61. Arch Neurol -- Abstract: Clinical Presentation And Pharmacological Therapy In Co Dissociation of numbers and objects in corticobasal degeneration and semantic The corticobasal degeneration syndrome overlaps progressive aphasia and http://archneur.ama-assn.org/cgi/content/abstract/55/7/957

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 55 No. 7, July 1998 Featured Link E-mail Alerts Original Contribution Article Options Full text PDF Send to a Friend Readers Reply Submit a reply Related articles in this issue Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Kompoliti K Riley DE Articles that cite this article ISI Web of Science (53) ... Contact me when this article is cited Topic Collections Movement Disorders Parkinson Disease/ Parkinsonian Disorders Topic Collection Alerts Clinical Presentation and Pharmacological Therapy in Corticobasal Degeneration K. Kompoliti, MD C. G. Goetz, MD B. F. Boeve, MD D. M. Maraganore, MD J. E. Ahlskog, PhD, MD C. D. Marsden, FRCP K. P. Bhatia, MD P. E. Greene, MD S. Przedborski, MD E. C. Seal, MD

62. Corticobasal Degeneration - St. Joseph Mercy, Ann Arbor Michigan corticobasal degeneration St. Joseph Mercy Health System Hospitals serving AnnArbor, SE Michigan, Washtenaw County, Livingston County, Wayne County, http://www.sjmercyhealth.org/13233.cfm

@import url(default.css); Online Health Information Health Information - Rare Diseases and Disorders Back to Health Library Print This Page Email to a Friend National Organization for Rare Disorders, Inc. Corticobasal Degeneration Synonyms Disorder Subdivisions General Discussion Resources ... For a Complete Report Important It is possible that the main title of the report Corticobasal Degeneration is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Cortical-Basal Ganglionic Degeneration Cortico-Basal Ganglionic Degeneration (CBGD) CBGD Disorder Subdivisions None General Discussion Corticobasal degeneration is a rare progressive neurological disorder characterized by cell loss and shrinkage (atrophy) in certain areas of the brain (cerebral cortex and substantia nigra). Affected individuals may have sufficient muscle power for manual tasks but often have difficulty directing their movements appropriately. Initial symptoms typically appear in people during the sixth decade, and may include poor coordination, difficulty accomplishing goal-directed tasks (e.g., buttoning a shirt), and/or difficulty pantomiming actions. Symptoms usually begin on one side of the body (unilateral), but both sides may be affected as the disease progresses. Cognitive impairment (e.g., memory loss) and/or visual-spatial impairments may also occur. The exact cause of corticobasal degeneration is unknown.

63. Parkinson S Disease With Additional Symptoms corticobasal degeneration (CBD) is a relatively rare disorder, which althoughpresenting with some parkinsonism, is not misdiagnosed very often due to a http://www.mayo.edu/fpd/pd-info/parkplus.htm

Parkinson's Disease with Additional Symptoms 'Parkinson's Plus' is a name given to a group of disorders with parkinsonian symptoms, but with additional features. While the clinical symptoms of these disorders overlap with Parkinson's disease, the underlying neuropathology is often different and individuals may require alternate treatments. We've tried to provide an informative passage on each of these disorders, but for further information, please see our links for other sources. Dementia with Lewy Bodies Cortical Lewy bodies of dementia with Lewy bodies (DLB) are noticeably smaller and different in appearance, both with a standard H+E stain, and with an anti-synuclein staining (see figure). Prior to the identification of Lewy bodies in demented patients, the 50% (approx.) of dementia cases not attributable to pure Alzheimer's disease were assumed the result of vascular dementia. The discovery of Lewy bodies in the brains of demented patients by Kosaka and coleagues (1984) prompted a variety of new diagnoses i.e. dementia with Lewy bodies, diffuse Lewy body disease, Lewy body variant of Alzheimer's disease and others. More recently, the umbrella term 'Dementia with Lewy bodies' has been used - distinctions between different Lewy dementias were probably due to the variable bias between research groups. As a result, today's DLB is probably the second most common form of dementia after Alzheimer's disease. In DLB, patients usually initially develop Alzheimer's like dementia symptoms or parkinsonian signs and subsequently progress to symptoms of the other condition. McKeith and colleagues (1996) defined the features of possible or probable DLB diagnoses. These are (2 needed for a probable, 1 for a possible diagnosis):

64. Pathology Of Degenerative CNS Diseases corticobasal degeneration (CBD) is classified as an akinetic rigid movement corticobasal degeneration neuropathologic and clinical heterogeneity. http://www-medlib.med.utah.edu/WebPath/TUTORIAL/CNS/CNSDG.html

CNS Degenerative Diseases Return to the tutorial menu. Alzheimer's Disease Senile dementia of the Alzheimer's type (SDAT), or Alzheimer's disease (AD) is becoming more common in developed nations as the population includes more and more older persons. There is no known cause for the disease. It is not known why some people present as early as 30 or 40 years of age with dementia while others do not present until their late 70's or 80's. Familial cases with a defined inheritance pattern account for only 5 to 10% of Alzheimer's disease. Familial cases tend to have an earlier age at onset. Genetic defects in familial cases have been identified on chromosomes 21, 19, 14, 12 and 1. The so-called "early onset" cases of AD in persons in their 30's, 40's, and 50's may have a genetic basis. Less than 1% of early onset AD cases are linked to a genetic defect on chromosome 21 (which may explain the appearance of Alzheimer's disease in persons with Down syndrome surviving to middle age) which affects amyloid precursor protein (APP), resulting in fibrillar aggregates of beta-amyloid that is toxic to neurons. About half of early onset AD cases are linked to mutations in the presenilin 1 gene on chromosome 14. A presenilin 2 gene has been discovered on chromosome 1, but this defect accounts for less than 1% of cases. The more typical "late onset" cases of AD occurring after age 60 may have underlying genetic defects. A genetic locus on chromosome 19 encodes for a cholesterol transporter called apolipoprotein E (apoE). The E4 variant of apoE, which increases deposition of fibrillar beta-amyloid, can be found in 40% of AD cases. However, the presence of apoE4 is neither necessary nor sufficient for development of AD, so testing for it is not warranted. A genetic locus on chromosome 12 that encodes for alpha-2-macroglobulin may be found in 30% of AD cases. Mutations in the tau gene which codes for

65. Corpus Callosum Atrophy & Cognitive Impairment Atrophy of the Corpus Callosum, Cortical Hypometabolism, and Cognitive Impairmentin corticobasal degeneration. http://www.geocities.com/HotSprings/3468/corpus-callosum.html

Corpus Callosum Atrophy And Cognitive Impairment Abstracts Local tissue damage assessed with statistical mapping analysis of Brain Magnetization Transfer Ratio: relationship with functional status of patients in the earliest stage of Multiple Sclerosis AJNR Am J NeuroRadiol 2005 Jan;26(1):119-27 Mechanisms of Normal-Appearing Corpus Callosum injury related to PeriCallosal T lesions in Multiple Sclerosis using directional Diffusion Tensor and 1H MRS imaging J Neurol NeuroSurg Psychiatry 2004 Sep;75(9):1281-6 Multiple Sclerosis pathology in the Normal and Abnormal Appearing White Matter of the Corpus Callosum by Diffusion Tensor Imaging Mult Scler 2004 Aug;10(4):392-7 Corpus Callosum Axonal injury in Multiple Sclerosis measured by Proton Magnetic Resonance Spectroscopic imaging Arch Neurol 2004 Jul;61(7):1081-6 Directional Diffusion in Relapsing/Remitting Multiple Sclerosis: a possible in vivo signature of Wallerian Degeneration J Magn Reson Imaging 2003 Oct;18(4):420-6 Diffusely elevated Cerebral Choline and Creatine in Relapsing/Remitting Multiple Sclerosis Magn Reson Med 2003 Jul;50(1):190-5 Cognitive correlates of SupraTentorial Atrophy on MRI in Multiple Sclerosis Acta Neurol Scand 2001 Oct;104(4):214-23

66. CBD - Progressive Supranuclear Palsy (PSP-Europe) Association Feifel, E, Brenner, M, Teiwes, R et al corticobasal degeneration. Ikeda, K,Akiyama, H ,Iritani, S et al corticobasal degeneration with primary http://www.pspeur.org/about-cbd.asp

67. British Library Direct: Order Details Order from the British Library LimbKinetic Apraxia in corticobasal degenerationClinical and Kinematic Features Movement Disorders -new York- http://direct.bl.uk/research/50/0C/RN125246564.html

This is an article from British Library Direct, a new service that allows you to search across 20,000 journals for free and order full text using your credit card. Buy this article Search British Library Direct Return to Google Article details Article title Limb-Kinetic Apraxia in Corticobasal Degeneration: Clinical and Kinematic Features Author Leiguarda, R. C. Merello, M. Nouzeilles, M. I. Balej, J. Rivero, A. Nogues, M. Journal title MOVEMENT DISORDERS -NEW YORK- Bibliographic details 2003, VOL 18; PART 1, pages 49-59 Publisher Lippincott-Raven; 1999 Country of publication USA ISBN ISSN Language English Pricing To buy the full text of this article you pay: service charge Abstract: By using this site you agree to our terms and conditions Privacy policy We welcome your comments

68. Corticobasal corticobasal degeneration. 4 Patient Support Information corticobasal degenerationfactsheet National Institute for Neurological Disorders and Stroke http://www.ion.ucl.ac.uk/library/patient/corticobasal.htm

Corticobasal degeneration Patient Support Information Corticobasal degeneration factsheet: National Institute for Neurological Disorders and Stroke Support Groups Pick's Disease Support Group 8 Brooksby Close Oadby Leicester Tel : 0116 271 1414 Fax : 0870 706 0958 Email: info@pdsg.org.uk For carers of frontotemporal dementia: Pick's Disease, Frontal Lobe Degeneration, Dementia with Lewy Bodies, Corticobasal Degeneration and Alcohol Related Dementia. WE MOVE 204 West 84th Street, New York, NY 10024, USA Outside the US, Tel: 212-241-8567 Fax: 212-987-7363 Email: wemove@wemove.org Excellent website on movement disorders. Includes: Information on disorders and treatment; Answers to FAQ's; An international listing of support and advocacy organizations and links to their web sites; A schedule of regional and national support group events; Web chats; News on the latest research; Links to other sites of interest and affinity groups.

69. Entrez PubMed corticobasal degeneration and progressive supranuclear palsy share a common tauhaplotype. Houlden H, Baker M, Morris HR, MacDonald N, PickeringBrown S, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

70. Entrez PubMed BACKGROUND corticobasal degeneration has been mainly described as a movementdisorder, but cognitive impairment is also increasingly noted. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2

71. Corticobasal Degeneration -- Gibb Et Al. 112 (5): 1171 -- Brain Dissociation of numbers and objects in corticobasal degeneration and semanticdementia Language function and dysfunction in corticobasal degeneration http://brain.oxfordjournals.org/cgi/content/abstract/112/5/1171

JOURNAL HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed ... Cited by other online articles Search for citing articles in: ISI Web of Science (357) Request Permissions PubMed PubMed Citation Articles by Gibb, W. R. Articles by Marsden, C. D. ARTICLES Corticobasal degeneration WR Gibb, PJ Luthert and CD Marsden Department of Neuropathology, National Hospitals for Nervous Diseases, Maida Vale. Three patients with clinical and pathological features of corticobasal degeneration are described. They presented with a progressive disease bearing some clinical resemblance to Steele-Richardson-Olszewski syndrome and displaying some pathological features of Pick's disease. Their illness began at the age of 59 to 66 yrs with focal dystonia and myoclonus of an arm, the 'alien hand' sign, or an akinetic-rigid syndrome. They developed a

72. Corticobasal Degeneration. A Clinical Study Of 36 Cases -- Rinne Et Al. 117 (5): Dissociation of numbers and objects in corticobasal degeneration and corticobasal degeneration and progressive supranuclear palsy share a common tau http://brain.oxfordjournals.org/cgi/content/abstract/117/5/1183

JOURNAL HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed ... Cited by other online articles Search for citing articles in: ISI Web of Science (220) Request Permissions PubMed PubMed Citation Articles by Rinne, J. O. Articles by Marsden, C. D. ARTICLES Corticobasal degeneration. A clinical study of 36 cases JO Rinne, MS Lee, PD Thompson and CD Marsden University Department of Clinical Neurology, Institute of Neurology, London, UK. The presenting features and their subsequent evolution in 36 patients with pathologically proven or clinically probable corticobasal degeneration are described. The most common initial complaint was of a unilateral 'clumsy, stiff or jerky arm' (n = 20). Typically the arm was akinetic, rigid and apraxic. In about a third of these the arm was held in a striking and

73. MDVU Resource Library - Corticobasal Degeneration - Causes Of Corticobasal Degen Unfortunately, the cause of CBD is entirely unknown. There is currently no strongevidence to suggest CBD is an inherited disease, and no other risk factors http://www.mdvu.org/library/disease/cbd/cbd_cau.html

WE MOVE 204 West 84th Street New York, NY 10024 E-mail: wemove@wemove.org Resource Library Movement Disorders Description Causes of Corticobasal Degeneration ... Approaches to Treatment Resource Library Research News Our Mission Professional Services Make a Donation ... Contact Us Corticobasal Degeneration Causes of Corticobasal Degeneration Unfortunately, the cause of CBD is entirely unknown. There is currently no strong evidence to suggest CBD is an inherited disease, and no other risk factors, such as toxins or infections, have been identified. Studies of brain tissue of individuals with CBD show certain characteristic cell changes. Similar, although not identical, changes are observed in two other neurodegenerative diseases, Pick's disease and progressive supranuclear palsy. These changes, involving a brain protein called tau, have provided researchers some initial clues in their search for the causes of CBD.

74. MDVU Resource Library - Corticobasal Degeneration - Symptoms Of Corticobasal Deg Symptoms of CBD usually begin after age 60. The initial symptoms of CBD are oftenstiffness, shakiness, jerkiness, slowness, and clumsiness, in either the http://www.mdvu.org/library/disease/cbd/cbd_sym.html

WE MOVE 204 West 84th Street New York, NY 10024 E-mail: wemove@wemove.org Resource Library Movement Disorders Description Causes of Corticobasal Degeneration ... Approaches to Treatment Resource Library Research News Our Mission Professional Services Make a Donation ... Contact Us Corticobasal Degeneration Symptoms of Corticobasal Degeneration Symptoms of CBD usually begin after age 60. The initial symptoms of CBD are often stiffness, shakiness, jerkiness, slowness, and clumsiness, in either the upper or lower extremities. Other initial symptoms may include dysphasia (difficulty with speech generation), dysarthria (difficulty with articulation), difficulty controlling the muscles of the face and mouth, or walking and balance difficulties. Symptoms usually begin on one side of the body, and spread gradually to the other. Some patients (probably more than commonly recognized in the past) may have memory or behavioral problems as the earliest or presenting symptoms. CBD is a progressive disease, meaning the symptoms worsen over time. Over the course of one to several years, most people with CBD gradually worsen, with symptoms progressing to involve upper and lower extremities and other body regions. Symptoms of advanced CBD include: parkinsonism (rigidity, slow movements, postural instability)

75. Neurology -- Collected Resources : Corticobasal Degeneration Limb apraxia in corticobasal degeneration and progressive supranuclear palsy Sonographic discrimination of corticobasal degeneration vs progressive http://www.neurology.org/cgi/collection/corticobasal_degeneration

HOME HELP FEEDBACK SUBSCRIPTIONS ... SEARCH RESULT QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: Corticobasal degeneration Citations 1-8 of 8 total displayed. Most recent content (8 Feb 2005): ARTICLES Limb apraxia in corticobasal degeneration and progressive supranuclear palsy Paola Soliveri, Sylvie Piacentini, and Floriano Girotti Neurology 2005; 64: 448-453. [Abstract] [Full text] [PDF] Past content (since Oct 2001): ARTICLES Sonographic discrimination of corticobasal degeneration vs progressive supranuclear palsy U. Walter, D. Dressler, A. Wolters, T. Probst, A. Grossmann, and R. Benecke Neurology 2004; 63: 504-509. [Abstract] [Full text] [PDF] ARTICLES Dissociation of numbers and objects in corticobasal degeneration and semantic dementia C. H. Halpern, G. Glosser, R. Clark, J. Gee, P. Moore, K. Dennis, C. McMillan, A. Colcher, and M. Grossman Neurology 2004; 62: 1163-1169. [Abstract] [Full text] [PDF] BRIEF COMMUNICATIONS mutation screen of sporadic cases with cerebral cavernous malformations D. J. Verlaan, S. B. Laurent, U. Sure, H. Bertalanffy, E. Andermann, F. Andermann, G. A. Rouleau, and A. M. Siegel

76. Pathologic Heterogeneity In Clinically Diagnosed Corticobasal Degeneration -- Bo Sonographic discrimination of corticobasal degeneration vs progressive supranuclearpalsy Language function and dysfunction in corticobasal degeneration http://www.neurology.org/cgi/content/abstract/53/4/795

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Full Text Full Text (PDF) Correspondence: ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Boeve, B. F. Articles by Petersen, R. C. Neurology American Academy of Neurology Articles Pathologic heterogeneity in clinically diagnosed corticobasal degeneration B. F. Boeve, MD D. M. Maraganore, MD J. E. Parisi, MD J. E. Ahlskog, PhD, MD N. Graff-Radford, MBBCh, MRCP (UK) R. J. Caselli, MD D. W. Dickson, MD E. Kokmen, MD and R. C. Petersen, PhD, MD From the Departments of Neurology (Drs. Boeve, Maraganore, Ahlskog, Kokmen, and Petersen), Laboratory Medicine and Pathology (Dr. Parisi), Mayo Clinic, Rochester, MN; Department of Neurology (Dr. Graff-Radford) and the Neuropathology Laboratory (Dr. Dickson), Mayo Clinic, Jacksonville, FL; and Department of Neurology (Dr. Caselli), Mayo Clinic, Scottsdale, AZ. Address correspondence and reprint requests to Dr. Bradley F. Boeve, Department of Neurology, 200 1st Street SW, Rochester, MN 55905.

77. Health/Conditions And Diseases/Neurological Disorders/Brain Diseases/Corticobasa url www.tornadodesign.com/cbgd/; corticobasal degeneration CorticobasalGanglionic Degeneration (CBGD) Article by Timothy C. Hain, MD from Northwestern http://www.thedoctorslounge.net/dir/Health/Conditions_and_Diseases/Neurological_

Advertisement Powered by Careerbuilder Search for: Home Humor Advertising Contact ... Links Specialties Cardiology Chest diseases Dermatology Endocrinology ... Urology Other Sections Membership Research Tools Medical Tutorials Medical Software ... Specialized Centers Headlines: The Medical Website Directory Popular Categories Popular Links Web Sites report abuse/spam url: report-abuse.dmoz.org/?cat=Health/Conditions_and_D... Caregivers Guide Guide for Corticalbasal Ganglionic Degeneration. url: www.tornadodesign.com/cbgd/ Corticobasal Degeneration Information sheet compiled by the National Institute of Neurological Disorders and Stroke. url: www.ninds.nih.gov/health_and_medical/disorders/cor... Corticobasal Ganglionic Degeneration (CBGD) Article by Timothy C. Hain, MD from Northwestern University Medical School. url: www.neuro.northwestern.edu/meded/MOVEMENT/corticob... Update on Corticobasal Degeneration Presents an article on CBGD by Bradley F. Boeve, MD. url: www.tornadodesign.com/cbgd/boeve_updateoncbgd.htm AltaVista url: www.altavista.com/web/results?q=%22corticobasal%2b...

78. Corticobasal Degeneration Substantiated By Imaging Studies Key Words Letters • corticobasal degeneration • MRI Studies. TO THE EDITORcorticobasal degeneration (CBD) is a slowly progressive disorder, http://ajgp.psychiatryonline.org/cgi/content/full/13/4/333

79. U Of L Neurology/ Speciality Divisions/ Movement Disorders Neuropathologic criteria for corticobasal degeneration and related disorders; 3.Validation of ORD neuropathologic criteria http://www.louisville.edu/medschool/neuro/academics/divisions/mov_dis.html

Home General Info Academics Patients ... Academics The Movement Disorder Program The Movement Disorder Program is composed of Dr. Irene Litvan and staff. The Movement Disorder Program has three main goals: "patient care", "clinical research" and "education." Patient care The Movement disorders program is dedicated to providing the best diagnostic, therapeutic, palliative, and supportive care to patients with movement disorders, cognitive deficits, and neurodegenerative diseases, with a focus on Parkinsons and Parkinsonian disorders. Patient care begins with an in-depth evaluation and consultation by Dr. Litvan, a movement disorders specialist of more than 15 years experience, and continues through treatment, therapies, and ongoing support. The main objective is on improving the quality of life for both patients and caregivers. In addition to diagnosis, therapeutic treatment, and ongoing support, patients may be able to participate in research, which will further our knowledge of these disorders and hopefully one day lead to either progression halting treatments or cures for people suffering from these disorders. Clinical research Clinical research is focused on discovering not only the causes and effects of, but also treatments and possible cures for a variety of movement disorders, including Parkinson's disease (PD), Progressive Supranuclear Palsy (PSP), and Corticobasal Degeneration (CBD). Basal ganglia and frontal lobular function as they relate to these disorders are of particular interest.

80. The Health Library — Nervous System And Brain corticobasal degeneration. corticobasal degenerationNINDS CorticobasalDegenerationWe Move corticobasal degenerationAssociation for Frontotemporal http://healthlibrary.stanford.edu/resources/internet/bodysystems/neuro_braindise

Diseases and Disorders Use these links to jump directly to your topic of interest in Nervous System and Brain: Signs and Symptoms: Pain Neurologic Manifestations Language Disorders Perceptual Disorders Central Nervous System: Brain Diseases Brain Injury Infections Malformations ... Tumors Other Diseases and Disorders: Autoimmune Nervous System Diseases Autonomic Nervous System Diseases Cranial Nerve Disorders Degenerative Nervous System Diseases ... Sleep Disorders Other Topics: General Nervous System and Brain Anatomy Diagnostic Procedures Neural Transplantation Brain Diseases (Jump to: General Information Alpers' Disease Corticobasal Degeneration Epilepsy ... Neuroleptic Malignant Syndrome General Information Cerebellar Degeneration:NINDS Cerebellar Hypoplasia:NINDS Cerebral Atrophy:NINDS Encephalopathy:NINDS ... Brain Diseases: MedlinePlus Alpers' Disease Alpers' Disease:NINDS Alpers' Disease:Institute of Child Health, UK Corticobasal Degeneration Corticobasal Degeneration:NINDS Corticobasal Degeneration:We Move Corticobasal Degeneration:Association for Frontotemporal Dementias Epilepsy General Information Epilepsy:AANF Epilepsy:Novartis Foundation for Gerontology [PDF] Seizures and Epilepsy: Hope Through Research:NINDS Seizures and Epilepsy:Lucile Packard Children's Hospital About Epilepsy:Johns Hopkins Epilepsy Center History of Epilepsy:Epilepsy.com

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