81. Ann Intern Med -- Sign In Page In aplastic anemia, blood does not form, leading to deficiencies of granulocytes In the past 30 years, morbidity and mortality from aplastic anemia have http://www.annals.org/cgi/content/full/135/7/524

Search Annals: Advanced search Home Current Issue Past Issues ... ACP Online This item requires a subscription to Annals of Internal Medicine Online. Please note: PDFs are free 6 months after publication. Full Text Aplastic Anemia: Which Treatment? Abkowitz Ann Intern Med. To view this item, select one of the options below: Sign In User Name Sign in without cookies. Can't get past this page? Help with Cookies. Need to Activate? Password Forgot your user name or password? Purchase Short-Term Access Pay per Article - You may access this article (from the computer you are currently using) for 1 day for US$20.00 Pay for Admission - You may access all content in Annals of Internal Medicine Online (from the computer you are currently using) for 24 hours for US$29.00. Regain Access - You can regain access to a recent Pay per Article or Pay for Admission purchase if your access period has not yet expired. Sign Up Subscribe to the Journal - Subscribe to the print and/or online journal. Article Table of Contents PDF of this article (PDFs free after 6 months) Services Send comment/rapid response letter Notify a friend about this article Alert me when this article is cited Add to Personal Archive ... ACP Search PubMed Articles in PubMed by Author: Abkowitz, J. L.

82. Acquired Aplastic Anemia -- Young 136 (7): 534 -- Annals Of Internal Medicine In aplastic anemia, hematopoiesis fails Blood cell counts are extremely low, The pathophysiology of aplastic anemia is now believed to be http://www.annals.org/cgi/content/abstract/136/7/534

Search Annals: Advanced search Home Current Issue Past Issues ... ACP Online Article Table of Contents Full Text of this article PDF of this article (PDFs free after 6 months) Figures/Tables List Services Send comment/rapid response letter Notify a friend about this article Alert me when this article is cited Add to Personal Archive ... ACP Search PubMed Articles in PubMed by Author: Young, N. S. Related Articles in PubMed PubMed Citation PubMed UPDATE Acquired Aplastic Anemia Neal S. Young, MD In aplastic anemia, hematopoiesis fails: Blood cell counts are extremely low, and the bone marrow appears empty. The pathophysiology of aplastic anemia is now believed to be immune-mediated, with active destruction of blood-forming cells by lymphocytes. The aberrant immune response may be triggered by environmental exposures, such as to chemicals and drugs or viral infections and, perhaps, endogenous antigens generated by genetically altered bone marrow cells. In patients with post-hepatitis aplastic anemia, antibodies to the known hepatitis viruses are absent; the unknown infectious agent may be more common in developing countries, where aplastic

83. Aplastic Anemia - Cambridge University Press Stem cell defect in aplastic anemia JCW Marsh and NG Testa; 2. Interrelation between aplastic anemia and paroxysmal nocturnal hemoglobinuria G. Socié, http://www.cambridge.org/uk/catalogue/catalogue.asp?isbn=0511036256

84. Aplastic Anemia - Cambridge University Press The first book on aplastic anemia to have such an emphasis on treatment Stem cell defect in aplastic anemia JCW Marsh and NG Testa; 2. http://www.cambridge.org/catalogue/catalogue.asp?isbn=0511036256

85. Aplastic Anemia: BC Cancer Agency Reviewed 26 July 2005 General Information aplastic anemia and MDS International Foundation http://www.bccancer.bc.ca/PPI/RecommendedLinks/CancerRelatedWebsites/AplasticAne

Agency Links: Home Contact Us Legal Privacy ... Cancer Websites Aplastic Anemia Recommended Links Cancer Websites General Cancer Websites Advocacy ... After Cancer Aplastic Anemia Beauty Breast Clinical Trials Colorectal ... Waldenstrom's Macroglobulinemia Cancer Websites - Aplastic Anemia Print Wizard Print this Page Reviewed: 26 July 2005 General Information Aplastic Anemia and MDS International Foundation Print Wizard Print this Page The BC Cancer Agency is a part of the Provincial Health Services Authority If you notice a problem with this page, please report it via the Bug Report Form . Thank you. Unofficial document if printed . Please refer to the following web address for up-to-date information:

86. Secondary Aplastic Anemia Alternative Names. Anemia secondary aplastic; Acquired aplastic anemia. Causes. Secondary aplastic anemia results from injury to stem cells. http://www.lifespan.org/ADAM/English/HIE/000529.htm

Careers at Lifespan Volunteer your time Other ways to give Lifespan's A - Z Health Information Library Injury Disease Nutrition Poison ... Prevention Secondary aplastic anemia Definition Secondary aplastic anemia is a failure of the bone marrow to form enough blood cells. All blood cell types are affected. Alternative Names Anemia - secondary aplastic; Acquired aplastic anemia Causes Secondary aplastic anemia results from injury to stem cells. Normal stem cells divide and differentiate into all blood cell types. Thus, when stem cells are injured, there is a reduction in red blood cells, white blood cells, and platelets. This condition can be caused by chemotherapy, drug therapy to suppress the immune system, radiation therapy, toxins such as benzene or arsenic, drugs, pregnancy, and congenital disorders. When the cause is unknown, it is then referred to as idiopathic aplastic anemia The disease may be acute or chronic and is usually gets worse unless the cause is removed. Bone marrow aspiration Blood types Review Date: 5/6/2003 Reviewed By: Ezra E. W. Cohen, M.D., Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL. Review provided by VeriMed Healthcare Network.

87. LII - Results For "aplastic Anemia" aplastic anemia MDS International Foundation, Inc. The first week in December is National aplastic anemia Awareness Week, and this Web site has http://www.lii.org/advanced?searchtype=subject;query=Aplastic anemia;subsearch=A

88. Congenital Aplastic Anemia Caused By Mutations In The SBDS Gene: A Rare Presenta aplastic anemia was diagnosed at birth for a first child from healthy Key Words aplastic anemia • hematology • genotype • congenital • bone marrow http://pediatrics.aappublications.org/cgi/content/abstract/114/3/e387

QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: PEDIATRICS Vol. 114 No. 3 September 2004, pp. e387-e391 (doi:10.1542/peds.2003-0651-F) This Article Full Text Full Text (PDF) P ... Citation Map Services E-mail this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Kuijpers, T. W. Articles by Hennekam, R. C. M. Related Collections ELECTRONIC ARTICLE Congenital Aplastic Anemia Caused by Mutations in the SBDS Gene: A Rare Presentation of Shwachman-Diamond Syndrome Clinical Findings. Aplastic anemia was diagnosed at birth for a first child from healthy nonconsanguineous parents. The girl had hypoglycemia, which normalized within 2 months. Cow milk allergy was suspected initially, because of skin lesions and diarrhea, followed by severe growth retardation. Clinical and radiologic symptoms gradually became typical for Shwachman-Diamond syndrome. Two common mutations in the

89. ATE Responses One of the younger female members of my family has aplastic anemia Ed. Is there any connection that has been documented between aplastic anemia and any http://www.mdausa.org/experts/question.cfm?id=2145

90. Kailee Wells, And I Have Aplastic Anemia (Very Severe Aplastic Anemia). I Need A Hi, I m Kailee Wells, and I have aplastic anemia (Very Severe aplastic anemia). My family and doctors are searching for a bone marrow donor for me because I http://www.kaileegetwells.com/

Dear Friends – As you may know, I was diagnosed with Severe Aplastic Anemia in January of 2002. I had just turned 5 years old. Since then, I have had every possible medical treatment for this disease, including several different rounds of profound immune-suppression. My family, doctors and many other people have continuously searched for a matching bone marrow donor for me because a successful bone marrow transplant is my last chance to get rid of this “stupid Aplastic Anemia” once and for all! My parents, with the help of many, many others, have worked with people all over the world to let everyone know about the need for people to become committed potential bone marrow donors. It’s simple. It’s easy. I just know that if people knew that a finger poke is all that is needed to register your marrow, everyone would join the world marrow registry. And please don’t forget to donate blood and platelets as often as you can. I need transfusions every week, and there are thousands of others just like me who depend on the loving kindness of others to live, until we get rid of our diseases. We urge you to join a marrow registry by contacting your local blood center. If you are already a blood donor, ask to register your marrow the next time you give blood. Let every expectant parent know that they can help by donating their baby's umbilical cord free of charge. Help by organizing a bone marrow donor drive where you live and work. Together, we can save thousands of people like me who continue to search and hope for a match.

91. Kailee Wells, And I Have Aplastic Anemia (Very Severe Aplastic Anemia). I Need A Hi, I m Kailee Wells, and I have aplastic anemia (Very Severe aplastic anemia). My family and doctors are searching for a bone marrow donor for me because I http://www.kaileegetwells.com/update.htm

Kailee Home from the Hospital! Photos from the Hospital I love to get messages from people. Please sign my Guestbook! Children's Hospital of Wisconsin, Kailee's Hospital in Milwaukee Dr. David A. Margolis, Kailee's Doctor at Children's Hospital, Milwaukee, WI September 6, 2005 Dear Friends and Family - It looks as though all systems are a go for China. There have been so many obstacles that at times we felt as though this trip with Kailee may not be doable. Everyday a new problem seems to arise, but then, as quickly as I can say "Ah, a new problem..oh well, get to the back of the line, there are fifteen problems ahead of you," two or three on the list are resolved. The lesson for us has been persistence. There always seems to be some other way to solve the problem at hand. Whether the latest hurdle is how to get Kailee healthy enough to travel, how to keep her safe during travel (ie. airplane germs), how to make sure she can have blood and platelet transfusions in China, how to arrange for us to continue as her blood/platelet donor, what to do if she would have a reaction to a blood product, how to avoid problems with food and water, where to stay, how to get a Chinese cell phone, current passports, visas, travel immunizations for an immune compromised child, translation of the new poster, language barriers, time zone differences, etc....there has always been a way to solve the problem. A lesson just as important has been the fact that we have been able to do none of this on our own. Dr. Margolis and his colleagues have been generous with their time in communicating with the Chinese blood bank, the doctors at the hospital in Beijing, the China Marrow Donor Program, the China Red Cross, and with answering our questions.

92. Disease Category Listing (282): Aplastic Anemia CenterWatch Listing of Clinical Research Trials for aplastic anemia. http://www.centerwatch.com/patient/studies/cat282.html

Clinical Trials: Aplastic Anemia New York New York; Columbia-Presbyterian Medical Center Study of standard chemotherapy and radiotherapy before allogeneic stem cell transplantation New York; Columbia-Presbyterian Medical Center Study of transplantation using umbilical cord and placental blood Back to Clinical Trials by Medical Areas Research centers specializing in this illness area Additional resources ... in this illness area This site is run by CenterWatch, a publishing company that focuses on the clinical trials industry. The information provided in this service is designed to help patients find clinical trials that may be of interest to them, and to help patients contact the centers conducting the research. CenterWatch is neither promoting this research nor involved in conducting any of these trials. Trial listing updated: September 7, 2005 at 2:29:56 PM Patient Resources: [ Trial Listing Notification Services Drug Directories About Clinical Research ... Patient Bookstore Professional Resources: [ Research Center Profiles Industry Provider Profiles Industry News Professional Resources ... Professional Bookstore General: [ Search Site Map Your Privacy CW World ... Home This site was developed in association with Illumina Interactive , Boston, MA

93. Aplastic Anemia : Epilepsy.com/Professionals Epilepsy and seizure diagnosis, treatment, and information for Professionals. http://professionals.epilepsy.com/page/hematologic_aplastic_anem.html

Search epilepsy.com/professionals: WHO IS EPILEPSY.COM DONATE PROFESSIONAL FORUM CO-EXISTING DISORDERS ... RESOURCE LIBRARY Aplastic anemia Co-Existing Disorders Hematologic Disorders Aplastic anemia Author: JP Sepkuty and PW Kaplan Total destruction of the hematopoietic elements leads to the clinical entity known as aplastic anemia. Aplastic anemia can arise by several mechanisms—immunologic, infectious, constitutional, idiopathic , and physicochemical. This discussion is limited to chemically mediated aplastic anemia induced by antiepileptic drugs (AEDs). Incidence of aplastic anemia The overall incidence of aplastic anemia is approximately two per million in Europe and Israel, four per 1 million in Bangkok, and higher in rural Thailand. Mortality statistics indicate an equal gender ratio and a preponderance in the elderly, but at referral centers the median age is approximately 25 years. Among patients treated with AEDs, the incidence is higher. A cohort study by Blackburn and coworkers shows the overall rate of blood dyscrasias (including dyscrasias other than aplastic anemia) as 3 to 4 per 100,000 prescriptions over a period of almost 4 years. The authors of the study concluded that the risk of serious hematologic abnormalities with AEDs was very low. (This study was published in 1990, before the introduction of felbamate). Kaufman and coworkers analyzed 31 reported cases of aplastic anemia associated with the taking of felbamate.

94. C-Health : Aplastic Anemia The blood that circulates throughout the body performs a number of critical functions. It delivers oxygen, removes carbon dioxide, http://chealth.canoe.ca/condition_info_details.asp?disease_id=264&rot=4

95. FIRSTConsult - Sdfdsf FIRSTConsult, aplastic anemia (Medical Condition File). Published for medical students and primary healthcare providers by Elsevier. http://www.firstconsult.com/?action=view_article&id=1014695&type=101&bref=1

96. University Of Chicago Comer Children's Hospital: Aplastic Anemia Detailed information on aplastic anemia, including cause, symptom, diagnosis, and treatment. http://www.uchicagokidshospital.org/online-library/content=P02312

@import "/css/style.css"; @import "/css/gs.css"; Home Contact Us Pediatric Specialties Find A Physician ... Blood Disorders Aplastic Anemia What is aplastic anemia? Aplastic anemia occurs when the bone marrow produces too few of all types of blood cells: red cells, white cells, and platelets. A reduced number of red blood cells causes the hemoglobin (a type of protein in the red blood cells that carries oxygen to the tissues of the body) to drop. A reduced number of white blood cells causes the patient to be susceptible to infection. A reduced number of platelets can cause the blood not to clot as easily. What causes aplastic anemia? Aplastic anemia in children has multiple causes. Some of these causes are idiopathic, meaning they occur sporadically for no known reason. Other causes are secondary, resulting from a previous illness or disorder. Nearly 50 to 75 percent of childhood cases of aplastic anemia occur sporadically for no known reason. Acquired causes, however, may include: history of specific infectious diseases such as hepatitis, Epstein-Barr virus (EBV), cytomegalovirus (CMV), parvovirus B19, or human immunodeficiency virus (HIV) history of taking certain medications exposure to certain toxins such as heavy metals exposure to radiation history of an autoimmune disease such as lupus Children may also inherit a disorder that predisposes them to developing aplastic anemia. Some disorders that are known to predispose a child to aplastic anemia include the following:

97. Acquired Aplastic Anemia Acquired aplastic anemia is a rare disorder caused by profound, almost complete bone marrow failure. Bone marrow is the spongy substance found in the center http://www.bchealthguide.org/kbase/nord/nord83.htm

var hwPrint=1;var hwDocHWID="nord83";var hwDocTitle="Acquired Aplastic Anemia";var hwRank="1";var hwSectionHWID="nord83-Header";var hwSource="en-caQ2_05";var hwDocType="Nord"; National Organization for Rare Disorders, Inc. Acquired Aplastic Anemia Important It is possible that the main title of the report Acquired Aplastic Anemia is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Idiopathic Aplastic Anemia Disorder Subdivisions None General Discussion Resources P.O. Box 613 Annapolis, MD 21404-0613 USA Tel: 4108670242 Fax: 4108670240 Tel: 8007472820 Email: help@aamds.org Internet: http://www.aamds.org Earl J. Goldberg Aplastic Anemia Foundation P.O. Box1324 North Brook, IL 60065 Tel: (847)559-0688 Internet: http://www.ejgaaf.org NIH/National Heart, Lung and Blood Institute 31 Center Drive MSC 2480 Building 31A Rm 4A16 Bethesda, MD 20892-2480 Tel: (301)592-8573 Fax: (301)480-4907 Email: nhlbiinfo@rover.nhlbi.nih.gov Internet: http://www.nhlbi.nih.gov/

98. University Of Chicago Hospitals: Aplastic Anemia Detailed information on aplastic anemia, including cause, symptom, diagnosis, and treatment. http://www.uchospitals.edu/online-library/library.html?content=P00075

99. Aplastic Anemia aplastic anemia disease summary. aplastic anemia is a rare, noncontagious and often life-threatening disorder that results from the unexplained failure http://www.stjude.org/disease-summaries/0,2557,449_2168_7837,00.html

@import url(/StJude/CDA/Common/CSS/default.css); @import url(/StJude/CDA/Common/CSS/default_lists.css); @import url(/StJude/CDA/Common/CSS/default_content_types.css); @import url(/StJude/Common/CSS/St_Jude_Clinical_Science); In order for our site to display correctly you will need a newer version of your web browser. The following browsers support numerous web standards including CSS, XHTML, and the DOM (a universal means of controlling the behavior of web pages): v7 or higher (all platforms), Mozilla FireFox (Windows), Camino (Mac OS X), Galeon (Linux GNOME Desktop) or other browser stemming from the Mozilla.org project. Opera v7 or higher (Windows, Linux) Apple's Safari (Mac OS X) Konqueror (Linux KDE Desktop) Microsoft Internet Explorer v6 or higher (Windows) or v5 or higher (Macintosh) St. Jude Children's Research Hospital Finding Cures. Saving Children. About St. Jude News Donate Now Contact Us ... Ways to Help Stem Cell BMT Home Clinical Science Home Disease Information Stem Cell BMT Related Topics Ulrike M. Reiss, MD

100. UpToDate Aplastic Anemia: Pathogenesis; Clinical Manifestations; And Diagnosis INTRODUCTION — aplastic anemia is characterized by diminished or absent The designation aplastic anemia is more than 90 years old and is a misnomer http://patients.uptodate.com/topic.asp?file=red_cell/5732

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