81. HANFORD BERYLLIUM QUESTIONS AND ANSWERS Am I likely to develop beryllium disease because I worked in one of these Should I take the blood test to see if I have beryllium disease if I ve worked http://www.hanford.gov/safety/beryllium/q&a.htm

HANFORD BERYLLIUM QUESTIONS AND ANSWERS What is beryllium? Are we still using beryllium at Hanford? What about using non-sparking tools? I've heard they contain beryllium. Do they present the same hazard? Do most people who work with beryllium end up with disease? ... Information from National Jewish Medical and Research Center. ( * ) denotes Questions and Answers taken directly from Federal Register 10 CFR 850. What is beryllium? Beryllium is a silver-gray metallic element used as pure metal, in beryllium-copper and other alloys, and as beryllium oxide. In nature, beryllium can be found in compounds in mineral rocks, coal, soil, and volcanic dust. It is processed in soluble and insoluble forms. Beryllium has many applications due to its strength, lightweight, relatively high melting point, corrosion resistance, and good neutron moderation, thermal conductivity and machinability. Beryllium is purified for use in electrical parts, machine parts, ceramics, aircraft parts, nuclear weapons, and mirrors. With its advantages come several serious disadvantages, the most significant of these is the toxicity of beryllium dust, fumes and soluble salts. Are we still using beryllium at Hanford?

82. 09/21/00 Committee On The Judiciary - Rosenman Statement Chronic beryllium disease primarily affects the lungs. Most individuals we have diagnosed with Chronic beryllium disease or sensitization have been http://www.globalsecurity.org/wmd/library/congress/2000_h/rose0921.htm

var zflag_nid="224"; var zflag_cid="85/41/16/1"; var zflag_sid="1"; var zflag_width="728"; var zflag_height="90"; var zflag_sz="14"; Education Jobs Home Loans Travel ... Public Eye var zflag_nid="224"; var zflag_cid="100/69/43/16/1"; var zflag_sid="1"; var zflag_width="120"; var zflag_height="600"; var zflag_sz="8"; Choose: HTML TEXT AOL Weapons of Mass Destruction (WMD) Testimony of Kenneth D. Rosenman, M. D. Regarding Bills on Compensation for Beryllium-Related Illness Before the Subcommittee on Immigration and Claims of the Committee on the Judiciary Kenneth D. Rosenman, M. D. Professor of Medicine Michigan State University Department of Medicine 117 West Fee Hall East Lansing, MI 48824-1316 Rosenman@msu.edu FAX: 517-432-3606 Summary Chronic Beryllium Disease primarily affects the lungs. It is a progressive, potentially fatal disease with few treatment options, that may occur years after beryllium exposure has ended. Among 1,370 individuals tested at two beryllium extraction facilities in Eastern Pennsylvania, 72 (5.3%) people were diagnosed with Chronic Beryllium Disease and 73 (5.3%) were diagnosed with sensitization. Pennsylvania Workers’ Compensation Law precludes filing a workers’ compensation claim more than five years after cessation of exposure. Most individuals we have diagnosed with Chronic Beryllium Disease or sensitization have been precluded from filing by this statute of limitation. Some have been denied medical coverage by their existing health insurance plan because they have a work-related disease. Accordingly, they have been left to fend for themselves to pay their medical bills.

83. Beryllium Exposure: The "Unrecognized Epidemic" There is an unrecognized epidemic of chronic beryllium disease, says one of But he and beryllium disease experts worry that OSHA s delay in setting a http://www.businessweek.com/magazine/content/05_18/b3931048_mz011.htm

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84. Genomics|HuGENet|Fact Sheets|HLA-DPB1 *E69 And Chronic Beryllium Disease HLADPB1 and chronic beryllium disease A HuGE review. Risks of beryllium disease related to work processes at a metal alloy, and oxide production plant http://www.cdc.gov/genomics/hugenet/factsheets/FS_Beryllium.htm

home fact sheets HLA-DPB1 *E69 and Chronic Beryllium Disease PUBLISHED: April 10, 2003 AUTHORS: Ainsley Weston , Kathleen Kreiss, Michael Andrew, Erin McCanlies GENE HLA-DPB1 is located on chromosome 6p12.3 and codes for Human Leukocyte Antigen, a Major Histocompatibility Class II (MHCII) molecule. MHCII molecules are heterodimeric, having a and ß chains, codes for the ß chain. These molecules are responsible for initiation of the immune response through antigen presentation to T cells. PREVALENCE OF GENE VARIANTS There are 103 known variants of HLA-DPB1 Table 1 ). The supratypic marker HLA-DPB1 , coding for glutamic acid at the 69th residue of the mature protein, is found in 34 of those variants. The allelic frequency of the supratypic marker HLA-DPB1 DISEASE BURDEN Chronic Beryllium Disease (CBD) is caused by exposure to beryllium (Be), in the form of particles of BeO, BeF, other Be-salts, Be-metal, or Be-alloy. It has been estimated that approximately 1-12% of workers in the primary industry are immunologically sensitized to beryllium. Of those, 36-100% develop CBD ( ). There is evidence that certain tasks, such as machining which has a relatively high exposure, pose greatest risk of CBD (

85. Genomics|HuGENet|Reviews|HLA-DPB1 And Chronic Beryllium Disease The mission of the Office of Genomics and Disease Prevention is to integrate advances in human genetics into public health research, policy, and programs. http://www.cdc.gov/genomics/hugenet/reviews/beryllium.htm

home reviews HLA-DPB1 and chronic beryllium disease Archived: 9/30/2002 This paper was published with modifications in: Am J of Epidem, 2003; 157:388-398 PubMed ID: 12615603 HLA-DPB1 and Chronic Beryllium Disease by Erin C. McCanlies , Kathleen Kreiss , Michael Andrew and Ainsley Weston Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV. Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV. Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV. Received for publication December 20, 2001; accepted for publication September 30, 2002. Gene Gene Variants Disease Associations ... Medical Literature Search AT-A-GLANCE Abbreviations : Arg, arginine; Asp, aspartic acid; BHWCD, beryllium hypersensitivity without clinical disease; CBD, chronic beryllium disease; CI, confidence interval; Glu, glutamic acid; HLA, human leukocyte antigen; Lys, lysine; OR, odds ratio; TNF-, tumor necrosis factor-. GENE The human leukocyte antigen (HLA) complex comprises closely linked genes located on the short arm of chromosome 6 that include HLA-A -B -C , and - D . The HLA-A -B , and -C loci code for class I molecules. The

86. Eco-USA: Beryllium This condition is called chronic beryllium disease. Both the shortterm, pneumonia-like disease and the chronic beryllium disease can be fatal. http://www.eco-usa.net/toxics/berylium.shtml

ECO-USA SEARCH Toxics Waste Sites ... Animals Habeck Toxics : Beryllium Beryllium Introduction Fate and Transport Exposure Pathways Metabolism ... Health Effects Introduction Beryllium is a hard, grayish element that does not occur naturally. The element does occur as a chemical component of certain rocks, coal and oil, soil, and volcanic dust. Two kinds of mineral rocks, bertrandite and beryl, are mined commercially for the recovery of beryllium. Very pure gem-quality beryl is better known as either aquamarine (blue or blue-green) or emerald (green). Beryllium is also present in a variety of compounds. They do not have any particular smell. There are two types of beryllium compounds, those that dissolve in water and those that do not. Most of the beryllium ore that is mined is converted into alloys (mixtures of metals). Most of these alloys are used in making electrical and electronic parts or as construction materials for machinery and molds for plastics. Pure beryllium metal has applications in nuclear weapons and reactors, aircraft and space vehicle structures and instruments, X-ray machines, and mirrors. Beryllium oxide is also made from beryllium ores and is used to make specialty ceramics for electrical and high-technology applications. Beryllium enters the air, water, and soil as a result of natural and human activities. Emissions from burning coal and oil increase beryllium levels in air. Beryllium enters waterways from the wearing away of rocks and soil. Most of the man-made beryllium that enters waterways comes when industry dumps waste water and when beryllium dust in the air from industrial activities settles over water. Beryllium, as a chemical component, occurs naturally in soil; however, disposal of coal ash, incinerator ash, and industrial wastes may increase the concentration of beryllium in soil.

87. Beryllium Disease Beryllium Support Group support group for chronic beryllium disease EcoIndiana Beryllium Toxicological profile of beryllium, including information on http://www.ability.org.uk/Beryllium_Disease.html

Our Aims Services Stats ... Z Beryllium Disease Beryllium is a toxic substance that can be harmful, depending on the amount and duration of exposure. Fact sheet from the National Jewish Medical and Research Center Beryllium Support Group support group for chronic beryllium disease EcoIndiana Beryllium Toxicological profile of beryllium, including information on environmental fate and transport, exposure pathways, metabolism, and health effects ... Webmaster . Site Design by Ability "see the ability, not the disability" Acknowledgments

88. EPA: Federal Register: Chronic Beryllium Disease Prevention Programs; Worker Saf Chronic beryllium disease Prevention Programs; Worker Safety and Health , Federal Register document. http://www.epa.gov/fedrgstr/EPA-IMPACT/2003/December/Day-08/i30287.htm

Federal Register Environmental Documents Recent Additions Contact Us Print Version Search: EPA Home Federal Register FR Years FR Months ... and Regulations Chronic Beryllium Disease Prevention Programs; Worker Safety and Health rule851.comments@hq.doe.gov noting ``Worker Safety and Health Rule Comments'' in the subject line. Where possible, commenters should identify the specific section to which they are responding. Copies of the public hearing transcripts, written comments received, and any other docket material may be reviewed on the Web site specially established for this proceeding. The Internet Web site is http://www.eh.doe.gov/whs/rulemaking The public hearings for this rulemaking will be held at the following addresses: Arlington, VA (Washington, DC): Marriott Crystal City Hotel, 1999 Jefferson Davis Highway, Arlington, VA 22202. Golden, CO (Denver): DOE National Renewable Energy Laboratory, Visitor Center, Auditorium, 15013 Denver West Parkway, Golden, CO 80401 (I-70, Exit 263, right at top of exit ramp if coming from Denver, left at stop sign, building on right). For more information concerning public participation in this rulemaking proceeding, see section IV of this notice of proposed rulemaking (Public Comment Procedures). FOR FURTHER INFORMATION CONTACT: Jacqueline D. Rogers, U.S. Department of Energy, 1000 Independence Avenue SW., Washington, DC 20585-0270, 301-903-5684, e-mail:

89. EPA - Air Toxics Website - Beryllium Compounds Symptoms of chronic beryllium disease include irritation of the mucous membranes, reduced lung capacity, shortness of breath, fatigue, anorexia, dyspnea, http://www.epa.gov/ttn/atw/hlthef/berylliu.html

Technology Transfer Network Air Toxics Website Contact Us Print Version Search: EPA Home Technology Transfer Network Air Toxics Website Implementation ... TTN Home Beryllium Compounds BERYLLIUM COMPOUNDS (A) Hazard Summary-Created in April 1992; Revised in January 2000 Please Note: The main sources of information for this fact sheet are EPA's Integrated Risk Information System (IRIS) , which contains information on oral chronic toxicity and the RfD and inhalation chronic toxicity and the RfC , and the carcinogenic effects of beryllium including the unit cancer risk for inhalation exposure, EPA's Toxicological Review of Beryllium and Compounds , and the Agency for Toxic Substances and Disease Registry's (ATSDR's) Toxicological Profile for Beryllium Uses Pure beryllium and its metal alloys have applications in electrical components, tools, structural components for aircraft, missiles, and satellites, and other metal-fabricating uses. ( Beryllium is also used in consumer products, such as televisions, calculators, and personal computers. (

90. Haz-Map: Occupational Exposure To Hazardous Agents Comments, Acute beryllium disease has not been seen in the United States since beryllium Chronic beryllium disease (CBD) is a granulomatous interstitial http://hazmap.nlm.nih.gov/cgi-bin/hazmap_generic?tbl=TblDiseases&id=26

91. Chronic Beryllium Disease And Cancer Risk Estimates With Uncertainty For Berylli Chronic beryllium disease and Cancer Risk Estimates with Uncertainty for Beryllium Released to the Air from the Rocky Flats Plant, atmospheric transport http://ehp.niehs.nih.gov/docs/1999/107p731-744mcgavran/abstract.html

Author Keyword Title Full Environmental Health Perspectives EHP ) is a monthly journal of peer-reviewed research and news on the impact of the environment on human health. EHP content is free online and available in print issues through paid subscription. Volume 113, Number 9 September 2005 Environmental Health Perspectives Volume 107, Number 9, September 1999 Chronic Beryllium Disease and Cancer Risk Estimates with Uncertainty for Beryllium Released to the Air from the Rocky Flats Plant Patricia D. McGavran, Arthur S. Rood, and John E. Till Environmental Risk Assessment, Inc., Boise, Idaho, USA K-Spar, Inc., Rigby, Idaho, USA Risk Assessments Corporation, Neeses, South Carolina, USA Abstract . Predicted air concentrations were well below the current reference concentration derived by the EPA for beryllium sensitization. Key words : atmospheric transport modeling, beryllium, chronic beryllium disease, exposure assessment, lung cancer, uncertainty. Environ Health Perspect 107:731-744 (1999). [Online 3 August 1999] http://ehpnet1.niehs.nih.gov/docs/1999/107p731-744mcgavran/ abstract.html

92. Beryllium Disease Expert To Lecture In Mid-Columbia Three Hanford workers have been diagnosed with chronic beryllium disease. He is recognized internationally as an expert on beryllium lung disease and http://www.tri-cityherald.com/news/2001/0115/Story5.html

Front page Sports Business Contact the Herald ... Circulation Tri-City Herald Online exclusive: Sign up to receive the Tri-City Herald Recipe of the Week via email. Search the Tri-City Herald Death notices Job openings at the Herald Special reports Hanford Reach National Monument Snake dams Kennewick Man Hydroplanes Beryllium disease expert to lecture in Mid-Columbia This story was published 1/15/2001 By Annette Cary Herald staff writer Mid-Columbia doctors should be better prepared to treat chronic beryllium disease after this week. It's a respiratory illness caused by exposure to the exotic metal beryllium making nuclear sites such as Hanford one of the relatively few places in the world where it's seen. Consequently, few doctors know much about the disease. However, the Hanford Environmental Health Foundation is bringing the doctor who has written much of the medical literature on the disease to the Tri-Cities this week. "Our goal is to provide as much current information as possible and to establish resources for the local providers," said Dr. William Brady, Hanford medical director. Dr. Lee Newman of Denver will meet with the Benton-Franklin County Medical Society, other health groups, Hanford management, Hanford's Beryllium Awareness Group and concerned Hanford workers and their families Tuesday through Friday. He'll be discussing detection, diagnosis and prevention.

93. Chronic Beryllium Disease Prevention Program which you can see by clicking here. To find out more about the Chronic beryllium disease Prevention Program, visit its web site by clicking here. http://www.oha.doe.gov/beryllium.htm

The Office of Hearings and Appeals Will Handle Dispute Resolution On November 24, 1999, the Secretary of Energy, Bill Richardson, signed a final rule establishing the Chronic Beryllium Disease Prevention Program. The rule creates Part 850 of Title 10 of the Code of Federal Regulations. Under section 850.5, the Office of Hearings and Appeals will resolve disputes that arise under the program. This section appears on page 68906 of the Federal Register notice, which you can see by clicking here To find out more about the Chronic Beryllium Disease Prevention Program, visit its web site by clicking here

94. `Don't Worry About It,' Applicants Told There is no mention that people die from beryllium disease. The first case of beryllium disease at Brush s Tucson plant occurred in 1986. http://www.azstarnet.com/beryllium/0509n04.html

/* You may give each page an identifying name, server, and channel on the next lines. */ var pageName="" var server="" var channel="beryllium" var pageType="static" var pageValue="" var prop1="SN News" var prop2="" var prop3="" var prop4="" var prop5="" var prop6="news" var prop7="local_news" var prop8="" var prop9="" var prop10="" /********* INSERT THE DOMAIN AND PATH TO YOUR CODE BELOW ************/ /********** DO NOT ALTER ANYTHING ELSE BELOW THIS LINE! *************/ var s_code=' ' Please Select a Site: StarNet Calendar Hourly Update Sports Varsity Sports Entertainment Education Health Travel Features Tech Business SN Community Education UA Sports SN Site Map Restaurants Movies Border News Weather Today's Star Front Page Local News Sports Opinion Business Accent All Headlines Classifieds Jobs Real Estate Apartments Autos Funeral notices Sunday, 9 May 1999 `Don't worry about it,' applicants told By Enric Volante and Rhonda Bodfield Sander The Arizona Daily Star For 10 years, Norma Flores told people not to worry about getting chronic beryllium disease. Flores worked at Brush Wellman's Tucson factory, where she recruited people to handle beryllium, a potentially deadly metal.

95. Compartmentalized Immune Response Reflects Clinical Severity Of Beryllium Diseas Although beryllium disease has been associated with a bronchoalveolar lavage (BAL) In beryllium disease patients we correlated the BAL cellular http://ajrccm.atsjournals.org/cgi/content/abstract/150/1/135

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS This Article Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Cited by other online articles PubMed PubMed Citation Articles by Newman, L. S. Articles by King, T. E., Jr Am. J. Respir. Crit. Care Med., Vol 150, No. 1, Jul 1994, 135-142. Compartmentalized immune response reflects clinical severity of beryllium disease LS Newman, C Bobka, B Schumacher, E Daniloff, B Zhen, MM Mroz and TE King Jr Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado. Although beryllium disease has been associated with a bronchoalveolar lavage (BAL) lymphocytosis and T cell-mediated immune response, we do not know if either the BAL cellular profile or the compartmentalized pulmonary response to the antigen reflect the severity of the disease. We studied 110 subjects divided into three groups of subjects: beryllium disease patients (n = 55), beryllium-sensitized patients without disease (n = 8), and

96. ATSDR - ToxFAQs™: Beryllium Fact sheet published by the Agency for Toxic Substances and disease Registry answers the most frequently asked health questions about beryllium. http://www.atsdr.cdc.gov/tfacts4.html

Search Index Home Glossary ... Contact Us CONTENTS Highlights What is beryllium? What happens to beryllium when it enters the environment? How might I be exposed to beryllium? ... Contact Information RELATED RESOURCES Public Health Statement Toxicological Profile A-Z INDEX A B C D ... P Q  R S T U ... V W  X  Y  Z ATSDR RESOURCES ToxFAQs ToxFAQs Public Health Statements Toxicological Profiles ... Division of Toxicology September 2002 for Beryllium Berilio CAS# This fact sheet answers the most frequently asked health questions about beryllium. For more information, you may call the ATSDR Information Center at 1-888-422-8737. This fact sheet is one in a series of summaries about hazardous substances and their health effects. This information is important because this substance may harm you. The effects of exposure to any hazardous substance depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other chemicals are present. HIGHLIGHTS: People working or living near beryllium industries have the greatest potential for exposure to beryllium. Lung damage has been observed in people exposed to high levels of beryllium in the air. About 1-15% of all people occupationally-exposed to beryllium in air become sensitive to beryllium and may develop chronic beryllium disease (CBD), an irreversible and sometimes fatal scarring of the lungs. CBD may be completely asymptomatic or begin with coughing, chest pain, shortness of breath, weakness, and/or fatigue. Beryllium has been found in at least 535 of the 1,613 National Priorities List sites identified by the Environmental Protection Agency (EPA).

97. Groups Warn Of Beryllium Lung Disease CNN http://cnn.com/2001/HEALTH/conditions/09/03/health.metal.reut/index.html

98. Penn Lung Center: Services And Programs - Sarcoidosis & Beryllium-Induced Lung D berylliumInduced Lung disease Penn is internationally recognized as a referral center for the evaluation, diagnosis and treatment of patients with chronic http://www.pennhealth.com/lung/services/sarc.html

Appointments Medical Services Health Information Find a Doctor Search: Overview Services and Programs General Thoracic Surgery Asthma Care ... Health Information Sarcoidosis The University of Pennsylvania Health System has participated in multi-center NIH-sponsored studies in sarcoidosis as well as drug company-sponsored clinical trials. A multidisciplinary approach is taken for patients with chronic sarcoidosis and difficult treatment issues. Patients are offered state-of-the-art diagnostic facilities and cuting-edge treatment options. Beryllium-Induced Lung Disease Penn is internationally recognized as a referral center for the evaluation, diagnosis and treatment of patients with chronic beryllium disease. In addition, our staff is available to assist industry in the development of cost-effective screening programs for beryllium disease, and in the evaluation and treatment of symptomatic workers. Pulmonary Medicine Faculty Milton D. Rossman, MD

99. C&EN: IT'S ELEMENTAL: THE PERIODIC TABLE - BERYLLIUM Seventy years after the discovery that beryllium dust causes disease, The disease can be caused by virtually any form of beryllium dust or fumes, http://pubs.acs.org/cen/80th/beryllium.html

Periodic Table Element Symbols Ac Ag Al Am Ar As At Au B Ba Be Bh Bi Bk Br C Ca Cd Ce Cf Cl Cm Co Cs Cr Cu Db Ds Dy Es Er Eu F Fe Fm Fr Ga Gd Ge H He Hf Hg Ho Hs I In Ir K Kr La Li Lr Lu Md Mg Mn Mo Mt N Na Nb Nd Ne Ni No Np O Os P Pa Pb Pd Pm Po Pr Pt Pu Ra Rb Re Rf Rh Rn Ru S Sb Sc Se Sg Si Sm Sn Sr Ta Tb Tc Te Th Ti Tl Tm U Uub Uuq Uuu V W Xe Y Yb Zn Zr Element Names Actinium Aluminum Americium Antimony Argon Arsenic Astatine Barium Berkelium Beryllium Bismuth Bohrium Boron Bromine Cadmium Calcium Californium Carbon Cerium Cesium Chlorine Chromium Cobalt Copper Curium Darmstadtium+ Dubnium Dysprosium Einsteinium Erbium Europium Fermium Fluorine Francium Gadolinium Gallium Germanium Gold Hafnium Hassium Helium Holmium Hydrogen Indium Iodine Iridium Iron Krypton Lanthanum Lawrencium Lead Lithium Magnesium Manganese Meitnerium Mendelevium Mercury Molybdenum Neodymium Neon Neptunium Nickel Niobium Nitrogen Nobelium Osmium Oxygen Palladium Phosphorus Platinum Plutonium Polonium Potassium Praseodymium Promethium Protactinium Radium Radon Rhenium Rhodium Rubidium Ruthenium Rutherfordium Samarium Scandium Seaborgium Selenium Silicon Silver Sodium Strontium Sulfur Tantalum Technetium Tellerium Terbium Thallium Thorium Thulium Tin Titanium Tungsten Uranium Vanadium Xenon Ytterbium Yttrium Zinc Zirconium Author Names M. Feroze Ahmed

100. Occupational Safety & Health Reporter - Plant Worker With Beryllium-Related Dise beryllium Plant Worker With berylliumRelated disease Is Time-Barred from Suing Former Employers. A former beryllium manufacturing plant employee in http://subscript.bna.com/SAMPLES/osh.nsf/0/a7c24387144669a985256fc00000338f?Open

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