1. EMedicine - Central Pontine Myelinolysis : Article By Christopher C Luzzio, MD central pontine myelinolysis An introduction, clinical features, differencials,work up, treatment and follow up. http://www.emedicine.com/neuro/topic50.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Neurology Neurotoxicology Central Pontine Myelinolysis Last Updated: March 3, 2005 Rate this Article Email to a Colleague Synonyms and related keywords: osmotic myelinolysis, CPM, hyponatremia, noninflammatory demyelination, stripping of the myelin sheath, alcoholism, liver disease, malnutrition AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Christopher C Luzzio, MD , Clinical Assistant Professor, Department of Neurology, University of Wisconsin at Madison Christopher C Luzzio, MD, is a member of the following medical societies: American Academy of Neurology Editor(s): Howard A Crystal, MD , Professor, Departments of Neurology and Pathology, State University of New York Downstate; Francisco Talavera, PharmD, PhD , Senior Pharmacy Editor, eMedicine;

2. Dr. Koop - Central Pontine Myelinolysis A definition of central pontine myelinolysis, including the causes, risks, prevention, symptoms, diagnosis, treatment, prognosis and complications. http://www.drkoop.com/ency/article/000775.htm

Home Health Reference Central pontine myelinolysis Jul 29, 2005 Search: Dr.Koop MEDLINE Diseases Symptoms Procedures Natural Medicine ... Drug Library Inside DrKoop News Archive Animations Health Videos Health Tools ... Newsletters Central pontine myelinolysis Injury Disease Nutrition Poison ... Prevention Central pontine myelinolysis Definition: Central pontine myelinolysis is nerve damage caused by the destruction of the layer ( myelin sheath ) covering nerve cells in the brainstem (pons). Alternative Names: CPM Causes, incidence, and risk factors: The destruction of the myelin sheath that coats nerve cells prevents signals from being properly conducted within the nerve. This decreases its ability to communicate with other cells. The most common cause of central pontine myelinolysis is a rapid, drastic change in sodium levels in the body. Most commonly, this occurs when someone is being treated for low levels of sodium ( hyponatremia ) and the levels rise too fast. It also can occasionally occur when high levels of sodium in the body (hypernatremia) are corrected too quickly. This condition does not occur on its own. It is a complication of treatment for other conditions or the other conditions themselves.

3. MedlinePlus Medical Encyclopedia Central Pontine Myelinolysis central pontine myelinolysis Contents of this page Illustrations. Alternative names. Definition. Causes, incidence, and risk factors http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

4. MedlinePlus Medical Encyclopedia: Central Pontine Myelinolysis central pontine myelinolysis is nerve damage caused by the destruction of the layer The most common cause of central pontine myelinolysis is a rapid, http://www.nlm.nih.gov/medlineplus/ency/article/000775.htm

@import url(/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Central pontine myelinolysis Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Central nervous system Alternative names Return to top CPM Definition Return to top Central pontine myelinolysis is nerve damage caused by the destruction of the layer ( myelin sheath ) covering nerve cells in the brainstem (pons). Causes, incidence, and risk factors Return to top The destruction of the myelin sheath that coats nerve cells prevents signals from being properly conducted within the nerve. This decreases its ability to communicate with other cells. The most common cause of central pontine myelinolysis is a rapid, drastic change in sodium levels in the body. Most commonly, this occurs when someone is being treated for low levels of sodium ( hyponatremia ) and the levels rise too fast. It also can occasionally occur when high levels of sodium in the body (hypernatremia) are corrected too quickly. This condition does not occur on its own. It is a complication of treatment for other conditions or the other conditions themselves.

5. Central Pontine Myelinolysis a CHORUS notecard document about central pontine myelinolysis http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

6. AllRefer Health - Central Pontine Myelinolysis (CPM) central pontine myelinolysis (CPM) information center covers causes, prevention,symptoms, diagnosis, treatment, incidence, risk factors, signs, tests, http://health.allrefer.com/health/central-pontine-myelinolysis-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Central Pontine Myelinolysis Central Pontine Myelinolysis Definition Prevention Treatment Expectations or Prognosis ... Go To Main Page Alternate Names : CPM Definition Central pontine myelinolysis is a condition characterized by nerve damage caused by the destruction of the covering layer ( myelin sheath) of nerve cells in the brainstem (pons). Central Nervous System The destruction of the myelin sheath that coats nerves inhibits impulse conduction within the cell and thus decreases its ability to communicate with other cells. The most common cause of central pontine myelinolysis is a rapid, drastic change in sodium levels in the body. Most commonly, this occurs when someone is being treated for low levels of sodium ( hyponatremia ) and the levels rise too fast, but it can occasionally occur when high levels of sodium in the body (hypernatremia) are corrected too quickly.

7. Dr. Koop - Central Pontine Myelinolysis central pontine myelinolysis is nerve damage caused by the destruction of the layer () covering nerve cells in the brainstem (pons). http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

8. AllRefer Health - Central Pontine Myelinolysis (CPM) Information central pontine myelinolysis (CPM) information center covers definition, alternativenames, Overview, Causes, Risk Factors, Symptoms Signs, http://health.allrefer.com/health/central-pontine-myelinolysis.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Central Pontine Myelinolysis Alternate Names : CPM Definition Central pontine myelinolysis is a condition characterized by nerve damage caused by the destruction of the covering layer ( myelin sheath) of nerve cells in the brainstem (pons). Central Nervous System Jump to a section Definition Prevention Treatment Expectations or Prognosis ... Calling Your Health Care Provider Topics that might be of interest to you Alcoholism Cranial Mononeuropathy VI Delirium Dilutional Hyponatremia (SIADH) ... Nerve Conduction Velocity Other Topics Chronic Confusion Consciousness - Decreased Constipation ... Weakness From Our Sponsors: A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's

9. Dr. Koop - Central Pontine Myelinolysis A definition of central pontine myelinolysis, including the causes, risks, prevention, symptoms, diagnosis, treatment, prognosis and complications. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

10. Dr. Koop - Central Pontine Myelinolysis central pontine myelinolysis is nerve damage caused by the destruction of thelayer () covering nerve cells in the brainstem (pons). http://www.drkoop.com/ency/93/000775.html

Home Health Reference Central pontine myelinolysis Jul 29, 2005 Search: Dr.Koop MEDLINE Diseases Symptoms Procedures Natural Medicine ... Drug Library Inside DrKoop News Archive Animations Health Videos Health Tools ... Newsletters Central pontine myelinolysis Injury Disease Nutrition Poison ... Prevention Central pontine myelinolysis Definition: Central pontine myelinolysis is nerve damage caused by the destruction of the layer ( myelin sheath ) covering nerve cells in the brainstem (pons). Alternative Names: CPM Causes, incidence, and risk factors: The destruction of the myelin sheath that coats nerve cells prevents signals from being properly conducted within the nerve. This decreases its ability to communicate with other cells. The most common cause of central pontine myelinolysis is a rapid, drastic change in sodium levels in the body. Most commonly, this occurs when someone is being treated for low levels of sodium ( hyponatremia ) and the levels rise too fast. It also can occasionally occur when high levels of sodium in the body (hypernatremia) are corrected too quickly. This condition does not occur on its own. It is a complication of treatment for other conditions or the other conditions themselves.

11. Demyelinating Diseases - Internet Handbook Of Neurology demyelinating diseases, multiple sclerosis, leukodystrophy, central pontine myelinolysis, progressive multifocal leukoencephalopathy http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

12. Central Pontine Myelinolysis Was First Described By Adams Et Al... central pontine myelinolysis consists of demyelination without inflammation in central pontine myelinolysis. Archives of Neurology and Psychiatry, 1959; http://www.indegene.com/Neu/ClinRound/indNeuCase10.html

Central Pontine Myelinolysis Following Hemodialysis Author: Dr R Dewan, Dr Rahul Rai, Dr Praveen Gupta, Dr Rahul Anand, Dr Pankaj Mehta, Dr Sameer Gulati Hospital: Depatment of Medicine, Maulana Azad Medical College, New Delhi Introduction Central pontine myelinolysis was first described by Adams et al in 1959 during the course of studying the neuropathology of alcoholism. The lesion was localized to the central rostral part of the pons and consisted of a sharply outlined focus of myelin destruction. Quadriplegia and pseudobulbar palsy were the main clinical findings. CPM was usually a postmortem diagnosis till the advent of the CT and the MRI. We report this interesting case of a young lady who developed CPM following hemodialysis. Case Report A young 26-year-old lady, a diagnosed case of Hypertension with MPGN with Chronic Renal Failure, was admitted with complaints of sudden onset loss of consciousness. The patient had developed altered sensorium 4 days before presentation, for which she was taken to a private nursing home and was hemodialysed twice. Following dialysis she developed drooping of the right eyelid and progressive paraparesis. Following this the patient developed loss of consciousness, when she was brought to our hospital. There was no other significant history. On examination the patient was unconscious, not responding to painful stimulus and a blood pressure of 180/130. The general physical examination showed pallor and facial puffiness but no icterus, clubbing or lymphadenopathy. Chest, CVS and per abdomen examination was normal. CNS examination revealed deep comatose state, a right third nerve palsy, paraparesis, which later progressed to quadriparesis, with bilateral up-going plantars.

13. Metabolic Disorders Central Pontine Myelinolysis Neuropathology of MarchiafavaBignami Disease and central pontine myelinolysis http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

14. Central Pontine Myelinolysis - Indegene Bulletin Board Author, Topic central pontine myelinolysis. NK, posted 2511-2003 0154 AM.Is there a cure for central pontine myelinolysis ? If not, any suggestions ? http://www.indegene.com/bb/ubb/Forum2/HTML/000832.html

Indegene Bulletin Board ASK Indegene Central pontine myelinolysis preferences faq search UBBFriend: Email This Page to Someone! ... next oldest topic Author Topic: Central pontine myelinolysis NK posted 25-11-2003 01:54 AM Is there a cure for Central pontine myelinolysis ? If not, any suggestions ? All times are IST next newest topic next oldest topic Administrative Options: Close Topic Archive/Move Delete Topic Hop to: Select a Forum List of Forums: ASK Indegene Medical Waste Management Medico Legal Issues Hospital Management Issues Nootropil Contact Us Home Powered by Infopop www.infopop.com Ultimate Bulletin Board 5.47a

15. CENTRAL PONTINE MYELINOLYSIS central pontine myelinolysis A condition characterized by damage to the myelin (sheath) layer of nerve cells in the pons (brainstem). http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

16. Singapore Medical Journal Osmotic myelinolysis (central pontine myelinolysis). CLINICAL COURSE. The patientdid not improve clinically over the following months. http://www.sma.org.sg/smj/4101/articles/4101me1ans.htm

Journals Present Issue Past Issues THESMANEWS Present Issue Past Issues SMJ Editorial Board Letters to the Editor Instructions to Authors S I N G A P O R E M E D I C A L J O U R N A L This site is supported by Health ONE Singapore Med J 2000; Vol 41(1): Clinics in Diagnostic Imaging (45) C Y Chan, H S Lam, J R Jinkins IMAGE INTERPRETATION MR scans showede a 1 cm area of T2 hyperintensity in the central pontine region (Fig 1a) . In a patient with a history of sodium replacement, this finding is in keeping with osmotic myelinolysis (or central pontine myelinolysis). Multiple areas of T2 hyperintensity were seen in the basal ganglia and deep white matter (Fig 1b) , representing part of the same process. DIAGNOSIS Osmotic myelinolysis (central pontine myelinolysis) CLINICAL COURSE The patient did not improve clinically over the following months. She developed spastic tetraparesis, pseudobulbar palsy and horizontal nystagmus. Because of mutism, antidepressants were tried but they were not effective. She remained bed-ridden and ventilator-dependent. During her hospital stay, she developed several episodes of chest and urinary tract infection which were controlled with antibiotics. The patient finally died one year later due to multiple organ failure and sepsis. DISCUSSION Osmotic myelinolysis (OM) is a demyelinating disease that can develop following rapid correction of hyponatremia from any cause. It was originally described in chronic alcoholics. Other reported associations include malnourished status, renal failure, diabetes mellitus, and post-orthotopic liver transplantation

17. EMedicine - Central Pontine Myelinolysis Article By Christopher central pontine myelinolysis An introduction, clinical features, differencials, work up, treatment and follow up. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

18. REFERENCES central pontine myelinolysis clinical and MRI correlates. Postgrad Med J 1995;7143042. Reversal of MR findings of central pontine myelinolysis. http://www.sma.org.sg/smj/4101/references/4101me1ref.htm

REFERENCES Ho VB, Fitz CR, Yoder CC, Geyer CA. Resolving MR features in osmotic myelinolysis (central pontine and extrapontine myelinolysis). AJNR 1993; 14:163-7. Martin PJ, Young CA. Central pontine myelinolysis: clinical and MRI correlates. Postgrad Med J 1995; 71:430-42. Laaureno R, Karp BI. Myelinolysis after correction of hyponatremia. Ann Intern Med 1997; 126:57-62. McGraw P, Edwards-Brown MK. Reversal of MR findings of central pontine myelinolysis. J Comput Assist Tomogr 1998; 22:989-91. Gregorio L, Sutton CL, Lee DA. Central pontine myelinolysis in a previously healthy 4-year-old child with acute rotavirus gastroenteritis. Pediatrics 1997; 99:738-43. Karp BI, Laureno R. Pontine and extrapontine myelinolysis: a neurologic disorder following rapid correction of hyponatremia. Medicine (Baltimore) 1993; 72:359-73. Korogi Y, Takahashi M, Shinzato J, Sakamoto Y, Mitsuzaki K, Hirai T, et al. MR findings in two presumed cases of mild central pontine myelinolysis. AJNR 1993; 14:651-4. Gocht A, Colmant HJ. Central pontine and extrapontine myelinolysis: a report of 58 cases. Clin Neuropathol 1987; 6:262-70.

19. ? Central Pontine Myelinolysis A medical encycopedia article on the topic central pontine myelinolysis http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

20. Central Pontine Myelinolysis Medical Information central pontine myelinolysis Information from Drugs.com. http://www.drugs.com/enc/central_pontine_myelinolysis.html

Home New Drugs Latest News Drug Interactions ... Forum Drugs.com - prescription drug and medicine information available on over 24,000 approved- medications and pharmaceuticals, including side effects and drug interactions. Log-in Register Advertisement Buy a Link Now Special Offers From our sponsors Categories Diabetes Gastro Center Weight Loss AIDS/HIV ... Sexual Health Advertisement Advanced Search Or click the first letter of a drug name: A B C D ... Z Central pontine myelinolysis Injury Disease Nutrition Poison ... Central nervous system Central pontine myelinolysis Definition Central pontine myelinolysis is nerve damage caused by the destruction of the layer ( myelin sheath ) covering nerve cells in the brainstem (pons). Alternative Names CPM Causes The destruction of the myelin sheath that coats nerve cells prevents signals from being properly conducted within the nerve. This decreases its ability to communicate with other cells. The most common cause of central pontine myelinolysis is a rapid, drastic change in sodium levels in the body. Most commonly, this occurs when someone is being treated for low levels of sodium ( hyponatremia ) and the levels rise too fast. It also can occasionally occur when high levels of sodium in the body (hypernatremia) are corrected too quickly.

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