21. Charcot-Marie-Tooth Disease / Family Village Library CharcotMarie Tooth Disease (CMT) is the most common neuromuscular disease in the world. It is sometimes referred to as Hereditary Motor and Sensory http://www.familyvillage.wisc.edu/lib_cmtd.htm

Charcot-Marie-Tooth Disease Synonym: Peroneal Muscular Atrophy, Hereditary Motor and Sensory Neuropathy Who to Contact Where to Go to Chat with Others Learn More About It Web Sites ... Search Google for "Charcot-Marie-Tooth Disease" Who to Contact Charcot-Marie-Tooth Association 2700 Chestnut Street Chester, PA 19013-4867 1-800-606-CMTA (phone) 1-610-499-9267 (fax) E-mail: CMTAssoc@aol.com Web: http://www.charcot-marie-tooth.org/ Works to educate, fund research, and promote public awareness of CMT, the most commonly inherited peripheral neuropathy. Where to Go to Chat with Others CMT-Support Charcot-Marie Tooth Disease (CMT) is the most common neuromuscular disease in the world. It is sometimes referred to as "Hereditary Motor and Sensory Neuropathy" or HMSN. About one in 2500 people or over 2,000,000 people now have one of the many types of CMT. This group is for sharing feelings as well as life's ups and downs, learning, and mutual support for people with CMT, their friends, families, medical professionals, and anyone that wants to learn about CMT. CMT US CMT US shares resources, positive living strategies, practical suggestions, and new treatment paradigms for Charcot Marie Tooth Disease(CMT), also known as Hereditary Motor and Sensory Neuropathy.

22. Charcot-Marie-Tooth Disease - Podiatrychannel CharcotMarie-Tooth (CMT) is an inherited, degenerative disease that causes muscle weakness and atrophy of the hand, forearm, leg, and foot. http://www.podiatrychannel.com/charcot/

Home Search SiteMap Ask the Dr. ... Medical Store CHARCOT-MARIE- TOOTH DISEASE Overview Cause Symptoms Diagnosis ... Treatment CONDITIONS Achilles Tendonitis Allergic Contact Dermatitis Ankle Injuries Athlete's Foot Brachymetatarsia Bunions ... Charcot-Marie-Tooth Disease Claw Toes Complex regional pain syndrome (CRPS) Corns Diabetes Fibromyalgia Gout ... Xerosis TREATMENT OPTIONS Orthotics DIAGNOSTIC TESTS CT Scan MRI Scan RESOURCES DPMLocator Anatomy Clinical Trials Glossary ... What Is a Podiatrist? Videos FOR DOCTORS ONLY Website Services Get Listed in DPMLocator ABOUT US Healthcommunities.com Testimonials Link to podiatrychannel Overview Charcot-Marie-Tooth (CMT) disease, also known as hereditary motor and sensory neuropathy (HMSN), is an inherited, degenerative nerve disorder that causes muscle weakness and atrophy in the feet, legs, hands, and forearms. It is characterized by progressive loss of use and sensation in the limbs. Charcot, Marie, and Tooth are the names of the physicians who identified the disease and described its symptoms. It is not the same as Charcot's foot disease , a neuropathic joint disease that is a common complication of diabetes mellitus.

23. Genome.gov | Learning About Charcot-Marie-Tooth Disease What do we know about charcotmarie-tooth disease? charcot-marie-tooth disease (CMT) is an inherited neurological disease characterized by a slowly http://www.genome.gov/11009201

triggerParms["cpp_5"] = "Referer:"+ cppUrlPatch (""); // Optional Home About NHGRI Newsroom Staff ... Specific Genetic Disorders Learning About Charcot-Marie-Tooth Disease Learning About Charcot-Marie-Tooth Disease What do we know about Charcot-Marie-Tooth disease? Is there a gene implicated in Charcot-Marie-Tooth? NHGRI Clinical Research on Charcot-Marie-Tooth Additional Resources for Charcot-Marie-Tooth Disease What do we know about Charcot-Marie-Tooth disease? Charcot-Marie-Tooth disease (CMT) is an inherited neurological disease characterized by a slowly progressive degeneration of the muscles in the foot, lower leg, hand, and forearm, and a mild loss of sensation in the limbs, fingers, and toes. The first sign of CMT is generally a high arched foot or gait disturbances. Other symptoms of the disorder may include foot-bone abnormalities such as high arches and hammer toes, problems with hand function and balance, occasional lower leg and forearm muscle cramping, loss of some normal reflexes, occasional partial sight and/or hearing loss, and, in some individuals, scoliosis (curvature of the spine). People with CMT disease usually begin to experience symptoms in adolescence or early adulthood. There is no cure for the disease, but there are treatment options, including physical therapy and bracing. Life expectancy is usually normal.

24. CHARCOT MARIE TOOTH charcotmarie-tooth disease is a hereditary disorder marked by slowly progressive In both types of charcot-marie-tooth disease, there is normal life http://www.mda.org.au/specific/mdacmt.html

FACT SHEET CHARCOT - MARIE - TOOTH DISEASE What is Chacot-Marie-Tooth disease? Charcot-Marie-Tooth disease is a hereditary disorder marked by slowly progressive muscle weakness in the feet, lower legs, hands and forearms, and a mild loss of sensation in limbs, fingers, and toes. The weakness results from the degeneration of nerves that stimulate muscle rather than from a degenerative process in the muscle tissue itself. The disorder, named for three physicians who first identified it in 1886, is also known as peroneal muscular atrophy because if primarily affects the peroneal muscles. which are located in the lower leg. There are now thought to be at least two types of the disease - hypertrophic and neuronal - that differ to some degree in severity. How disabling is the disease? In both types of Charcot-Marie-Tooth disease, there is normal life expectancy, limited disability, and very slow progression of the disease. Some patients, however, experience rapid progression and severe disability. What are the early symptoms?

25. BBC - Health - Conditions - Charcot-Marie-Tooth Disease Discover the causes, symptoms and treatments of this neurological disorder. http://www.bbc.co.uk/health/conditions/charcotmarietooth1.shtml

@import url('/includes/tbenh.css') ; Home TV Radio Talk ... A-Z Index FRIDAY 9th September 2005 Text only BBC Homepage Lifestyle Health ... Help Like this page? Send it to a friend! Charcot-Marie-Tooth disease Dr Trisha Macnair Discover the symptoms and treatments of this inherited neurological disorder, plus links to some useful support groups in the UK and abroad. In this article What is it? Symptoms Who's affected? Diagnosis and treatment What is it? Charcot-Marie-Tooth disease - also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy - is the name given to a group of conditions where the nerves to the muscles, particularly in the lower leg and hands, don't work properly. The part of the nerves carrying sensory signals back towards the brain may also be affected, leading to altered sensation in the affected areas. There are at least four different types of HMSN, which were originally classified on the basis of electrical tests of nerve conduction. But as genetic causes for these different conditions are discovered, so HMSN conditions are being reclassified into a wider group of disorders. Other features include high arched feet in many cases and, in some less common types, deafness, problems with vision, paralysis of the vocal cords and breathing difficulties.

26. Charcot-Marie-Tooth Disease - MayoClinic.com charcotmarie-tooth disease includes a group of disorders that affect the peripheral nerves, causing muscle weakness and loss of muscle bulk. http://www.mayoclinic.com/invoke.cfm?id=DS00557

27. Charcot-Marie-Tooth Disease (www.whonamedit.com) charcotmarie-tooth disease A syndrome characterized by slowly progressive wasting and weakness of distal muscle of the arms and feet, the commonest http://www.whonamedit.com/synd.cfm/30.html

Home List categories Eponyms A-Z Biographies by country ... Contact Whonamedit.com does not give medical advice. This survey of medical eponyms and the persons behind them is meant as a general interest site only. No information found here must under any circumstances be used for medical purposes, diagnostically, therapeutically or otherwise. If you, or anybody close to you, is affected, or believe to be affected, by any condition mentioned here: see a doctor. A recommendation: Hypography is an open community about science and all things related Charcot-Marie-Tooth disease Also known as: Charcot-Marie syndrome Charcot-Marie-Tooth-Hoffmann disease (Johann Hoffmann) Charcot-Marie-Tooth-Hoffmann syndrome (Johann Hoffmann) Tooth muscular atrophy Tooth’s syndrome Synonyms: Atrophia musculorum progressiva neurotica sive neuralis, hereditary motor and sensory neuropathy I (HMSN I), neuropathic muscular atrophy, peroneal muscle atrophy. Associated persons: Jean-Martin Charcot Johann Hoffmann Pierre Marie Howard Henry Tooth Description: Charcot-Marie-Tooth disease, the so-called neural or spinal form of muscular atrophy, is the commonest disease within a group of conditions called Hereditary Motor and Sensory Neuropathies (HMSN).

28. Charcot-Marie-Tooth Disease (CMT) Penn State Hershey Medical Center provides world class care and services to patients. http://www.hmc.psu.edu/healthinfo/c/cmt.htm

29. Charcot-Marie-Tooth Disease (hereditary) charcotmarie-tooth disease defines a group of inherited, slowly progressive disorders that result from progressive damage to nerves. http://www.healthcentral.com/ency/408/000727.html

Dr. Dean TV Specials Newsletters Home ... Health Tools Search Choose a Health Topic * All Health Topics * Acne Addictions AIDS/HIV Alcohol Abuse Allergies Alternative Medicine Alzheimer's Arthritis Asthma Attention Deficit Disorder (ADHD) Backache Bipolar Affective Disorder Birth Control Blood Blood Pressure Bone/Joint/Tendon Bowel Brain Breast cancer Cancer Cerebral Palsy Cholesterol Cramps Crohn's Disease Cysts Dental/Oral Depression Diabetes Diet, Fitness, Looks Disabled/Special Needs Drug Abuse Ear/Nose/Throat Eating/Appetite Eczema Encephalitis Eye/Vision Fatigue Fever Flu Food Poisoning Foot Gallbladder Gastrointestinal Genetic/Congenital GERD/Heartburn Hair Loss Hair/Scalp Headache Hearing Heart Disease, Stroke Heat/Sunstroke Hepatitis Hernia Herpes High Blood Pressure Hormonal Immune Disorders Immunizations/Vaccines Impotence Incontinence/Bladder Infections Injuries Kidney/Urinary Kids Learning Disabilities Liver Lung Cancer Men Menopause, Postmenopause Migraine Mobility/Balance Multiple Sclerosis Muscle Neural Nosebleeds Pain Parasites Pituitary PMS Pregnancy Prostate Cancer Prostate Disorders Psoriasis Psychological Raynaud's Disease Respiratory Reye Syndrome Rheumatoid Arthritis Schizophrenia Seniors Sensory Sexually Transmitted Disease Skin Sleep Speech Disorders Spinal Thyroid Trauma Weight Loss Women Yeast Infections Home Health Encyclopedia Charcot-Marie-Tooth disease (hereditary) Charcot-Marie-Tooth disease (hereditary) Injury Disease Nutrition Poison ... Prevention Charcot-Marie-Tooth disease (hereditary) Definition: Charcot-Marie-Tooth disease defines a group of inherited, slowly progressive disorders that result from progressive damage to nerves. Symptoms include

30. Charcot-Marie-Tooth Disease- Health Encyclopedia And Reference charcotmarie-tooth disease Symptoms, Treatments and Medications. http://www.healthcentral.com/encyclopedia/408/678/CharcotMarieTooth_Disease.html

Dr. Dean TV Specials Newsletters Home ... Health Tools Search Choose a Health Topic * All Health Topics * Acne Addictions AIDS/HIV Alcohol Abuse Allergies Alternative Medicine Alzheimer's Arthritis Asthma Attention Deficit Disorder (ADHD) Backache Bipolar Affective Disorder Birth Control Blood Blood Pressure Bone/Joint/Tendon Bowel Brain Breast cancer Cancer Cerebral Palsy Cholesterol Cramps Crohn's Disease Cysts Dental/Oral Depression Diabetes Diet, Fitness, Looks Disabled/Special Needs Drug Abuse Ear/Nose/Throat Eating/Appetite Eczema Encephalitis Eye/Vision Fatigue Fever Flu Food Poisoning Foot Gallbladder Gastrointestinal Genetic/Congenital GERD/Heartburn Hair Loss Hair/Scalp Headache Hearing Heart Disease, Stroke Heat/Sunstroke Hepatitis Hernia Herpes High Blood Pressure Hormonal Immune Disorders Immunizations/Vaccines Impotence Incontinence/Bladder Infections Injuries Kidney/Urinary Kids Learning Disabilities Liver Lung Cancer Men Menopause, Postmenopause Migraine Mobility/Balance Multiple Sclerosis Muscle Neural Nosebleeds Pain Parasites Pituitary PMS Pregnancy Prostate Cancer Prostate Disorders Psoriasis Psychological Raynaud's Disease Respiratory Reye Syndrome Rheumatoid Arthritis Schizophrenia Seniors Sensory Sexually Transmitted Disease Skin Sleep Speech Disorders Spinal Thyroid Trauma Weight Loss Women Yeast Infections Home Seniors Arthritis Charcot-Marie-Tooth Disease Health Encyclopedia - Diseases and Conditions A B C D ... Y Charcot-Marie-Tooth Disease What is the Definition of Charcot-Marie-Tooth Disease?

31. Charcot-Marie-Tooth Disease CHC Wausau Hospital s Medical Library and Patient Education Center provides research services and healthcare information to physicians, http://www.chclibrary.org/micromed/00042210.html

Main Search Index Definition Description Causes ... Resources Charcot-Marie-Tooth disease Definition Charcot-Marie-Tooth disease (CMT) is the name for a group of inherited disorders of nerve conduction causing weakness and mild loss of sensation in the limbs. Description CMT affects the peripheral nerves, those groups of nerve cells carrying information to and from the spinal cord. CMT decreases the ability of these nerves to carry motor commands to muscles, especially those furthest from the spinal cord in the feet and hands. As a result, these muscles are weakened. CMT also causes mild sensory loss. CMT is named for the three neurologists who first described it, and does not involve the teeth in any way. It is also known as hereditary motor and sensory neuropathy, and is also sometimes called peroneal muscular atrophy, referring to the muscles in the leg affected early on in the disease. Causes The symptoms grouped together under the name CMT can be caused by any of at least six different genetic defects. Most of the defects, identified as of early 1998, affect myelin, the coating that insulates nerve cells to promote efficient conduction. Myelin defects cause either a reduction in nerve conduction velocities, or a diminished nerve signal. CMT is currently subdivided into type 1A, type 1B, type 2, and type X, based on the particular genetic defect involved. All but type X exhibit the inheritance pattern known as autosomal dominant. In this pattern, only one defective gene copy is needed to develop the disease, which may be inherited from either parent (who will also have the disease). A person with CMT of this type has a 50% chance of passing the gene along to each offspring. CMT type X is inherited as an X-linked trait, meaning the gene is carried on the X chromosome. Women carry two X chromosomes, while men carry only one. Without a "backup" copy of the normal gene, a man with the CMT type X gene is more likely to be seriously affected than is a woman. Expression of the gene does occur in women to a lesser extent, leading to disease of variable severity. Affected men may pass the gene on to their daughters, but not to their sons.

32. Encyclopaedia Topic : Charcot-Marie-Tooth Disease, Section : Introduction CharcotMarie-Tooth (CMT) disease is named after the three neurologists who first Dejerine-Sottas Disease is also very similar to Charcot-Marie-Tooth http://www.nhsdirect.nhs.uk/en.asp?TopicID=622

33. Encyclopaedia Topic : Charcot-Marie-Tooth Disease, Section : Symptoms NHS Direct Online Health Encyclopaedia. charcotmarie-tooth disease The disease weakens the muscles and people with CMT will usually experience some http://www.nhsdirect.nhs.uk/en.asp?TopicID=622&AreaID=4097&LinkID=3172

34. Charcot-Marie-Tooth Disease Feature article describes the charcotmarie-tooth diseases, their diagnoses, and treatments. http://rarediseases.about.com/cs/cmt/a/032001.htm

var zLb=8; var zIoa1 = new Array('Elsewhere on the Web','Charcot-Marie-Tooth Association (U.S.)','http://www.charcot-marie-tooth.org/site/content/','MDA: Facts About Charcot-Marie-Tooth Disease','http://www.mdausa.org/publications/fa-cmt.html'); var zIoa2 = new Array('Elsewhere on the Web','NINDS: Charcot-Marie-Tooth Disorder Info Page','http://www.ninds.nih.gov/health_and_medical/disorders/charcot_doc.htm'); zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a70' About Rare / Orphan Diseases Information by Disease Type Brain and Nervous System Charcot-Marie-Tooth Disease Rare Diseases Essentials Rare Diseases: Basic Information Rare Diseases Support Groups ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the Rare / Orphan Diseases newsletter! See Online Courses Search Rare / Orphan Diseases Stay up to date! Compare Prices Email to a friend ... Print this page Elsewhere on the Web Charcot-Marie-Tooth Association (U.S.)

35. Gene Associated With Charcot-Marie-Tooth Disease Identified Several years ago researchers identified a region on chromosome 1 as having the gene responsible for charcotmarie-tooth disease (CMT), a degenerative nerve http://rarediseases.about.com/b/a/080108.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a70' About Rare / Orphan Diseases Rare Diseases Essentials ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the Rare / Orphan Diseases newsletter! See Online Courses Search Rare / Orphan Diseases Gene associated with Charcot-Marie-Tooth disease identified Rare/Orphan Diseases Blog Main April 19, 2004 Gene associated with Charcot-Marie-Tooth disease identified Several years ago researchers identified a region on chromosome 1 as having the gene responsible for Charcot-Marie-Tooth disease (CMT), a degenerative nerve disorder, but did not know the exact gene involved. Researchers at the Duke Center for Human Genetics have now identified a gene, known as mitofusin 2, that is associated with CMT type 2A. The gene is critical to the development of mitochondria, the structures in a cell that produce energy. The research was reported in the April 4, 2004, issue of Nature Genetics Email a Friend Display Latest Headlines Read Archives Advertisement Most Popular Muscular Dystrophy ALD and Lorenzo's Oil Progeria Syndromes Leprosy (Hansen's Disease) ... The Elephant Man What's Hot Muscular Dystrophy Autoimmune Kidney Disease Minamata Disease Charcot-Marie-Tooth Disease ... Meckel-Gruber Syndrome adunitCM(150,100,'x55')

36. Healthfinder® - Charcot-Marie-Tooth Disease Carefully selected government and nonprofit health information on charcotmarie-tooth disease. http://www.healthfinder.gov/Scripts/SearchContext.asp?topic=151

37. Healthfinder® — Charcot-Marie-Tooth Disease Fact Sheet This is a fact sheet about charcotmarie-tooth disease. CMT, also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy, http://www.healthfinder.gov/Scripts/ShowDocDetail.asp?doc=7202&lang=1

38. Types Of Peripheral Neuropathy - Hereditary - Charcot-Marie-Tooth Disease (CMT) charcotmarie-tooth disease (CMT) is a broad term used to describe a group of inherited neurological disorders characterized by a slowly progressive http://millercenter.uchicago.edu/learnaboutpn/typesofpn/hereditary/charcotmariet

What is Peripheral Neuropathy Peripheral Neuropathy Symptoms Types of Peripheral Neuropathy Evaluation and Tests ... Frequently Asked Questions Types of Peripheral Neuropathy - Hereditary Idiopathic Pre-diabetic/Diabetic Hereditary Toxic/Secondary to Drugs ... Other Types of PN Charcot-Marie-Tooth Disease (CMT) Charcot-Marie-Tooth disease (CMT) is a broad term used to describe a group of inherited neurological disorders characterized by a slowly progressive degeneration of the muscles in the foot, lower leg, hand, and forearm, and a mild loss of sensation in the limbs, fingers, and toes. Three French doctors, Jean-Marie Charcot, Pierre Marie, and Howard Henry Tooth, discovered CMT in 1886. Although CMT is one of the most common inherited neuromuscular disorders, it is often misdiagnosed. The number of people in the United States that have CMT is currently estimated to be 125,000. The symptoms of CMT depend on which form of the disease is inherited, but generally start between mid-childhood and early adulthood. The first signs are usually foot abnormalities, such as an unusually high arch or flexed ("hammer") toes. People with CMT often trip on curbs. Sprained ankles and fractures of the ankles and lower legs are not uncommon. As the disease progresses, muscle weakness and wasting leads to difficulties with walking, running and balance. If the hands are affected, daily activities such as turning doorknobs, fastening buttons, or writing can become difficult. The disease is slowly progressive and, although many patients need to wear a brace to prevent their feet from dragging, the leg and foot problems are rarely disabling enough to require a wheelchair. CMT is not a fatal disease and the disorder does not affect normal life expectancy.

39. Charcot-Marie-Tooth Disease charcotmarie-tooth disease. From MayoClinic.com Special to CNN.com. Overview. Charcot-Marie-Tooth (CMT) disease broadly includes a group of progressive http://www.cnn.com/HEALTH/library/DS/00557.html

var cnnSiteWideCurrDate = new Date(2005, 8, 8); International Edition Member Services Home Page World ... Contact Us In association with: RELATED STORIES Brain and nervous system definitions Muscular dystrophy INFORMATION CENTERS: Pick a category Health Centers Family Health Men's Health Women's Health Children's Health Seniors' Health Working Life Pain Management Condition Centers Immune System Allergy Alzheimer's Arthritis Respiratory System Cancer Endocrine System Digestive System Heart and Blood Infectious Disease Mental Health Note: All links within content go to MayoClinic.com Diseases and Conditions Charcot-Marie-Tooth disease From MayoClinic.com Special to CNN.com Overview Charcot-Marie-Tooth (CMT) disease broadly includes a group of progressive hereditary disorders that cause nerve damage (neuropathy). The damage in CMT occurs to your peripheral nerves or to the insulation covering your nerves (myelin sheath). The peripheral nerves are those outside of your central nervous system (brain and spinal cord). CMT most often affects the legs, feet and hands. It generally results in muscle weakness and loss of muscle bulk. In some cases, it may cause a mild loss of sensation. Named after the three physicians who first identified the disorder in 1886, CMT is a common inherited neurological disorder. It affects approximately 150,000 people in the United States and occurs in all races and ethnic groups. CMT most often is discovered between midchildhood and age 30, but can develop at any age.

40. Information On Charcot Marie Tooth Disease And Brain Disorders At MedicineNet.co Learn about charcotmarie-tooth disease, an inherited neurological disorder. http://www.medicinenet.com/charcot-marie-tooth-disease/article.htm

document.writeln(''); MedicineNet Home > Charcot-Marie-Tooth-Disease search help Printer-Friendly Format FREE Newsletters Email to a Friend ... Next Charcot-Marie-Tooth-Disease What is Charcot-Marie-Tooth-disease? What are the symptoms of Charcot-Marie-Tooth-disease? What are the types of Charcot-Marie-Tooth-disease? What causes Charcot-Marie-Tooth-disease? ... What research is being done on Charcot-Marie-Tooth-disease? What is Charcot-Marie-Tooth-disease? Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States. The disease is named for the three physicians who first identified it in 1886 - Jean-Martin Charcot and Pierre Marie in Paris, France, and Howard Henry Tooth in Cambridge, England. CMT, also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy, comprises a group of disorders that affect peripheral nerves. The peripheral nerves lie outside the brain and spinal cord and supply the muscles and sensory organs in the limbs. Disorders that affect the peripheral nerves are called peripheral neuropathies. What are the symptoms of Charcot-Marie-Tooth-disease?

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