41. Echo In Context: Chest Pain Lecture aortic valve disease in the adult Stenosis, sclerosis and Lecture aortic valve disease combined with Ischemic or mitral disease When to http://www.echoincontext.com/2003_video.asp

LEARN MORE: Anatomy Surgery Prosthesis Contrast ... HOME TELECONFRENCES The Changing Left Ventricle Aortic Valve Disease: New Dimensions in Evaluation and Management Heart Failure: Echo's Role in and Emerging Health Crisis Mitral Regurgitation: New Concept ... Changing the Outcome of Coronary Artery Disease ECHO GRAND ROUNDS Digital Integration LEARN THE BASICS Echocardiography Doppler Echo VIDEO ARCHIVES Chest Pain in Children and Adults Mitral Regurgitation: New Concepts Diastolic and Systolic Function Changing the Outcome of CAD BROADCAST SUPPLEMENTS 2000 MV 2001 Chest Pain 2002 Heart Failure Introduction Aortic Valve Disease: Setting the Stage (4 min) Real Player Windows Media Part I: Etiology and current therapy Lecture Aortic valve disease in the adult: Stenosis, sclerosis and atherosclerosis (8 min) Real Player Windows Media Lecture: Aortic valve disease in the young: Congenital lesions (6 min) Real Player Windows Media Case Studies (11 min) Real Player Windows Media Anatomy for Imaging (10 min) Real Player Windows Media Lecture: Aortic valve replacement: The option of minimally invasive (6 min) Real Player Windows Media Part II: Functional Evaluation Aortic Gradient (4 min) Real Player Windows Media Patient Demo: Gradient in a patient (2 min) Real Player Windows Media Aortic Valve Area (4 min) Real Player Windows Media Patient Demo: AoVA in a patient (3 min) Real Player Windows Media Stress Testing in AS (4 min)

42. Wisconsin Heart ? Treatment Of Heart And Vascular Disease - Aortic Valve Diseas When aortic valve disease is present, the valve no longer opens or closes A person with aortic valve disease may initially experience no symptoms or http://www.wiheart.cardiologydomain.com/handler.cfm?event=practice,template&cpid

43. The Health Library — Cardiovascular (Jump to Overviews Valve Repair Replacement aortic valve disease Mitral Valve Disease Pulmonary Valve Disease Tricuspid Valve Disease ) http://healthlibrary.stanford.edu/resources/internet/bodysystems/cardio_valve.ht

Diseases and Disorders Use these links to jump directly to your topic of interest in Cardiovascular: Heart Diseases: Angina Arrhythmia Congenital Heart Disease Coronary Artery Disease ... Other Heart Diseases Vascular Diseases: Aneurysms Aortic Diseases Hypertension (High Blood Pressure) Hypotension (Low Blood Pressure) ... Venous Diseases Cardiovascular Disease Treatment: Medication Surgery Heart Transplantation Other Topics: General Cardiovascular Anatomy Cholesterol Diagnostic Procedures ... Homocysteine Heart Valve Diseases (Jump to: Overviews Aortic Valve Disease Mitral Valve Disease Pulmonary Valve Disease ... Tricuspid Valve Disease Overviews Valve Disease:Texas Heart Institute Valve Disease:Cleveland Clinic Heart Center Heart Valve Diseases: MedlinePlus See also Congenital Heart Disease Aortic Valve Disease Diseases of the Aortic Valve:Texas Heart Institute Aortic Valve Calcification (Sclerosis): Mayo Clinic Aortic Valve Regurgitation:WebMD Aortic Valve Stenosis:WebMD Mitral Valve Disease Diseases of the Mitral Valve:Texas Heart Institute Mitral Valve Prolapse: What You Should Know: American Academy of Family Physicians Mitral Valve Prolapse: A Patient Guide:Heart Information Network Mitral Valve Prolapse:Cleveland Clinic Heart Center ... Mitral Valve Stenosis:WebMD Pulmonary Valve Disease Diseases of the Pulmonary Valve:Texas Heart Institute Pulmonary Stenosis:Merck Manual Tricuspid Valve Disease Diseases of the Tricuspid Valve:Texas Heart Institute Tricuspid Valve Disease:Cleveland Clinic Heart Center Tricuspid Regurgitation:Merck Manual Tricuspid Stenosis:Merck Manual Heart Valve Repair and Replacement

44. Surgery Cures Aortic Valve Disease Dr. Paul Donohue — . Surgery cures aortic valve disease Dear BM The aortic valve prevents blood from leaking back into the heart after it has been http://www.heraldtribune.com/apps/pbcs.dll/article?AID=/20041028/COLUMNIST82/410

45. Access To Articles : Nature Nine affected family members had aortic valve disease (Fig. 1b,g). Figure 1 NOTCH1 mutations segregate with familial aortic valve disease. http://www.nature.com/nature/journal/vaop/ncurrent/full/nature03940.html

Accessibility statement Jump to main content Jump to main navigation Jump to search ... ABOUT NPG E-MAIL: PASSWORD Save password Forgotten password? MY ACCOUNT E-ALERTS SUBSCRIBE ... REGISTER Text to search for Advanced search Journal home Subscribe now! ACCESS Most users gain access to full text articles through a site license. This is available to institutional customers only. For further information visit the Librarian Gateway. Full-text articles are also available through a number of other options: I want to purchase this article Select this option to view this article immediately and access it for seven days. Price: US$30* In order to purchase this article you must be a registered user. Click here to register or log in above. I want to subscribe to Nature Select this option to purchase a personal subscription. I am already a personal subscriber to Nature Personal subscribers to Nature can view this article. To do this you need to associate your subscription with your registration via the My Account page. If you already have an active online subscription log in via the login box in the top right-hand corner of this page. You can request the document from a number of document delivery services: British Library Document Supply Centre CISTI Canadian Institute for Scientific and Technical Information Infotrieve Thomson ISI Document Delivery You can also request the document from your local library through interlibrary loan services.

46. Figure 1 | Mutations In NOTCH1 Cause Aortic Valve Disease : Nature NOTCH1 mutations segregate with familial aortic valve disease. From the following article. Mutations in NOTCH1 cause aortic valve disease http://www.nature.com/nature/journal/vaop/ncurrent/fig_tab/nature03940_F1.html

Accessibility statement Jump to main content Help Nature.com site index ... ABOUT NPG Nature Journal home Archive Letters to Nature Full text Figure 1 FIGURE 1. mutations segregate with familial aortic valve disease. From the following article: Mutations in cause aortic valve disease Vidu Garg, Alecia N. Muth, Joshua F. Ransom, Marie K. Schluterman, Robert Barnes, Isabelle N. King, Paul D. Grossfeld and Deepak Srivastava Nature doi BACK TO ARTICLE a , Kindred with five generations (indicated with Roman numerals) affected by congenital heart disease and valve calcification. Participating members of each generation are indicated numerically. Deceased family members (slash) were unavailable for mutation analysis. Squares, males; circles, females. b , Cardiac phenotype in affected family members. AI, aortic insufficiency; AS, aortic stenosis; AV, aortic valve; BAV, bicuspid aortic valve; TOF, tetralogy of Fallot; VSD, ventricular septal defect. c , Sequence chromatogram of affected family members. d , Kindred with three members affected by congenital heart disease. e , Cardiac phenotype of family B. DORV, double-outlet right ventricle; HLV, hypoplastic left ventricle; MA, mitral atresia; MS, mitral stenosis.

47. UWTV Program: Valve Replacement: Aortic Valve Disease Valve Replacement aortic valve disease The University of Washington Regional Heart Center presents patient case studies focusing on valve replacement. http://www.uwtv.org/programs/displayevent.asp?rid=1288

48. Heart Valve Replacment Calcific aortic valve disease. The most common acquired lesion in the practice cardiac medicine is calcific aortic valve disease with aortic stenosis. http://www.womensheartfoundation.org/content/HeartSurgery/heart_valve_replacment

Valve Surgery Options Introduction Approximately 70,000 heart valve replacement procedures are performed annually in the United States for conditions ranging from Mitral Valve Stenosis resulting from rheumatic fever, Mitral Regurgitation from "floppy" valves, and Calcified Aortic Stenosis encountered in large numbers of aging patients, particularly elderly women. Mitral Valve Stenosis Mitral valve stenosis occurs predominantly in women. The reasons for this are unknown but it has been documented in virtually every clinical series about the disease since the turn of the century. The incidence of rheumatic disease has markedly decreased in the United States due to better prophylaxis treatment of streptococcal infections with the use of antibiotics. Paradoxically, the treatment of mitral valve stenosis may be increasing. The reasons are related to immigration and the incidence of rheumatic heart disease in third-world countries. Immigrants from southeast Asia and South and Central America currently comprise a large number of patients in the United States with rheumatic heart disease. Mitral Regurgitation Mitral valve regurgitation (also referred to as mitral valve prolapse or MVP) follows a very different path for a woman versus a man. The condition of mitral valve prolapse is commonly diagnosed in young females yet the incidence in elderly women decreases markedly. Conversely, there is a fairly consistent incidence of mitral prolapse in the male population at both young and old age. Recent studies have indicated that, for men, the incidence of mitral prolapse requiring surgical intervention is higher than for women and it increases with age (Wilcken DEL, HickeyAJ Liftime: Risk for patients with mitral valve prolapse of developing severe valve regurgitation requiring surgery.

49. Cardiac Surgery In The Adult -- Collected Resources : Valve Disease Part IVa Valvular Heart Disease aortic valve disease Pathophysiology of aortic valve disease Tomislav Mihaljevic, Subroto Paul, Lawrence H. Cohn, http://cardiacsurgery.ctsnetbooks.org/cgi/collection/valve_disease?ck=nck

50. Florida State University College Of Medicine Digital Library Miscellaneous aortic valve disease Patient/Family Resources. MedlinePlus (National Library of Medicine) Health Topics Index. Heart Valve Diseases List of http://fsumed-dl.slis.ua.edu/patientinfo/cardiology/valvular/aorticvalvedisease.

Patient/Family Resources by Topic: Cardiovascular Disorders Aortic Valve Disease Patient/Family Resources Spanish Miscellaneous See also: Aortic Stenosis Patient/Family Resources General Cardiovascular Disorders Patient/Family Resources Aortic Valve Disease Clinical Resources MD Consult: Homepage Medical Library subscription INFO Patient Handouts Table of content Aortic Valve Stenosis: Access document Image American Heart Association: Homepage Heart and Stroke A-Z Guide: Table of contents Aortic Regurgitation: Access document Congenital Heart Disease: Access document MedlinePlus and the Patient Education Institute: Homepage Interactive Health Tutorials: Table of contents Heart Valve Replacement: List of documents MedlinePlus Medical Encyclopedia: Table of contents Aortic Stenosis: English Spanish Aortic Insufficiency: English Spanish Aortic Arch Syndrome: English Spanish Merck Manual - Second Home Edition Table of contents Section 3. Heart and Blood Vessel Disorders: Table of contents Chapter 28. Heart Valve Disorders Topics: Table of contents Introduction: Access document Aortic Regurgitation: Access document Aortic Stenosis: Access document Spanish MedlinePlus Medical Encyclopedia: Table of contents Aortic Stenosis: English Spanish Aortic Insufficiency: English Spanish Aortic Arch Syndrome: English Spanish Miscellaneous Aortic Valve Disease Patient/Family Resources MedlinePlus (National Library of Medicine) Health Topics: Index Heart Valve Diseases: List of documents YAHOO - Health:Diseases and Conditions:Heart Diseases Additional Cardiology resources (

51. Northwestern Memorial Hospital - Exceptional Care In The Heart Of Chicago aortic valve disease occurs in two basic forms stenosis and regurgitation. If it is determined that surgery is required for aortic valve disease, http://www.nmh.org/nmh/heart/heartvalvedisease/aorticvalve.htm

Home About Us Jobs Directions ... Contact Us Northwestern Memorial Hospital Logo Physician Finder Hospital Guide Health Information Healthcare Professionals Navigation Exceptional Care in the Heart of Chicago About Us Bluhm Cardiovascular Institute Special Needs Visitor Information Parking Options Clinical Centers Atrial Fibrillation Coronary Disease Heart Failure Heart Valve Disease ... Women's Cardiovascular Health Specialists Cardiac Behavioral Medicine Cardiovascular Anethesiologists Cardiovascular Radiologists Cardiologists ... Vascular Surgeons Latest News In the News Viewpoint Innovations Cardiovascular Support Groups ... Cardiovascular Institute Center for Heart Valve Disease Aortic Valve The Center for Heart Valve Disease has a multidisciplinary team to diagnose and treat aortic valve disease. The team includes cardiac surgeons, cardiologists and cardiac nurses with specialized training and experience with valvular disease. The Center uses sophisticated echocardiography and cardiac magnetic resonance imaging techniques to assess both the aortic valve and overall heart function to accurately qualify and quantify the extent of aortic valve disease so that optimal strategies for management can be formulated.

52. Ross Pulmonary Autograft For Aortic Valve Replacement 1996;8(4)328335. Chambers JC, Somerville J, Stone S, Ross DN. Pulmonary autograft procedure for aortic valve disease. Circulation. 1997;96(7)2206-2214. http://www.aetna.com/cpb/data/CPBA0407.html

Document Utilities Home Clinical Policy Bulletins Medical Clinical Policy Bulletins Number: Subject: Ross Pulmonary Autograft for Aortic Valve Replacement Reviewed: July 23, 2004 Important Note Each benefit plan defines which services are covered, which are excluded, and which are subject to dollar caps or other limits. Members and their providers will need to consult the member's benefit plan to determine if there are any exclusions or other benefit limitations applicable to this service or supply. The conclusion that a particular service or supply is medically necessary does not constitute a representation or warranty that this service or supply is covered (i.e., will be paid for by Aetna) for a particular member. The member's benefit plan determines coverage. Some plans exclude coverage for services or supplies that Aetna considers medically necessary. If there is a discrepancy between this policy and a member's plan of benefits, the benefits plan will govern. In addition, coverage may be mandated by applicable legal requirements of a State, the Federal government or CMS for Medicare and Medicaid members. CMS's Coverage Issues Manual can be found on the following website: http://cms.hhs.gov/manuals/pub06pdf/pub06pdf.asp

53. Aortic Valve Disease Definition. aortic valve disease entails damage to, and dysfunction of, the aortic valve, aortic valve disease can be congenital, result from infection, http://ww3.komotv.com/global/story.asp?s=2848775&ClientType=Printable

54. Wockhardt Hospital-Know Your Heart-Valve Disease Mitral valve Disease · aortic valve disease · Multiple Valve disease. Non- Rheumatic. · Mitral Valve Prolapse, Flail Leaflet · Aortic Valve http://www.whhi.com/valve.htm

Valve Disease - Rheumatic - Non- Rheumatic :: Aortic Stenosis :: Aortic Regurgitation Valvular heart disease describes structural or functional abnormalities of single or multiple cardiac valves that results in alteration in blood flow across the valve. According to the causes it can be classified as: Rheumatic Rheumatic origin: Preceded by rheumatic fever Rheumatic fever Is an inflammatory disease, which occurs as a delayed sequel to pharyngeal infection with Beta hemolytic streptococci (Bacteria). This may lead to rheumatic heart disease if not treated properly on time. Rheumatic endocarditis Primarily affects the valve leading to fibrous thickening of the valve leaflets or even calcification leads to stenosis. Mitral and aortic valve commonly involved. Management: Antibiotics-Penicillin is the drug of choice. Salicylates and corticosteroids are also used. Non-Rheumatic Non-rheumatic origin: Caused by congenital malformations, bacterial endocarditis, syphilis etc.

55. Learning Ctr : Ross Procedure : Patient Selection In the advanced stages, aortic valve disease can cause chest pain (angina), fainting during exercise, exertional shortness of breath, or congestive heart http://www.hsforum.com/stories/storyReader$1473

Learning Center Home Journal Select Issue... Vol 8 / Issue 4 Vol 8 / Issue 3 Vol 8 / Issue 2 Vol 8 / Issue 1 Vol 7 / Issue 6 Vol 7 / Issue 5 Vol 7 / Issue 4 Vol 7 / Issue 3 Vol 7 / Issue 2 Vol 7 / Issue 1 Vol 6 / Issue 6 Vol 6 / Issue 5 Vol 6 / Issue 4 Vol 6 / Issue 3 Vol 6 / Supp 1 Vol 6 / Issue 2 Vol 6 / Issue 1 Vol 5 / Issue 4 Vol 5 / Issue 3 Vol 5 / Supp 4 Vol 5 / Supp 3 Vol 5 / Supp 2 Vol 5 / Issue 2 Vol 5 / Supp 1 Vol 5 / Issue 1 Vol 4 / Issue 4 Vol 4 / Issue 3 Vol 4 / Issue 2 Vol 4 / Issue 1 Vol 4 / Supp 1 Vol 3 / Issue 4 Vol 3 / Issue 3 Vol 3 / Issue 2 Vol 3 / Issue 1 Vol 2 / Issue 4 Vol 2 / Issue 3 Vol 2 / Issue 2 Vol 2 / Issue 1 Vol 1 / Issue 2 Vol 1 / Issue 1 Subscribe Search Discussion Forums Read Discussions Join Multimedia Meeting Highlights Lecture Presentations Surgical Video Library Private Lecture Series ... Audio Interviews Resources Medline Learning Center New Tech Center Meetings ... Editorial Board Sponsors More Sponsors Site News Sign up for our newsletter: Ross Procedure Sections: Introduction History Anatomy Patient Selection ... Pediatric Ross Patient Selection Not every patient is a candidate for the Ross procedure. The surgeons goal is to wed the proper valve substitute to the patient according to the anatomy and physiology that best suits that particular situation. Surgical judgement is needed to decide when the benefits of the autotransplant operation outweigh the potential disadvantages. For a further discussion on the advantages and disadvantages, please review the section on

56. Congenital Ross Procedure rather than the normal three, is another cause of aortic valve disease. When aortic valve disease is suspected, your doctor will order an ECHOCARDIOGRAM http://heart.amc.edu/ross_procedure.htm

Congenital Heart Program Main The Congenital Heart Program, Albany Medical Center Ross Procedure Sir Donald Ross in England first described the Ross procedure in 1966. Since that time, the Ross procedure has been performed thousands of times in adult and pediatric patients worldwide with excellent results. The Ross procedure is generally performed for young adults and children with aortic valve disease. The aortic valve may require replacement due to aortic valve stenosis (narrowing) or aortic valve incompetence (leaking). The causes of aortic valve failure are many. The causes include endocarditis (infection of the valve) or other infections, such as rheumatic fever. Congenital (present from birth) defects, such as a bicuspid aortic valve where the valve has two leaflets rather than the normal three, is another cause of aortic valve disease. The Ross procedure is one of many options for the treatment of aortic valve disease. Your cardiologist and surgeon will discuss with you the best procedure for you or your child. Each option has its own strengths and weaknesses. The one to chose is individualized to each patient depending on lifestyle, age, associated medical conditions, and a number of other factors. The Ross procedure involves using the patient's own pulmonary valve as a replacement for his or her diseased aortic valve (see ILLUSTRATION). During the procedure, the patient's pulmonary valve is harvested and then sewn into the aortic position after removing the diseased aortic valve. The pulmonary valve is used because it is a similar size to the aortic valve, it has the potential to grow when used in children (which artificial valves cannot do), and it is well suited to the high pressures in the aorta. A homograft (human cadaver) valve is then used to replace the patient's valve in the lower pressure pulmonary artery system.

57. Newswise Mutations in NOTCH1 Gene Cause aortic valve disease. Libraries Science News, Keywords aortic valve disease HEART DEFECT HEART DISEASE MUTATIONS NOTCH1 GENE http://www.newswise.com/articles/view/513172/

Username: Password: forgotten login how to register ABOUT NEWSWISE Overview of Services ... How to Register Source: UT Southwestern Medical Center Released: Fri 15-Jul-2005, 14:00 ET Embargo expired: Sun 17-Jul-2005, 13:00 ET Printer-friendly Version Mutations in NOTCH1 Gene Cause Aortic Valve Disease Libraries Science News Keywords AORTIC VALVE DISEASE HEART DEFECT HEART DISEASE MUTATIONS NOTCH1 GENE Contact Information Available for logged-in reporters only Description By studying five generations of a Dallas family, UT Southwestern Medical Center researchers have discovered that a mutation in a key gene causes aortic valve disease, a common heart birth defect as well as a major contributor to adult heart disease. In the study, available in the online edition of the journal Nature , researchers scanned the DNA of 11 members of a family that was affected with aortic heart disease. The patients ranged from children with severe narrowing of the aortic valve to 50- and 60-year-olds who had such severe calcium buildup on their heart valves that they required replacement valves. The UT Southwestern researchers found that all the relatives with some manifestation of aortic valve disease had a mutation in a gene called NOTCH1.

58. Aortic Valve Disease An aortic valve disorder usually does not cause any symptoms in its early stages. Infection on an abnormal aortic valve leads to a disease called infective http://heart-disease.health-cares.net/aortic-valve-disease.php

59. Log In Problems Summary of the natural history and pathophysiology of aortic stenosis and regurgitation, surgical indications, and the advantages and disadvantages of http://www.medscape.com/viewarticle/466235

Unable to Deliver Requested Page In order to use Medscape, your browser must be set to accept cookies delivered by the Medscape site. To find out how to adjust your browser settings to accept cookies, please click here Medscape uses cookies to customize the site based on the information we collect at registration. The cookies contain no personally identifiable information and have no effect once you leave the Medscape site. You can read more about our use of cookies in our About Medscape Help WebMD Health

60. Log In Problems Many patients requiring coronary artery bypass graft (CABG) surgery will have concurrent mild or moderate aortic stenosis (AS) or aortic insufficiency (AI). http://www.medscape.com/viewarticle/417257

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