41. Information About Charcot-Marie-Tooth Disease This site contains information about charcotmarie-tooth disease. http://www.mamashealth.com/head/charcot.asp

Mamashealth.com Home Brain and Nerve Conditions Amyotrophic Lateral Sclerosis Aneurysm Aphasia Cerebral Palsy ... Vertigo Links Email Mama What is Charcot-Marie-Tooth Disorder? Charcot-Marie-Tooth disease is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States. Charcot-Marie-Tooth disease comprises a group of disorders caused by mutations in genes that affect the normal function of the peripheral nerves. Charcot-Marie-Tooth disease is also called hereditary motor and sensory neuropathy or peroneal muscular atrophy. It was discovered in 1886 by three physicians, Jean-Marie-Charcot, Pierre Marie, and Howard Henry Tooth. Symptoms of Charcot-Marie-Tooth disease? Some common features are: weakness of the foot and lower leg muscles, foot drop a high-stepped gait high foot arches and hammertoes What Causes Charcot-Marie-Tooth disease? Charcot-Marie-Tooth disease is caused by defects in the genes for proteins found in the fibers that carry electrical signals between the brain and spinal cord and the rest of the body. The disease is also caused by defects in the genes for proteins found in myelin. Myelin is a coating on axons that insulates and nourishes them. Can Charcot-Marie-Tooth disease be treated?

42. Charcot-Marie-Tooth Disease charcotmarie-tooth disease Updated August 4, 2005. The Basics charcot-marie-tooth disease Information Page National Institute of Neurological Disorders http://www.noah-health.org/en/bns/disorders/charcot/

Skip navigation About NOAH Help English Spanish Both Advanced NOAH Brain and Nervous System Change text size: Charcot-Marie-Tooth Disease Updated: August 4, 2005 The Basics Charcot-Marie-Tooth Disease Information Page National Institute of Neurological Disorders and Stroke Diagnosis and Symptoms Characteristics and Symptoms of CMT Charcot-Marie-Tooth Association Genetics Charcot-Marie-Tooth Disease Genetics Home Reference Care and Treatment Living With Charcot-Marie-Tooth Disease CMT International Information Resources Charcot-Marie-Tooth Association Researched by NOAH Contributing Editor: NOAH Team NOAH Brain and Nervous System Specific Nervous System Disorders > Charcot-Marie-Tooth Disease Health Topics Index A to Z Page of the Month Advanced Search ... Feedback

43. Search Result For "Charcot-Marie-Tooth Disease" Charcot Marie Tooth Disease (Foot Problems); Drugs Which Aggravate or Exacerbate CMT; Living With charcotmarie-tooth disease; A Simple Guide to http://www.noah-health.org/search/results.php?lang=1&keyword=Charcot-Marie-Tooth

44. Charcot-Marie-Tooth Disease (hereditary) Medical Information charcotmarie-tooth disease (hereditary) Information from Drugs.com. http://www.drugs.com/enc/charcot_marie_tooth_disease__hereditary_.html

Home New Drugs Latest News Drug Interactions ... Forum Drugs.com - prescription drug and medicine information available on over 24,000 approved- medications and pharmaceuticals, including side effects and drug interactions. Log-in Register Advertisement Buy a Link Now Special Offers From our sponsors Categories Diabetes Gastro Center Weight Loss AIDS/HIV ... Sexual Health Advertisement Advanced Search Or click the first letter of a drug name: A B C D ... Z Charcot-Marie-Tooth disease (hereditary) Injury Disease Nutrition Poison ... Central nervous system Charcot-Marie-Tooth disease (hereditary) Definition Charcot-Marie-Tooth disease defines a group of inherited, slowly progressive disorders that result from progressive damage to nerves. Symptoms include numbness and wasting of muscle tissue, first in the feet and legs, then in the hands and arms. Alternative Names Progressive neuropathic (peroneal) muscular atrophy; Hereditary peroneal nerve dysfunction; Neuropathy - peroneal (hereditary); Hereditary motor and sensory neuropathy Causes Charcot-Marie-Tooth diseases involve damage to nerves (neuropathy), usually from loss of the electrical insulation (

45. THE MERCK MANUAL--SECOND HOME EDITION, Hereditary Neuropathies In Ch. 95, Periph They include some forms of charcotmarie-tooth disease, Refsum s disease (see charcot-marie-tooth disease is the most common hereditary neuropathy, http://www.merck.com/mmhe/sec06/ch095/ch095i.html

var externalLinkWarning = "The link you have selected will take you to a site outside Merck and The Merck Manuals.*n*nThe Merck Manuals do not review or control the content of any non-Merck site. The Merck Manuals do not endorse and are not responsible for the accuracy, content, practices, or standards of any non-Merck sources."; Search The Second Home Edition , Online Version Search Index A B C D ... Z Sections Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders ... Women's Health Issues Resources Anatomical Drawings Multimedia Pronunciations Weights and Measures ... , Online Version Section Brain, Spinal Cord, and Nerve Disorders Chapter Peripheral Nerve Disorders Topics Introduction Hereditary Neuropathies Mononeuritis Multiplex Mononeuropathy Muscle Stimulation Disorders Neuromuscular Junction Disorders ... Thoracic Outlet Syndromes Hereditary Neuropathies Buy The Book Print This Topic Email This Topic Pronunciations atrophy Charcot-Marie-Tooth disease mononeuropathy muscular atrophy ... thoracic Hereditary neuropathies affect the peripheral nerves, causing subtle symptoms that worsen gradually. Hereditary neuropathies may affect only motor nerves (motor neuropathies), only sensory nerves (sensory neuropathies), or both sensory and motor nerves (sensory-motor neuropathies). Some hereditary neuropathies are relatively common but often are not recognized. Hereditary sensory neuropathies are especially rare.

46. Charcot-Marie-Tooth Disease Definition - Medical Dictionary Definitions Of Popul Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=13609

47. Charcot-Marie-Tooth Disease - Wikipedia, The Free Encyclopedia charcotmarie-tooth disease, also known as Hereditary Motor and Sensory Neuropathy (HMSN) or Peroneal Muscular Atrophy, is an inherited disorder of nerves http://en.wikipedia.org/wiki/Charcot-Marie-Tooth_disease

Wikimedia needs your help in the final day of its fund drive. See our fundraising page Over US$240,000 has been donated since the drive began on 19 August. Thank you for your generosity! Charcot-Marie-Tooth disease From Wikipedia, the free encyclopedia. The foot of a person with Charcot-Marie-Tooth. The lack of muscle, high arch, and hammer toes are signs of the genetic disease. Charcot-Marie-Tooth disease , also known as Hereditary Motor and Sensory Neuropathy (HMSN) or Peroneal Muscular Atrophy, is an inherited disorder of nerves neuropathy ) that is characterized by loss of muscle tissue and touch sensation, predominantly in the feet and legs but also in the hands and arms in the advanced stages of disease. The disease is presently incurable. The disorder is caused by the absence of molecules that are essential for normal function of the nerves due to deficiencies in the structure of the genes coding these molecules. The absence of these chemical substances gives rise to dysfunction either in the axon or the myelin sheath of the nerve cell.

48. Charcot-Marie-Tooth Disease - Areas Of Research - MRDDRC Symptoms and genetic basis. charcotmarie-tooth disease (CMT) is the most commonly inherited peripheral neuropathy with a prevalence of 1 in 2500 births. http://mrrc.pedi.bcm.tmc.edu/research areas/cmt.html

Charcot-Marie-Tooth disease Symptoms and genetic basis: Charcot-Marie-Tooth disease (CMT) is the most commonly inherited peripheral neuropathy with a prevalence of 1 in 2500 births. It is characterized by a progressive deterioration of peripheral nerves (nerves that are not a part of the central nervous system) and the consequent wasting away of muscles at the ends of arms and legs. The most common subtype of CMT is called CMT1A, which starts in the second or third decade of life, and which has symptoms ranging from mild loss of motor and sensory function to severe hand and foot deformities. CMT1A is caused by a duplication of the region of chromosome 17 that contains a gene called PMP22. This gene duplication results in overproduction of the corresponding protein product. Ongoing research at the Baylor College of Medicine Mental Retardation Developmental Disabilities Research Center: Further understanding of the disease There are several approaches being taken at Baylor College of Medicine to develop a more comprehensive understanding of peripheral nerve biology and the disturbances that cause Charcot-Marie-Tooth disease and related disorders. These approaches include the study of genes known to be involved and searches for others, genetic comparisons between humans and other species, and investigation of genetic mutations that occur in Charcot-Marie-Tooth disease patients.

49. Orthoseek | Orthopedic Topics | Charcot-Marie-Tooth Disease charcotmarie-tooth disease or Peroneal Muscular Atrophy is the commonest disease within a charcot-marie-tooth disease is also known as HMSN Type I, http://www.orthoseek.com/articles/cmtdisease.html

Charcot-Marie-Tooth Disease What is it? Charcot-Marie-Tooth disease or Peroneal Muscular Atrophy is the commonest disease within a group of conditions called Hereditary Motor and Sensory Neuropathies (HMSN) . This group of diseases are caused by degeneration of the peripheral nerves, nerve roots, and even the spinal cord. Charcot-Marie-Tooth disease is also known as HMSN Type I, and is the most common disease in the group. The nerves that supply the small muscles of the feet are affected, causing weakness and deformity in the feet. There is also loss of position and vibration sense to the feet. Much later, the small muscles of the hands are also affected. What causes it? The disease is hereditary, and is inherited as an autosomal dominant trait. What are the symptoms? The affected child presents with high arches in his feet, as well clumsiness and pain in his feet and legs. Due to muscle imbalance in the feet, the child may develop a dropfoot , as well as a cavus foot , where the arch of the foot is very pronounced and fixed. Later, if the small muscles of the hands are also affected, he may develop clawing of the fingers. The affected child has normal intelligence, and a normal life span.

50. Charcot-Marie-Tooth Disease charcotmarie-tooth disease is named for French neurologists Jean M. Charcot The neuronal form of charcot-marie-tooth disease normally appears after the http://ww3.komotv.com/Global/story.asp?S=2314422

51. UniProt Knowledgebase Keyword: Charcot-Marie-Tooth Disease Protein which, if defective, causes charcotmarie-tooth disease (CMT), a heterogeneous group of hereditary motor and sensory neuropathies (HMSN) http://www.expasy.org/cgi-bin/get-entries?KW=Charcot-Marie-Tooth disease

52. Charcot-Marie-Tooth Disease - Enpsychlopedia charcotmarie-tooth disease, also known as Hereditary Motor and Sensory Neuropathy (HSNM) or Peroneal Muscular Atrophy, is an inherited disorder of nerves http://psychcentral.com/psypsych/Charcot-Marie-Tooth_disease

home resource directory disorders quizzes ... support forums Advertisement ( Charcot-Marie-Tooth disease Missing image Charcot-marie-tooth-foot.jpg The foot of a person with Charcot-Marie-Tooth. The lack of muscle, high arch, and hammer toes are signs of the genetic disease. Charcot-Marie-Tooth disease , also known as Hereditary Motor and Sensory Neuropathy (HSNM) or Peroneal Muscular Atrophy, is an inherited disorder of nerves neuropathy ) that is characterized by loss of muscle tissue and touch sensation, predominantly in the feet and legs but also in the hands and arms in the advanced stages of disease. The disease is presently incurable. The disorder is caused by the absence of molecules that are essential for normal function of the nerves due to deficiencies in the structure of the genes coding these molecules. The absence of these chemical substances gives rise to dysfunction either in the axon or the myelin sheath of the nerve cell. Symptoms usually begin in late-childhood or early adulthood. Usually, the initial symptom is foot drop due to involvement of the peroneal nerve, which is responsible for raising the feet, early in the course of the disease. This can also cause hammer toe, where the toes are always curled. Wasting of muscle tissue of the lower parts of the legs may give rise to "stork leg" appearance. Symptoms and progression of the disease can vary. Extreme emotional stress is thought to hasten the progression. The diagnosis is established by electromyography examination (which shows that the velocity of nerve impulse conduction is decreased and the time required to charge the nerve is increased) and nerve

53. Charcot-Marie-Tooth Disease charcotmarie-tooth disease (CMT) is a group of genetic disorders that affects movement and sensation in the limbs. The disease progresses slowly and causes http://healthgate.partners.org/browsing/browseContent.asp?fileName=11965.xml&tit

54. Gene Dynamin 2 Underlies One Form Of Charcot-Marie-Tooth Disease ? A gene that plays many fundamental roles in cells throughout the body has, for the first time, been implicated in human disease, according to researchers http://www.news-medical.net/?id=7591

55. Gene Dynamin 2 Underlies One Form Of Charcot-Marie-Tooth Disease ? A gene that plays many fundamental roles in cells throughout the body has, for the first time, been implicated in human disease, according to researchers http://www.news-medical.net/print_article.asp?id=7591

56. CHARCOT-MARIE-TOOTH DISEASE : Contact A Family - For Families With Disabled Chil Contact a Family is a UK charity for families with disabled children. We offer information on specific conditions and rare disorders. http://www.cafamily.org.uk/Direct/c27.html

printer friendly CHARCOT-MARIE-TOOTH DISEASE home how we can help medical information index of conditions ... how you can help Did you find this page helpful? yes no Charcot-Marie-Tooth disease: CMT: Peroneal Muscular Atrophy: Hereditary Motor and Sensory Neuropathy This is a genetic disorder characterised by slowly progressive muscular weakness. Onset is in the lower limbs first causing weakness around the ankles and, often, an abnormality in the shape of the feet (high in-step.) After many years, weakness may develop in the hands and spread upwards in the lower limbs to affect the knees and thighs. Mild loss of sensation may be present in the feet and hands. The onset of the condition may be from childhood to late middle or old age. Inheritance patterns Autosomal dominant is the most common pattern of inheritance. Autosomal recessive (least common) X-linked passed to both sons and daughters. However, affected sons will usually display more severe symptoms. Prenatal diagnosis In families who have Type 1a prenatal diagnosis is now becoming available but is rarely requested.

57. Disease - Charcot-Marie-Tooth Disease (CMT) CharcotMarie-Tooth (CMT) disease is the most common inherited neurological disorder, affecting approximately 150000 Americans. CMT patients slowly lose http://disability.ucdavis.edu/resources/diseases/list/disease.asp?id=5

58. The Physician And Sportsmedicine: Charcot-Marie-Tooth Disease In A High School T A closer look revealed subtle symptoms of charcotmarie-tooth disease (CMT), Drugs That May Be Toxic to Patients Who Have charcot-marie-tooth disease http://www.physsportsmed.com/issues/2002/10_02/stadler.htm

Charcot-Marie-Tooth Disease in a High School Tennis Player Teresa S. Stadler, MD David Ross, MD THE PHYSICIAN AND SPORTSMEDICINE - VOL 30 - NO. 10 - OCTOBER 2002 In Brief: A high school tennis player had recurrent ankle sprains that were initially attributed to incomplete rehabilitation. A closer look revealed subtle symptoms of Charcot-Marie-Tooth disease (CMT), a common, inherited neuromuscular disorder. This case underscores the importance of a wide differential diagnosis when encountering recurrent conditions. Early diagnosis of CMT is imperative so that appropriate injury-prevention measures can be taken. T he underlying cause of recurrent ankle sprains may be improper rehabilitation; however, other, less apparent, conditions may be the source. A comprehensive history and physical examination may lead to the diagnosis of Charcot-Marie-Tooth (CMT) disease, as in the following case. Awareness of this fairly common condition may lead to early diagnosis and prevent recurrent ankle injuries in an otherwise healthy patient. Case Report A 16-year-old male varsity tennis player came to our sports medicine clinic with persistent right ankle pain 2 days after he had an inversion injury while sidestepping in a tennis match. He was able to walk off the court but was not able to continue playing that day. The ankle did not swell.

59. Arch Neurol -- Disease Course Of Charcot-Marie-Tooth Disease Type 2 And Comorbid Disease Course of charcotmarie-tooth disease Type 2 and Comorbidity—Reply Laurien L. Teunissen, Nicolette C. Notermans, Hessel Franssen, Baziel GM van http://archneur.ama-assn.org/cgi/content/extract/61/9/1470

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 61 No. 9, September 2004 Featured Link E-mail Alerts Correspondence Article Options Full text PDF Send to a Friend Readers Reply Submit a reply Related articles in this issue Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Gemignani F Marbini A Contact me when this article is cited Topic Collections Quality of Life Genetic Disorders Neuromuscular diseases Pain ... Topic Collection Alerts Disease Course of Charcot-Marie-Tooth Disease Type 2 and Comorbidity Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. We read with great interest the article by Teunissen et al in which the evolution of Charcot-Marie-Tooth disease type 2 (CMT2) was thoroughly quantified by examining a cohort of 43 patients during a 5-year period. Some points deserve further

60. Arch Neurol -- Disease Course Of Charcot-Marie-Tooth Disease Type 2 And Comorbid Disease Course of charcotmarie-tooth disease Type 2 and Comorbidity—Reply Two patients had previously been treated for hypothyroid disease. http://archneur.ama-assn.org/cgi/content/extract/61/9/1470-a

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 61 No. 9, September 2004 Featured Link E-mail Alerts Correspondence Article Options Full text PDF Send to a Friend Readers Reply Submit a reply Related articles in this issue Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager Articles in PubMed by Teunissen LL Wokke JH Contact me when this article is cited Topic Collections Quality of Life Genetic Disorders Neuromuscular diseases Pain ... Topic Collection Alerts Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. In reply We thank Gemignani and Marbini for their important comments on our 5-year prospective study of disease course in CMT2. First, it is unlikely that comorbidity played an important role in the neurological deterioration of our patients; comorbidity

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