41. Corticobasal Degeneration corticobasal degeneration is a rare progressive neurological disorder characterizedby cell loss and http://my.webmd.com/hw/health_guide_atoz/nord1009.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report Corticobasal Degeneration Important It is possible that the main title of the report Corticobasal Degeneration is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Cortical-Basal Ganglionic Degeneration Cortico-Basal Ganglionic Degeneration (CBGD) CBGD Disorder Subdivisions None General Discussion Corticobasal degeneration is a rare progressive neurological disorder characterized by cell loss and shrinkage (atrophy) in certain areas of the brain (cerebral cortex and substantia nigra). Affected individuals may have sufficient muscle power for manual tasks but often have difficulty directing their movements appropriately. Initial symptoms typically appear in people during the sixth decade, and may include poor coordination, difficulty accomplishing goal-directed tasks (e.g., buttoning a shirt), and/or difficulty pantomiming actions. Symptoms usually begin on one side of the body (unilateral), but both sides may be affected as the disease progresses. Cognitive impairment (e.g., memory loss) and/or visual-spatial impairments may also occur. The exact cause of corticobasal degeneration is unknown.

42. Corticobasal Degeneration corticobasal degeneration. What is corticobasal degeneration? Corticobasaldegeneration is a progressive neurological disorder characterized by nerve cell http://www.clevelandclinic.org/health/health-info/docs/1200/1266.asp?index=5999&

43. Show-documents.asp corticobasal degeneration Written Information. Care Treatment. CorticobasalDegeneration New Search Contact Us Disclaimer Send This Link http://www.clevelandclinic.org/health/search/do-query.asp?TopicId=1290

44. Cortico Basal Degeneration corticobasal degeneration, a 4R tauopathy. corticobasal degeneration (CBD) is aslowly progressive neurodegenerative disorder characterized by an http://perso.wanadoo.fr/adna/CBD.html

Accueil Le laboratoire Maladie d'Alzheimer Autres maladies ... Base de donnŽes Corticobasal degeneration, a 4R tauopathy Corticobasal degeneration (CBD) is a slowly progressive neurodegenerative disorder characterized by an asymmetrical akinetic-rigid syndrome associated with cognitive (apraxia and aphasia) and extrapyramidal motor dysfunction (rigidity and dystonia). Moderate dementia emerges sometimes late in the course of the disease (Rinne et al., 1994). There is an overlap between progressive supranuclear palsy (PSP) and CBD (Feany et al., 1996), and it would be most helpful to distinguish these two pathologies on a neuropathological or immunochemical basis. By comparison, CBD is less prevalent, and usually dysplays a more severe cortical atrophy with fronto-parietal predominance partly sparing the central area. Neuropathology : Cytoskeletal pathology is complex, in that it combines conspicuous chromatolytic neurons in large numbers without argentophilic inclusions. Cortico glio-fibrillar plaques have also been described, as well as aberrant neurites in the white matter. The degenerative pathology of the basal ganglia and rhombencephalon is not as sharply targeted on specific nuclei as in PSP, and also involves a striking number of chromatolytic neurons. Astrocytic laques are large with a hollow center, while those from PSP are stained with anti-tau in their center, (tuffed plaques). Tau lesions in PSP and CBD are exclusively composed of tau isoforms with exon 10 (Sergeant et al, 1999)

45. Alzheimer corticobasal degeneration. Dementia pugilistica/autism with selfinjury behaviour.DownOs syndrome. FTDP-17. Gerstmann-Straussler-Scheinker disease (rarely) http://perso.wanadoo.fr/adna/tauparameters.html

Alzheimer Brain dis eases Research ... untington Hallenvorden IBM L ewy BD MSA NPiD c Parkinson D Guadeloupe Parkinson Dementia E^in Parkinson E^ Pick Prion P SP ... Semantic E^D SSP E^ ToD The biochemical parameters of tau pathology Introduction: Tau is an outstanding biochemical marker of neurofibrillary degeneration (NFD), well correlated with clinical manifestations. Tau pathology concerns many familial or sporadic neurodegenerative disorders , such as Alzheimer's disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick's disease (PiD), FTDP-17, myotonic dystrophy (MyoD), and many other diseases. Molecular parameters of Tau pathology help to understand the involvement of tau in the physiopathology of these diseases and to set up diagnoses and therapeutic strategies. Six main features define tau pathology: 1) the quantitative aspects, using western blots ; 2) the different biochemical signatures observed in AD, PSP, CBD, PiD, MyoD (one to four immunodetected electrophoretic bands); 3) the specific tau isoforms content of brain lesions. Indeed, "disease-specific" sets of tau isoforms aggregate to constitute 4 main categories of tau lesions: class 1: AD (all 6 isoforms), class 2: PSP/CBD (3 Exon10+ isoforms), class 3: PiD (3 Exon10- isoforms) and class 4: MyoD (mainly and sometimes exclusively the shortest tau isoform);

46. EMedicine - Cortical Basal Ganglionic Degeneration : Article By Anna M Barrett, Synonyms and related keywords corticobasal degeneration, corticodentatonigraldegeneration with neuronal achromasia, corticonigral degeneration with http://www.emedicine.com/NEURO/topic77.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Neurology Movement And Neurodegenerative Diseases Cortical Basal Ganglionic Degeneration Last Updated: August 10, 2005 Rate this Article Email to a Colleague Synonyms and related keywords: corticobasal degeneration, corticodentatonigral degeneration with neuronal achromasia, corticonigral degeneration with neuronal achromasia, extrapyramidal apractic syndrome, Pick complex disorders, Rebeiz disease, apraxia AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Anna M Barrett, MD , Director, Associate Professor of Physical Medicine and Rehabilitation, Stroke Rehabilitation Research Program, Kessler Medical Rehabilitation Research and Education Corporation Anna M Barrett, MD, is a member of the following medical societies: American Academy of Neurology , American Society of Neurorehabilitation, International Neuropsychological Society , and Society for Neuroscience Editor(s): Stephen T Gancher, MD

47. EMedicine - Apraxia And Related Syndromes : Article By Daniel H Jacobs, MD In corticobasal degeneration, memory is unaffected early. The differentialdiagnosis for corticobasal ganglionic degeneration includes Alzheimer disease http://www.emedicine.com/neuro/topic438.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Neurology Behavioral Neurology And Dementia Apraxia and Related Syndromes Last Updated: October 27, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: apraxia of speech, buccofacial apraxia, callosal apraxia, conceptual apraxia, dyspraxia, ideomotor apraxia, ideational apraxia, limb apraxia, limb kinetic apraxia, magnetic apraxia, motor agnosia, oral apraxia, parectropia, disorder of voluntary movement, voluntary movement disorder, alien hand syndrome AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Daniel H Jacobs, MD , Clinical Associate Professor, Department of Neurology, University of Florida Daniel H Jacobs, MD, is a member of the following medical societies: American Academy of Neurology , and Society for Neuroscience Editor(s): Stephen T Gancher, MD

48. Tau In CBD corticobasal degeneration (CBD) is clinically and pathologically similar to PSP.Age at onset is typically in the 7th decade, and the predominant symptoms http://www.binderlab.northwestern.edu/CBD.html

Tau-Related Neurodegenerative Diseases: Corticobasal Degeneration Corticobasal Degeneration (CBD) is clinically and pathologically similar to PSP . Age at onset is typically in the 7th decade, and the predominant symptoms are motor dysfunctions, including rigidity, ataxia, dysarthria, Parkinson’s-like signs, and in some cases, supranuclear gaze palsy. These symptoms and the underlying pathology frequently are asymmetric. CBD also exhibits clinical signs of cortical involvement: constructional apraxia (inability to perform complex movements), “alien hand” sign, and frontal dementia. Neuropathology involves the basal ganglia, corticospinal tracts, and parietal and frontal cortices. In the cortex white matter is as much involved as gray. Two types of neuronal pathology are observed: ballooned achromatic neurons that lack tau inclusions, and neurons with tau inclusions that resemble Pick bodies. As with PSP, glial involvement is massive, and includes coiled bodies and glial threads in the white matter. The astrocytic pathology consists of astrocytic plaques , rather than the tufted astrocytes of PSP.

49. Karger Publishers corticobasal degeneration and Frontotemporal Dementia Presentations in a Kindredwith corticobasal degeneration; Frontotemporal dementia; Neurogenetics http://content.karger.com/ProdukteDB/produkte.asp?Doi=48638

50. ScienceDaily -- Browse Topics: Health/Conditions_and_Diseases/Neurological_Disor Search corticobasal degeneration and Related Disorders CorticobasalDegeneration Information sheet compiled by the National Institute of http://www.sciencedaily.com/directory/Health/Conditions_and_Diseases/Neurologica

@import "/styles/navbar.css"; @import "/styles/tabStyles.css"; Set home page Bookmark site Add search Latest News ... Email to friend Text Size A A A Front Page ... Brain Diseases : Corticobasal Degeneration Subtopics See Also: Health: Conditions and Diseases: Rare Disorders Search Google: Corticobasal Degeneration News Books Links ... UCSF Study Finds Signaling Link In Fruit Fly Nervous System May Point To Target For Treating Neurodegenerative Disease (September 3, 2005) full story Pinpointing The Cause Of A Neurodegenerative Disorder (August 30, 2005) full story Solving The Mystery Of Mutated Proteins And The Brain (August 26, 2005) Cell . Dr. Huda Zoghbi and her colleagues have determined that a genetic mutation actually enhances the normal activity of a protein, and in the case of ataxin-1, the disease spinocerebellar ataxia type 1 results. full story New Research Suggests Heart Bypass Surgery Increases Risk Of Alzheimer's Disease (August 25, 2005) full story Scientists Focus On 'Dwarf Eye' Genetic Finding May Have Implications For Farsightedness And Nearsightedness, Too (August 24, 2005) full story Golfers With Low-back Pain May Be Helped By University Of Pittsburgh Research (August 18, 2005)

51. Corticobasal Degeneration (CBD) Discusses corticobasal degeneration, brain atrophy and degeneration of the nervecells in the brain associated with tau protein dysfunction. http://www.about-dementia.com/dementia/corticobasal-degeneration.php

Dementia Information Dementia Causes Brain Trauma Corticobasal Degeneration ... Tell a Friend Corticobasal Degeneration (CBD) Corticobasal degeneration (CBD) is a rare progressive neurological disorder resulting in the loss of nerve cells and brain atrophy in one or more regions of the brain. CBD occurs most commonly in the frontal and parietal lobes of the cerebral cortex region and in the large clusters of nerve cells called the basal ganglia , located in the striatum and sustantia nigra regions of the mid-brain. Diagnosing Corticobasal Degeneration Corticobasal degeneration, also called corticobasal ganglionic degeneration is initially characterized by a combination of Parkinson-like symptoms and a range of symptoms associated with the dysfunction of the corticobasal nerve cells. Because of its similarity to a number of other neural disorders, CBD is often diagnosed incorrectly. The Causes of CBD Although corticobasal degeneration has no known cause, research has identified a link between the disease and the abnormal accumulation and malfunction of tau protein in the nerve cells of the brain. Researchers are attempting to establish whether the cause of CBD may be related to a mutation of the tau gene.

52. Corticobasal Ganglionic Degeneration And/or Frontotemporal Dementia? A Report Of corticobasal degeneration (CBD) is currently considered by many authors to be adistinct Ikeda K. Basic pathology of corticobasal degeneration. http://www.jnnp.com/cgi/content/full/68/3/304

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Author Keyword(s) Vol Page [Advanced] This Article Abstract Full Text (PDF) Submit a response ... Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Mathuranath, P S Articles by Hodges, J. R Related Collections Other Neurology Dementia Related Article J Neurol Neurosurg Psychiatry 304-312 ( March ) Corticobasal ganglionic degeneration and/or frontotemporal dementia? A report of two overlap cases and review of literature P S Mathuranath a , John H Xuereb b , Thomas Bak a , John R Hodges a c a University of Cambridge Neurology Unit, Addenbrooke's Hospital, Cambridge, UK, b The Cambridge Brain Bank Laboratory, Department of Pathology (Histopathology Division), University of Cambridge, UK, c MRC Cognition and Brain Sciences Unit, Cambridge, UK

53. Dyspraxia In A Patient With Corticobasal Degeneration: The Role Of Visual And Ta The neuropsychological pattern of corticobasal degeneration comparison with Accuracy of the clinical diagnosis of corticobasal degeneration a http://www.jnnp.com/cgi/content/full/67/3/334

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Author Keyword(s) Vol Page [Advanced] This Article Abstract Full Text (PDF) Submit a response ... Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Graham, N. L Articles by Hodges, J. R Related Collections Neuropathology Other Neurology J Neurol Neurosurg Psychiatry 334-344 ( September ) Review Dyspraxia in a patient with corticobasal degeneration: the role of visual and tactile inputs to action Naida L Graham a b Adam Zeman c Andrew W Young d Karalyn Patterson b John R Hodges a b a University Neurology Unit, University of Cambridge, Cambridge, UK, b MRC Cognition and Brain Sciences Unit, Cambridge, UK, c Department of Clinical Neuroscience, Western General Hospital, Edinburgh, UK, d Department of Psychology, University of York, York, UK

54. BestTreatments Corticobasal Degeneration corticobasal degeneration. In this disease, the parts of your brain that control People usually start getting symptoms of corticobasal degeneration http://www.besttreatments.co.uk/btuk/glossary/11538.html

Glossary Corticobasal degeneration In this disease, the parts of your brain that control movement and speech gradually stop working. People usually start getting symptoms of corticobasal degeneration between the ages of 60 and 70 years old. At first, it makes you become stiff and move more slowly. Then, you become uncoordinated and tend to slur your speech and get muscle spasms. Close window

55. BioMed Central | Abstract | Corticobasal Degeneration corticobasal degeneration Panida Piboolnurak MD and Cheryl H Waters MD corticobasal degeneration is one of the neurodegenerative tauopathies, http://www.biomedcentral.com/1092-8480/5/161/abstract

home journals A-Z subject areas advanced search ... Issue 2 Viewing options Abstract Full text PDF Associated material: PubMed record Related literature: Articles citing this article on Google Scholar Other articles by authors Piboolnurak P ... Similar articles (PubMed) Tools: E-mail to a friend Download references Opinion Corticobasal Degeneration Panida Piboolnurak MD and Cheryl H Waters MD The Neurological Institute, 710 West 168th Street, Columbia University, New York, NY, 10032, USA Current Treatment Options in Neurology Published Abstract Corticobasal degeneration is one of the neurodegenerative tauopathies, which are defined as a group of heterogeneous dementias and movement disorders that are characterized neuropathologically by prominent intracellular accumulations of abnormal filaments formed by the microtubule-associated protein tau. Although there are no curative treatments, symptomatic and supportive management can be helpful. Many new therapies are still under development. However, more needs to be learned about the pathogenesis and molecular biology of this disease before an effective therapy can be developed. Terms and Conditions Privacy statement Information for advertisers Contact us

56. BioMed Central | Full Text | Corticobasal Degeneration To obtain access to Current Treatment Options in Neurology through your institutionuse the options below. If you would like information about a personal http://www.biomedcentral.com/1092-8480/5/161

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57. BCM-Neurology-Parkinson's Disease Center And Movement Disorders-Cortical-Basal G corticobasal degeneration Clinical and Research Aspects. Advances in NeurologySeries. LippincottRaven Publishers, 1999. (In press). Hanna PA, Doody RS. http://www.bcm.edu/neurology/struct/parkinson/ganglionic.html

Print This Page Close Window Cortical-Basal Ganglionic Degeneration Joseph Jankovic, M.D. What is Cortical-Basal Ganglionic Degeneration? As with the other atypical parkinsonian syndromes, treatment with levodopa and related medications is only rarely, if ever, helpful. Sometimes muscle spasms and jerking can be reduced with tranquilizers, or with botulinum toxin injections into affected parts of the body. References Jankovic J. Treatment of parkinsonian syndromes. In: Kurlan R, ed. The Treatment of Movement Disorders. J.B. Lippincott Company, Philadelphia, 1995:95-114. Kumar R, Bergeron C, Pollanen MS, Lang AE. Cortical-basal ganglionic degeneration. In: Jankovic J, Tolosa E, eds. Parkinson's Disease and Movement Disorders. Baltimore: Williams and Wilkins, 1998:297-316. Kompoliti K, Goetz CG, Boeve BF, et al. Clinical presentation and pharmacological therapy in corticobasal degeneration. Arch Neurol 1998;55:957-961.

58. Parkinson's Disease Center And Movement Disorders Clinic corticobasal degeneration (CBD) is a form of atypical parkinsonian (parkinsonismplus) Language function and dysfunction in corticobasal degeneration. http://www.bcm.edu/neurol/jankovic/educ_cbd.htm

Corticobasal Degeneration (CBD) Joseph Jankovic, M.D. Previous What and How Next Download Summary ( Printer-Friendly) As with the other atypical parkinsonian syndromes, treatment with levodopa and related medications is only rarely, if ever, helpful. Sometimes muscle spasms and jerking can be reduced with muscle relaxants, such as clonazepam, and with botulinum toxin injections into affected parts of the body. SELECTED REFERENCES Additional articles may be accessed through PubMed Doody RS, Jankovic J: The alien hand and related signs. J Neurol Neurosurg Psychiatry 1992;55:806-810. Graham NL, Bak T, Patterson K, Hodges JR. Language function and dysfunction in corticobasal degeneration. Neurology 2003;61:493-9. Kompoliti K, Goetz CG, Boeve BF, et al. Clinical presentation and pharmacological therapy in corticobasal degeneration. Arch Neurol 1998;55: 957-961. Litvan I, Agid Y, Goetz C, Jankovic J, et al. Accuracy of the clinical diagnosis of corticobasal degeneration: A clinicopathological study. Neurology 1997;48: 119-125. Litvan I, Grimes DA, Lang AE, Jankovic J, et al. Clinical features differentiating patients with postmortem confirmed progressive supranuclear palsy and corticobasal degeneration. J Neurol 1999;246 (suppl 2):1-5.

59. Health 24 - Alzheimer's & Dementia, Other Dementing Illnesses corticobasal degeneration (CBD) is a rare degenerative disorder characterised byprogressive cognitive impairment, Parkinsonism, impaired eye movements, http://www.health24.com/medical/Condition_centres/777-792-798-1575,17482.asp

Fitness Challenge Have you taken up the SARIE/Health24 Fitness Challenge? Chat to other participants! Medical Schemes Are you lost in a medical scheme maze? We answer all your questions. TERMS NEWSLETTER NEWS MEDICAL SCHEMES DIET FITNESS NATURAL MAN WOMAN CHILD MIND SEX TOOLS FIND SHOP EXPERTS TALK WIN function topNav(onoff) if onoff = 1 then if window.event.srcElement.classname = "top_nav_on" then window.event.srcElement.classname = "top_nav" else window.event.srcElement.classname = "top_nav_on" end if else if window.event.srcElement.classname = "top_nav_on" then window.event.srcElement.classname = "top_nav" else window.event.srcElement.classname = "top_nav_on" end if end if end function Medical Head 2 Toe Disease centres Acne ... Run/walk for health Links Find a buddy Sexuality Psychology Food as medicine ... Other dementing illnesses You are in: Medical Disease centres Other dementing illnesses Corticobasal degeneration Corticobasal degeneration (CBD) is a rare degenerative disorder characterised by progressive cognitive impairment, Parkinsonism, impaired eye movements, muscle twitchings and misidentification of limbs ("alien hand" syndrome). Advertisement Rate this article Poor Excellent Send this to a friend Previous Next Brain, bits and bytes

60. Arch Neurol -- Corticobasal Degeneration And Related Disorders (Advances In Neur corticobasal degeneration and Related Disorders (Advances in Neurology, vol 82).edited by Irene Litvan, Christopher G. Goetz, and Anthony E. Lang, 288 pp, http://archneur.ama-assn.org/cgi/content/extract/57/11/1654-a

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 57 No. 11, November 2000 Featured Link E-mail Alerts Book Reviews Article Options Full text PDF Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager Articles in PubMed by de Marcaida JA Contact me when this article is cited Corticobasal Degeneration and Related Disorders (Advances in Neurology, vol 82) Arch Neurol. Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. It is a pleasure to review this authoritative monograph on what the authors elect to label corticobasal degeneration (CBD). As the editors and contributors reiterate many times in their text, this is a rare condition about which little has definitively been established, a state of affairs reflected by the numerous

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