mutations in a gene on chromosome 10 known as PTEN. About 80 percent of people whose symptoms meet the criteria for a diagnosis of Cowden syndrome will have a PTEN mutation. Mutations in PTEN confer a 25 percent to 50 percent lifetime risk for breast cancer, about a 10 percent risk of thyroid cancer, and potentially up to a 5 percent to 10 percent risk of endometrial cancer, although this risk is still being evaluated. Some individuals who have inherited a germline PTEN mutation never develop cancer because they never get the second mutation necessary to knock out the function of the gene and start the process of tumor formation. This can make the cancer appear to skip generations in a family, when, in reality, the mutation is present. Persons with a mutation, regardless of whether they develop cancer, however, have a 50/50 chance to pass the mutation on to the next generation.

31. Kprones CowdenID10018 Cowden s disease a possible new syndrome with multiple system involvement. The cowden syndrome a clinical and genetic study in 21 patients. http://www.infobiogen.fr/services/chromcancer/Kprones/CowdenID10018.html

Atlas of Genetics and Cytogenetics in Oncology and Haematology Home Genes Leukemias Solid Tumours ... NA Cowden Disease Identity Other names Multiple hamartoma syndrome Inheritance autosomal dominant; high penetrance (close to 100% by the age of 30 yrs); highly variable expressivity (between and within families) Clinics Phenotype and clinics clinical manifestations usually occur during the 2nd and 3rd decade; they are dystrophic, hamartomatous or tumoral lesions including the following to variable extend: - mucocutaneous papillomatous lesions (facial papules, sometimes related to trichilemmoma; oral papillomatosis with cobblestone gingiva; acral keratoses) - both dystrophic and adenomatous multinodular goiter - intestinal tract polyps with variable histologies - adenosis and fibrocystic disease of the breast - macrocephaly - lipomas - genito-urinary abnormalities Overlapping syndromes Bannayan-Riley-Ruvalcaba syndrome including precocious stigmata of Cowden disease (macrocephaly, lipomas, genital pigmented macules, hamartomatous intestinal tract polyps) is considered as a pediatric form of Cowden disease Lhermitte Duclos syndrome or dysplastic gangliocytoma of the cerebelum is a rare and complex hamartomatous condition of the cerebellum which can occur alone but also in association with Cowden disease juvenile polyposis and Peutz Jeghers syndrome : Cowden disease, by its intestinal tract lesions can be linked to the scope of hereditary hamartomatous polyposis; molecular diagnosis can be useful in distinguishing juvenile polyposis, Peutz Jeghers syndrome or Cowden disease/Bannayan

32. Will The Real Cowden Syndrome Please Stand Up: Revised Diagnostic Criteria -- En cowden syndrome (CS, MIM 158350) is an autosomal dominant disorder with agerelated penetrance characterised by multiple hamartomas and a high risk of http://jmg.bmjjournals.com/cgi/content/extract/37/11/828

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Author Keyword(s) Vol Page [Advanced] This Article Full Text Full Text (PDF) Submit a response ... Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Eng, C. Related Collections Other Oncology Genetics J Med Genet 828-830 ( November ) Commentary Will the real Cowden syndrome please stand up: revised diagnostic criteria Charis Eng Clinical Cancer Genetics and Human Cancer Genetics Programs, Comprehensive Cancer Center, and Division of Human Genetics, Department of Internal Medicine, The Ohio State University, 420 W 12th Avenue (Suite 690 MRF), Columbus, OH 43210, USA; CRC Human Cancer Genetics Research Group, University of Cambridge, Cambridge, UK Correspondence to: Professor Eng, eng-1@medctr.osu.edu

33. Male Breast Cancer In Cowden Syndrome Patients With Germline PTEN Mutations -- F cowden syndrome (CS) is an autosomal dominant cancer susceptibility syndrome The cowden syndrome a clinical and genetic study in 21 patients. http://jmg.bmjjournals.com/cgi/content/full/38/3/159

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Author Keyword(s) Vol Page [Advanced] This Article Abstract Full Text (PDF) Submit a response ... Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Fackenthal, J. D Articles by Olopade, O. I Related Collections Cancer:other Genetics J Med Genet 159-164 ( March ) Male breast cancer in Cowden syndrome patients with germline PTEN mutations James D Fackenthal a , Deborah J Marsh b , Anne-Louise Richardson b , Shelly A Cummings a , Charis Eng c , Bruce G Robinson b , Olufunmilayo I Olopade a a Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, IL 60637, USA, b Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Sydney NSW 2065, and Department of Medicine, University of Sydney, NSW 2006, Australia, c Clinical Cancer Genetics and Human Cancer Genetics Program, Comprehensive Cancer Center, and Division of Human Genetics, Department of Internal Medicine, The Ohio State University, 690C Medical Research Facility, 420 West 12th Avenue, Columbus, OH 43201 USA, and CRC Human Cancer Genetics Research Group, University of Cambridge, UK

34. Cowden Syndrome - Definition From Biology-Online.org Definition and other additional information on cowden syndrome from BiologyOnline.orgdictionary. http://www.biology-online.org/dictionary/cowden_syndrome

Forum Tutorials Dictionary Directory ... C cowden syndrome cowden syndrome (Science: radiology) Multiple hamartoma syndrome GI ... tract hamartomas (including stomach and colon breast carcinoma thyroid carcinoma circumoral ... gingival hyperplasia See also: polyposis syndromes Search the dictionary About Us Contact Us Link to Us Chemistry ... Equations

35. Germline Mutations Of The PTEN Gene In Cowden Disease, An Inherited Breast And T cowden syndrome and LhermitteDuclos disease in a family a single genetic The cowden syndrome a clinical and genetic study in 21 patients, dm. Clin. http://www.nature.com/ng/journal/v16/n1/abs/ng0597-64.html

@import "/ng/style.css"; NATURE.COM NEWS@NATURE.COM NATUREJOBS NATUREEVENTS ... Help E-MAIL: PASSWORD: Save password Forgotten password? SEARCH JOURNAL Advanced search Journal home Archive Table of Contents ... For librarians NPG Resources Nature Nature Cell Biology Nature Medicine Nature Reviews Genetics ... Browse all publications Letter Nature Genetics doi:10.1038/ng0597-64 Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome Danny Liaw , Debbie J. Marsh , Jing Li , Patricia L. M. Dahia , Steven I. Wang , Zimu Zheng , Shikha Bose , Katherine M. Call , Hui C. Tsou , Monica Peacoke , Charis Eng Departments of Pathology, College of Physicians and Surgeons, Columbia University, 630 W. 168th St., New York, New York 10032, USA. Departments of Medicine, College of Physicians and Surgeons, Columbia University, 630 W. 168th St., New York, New York 10032, USA. Departments of Dematology, College of Physicians and Surgeons, Columbia University, 630 W. 168th St., New York, New York 10032, USA. . Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, D920C, Boston, Massachusetts 02115, USA.

36. Greenville Hospital System Genetics Cancer cowden syndrome, Printable View cowden syndrome isassociated with the following characteristics http://www.ghs.org/frame.php?pageid=P07171

37. Resources For Genetic Counselors - Cowden Syndrome B. Part of PTEN hamartoma tumor syndrome (PHTS). 1. Includes cowden syndrome,BannayanRiley-Ruvalcaba, Proteus syndrome, and Proteus-like syndrome http://www.genesoc.com/counseling2/article51.html

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38. Southeast Missouri Hospital - Cowden Syndrome cowden syndrome. The risk for breast cancer is increased with cowden syndrome,a rare autosomal dominant disorder that is also associated with a number of http://www.southeastmissourihospital.com/cancerresource/cowden.htm

Cowden Syndrome The risk for breast cancer is increased with Cowden syndrome, a rare autosomal dominant disorder that is also associated with a number of specific noncancerous features. Cowden syndrome is associated with the following characteristics: multiple hamartomatous lesions (benign, or noncancerous, tumors of normal organ tissue) of the skin and other organs, usually present by the late 20s macrocephaly (increased head size) increased risk of breast cancer, with an average age of onset ranging from 38 to 46 years increased risk of thyroid cancer increased risk of endometrial cancer Additional features can include noncancerous thyroid lesions, hamartomatous intestinal polyps, lipomas (benign fatty tumors), fibromas, uterine fibroids, and fibrocystic disease of the breast. Cowden syndrome is caused by mutations in a gene on chromosome 10 known as PTEN. About 80 percent of people whose symptoms meet the criteria for a diagnosis of Cowden syndrome will have a PTEN mutation. Mutations in PTEN confer a 25 percent to 50 percent lifetime risk for breast cancer, about a 10 percent risk of thyroid cancer, and potentially up to a 5 percent to 10 percent risk of endometrial cancer, although this risk is still being evaluated. Some individuals who have inherited a germline PTEN mutation never develop cancer because they never get the second mutation necessary to knock out the function of the gene and start the process of tumor formation. This can make the cancer appear to skip generations in a family, when, in reality, the mutation is present. Persons with a mutation, regardless of whether they develop cancer, however, have a 50/50 chance to pass the mutation on to the next generation.

39. Genetics Of PTEN In Cowden Syndrome And Sporadic Breast Cancer - Storming Media Germline mutations in PTEN on 10q23.3 cause 80% of classic cowden syndrome (CS)and SO of BannayanRiley-Ruvalcaba syndrome (CS) as well as up to 20% of http://www.stormingmedia.us/30/3038/A303893.html

Home About Us Contact Us View Cart ... Genetic Engineering and Molecular Biology Genetics of PTEN in Cowden Syndrome and Sporadic Breast Cancer Authors: Charis Eng OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS Abstract: Limitations: APPROVED FOR PUBLIC RELEASE Description: Final rept. 1 Oct 1998-30 Sep 2001 Pages: Report Date: OCT 2001 Report number: Keywords relating to this report: BREAST CANCER CHROMOSOMES DIAGNOSIS(GENERAL) EMBRYOLOGY ... VACCINES Printed Format - $25.95 Adobe PDF - $8.95 Please check the box for the format you wish to order. Shipping Terms About Electronic Delivery E-Mail a colleague Home About Us Contact Us View Cart ... Advanced Search

40. Genetics Of PTEN In Cowden Syndrome And Sporadic Breast Cancer - Storming Media cowden syndrome (CS) is an autosomal dominant disorder characterized by multiplehamartomas and a high risk of breast, thyroid and other cancers. http://www.stormingmedia.us/44/4483/A448383.html

Home About Us Contact Us View Cart ... Genetic Engineering and Molecular Biology Genetics of PTEN in Cowden Syndrome and Sporadic Breast Cancer Authors: Charis Eng OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS Abstract: Limitations: APPROVED FOR PUBLIC RELEASE Description: Annual rept. 1 Oct 1998-30 Sep 1999 Pages: Report Date: OCT 1999 Report number: Keywords relating to this report: BREAST CANCER CHROMOSOMES GENES GENETICS ... THYROID GLAND Printed Format - $25.95 Adobe PDF - $8.95 Please check the box for the format you wish to order. Shipping Terms About Electronic Delivery E-Mail a colleague Home About Us Contact Us View Cart ... Advanced Search

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