81. Development Of Cytotoxic Cerebral Edema In Rats Following cerebral edema is one of the major consequences of brain injuries such cerebral edema is always accompanied by electrolytic disturbance in brain tissue. http://www.cmj.org/information/full.asp?id=1295

82. Development Of Cytotoxic Cerebral Edema In Rats Following Development of cytotoxic cerebral edema in rats following intracaudatum injectionof tACPD, an agonist of metabotropic glutamate receptors http://www.cmj.org/information/abstract.asp?id=1295

83. Journal Of Cerebral Blood Flow & Metabolism - Abstract Of Article: Tumor Necrosi Tumor necrosis factor alpha neutralization reduced cerebral edema throughinhibition of cerebral edema, cerebral ischemia, matrix metalloproteinases, http://www.nature.com/jcbfm/journal/v25/n8/abs/9600086a.html

@import "/common/style/layout.css";/* do not edit this stylesheet */ @import "/common/style/main.css";/* do not edit this stylesheet */ @import "/aj/style/group.css";/* do not edit this stylesheet */ @import "/jcbfm/style/site.css";/* edit this stylesheet only */ Accessibility statement Jump to main content Jump to main navigation Jump to search ... ABOUT NPG E-MAIL: PASSWORD Save password Forgotten password? MY ACCOUNT E-ALERTS SUBSCRIBE ... REGISTER Text to search for Advanced search Journal home Archive Original Articles Abstract Original Article Tumor necrosis factor- neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia Naohisa Hosomi , Camelia R Ban , Takayuki Naya , Tsutomu Takahashi , Peng Guo , Xiao-yu R Song and Masakazu Kohno Second Department of Internal Medicine, Division of Stroke, Kagawa University School of Medicine, Kagawa, Japan Centocor, Inc. Radnor, Pennsylvania, USA naohisa@med.kagawa-u.ac.jp Received 20 July 2004; Revised 27 December 2004; Accepted 30 December 2004; Published online 23 February 2005. Top of page Abstract After focal cerebral ischemia, tumor necrosis factor-

84. Cerebral Edema And Intracranial Hypertension - Humana Press Humana Press publishes scientific and medical books, journals, ebooks, onlinejournals, and CD-ROMs for the research professional and physicians. http://www.humanapress.com/ChapterDetail.pasp?ccode=1-59259-772-6:063&isbn=1-592

85. Common Treatment For Diabetic Crisis In Children May Contribute To Rare But Ofte cerebral edema can lead to coma, neurological damage, and death. In all,cerebral edema accounts for 50 percent to 60 percent of diabetesrelated deaths http://www.scienceblog.com/community/older/2001/D/200114723.html

January 2001 From University of California, Davis - Medical Center Common treatment for diabetic crisis in children may contribute to rare but often fatal complication A common treatment for children in diabetic crisis should be abandoned in most cases because it appears to contribute to a rare but often-fatal complication known as cerebral edema, according to a study by researchers at UC Davis School of Medicine and Medical Center. The study also identifies two simple blood test measurements that can help doctors predict which patients are in greatest danger of developing the potentially deadly complication. The study, the largest and most statistically rigorous examination yet of risk factors for cerebral edema in children with diabetic ketoacidosis, appears in the Jan. 25 issue of the New England Journal of Medicine. The researchers found that bicarbonate, a common treatment for diabetic ketoacidosis, appears to increase the risk of cerebral edema, or swelling of the brain, which can be fatal. In ketoacidosis, toxic levels of acids called ketones build up in the blood. Bicarbonate is often given in the emergency department to reduce these acid levels. "In the past there has been some suspicion that giving bicarbonate can increase risk of cerebral edema, but ours is the first study to show that it can," said Nathan Kuppermann, senior author of the study, a pediatric emergency physician and associate professor of internal medicine at UC Davis. "I imagine doctors in emergency departments and pediatric intensive care units will put this knowledge into effect immediately."

86. NDI Terminology - Cerebral Edema NDI Foundation. cerebral edema. DEFINITION. Definition has yet to be entered.Check back later. The definitions used in this glossary of terminology either http://www.ndif.org/Terms/cerebral_edema.html

cerebral edema DEFINITION: Definition has yet to be entered. Check back later. The definitions used in this glossary of terminology either have been provided by the authors of the articles, or have been extracted wholly or in part, or paraphrased from the following sources: The American Medical Association Encyclopedia of Medicine , Charles B. Clayman, MD, Medical Editor, Random House, New York, 1989; Dorland's Illustrated Medical Dictionary , 28th Edition, W. B. Saunders Company, Philadelphia, 1994; The Random House Dictionary of the English Language , Unabridged Edition, 1966; Webster's Ninth New Collegiate Dictionary TERMINOLOGY WHERE THIS WORD IS USED TABLE of CONTENTS INFO. REQUEST ENTRANCE

87. Cerebral Edema In Childhood Diabetic Ketoacidosis: Natural History, Radiographic cerebral edema in Childhood Diabetic Ketoacidosis OBJECTIVE—Children whodevelop cerebral edema (CE) during diabetic ketoacidosis (DKA) exhibit http://care.diabetesjournals.org/cgi/content/abstract/27/7/1541

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Full Text Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Request Permissions PubMed PubMed Citation Articles by Muir, A. B. Articles by Rosenbloom, A. L. Diabetes Care by the American Diabetes Association, Inc. Clinical Care/Education/Nutrition Original Article Cerebral Edema in Childhood Diabetic Ketoacidosis Natural history, radiographic findings, and early identification Andrew B. Muir, MD Ronald G. Quisling, MD Mark C.K. Yang, PHD and Arlan L. Rosenbloom, MD Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida Department of Radiology, University of Florida College of Medicine, Gainesville, Florida Department of Statistics, University of Florida College of Medicine, Gainesville, Florida Address correspondence and reprint requests to Andrew Muir, MD, 1120 15th St., BG-1020, Augusta, GA 30912. E-mail:

88. Cerebral Edema Without Ketoacidosis Or Hyperosmolar Coma In A 16-Year- Old Boy - cerebral edema is a rare, but life threatening, complication of diabetic There is no documentation of the occurrence of cerebral edema outside the http://care.diabetesjournals.org/cgi/content/extract/28/3/753

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Full Text Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Request Permissions PubMed PubMed Citation Articles by Shastry, R. M. Articles by Bhatia, E. Diabetes Care Letters: Observations Cerebral Edema Without Ketoacidosis or Hyperosmolar Coma in a 16-Year- Old Boy Ram M. Shastry, MD Vijayalakshmi Bhatia, MD Ravi P. Sahu, MSC and Eesh Bhatia, MD, DNB From the Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India Address correspondence to Vijayalakshmi Bhatia, MD, Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India. E-mail: vbhatia@sgpgi.ac.in The first 20% of the full text of this article appears below.

89. Type 1 Diabetes And Sports Participation Predicting cerebral edema during Diabetic Ketoacidosis cerebral edema is adevastating complication of diabetic ketoacidosis and remains the leading http://www.idea2000.org/moreinfo/docs/Cerebral_Edema_during_Ketoacidosis.html

Predicting Cerebral Edema during Diabetic Ketoacidosis The New England Journal of Medicine January 25, 2001 Vol. 344, No. 4 Cerebral edema is a devastating complication of diabetic ketoacidosis and remains the leading cause of serious illness and death in children with diabetes mellitus. (1) The causes of cerebral edema are unknown, largely because of the lack of large-scale population-based studies. However, several hypotheses relating to possible antecedent risk factors and the effects of various treatment regimens have been proposed. (1) In this issue of the Journal, Glaser et al. (2) report the results of a retrospective analysis of cases of children with diabetic ketoacidosis at 10 centers. Among 6977 such children, the authors identified 61 with cerebral edema. The incidence of cerebral edema was 0.9 percent, a rate remarkably similar to that reported historically in the United States (3) and recently in the United Kingdom. (4) As in previous studies, the risk was highest among younger children with newly diagnosed diabetes. (1) The 21 percent mortality rate associated with cerebral edema was similar to that in the United Kingdom, (4) as was the morbidity rate, with a substantial 27 percent of the survivors having neurologic sequelae. The development of cerebral edema may be the result of the treatment that children receive for diabetic ketoacidosis; treatments such as high doses of insulin and the administration of bicarbonate or large volumes of hypotonic fluid would be the major culprits. (1) However, it is also possible that the condition is an idiosyncratic response to diabetic ketoacidosis. Thus far, no adequate proof for either hypothesis has been advanced.

90. The Turkish Journal Of Pediatrics Risk factors for cerebral edema in children with diabetic ketoacidosis. N EnglJ Med 2001; Predicting cerebral edema during diabetic ketoacidosis. http://tjp.dergisi.org/text.php3?id=245

91. Ketoacid Levels May Alter Osmotonicity In Diabetic Ketoacidosis And Precipitate Risk factors for cerebral edema in children with diabetic ketoacidosis. N EnglJ Med 2001;344264–9. Abstract/Free Full Text http://adc.bmjjournals.com/cgi/content/full/88/4/366-a

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Author Keyword(s) Vol Page [Advanced] This Article Extract Full Text (PDF) Additional Reference ... Alert me if a correction is posted Services Email this link to a friend Similar articles in ADC Online Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Puliyel, J M Articles by Bhambhani, V Related Collections Diabetes Other Pediatrics Archives of Disease in Childhood LETTER Ketoacid levels may alter osmotonicity in diabetic ketoacidosis and precipitate cerebral edema J M Puliyel and V Bhambhani St Stephens Hospital, Tis Hazari, Delhi, India Correspondence to Dr Puliyel; Keywords: diabetic ketoacidosis; diabetes; fluid management; cerebral oedema Inward and Chambers have called for a rethink of the management of diabetic ketoacidosis. In their article they quote a study

92. Entrez PubMed OBJECTIVE Children who develop cerebral edema (CE) during diabetic ketoacidosis (DKA)exhibit definable signs and symptoms of neurological collapse early http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

93. Entrez PubMed Acute cerebral edema due to lead intoxication is an unusual presentation in anadult. Here we describe an adult with pica presenting with severe http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

94. IIDRSI Cerebral Edema Translate this page Term, cerebral edema. Definition, Accumulation of fluid within the brain’s Term, edema cerebral (nm). Definition, Acumulación de fluido en el tejido http://www.med.univ-rennes1.fr/iidris/index.php?action=contexte&num=3753&mode=mu

95. High-Altitude Cerebral Edema - Detroit, Michigan HighAltitude cerebral edema - courtesy of Henry Ford Health System of Detroit,Michigan. http://www.henryfordhealth.org/115058.cfm

Choose a Section Return to Main Menu Minor Medical Concerns Major Medical Concerns Symptoms Environment-Related Concerns Activity Related Concerns High-Altitude Cerebral Edema High-altitude cerebral edema (HACE) is the medical term for a disorder (theoretically linked to brain swelling) that involves an alteration of mental status seen at high altitude, related to diminished atmospheric oxygen. Symptoms include difficulty walking (inability to walk a straight line, staggering, or frank inability to walk), headache (often throbbing), confusion, difficulty in speaking, drowsiness, vomiting, and, in severe cases, blindness, unconsciousness, paralysis, and/or coma. A victim may suffer from HACE and high-altitude pulmonary edema (HAPE) at the same time. Other symptoms may include hallucinations, paralysis of an arm and/or leg, and seizures. Victims are often gray or pale in appearance. Imbalance or the inability to walk heel to toe in a straight line is a very worrisome sign and should prompt immediate action to treat the victim. The treatment for HACE is immediate descent to an altitude below one at which the victim previously had no symptoms, and the

96. Bumetanide Reduces Cerebral Edema Formation In Rats With Diabetic Ketoacidosis - The mechanisms responsible for cerebral edema formation in diabetic ketoacidosis (DKA)are not well understood, although evidence suggests ischemia as a http://diabetes.diabetesjournals.org/cgi/content/abstract/54/2/510

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Full Text Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Request Permissions PubMed PubMed Citation Articles by Lam, T. I. Diabetes by the American Diabetes Association, Inc. Bumetanide Reduces Cerebral Edema Formation in Rats With Diabetic Ketoacidosis Tina I. Lam Steven E. Anderson Nicole Glaser , and Department of Physiology and Membrane Biology, University of California, Davis, California Department of Pediatrics, University of California, Davis, California The mechanisms responsible for cerebral edema formation in diabetic ketoacidosis (DKA) are not well understood, although evidence suggests ischemia as a contributing factor. Previous studies have shown that the Na-K-Cl cotransporter of cerebral microvascular endothelial cells and astrocytes is a major participant in ischemia-induced cerebral edema in stroke. The present study was conducted to

97. Proteinuria Precedes Cerebral Edema In Stroke-Prone Rats : A Magnetic Resonance After detection of cerebral edema (T2weighted MRI), 6 rats were killed for Results—SHRSP invariably developed cerebral edema in 30 days (range, http://stroke.ahajournals.org/cgi/content/abstract/29/1/167

This Article Full Text Full Text (PDF) Alert me when this article is cited ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Request Permissions PubMed PubMed Citation Articles by Blezer, E. L. A. Articles by Mayhan, W. G. Stroke. Original Contributions Proteinuria Precedes Cerebral Edema in Stroke-Prone Rats A Magnetic Resonance Imaging Study Erwin L. A. Blezer Merel Schurink Klaas Nicolay, PhD Gerard H. Jansen, MD Hein A. Koomans, MD, PhD Jaap A. Joles, DVM, PhD From the Departments of Nephrology (E.L.A.B., M.S., H.A.K., J.A.J.) and Experimental Neurology (P.R.D.B.), and Pathology (G.H.J.), University Hospital Utrecht, and Department of In Vivo NMR, Bijvoet Center, Utrecht University (E.L.A.B., K.N.), Utrecht, the Netherlands. Correspondence and reprint requests to Jaap A. Joles DVM, PhD, Department of Nephrology and Hypertension (F03.226), Utrecht University Hospital, PO Box 85500, 3508 GA Utrecht, Netherlands. E-mail Background and Purpose rats (SHRSP) subjected to high sodium intake develop severe hypertension, cerebral edema, and proteinuria, culminating in

98. FACTORES DE RIESGO DE EDEMA CEREBRAL EN NIÑOS CON CETOACIDOSIS DIABÉTICA Translate this page El edema cerebral ocurre en el 1% de los casos de cetoacidosis diabética en Los niños que presentaron edema cerebral comparados con el grupo control no http://www.intermedicina.com/Avances/Pediatria/APE26.htm

FACTORES DE RIESGO DE EDEMA CEREBRAL EN NIÑOS CON CETOACIDOSIS DIABÉTICA Palabras claves: factores de riesgo, edema cerebral, acidosis diabética. La cetoacidosis diabética ocurre en el 25-40% de los niños con diabetes mellitus tipo I recientemente diagnosticada, y puede recurrir luego, por asociarse con otras enfermedades o falta de cumplimiento del tratamiento. El edema cerebral ocurre en el 1% de los casos de cetoacidosis diabética en niños, pero cuando se presenta se asocia con un elevado porcentaje de mortalidad (40-90%). El mecanismo por el cual se produce el edema cerebral es todavía controvertido, por lo que Glaser y col. evaluaron la asociación de esta complicación con características demográficas, características bioquímicas inicial, intervenciones terapéuticas, y cambios en los valores de laboratorio durante el tratamiento. Encontraron una incidencia de edema cerebral de 0,9% de los casos de cetoacidosis diabética. El diagnóstico se basó en deterioro del estado mental acompañado por evidencia radiográfica. La hipocapnia causa vasoconstricción cerebral, deshidratación extrema con su consiguiente hipoxia cerebral, que se exacerba con la terapia con bicarbonato. La hiperglucemia sobreimpuesta altera la barrera hemato-encefálica, que se puede agravar luego de varias horas (4-12 hs) de tratamiento debido a la liberación de sustancias vasoactivas y mediadores de la inflamación. Este mecanismo se puede agravar con tratamientos con altas dosis de insulina y la administración de bicarbonato o grandes volúmenes de solución hipotónica.

99. EL_Movies http://cats.med.uvm.edu/cats_teachingmod/pathology/path302/np/neuro_infect/movie

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