41. TheFetus.net - Congenital Mesoblastic Nephroma -Andreas Rempen, MD,Thomas Kirchn Sonography cannot provide a clear distinction between congenital mesoblasticnephroma and nephroblastoma (Wilms tumor) because both are essentially http://www.thefetus.net/page.php?id=508

42. TheFetus.net - Neuroblastoma -Angela Regina Capelanes, MD*, Gloria Valero, MD&, Prenatal diagnosis of congenital Wilms tumor (nephroblastoma) presenting asfetal hydrops. Ultrasound in Obstetrics and Gynecology 16 (1), 8083l. http://www.thefetus.net/page.php?id=521

43. Nephroblastoma - Part A nephroblastoma (Wilms Tumor) Clinical Features congenital Mesoblastic Nephroma Clear Cell Sarcoma Malignant Rhabdoid Tumor Renal Cell Carcinoma http://sup.ultrakohl.com/uscap/abs-1998/nephr-A.htm

Back to Pediatric Renal Home Page REVIEW OF PEDIATRIC RENAL NEOPLASMS John Hicks Texas Children's Hospital, Houston, TX NEPHROBLASTOMA (WILMS TUMOR) INDEX Epidemiology Clinical Features Cytogenetics Components and Histologic Patterns ... Diffuse Anaplasia Nephroblastoma (Wilms Tumor): Epidemiology Incidence 5 to 6% of All Childhood Cancers n United States Cases per year in United States African-Americans Gender Ratio (bilateral tumors) Mean Age for Unilateral Tumors Male Female Mean Age for Bilateral Tumors Male Female 90% Occur in Children 8.1 per million children Highest Incidence 41 months 47 months 29 months 33 months Nephroblastoma (Wilms Tumor): Clinical Features Bilateral Tumors Abdominal Mass Abdominal Pain Acute Abdomen Hypertension Fever Hematuria Weight Loss Urinary Tract Infection Nausea/Vomiting Urogenital Anomalies (Renal Ectopia, Unilateral Agenesis, Horseshoe Kidney, Ureteral Duplication, Hypospadias, Cryptorchidism) Hemihypertrophy Aniridia Nephroblastoma (Wilms Tumor): Cytogenetics WT1 Tumor Suppressor Gene: A Constitutional Deletion Chromosome 11p13 WAGR Syndrome Nonhereditary Wilms Tumor (33%) 10 Exons Encoding for a 45-49 kd Protein Homology to Early Growth Response 1 (EGR1) Sequence Specific DNA Binding Regulate Transcription of Other Genes 30 to 40% of Wilms with Loss of Heterozygosity for region with WT1

44. Congenital Mesoblastic Nephroma congenital Mesoblastic Nephroma Light microscopy (A) and Ultrastructure (B) nephroblastoma (Wilms tumor) Clear Cell Sarcoma http://sup.ultrakohl.com/uscap/abs-1998/mesobl.htm

Back to Pediatric Renal Home Page REVIEW OF PEDIATRIC RENAL NEOPLASMS John Hicks Texas Children's Hospital, Houston, TX CONGENITAL MESOBLASTIC NEPHROMA INDEX Epidemiology Pathology Congenital Mesoblastic Nephroma: Epidemiology Most Common Renal Tumor of Early Infancy 62% Occur in First 3 months of Life 90% in First Year of Life Mean Age = 2 months Gender Ratio 1.0M:1.0F Asymptomatic Renal Mass Some Detected During Prenatal Ultrasound Delivery Hyper-reninism: Entrapped Normal Glomeruli With Overproduction of Renin Hypercalcemia: Prostaglandin E by Tumor Cells Congenital Mesoblastic Nephroma: Pathology Arise Unicentrally within Deep Parenchyma Near Renal Sinus Most Unilateral Tumors Infiltration of Renal Parenchyma with Indistinct Tumor-Kidney Interface - Requires Wide Resection Whorled Appearance Like Leiomyoma Hemorrhage, Necrosis and Cysts Unusual Possibly Markers for Adverse Outcome Most Behave in Benign Fashion Composed of Spindle Cells (resembles infantile fibromatosis) Entrapped Renal Tubules and Glomeruli Cartilage Hematopoietic Cells Lymphocytes at Periphery Tortuous Large Vascular Spaces Congenital Mesoblastic Nephroma: Light microscopy (A) and Ultrastructure (B) Figure 2A: Inerface between normal kidney and spindle cells of a mesoblastic nephroma. Renal tubules frequently become entrapped within this spindle cell tumor.

45. Department Of Paediatric Surgery congenital anomalies like Cleft Lip and Palate, Cystic Hygroma, Thyroglossal Cystand Hydronephrosis, Ectopia Vesicae and tumours like nephroblastoma http://www.aimshospital.org/paedsurg/Paedsurg.html

Services Support Services Staffing Contact Department of Paediatric Surgery The Department of Paeditaric Surgery specialises in the following disciplines: Minimal Access Endoscopic surgeries Paediatric Urology Congenital anomalies like Cleft Lip and Palate, Cystic Hygroma, Thyroglossal Cyst and other problems of head and neck Thoracic Surgical repairs such as Oesophageal Atresia Diaphragmatic Hernia, Eventeration and Lobar Emphysema Abdominal Surgeries like Atresia of Intestine, Imperforate Anus, Hirschsprung's Disease, Biliary Atresia, Choledochal Cysts, tumours of liver and adrenals. Single Stage Transanal pull through, etc. Congenital urinary tract repairs like Hypospadiasis, Posterior Urethral Valves, Vesico-Ureteric reflux, Hydronephrosis, Ectopia Vesicae and tumours like Nephroblastoma Paediatric trauma is also managed efficiently in the department Top Modalities available to our doctors include: Newborn and paediatric cystoscopes that enable us to do the surgeries without causing trauma to the urethra Newborn and paediatric bronchoscopes are utilized for many diagnostic procedures and also for removal of foreign bodies like peanuts Paediatric Laparoscopes are utilized for minimally invasive abdominal surgeries. Laparoscopic accessories include both 5mm and 3mm sizes with which the surgeries are being performed virtually scarless and painless

46. Advances In Anatomic Pathology - UserLogin A few undergo malignant transformation and advance to nephroblastoma. Nagahara N. A pathological study of nephroblastoma with congenital aniridia. http://www.anatomicpathology.com/pt/re/aapath/fulltext.00125480-200109000-00005.

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47. Uhrad.com - Pediatric Imaging Teaching Files Discussion Wilm s tumor (nephroblastoma) is the most common abdominal malignancy, Associated conditions include congenital genitourinary malformations, http://www.uhrad.com/pedsarc/peds048.htm

48. Nephroblastoma - Wilms Tumor - Information Page With HONselect Scientific articles from MEDLINE for nephroblastoma Diseases congenital,Hereditary, and Neonatal Diseases and Abnormalities http://www.hon.ch/HONselect/RareDiseases/EN/C04.557.435.595.html

InitBulle("navy","#F8F8F8","#000066",1); HONcode sites All Web sites HONselect News ... Images HONselect Search English French German Spanish Portuguese the word the part of word in MeSH term in MeSH term and description Information on "Nephroblastoma": Medical hierarchy and definition Research Articles Web resources Medical Images Medical News Medical Conferences Clinical Trials Hierarchy English French German Spanish Portuguese Nephroblastoma Definition: A malignant kidney tumor made up of three cell types: blastemal, stromal, and epithelial, but not all present in every case. Synonym(s): Wilms Tumor / Wilms' Tumor / Nephroblastomas / Tumor, Wilms / Narrow term(s): Denys-Drash Syndrome WAGR Syndrome See also: Genes, Wilms Tumor WT1 Proteins Browse New search Web resources for "Nephroblastoma" English French German Spanish Portuguese = Site with HON description - = Site with a robot description info: enter the site: (click below) domain of the site: HONcode - eMedicine - Wilms Tumor : Article by Arnold C Paulino, MD www.emedicine.com Wilms Tumor - Grundlagen www.med-rz.uni-sb.de HONcode - www.meb.uni-bonn.de

49. Wilms' Tumor And Congenital Hemihypertrophy: Report Of Five Cases And Review Of Wilms tumor and congenital hemihypertrophy report of five cases and review The possibility that Wilms tumor (nephroblastoma) has prenatal origins is http://pediatrics.aappublications.org/cgi/content/abstract/40/5/886

QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article P Rs: Submit a response Alert me when this article is cited Alert me when P ... Alert me if a correction is posted Services E-mail this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Fraumeni, J. F. Articles by Manning, M. D. Pediatrics, Nov 1967, 886-899, Vol 40, No. 5 Wilms' tumor and congenital hemihypertrophy: report of five cases and review of literature JF Fraumeni, CF Geiser and MD Manning Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20014. The possibility that Wilms' tumor (nephroblastoma) has prenatal origins is based on the histologic appearance suggesting embryonic maldevelopment, a peak incidence in early childhood, its detection among newborn children and in the fetus, and reported associations with congenital malformations. Among the anomalies found to occur excessively in a multi-hospital survey of children with Wilms' tumor were aniridia, genitourinary defects

50. Large Muscles Adrenal; nephroblastoma; Hepatoblastoma; Rhabdomyosarcoma Onset congenital;Occurs early in development during branchial arch formation; Clinical http://www.neuro.wustl.edu/neuromuscular/mother/mlarge.html

Front Search Index Links ... Patient Info LARGE OR PROMINENT MUSCLES Drugs Endocrinopathy Focal enlargement Infections ... Storage disorders Amyloidosis: Enlarged tongue Overusage Neural Myokymia Neuromyotonia Isaac's Syndrome Schwartz-Jampel Exercise: Bodybuilding Spasticity with persistent muscle spasms Orthostatic tremor Myotonia Congenita Hyperkalemic Periodic Paralysis Paramyotonia congenita Proximal myotonic myopathy (PROMM) ... Rippling Muscle Syndrome Partial Denervation Focal : Radiculopathy; Nerve lesion Later-onset Spinal Muscular Atrophies Polyneuropathy: HMSN I II Endocrinopathy Hypothyroid ... Acromegaly Muscular Dystrophies Disorders Dystrophinopathies Limb-Girdle Muscular Dystrophy: Myopathy with abnormal merosin Congenital muscular dystrophy with Respiratory failure Features causing hypertrophy Infections Cysticercosis Trichinosis Schistosomiasis Drug treatment adrenergic agonists: Albuterol; Clenbuterol Androgenic steroids Glycogen Amyloid Fatty replacement of muscle Gangliosidoses Focal enlargement Extremities or Trunk Focal partial denervation Complex repetitive discharges or Myokymia Old polio Focal myokymia Focal myositis : Acute onset; Pain

51. Archives Of The AFIP -- RadioGraphics 1995; 15: 653-669 Benign cystic differentiated nephroblastoma in an infant. congenital mesoblasticnephroma of infancy report of a case with unusual clinical behavior. http://www.rsna.org/REG/publications/rg/afip/privateM/1995/0015/0003/0653/10.htm

RadioGraphics Multilocular Cystic Renal Tumor in Children Radiologic-Pathologic Correlation Abstract Introduction and Historical Background Clinical Features Pathologic Features ... Source Information References References . Edmunds W. Cystic adenoma of the kidney. Trans Pathol Soc London 1892; 43:89 90. Return to: Introduction and Historical Background . Boggs LK, Kimmelstiel P. Benign multilocular cystic nephroma: report of two cases of so-called multilocular cyst of the kidney. J Urol 1956; 76:530-541. Return to: Introduction and Historical Background . Christ ML. Polycystic nephroblastoma. J Urol 1968; 98:570-575. Return to: Introduction and Historical Background . Fowler M. Differentiated nephroblastoma: solid, cystic, or mixed. J Pathol 1971; 105:215-217. Return to: Introduction and Historical Background . Landing BH. Well-differentiated and polycystic (benign?) Wilms' tumor. Cancer Semin 1968; 2:110-113. Return to: Introduction and Historical Background . Lazner J, Jureidini KF. Benign cystic differentiated nephroblastoma in an infant. S Austral Clin 1971; 5:279-283. Return to: Introduction and Historical Background . Brown JM. Cystic partially differentiated nephroblastoma. J Pathol 1975; 115:175-178.

52. OBGYN.net - Ultrasound Informal Case there was no tumor (ie. nephroblastoma, or congenital mesoblastic nephroma)or cystic structures in the parenchym, and the pelvis renalis visible but http://www.obgyn.net/us/us.asp?page=/us/present/0302/has_kidney

53. Wilms Tumor - Grundlagen Wilms´tumour or nephroblastoma was first described as a renal neoplasm by the association of nephroblastoma and other different congenital anomalies, http://www.med-rz.uni-sb.de/med_fak/kinderklinik/wilms2.htm

Therapieoptimierungsstudie zur Behandlung von Kindern und Jugendlichen mit einem Nephroblastom SIOP 93-01 / GPOH kingra@med-rz.uni-sb.de Basics: Wilms´tumour - the state of the art Epidemiology, Incidence Nephroblastoma, being 6 % of all malignancies in children, is the most common childhood renal tumour. The annual incidence rate of Wilms´tumour is 8 / 1.000.000 children under the age of 15 years, meaning that about 1 out of 100.000 children will suffer of this neoplasm. In Germany more than 100 new cases occur every year (3). The highest incidence rates are reported among United States blacks, in Finland and regions of France, the lowest rates are reported from Asia (4). World-wide the sex ratio is 1:1. The distribution of age at diagnosis peaks at 2 to 3 years in unilateral cases and is lower in children with a bilateral tumour. Bilateralisation will occur in 5 % of nephroblastoma (5). Aetiology and genetics In 1964 Miller et al. (6) reported for the first time of an association of Wilms´tumour and aniridia. Since that time the association of nephroblastoma and other different congenital anomalies, notably aniridia hemihypertrophy and malformations of genitalia (cryptorchidism, hypospadias, pseudohermaphroditism and gonadal dysgenesis) is well known. Aniridia and hemihypertrophy are extremely rare in the general population, and children with either of these conditions should be screened carefully for Wilms´tumour. The disease occurs in conjunction with neurofibromatosis, WAGR (Wilms´tumour, aniridia malformations of genitalia, retardation) Beckwith-Wiedemann (BWS), Drash (pseudohermaphroditism, glomerulopathy, and Wilms´tumour) and Perlman familial nephroblastomatosis (bilateral renal hamartomas, macrosomia, islet cell hypertrophy, unusual facial) malformation syndromes (7).

54. INTERNATIONAL PEDIATRIC UROLOGY NEPHROLOGY UPDATE Post-graduate 16.0016.20 congenital anomalies of the urinary bladder Epidemiology,diagnosis of nephroblastoma, vesico-prostatic rhabdomyosarcoma and genital http://www.epsa.org.eg/Heidelberg.html

HEIDELBERG UNIVERSITY In Cooperation with European Pediatric Surgeons Association (EUPSA) 15-17 September, 2005 Organisation: Prof. Dr. Karl Ludwig Waag Prof. Dr. Ahmed Hadidi Prof.Dr. Jean Michel Guys Prof. Dr. Burkhardt T.nshoff Prof. Dr. M Hohenfellner Prof. Dr. Alaa El Ghoneimi PD Dr. Stuart Hosie Dr. S Holland- Cunz Date: 15-17 September, 2005 Venue: Der Europ.ische Hof Hotel Europa Tel: (0049) 6221 515-0 69117 Heidelberg, Germany Official Language: English Congress Secretary: Mrs. D Ihrig Tel : 0049 621 383 2709 Fax: 0049 621 383 3823 e-mail: Kinderchirurgie@kch.ma.uni-heidelberg.de www.cvb-heidelberg.de info@cvb-heidelberg.de Tel: +49(0)6221/19433 Registration Fees EUPSA member Non EUPSA member Up to August 30th 170 € 200€ After August 30th Bank Account: Dresdner Bank- Mannheim Konto Nr. 658 786 000 Bankleitzahl : 670 800 50 Sonderkonto Kinderchirurgie 784 061/Pediatric Urology course Registration fees include: - Welcome reception - Course bag including - Coffee breaks for 3 days, lunches for 2 days

55. Dreddyclinic.com - Wilms' Tumor Also known as nephroblastoma, it s the most common malignant tumor of the kidney He or she will ask if there s a family history of cancer or congenital http://www.dreddyclinic.com/findinformation/ww/wilmstumor.htm

Home Up Ayurvedic Medicine Integrated Medicine ... Site map Ayurvedic - Integrated Medical Clinic - reliable health information ...Balance your health Wilms Tumor Special Programs Detoxification Program Weight Loss Program Anti-Aging-Program Fasting Program Study Programs Ayurvedic Massage Ayurvedic Basics Ayurvedic Studies Colon courses ... Study Program Colon Cleansing One of the most frequent bowel problems that people experience today is constipation . Why is the Colon Cleansing so important? Check it out. Newsroom Articles Ayurvedic Disease Men Health ... Women Health Downloads Pricelist for the treatments application form for the Ayurvedic courses You will need the free Acrobat Reader from Adobe to view and print some of the documents. WWW www.dreddyclinic.com Wilms' tumor - nephroblastoma A B C D ... Z CANCER Urinary Tract Prostate cancer Testicular cancer Bladder cancer Kidney cancer ... Wilms' tumor Wilms' tumor is is a cancerous tumor of the kidney that occurs in children.

56. Fetal Turmors - DIAGNOSIS OF CONGENITAL ABNORMALITIES - THE 18-23 WEEKS SCAN Examples include congenital neuroblastomas and hepatoblastomas in the first yearof life, while Wilms’ tumor (nephroblastoma) is extremely rare. http://www.centrus.com.br/DiplomaFMF/SeriesFMF/18-23-weeks/chapter-11/tumors.htm

Fetal Tumors Handbook of Fetal Abnormalities Algorithms Appendix Fetal tumors With the collaboration of Israel Goldstein Introduction Etiology and mechanisms of carcinogenesis Classification Intracranial ... Authors Introduction Etiology and mechanisms of carcinogenesis Developmental errors during embryonic and fetal maturation may result in embryonic tumors. One hypothesis is that more cells are produced than are required for the formation of an organ or tissue and the origins of embryonic tumors rest in developmental errors in these surplus embryonic rudiments. Embryonic tumors developing after infancy are explained by the persistence of cell rests or developmental vestiges. Developmentally anomalous tissue (such as hamartomas and dysgenic gonads) is a source of neoplasms in older children and adults. When any of this developmentally abnormal tissue is present at birth, it is inferred that the cells failed to mature, migrate or differentiate properly during intrauterine life. Benignity of fetal and infantile neoplasms Some neonatal and infantile tumors have a benign clinical behavior despite histological evidence of malignancy. Examples include congenital neuroblastomas and hepatoblastomas in the first year of life, and congenital and infantile fibromatosis, and sacrococcygeal teratomas in the first few months of life. The factors responsible for this ‘oncogenic period of grace’, which starts in utero and extends through the first few months of extrauterine life, are uncertain.

57. Conditions & Diseases - By Type congenital Kidney Malformations Diabetes Insipidus nephroblastoma Nephrotic Syndrome Potter Syndrome Tuberous sclerosis Urethral meatal stenosis http://www.pediatrix.com/body.cfm?id=568

58. Conditions & Diseases - Alphabetical nephroblastoma Neural Tube Defect (NTD, Spina Bifida) Nephrotic Syndrome Retinopathy of Prematurity (ROP) Rubella (German Measles) congenital http://www.pediatrix.com/body.cfm?id=569

59. Nephroblastoma nephroblastomas may be associated with a variety of congenital malformations nephroblastoma has a strong tendency to metastasize in lungs, liver, http://www.orpha.net/static/GB/nephroblastoma.html

Orphanet database access Nephroblastoma Direct access to data Summary Update : 04/09/2005 Orphanet database access

60. Protocol For The Examination Of Specimens From Patients With Wilms Tumor (Nephro This protocol applies to Wilms tumor (nephroblastoma) or other renal tumors There is a growing appreciation that congenital mesoblastic nephroma (CMN), http://arpa.allenpress.com/arpaonline/?request=get-document&doi=10.1043/1543-216

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