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         Antiphospholipid Syndrome:     more books (36)
  1. Positive Options for Antiphospholipid Syndrome (APS): Self-Help and Treatment by Triona Holden, 2003-03
  2. Hughes Syndrome: Antiphospholipid Syndrome
  3. Antiphospholipid Syndrome in Systemic Autoimmune Diseases, Volume 10 (Handbook of Systemic Autoimmune Diseases)
  4. The Antiphospholipid Syndrome II: Autoimmune Thrombosis (Pt. 2)
  5. The Antiphospholipid Syndrome by Ronald A. Asherson, Ricard Cervera, et all 1996-08-05
  6. Antiphospholipid Syndrome - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by ICON Health Publications, 2004-08-31
  7. Hughes Syndrome: Patients' Guide by Graham Hughes, 2001-04-02
  8. Antiphospholipid Thrombosis Syndromes, An Issue of Hematology/Oncology Clinics (The Clinics: Internal Medicine) by Roger L. Bick MDPhDFACP, William Baker, 2008-02-19
  9. Clinical Approach to Antiphospholipid Antibodies
  10. Dermatoses are often the first sign of APS.(Dermatology)(Antiphospholipid syndrome): An article from: Internal Medicine News by Jeff Evans, 2004-12-01
  11. Dermatoses are often the first sign of APS.(Dermatology)(Antiphospholipid syndrome): An article from: Internal Medicine News by Jeff Evans, 2004-12-01
  12. Catastrophic antiphospholipid syndrome
  13. Criteria for antiphospholipid syndrome revised.(Rheumatology): An article from: Internal Medicine News by Nancy Walsh, 2006-06-01
  14. Lifelong anticoagulant Tx warranted for APS.(Cardiovascular Medicine)(antiphospholipid syndrome): An article from: Internal Medicine News by Jeff Evans, 2004-10-01

81. Study Posting (3739) -- Trial #70481, Antiphospholipid Syndrome, Chicago, IL
CenterWatch Clinical Research Trial Posting for Research study for Antiphospholipid Antibody Syndrome (APS).
http://www.centerwatch.com/patient/studies/stu70481.html
Trial Information
Summary: Research study for Antiphospholipid Antibody Syndrome (APS).
Antiphospholipid antibody syndrome (APS) is a medical problem that is associated with health risks for the pregnant mother and her baby. The University of Chicago and Dr. Mary Stephenson are conducting a clinical study to further clarify the best doses of heparin that are advisable for use in treating this problem in pregnancy. While heparin has been shown to improve pregnancy success in women with APS, there has been limited research on how heparins are handled by the body during pregnancy. The evaluation of the body’s handling of a drug is called pharmacokinetics. Participants will be allowed to choose whether they wish to be treated with unfractionated heparin (UFH) or low molecular weight heparin (LMWH). The only study procedure beyond the care that is routinely provided includes 12-13 hour visits to the University of Chicago’s General Clinical Research Center once prior to pregnancy, once during each trimester and once after delivery. During these study visits, a small amount of blood will be drawn at specific times to measure the effect of the heparin over time. Dr. Stephenson and her research staff will monitor the pregnancy closely during the first trimester. The patient will then be transferred back to the referring physician for the remainder of the pregnancy.

82. Antiphospholipid Syndrome (APS): Laboratory Evaluation
antiphospholipid syndrome (APS) Laboratory Evaluation. APS is a risk factor for arterial and/or venous thromboembolic disease and pregnancy morbidity
http://www.medicine.uiowa.edu/Path_Handbook/Appendix/AnatomicPath/aps.html
Antiphospholipid Syndrome (APS): Laboratory Evaluation APS is a risk factor for arterial and/or venous thromboembolic disease and pregnancy morbidity (recurrent fetal loss, severe preeclampsia, and eclampsia). APS may be present in 12-30% of cases of systemic lupus erythematosus. The diagnostic criteria for APS were defined an international consensus conference (Sapporo, 1998). The laboratory criteria for APS are repeatable positive tests at moderate to high levels at least six weeks apart for either: Cardiolipin Antibody, IgG and IgM,Serum Cardiolipin Antibody, IgG,Serum Cardiolipin Antibody, IgM, Serum Lupus Anticoagulant, Citrated Whole Blood Although there is often concordance between ACL and LA, this is not always present. The rationale for requiring repeatable positive tests is to avoid potential false positives secondary to infectious disease since ACL may be induced by a variety of infectious agents, most notably syphilis. Infection-induced ACL are not associated with APS. They are directed at phospholipids alone while APS-associated ACL are also directed at the phospholipid binding protein called Beta-2-Glycoprotein I (B-2-GPI). For this reason, reagents for ACL testing include a source of B-2-GPI. Beta-2 Glycoprotein I Antibodies, IgG and IgM, Serum

83. Nursing: Managing Antiphospholipid Syndrome
Full text of the article, Managing antiphospholipid syndrome from Nursing, a publication in the field of Health Fitness, is provided free of charge by
http://www.findarticles.com/p/articles/mi_qa3689/is_200403/ai_n9405274
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ABNF Journal, The AIDS Treatment News AMAA Journal ... View all titles in this topic Hot New Articles by Topic Automotive Sports Top Articles Ever by Topic Automotive Sports Managing antiphospholipid syndrome Nursing Mar 2004 by Pullen, Richard L Jr Cannon, Jan Rushing, Jill
Save a personal copy of this article and quickly find it again with Furl.net. It's free! Save it. Review the puzzling pathophysiology and learn what you can do to help your patient ward off complications. By Richard L. Pullen, Jr., RN, EDD; Jan Cannon, RN, MSN; and Jill Rushing, RN, MSN Fighting fat isn't always a good thing, especially when phospholipid, a fat molecule in cell membranes, is under attack. Antiphospholipid syndrome (APS) is an autoimmune disorder that occurs when the immune system recognizes phospholipid as foreign and produces abnormal antibodies that react with it. Someone with APS can develop life-threatening complications in any organ. The diagnosis of APS is based on clinical signs and the presence of antiphospholipid antibodies in the patient's blood. The mnemonic CLOT summarizes the most common signs:

84. American Family Physician: A Discussion Of The Antiphospholipid Syndrome
The term antiphospholipid syndrome originally described the clinical association The criteria for diagnosis of antiphospholipid syndrome and the
http://www.findarticles.com/p/articles/mi_m3225/is_11_65/ai_87027928
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ABNF Journal, The AIDS Treatment News AMAA Journal ... View all titles in this topic Hot New Articles by Topic Automotive Sports Top Articles Ever by Topic Automotive Sports A Discussion of the Antiphospholipid Syndrome American Family Physician June 1, 2002 by Bill Zepf
Save a personal copy of this article and quickly find it again with Furl.net. It's free! Save it. The term "antiphospholipid syndrome" originally described the clinical association between antiphospholipid antibodies and a syndrome of hypercoagulability. The criteria for diagnosis of antiphospholipid syndrome and the terminology of the disease have evolved over the years as the relevant pathophysiology and immunology have become better understood. Levine and colleagues discuss antiphospholipid syndrome, an uncommon (but not rare) disease with serious risks of arterial and venous thrombosis as well as recurrent pregnancy loss. The most recent international consensus criteria for diagnosing antiphospholipid syndrome require the presence of a clinical and a laboratory marker of the syndrome before a definitive diagnosis can be made. The most sensitive laboratory test for antiphospholipid syndrome is the presence of anticardiolipin antibodies; however, lupus anticoagulant is a more specific sign. In large studies, as many as 5 percent of healthy control subjects have at least one of the autoantibodies associated with antiphospholipid syndrome. Most of these persons never develop any thrombotic or obstetric complications. Anti-b2-glycoprotein I autoantibodies are another class of autoantibodies strongly associated with the syndrome, but they are not presently included in the consensus criteria.

85. Antiphospholipid Syndrome (Hughes Syndrome) APS Thromboses
antiphospholipid syndrome (Hughes syndrome) Acupuncture and APS thromboses antiphospholipid syndrome chinese Herbal Medicine Centre body s immune system
http://www.geocities.com/mastertole/Hughes.html

86. Platelet-Endothelial Interactions: Sepsis, HIT, And Antiphospholipid Syndrome --
Molecular pathogenesis of the antiphospholipid syndrome. Circ Res. 2002;9029–37. Tissue factor pathway and the antiphospholipid syndrome. J Autoimmun.
http://www.asheducationbook.org/cgi/content/full/2003/1/497
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The American Society of Hematology
Platelet-Endothelial Interactions: Sepsis, HIT, and Antiphospholipid Syndrome
Theodore E. Warkentin William C. Aird and Jacob H. Rand Abstract Acquired abnormalities in platelets, endothelium, and their interaction occur in sepsis, immune heparin-induced thrombocytopenia (HIT), and the antiphospholipid syndrome. Although of distinct pathogeneses, these three disorders have several clinical features in common, including thrombocytopenia and the potential for life- and limb-threatening thrombotic events, ranging from microvascular arterial. In Section I, Dr. William Aird reviews basic aspects of endothelial-platelet interactions as a springboard to considering the common problem of thrombocytopenia (and its mechanism) in sepsis. The relationship

87. Nature Clinical Practice Gastroenterology & Hepatology | Bleeding Gastric Varice
Bleeding gastric varices and antiphospholipid syndrome antiphospholipid syndrome, gastric varices, nodular regenerative hyperplasia. Top of page
http://www.nature.com/ncpgasthep/journal/v2/n3/full/ncpgasthep0110.html
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Bleeding gastric varices and antiphospholipid syndrome
Daniel R Gaya*, Karin A Oien, Adrian J Stanley and Allan J Morris Correspondence
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danielgaya@aol.com Background A 35-year-old woman with a past history of antiphospholipid syndrome and near-fatal vascular thrombosis was transferred to Glasgow Royal Infirmary, UK, for investigation of 'obscure' gastrointestinal bleeding in the context of long-term oral anticoagulation therapy. Initial endoscopic examination revealed isolated gastric varices with stigmata of recent hemorrhage. She had no prior history of liver disease or portal hypertension. Investigations to ascertain the cause of her varices were performed. Investigations CT venography, endoscopic ultrasound and transjugular liver biopsy.

88. HOME Information About The Antiphospholipid Syndrome Purpose Of
Information about the antiphospholipid syndrome Purpose of Registry How the Registry Works Registry for the antiphospholipid syndrome
http://www.slrapls.org/
HOME Information about the Antiphospholipid Syndrome Purpose of Registry How the Registry Works Questionnaires ... Contact Us Registry for the Antiphospholipid Syndrome COORDINATING CENTER Oklahoma Medical Research Foundation
Oklahoma City, Oklahoma COLLABORATING STAFF Hospital for Joint Diseases
New York, New York COORDINATING STAFF Principal Investigator: Joan T. Merrill, M.D. Registry Administrator: Ranit C. Shriky Statistician: Swapan Nath, Ph.D. Data Manager: Paul Kamp Registry Coordinators: Fredonna Carthen
Angelique Shriky
Mary Franco
Roberta Lee, L.P.N.
Yen Yen DeLaCruz
Claudine Davis Laboratory Research Staff: Hongwei Zhang, M.D.
Kathleen O'Brien
Stan Kamp REGISTRY ADVISORY BOARD Jill P. Buyon, M.D.
Hospital for Joint Diseases, New York, N.Y. Peter Gregersen, M.D. North Shore University Hospital, Manhasset, N.Y. Bevra H. Hahn, M.D. University of California, Los Angeles, CA. John B. Harley, M.D., Ph.D. Oklahoma Medical Research Foundation, Oklahoma City, OK Robert G. Lahita, M.D., Ph.D. St. Vincent's Medical Center, New York, N.Y.

89. PharmGKB: Antiphospholipid Syndrome
Antibody Syndrome, Antiphospholipid; Antiphospholipid Antibody Syndrome; Antiphospholipid Antibody Syndromes; Syndrome, AntiPhospholipid; Syndrome,
http://www.pharmgkb.org/do/serve?objId=PA446375&objCls=Disease

90. Hughes Syndrome-Springer Internal Medicine Book
Osteoarticular Manifestations of antiphospholipid syndrome antiphospholipid syndrome in the Absence of Standard Antiphospholipid Antibodies
http://www.springeronline.com/sgw/cda/frontpage/0,11855,4-10069-22-48266163-deta
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91. BioMed Central | Abstract | Primary Versus Secondary Antiphospholipid Syndrome:
Primary Versus Secondary antiphospholipid syndrome Is This Lupus or Not? antiphospholipid syndrome is a hypercoaguable state characterized by recurrent
http://www.biomedcentral.com/1523-3774/6/445/abstract
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Primary Versus Secondary Antiphospholipid Syndrome: Is This Lupus or Not?
Jennifer M Grossman MD
Division of Rheumatology Department of Medicine, 1000 Veteran Ave Room 32-59 UCLA, Geffen School of Medicine UCLA, Los Angeles, CA, 90095, USA
Current Rheumatology Reports
Published
Abstract Antiphospholipid syndrome is a hypercoaguable state characterized by recurrent venous and/or arterial thrombosis and/or pregnancy complications of fetal loss, pre-eclampsia, or eclampsia in the presence of antiphospholipid antibodies. It was first described in the setting of systemic lupus erythematosus and subsequently recognized to also exist as an independent condition and in conjunction with a variety of other autoimmune, infectious, and malignant illnesses. These diseases have been called primary antiphospholipid syndrome and secondary antiphospholipid syndrome. However, the two conditions can have significant overlapping features. This paper reviews the similarities and the differences between the two conditions. Terms and Conditions Privacy statement Information for advertisers Contact us

92. NEJM -- Sign In
Review Article from The New England Journal of Medicine The antiphospholipid syndrome.
http://content.nejm.org/cgi/content/full/346/10/752

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93. NEJM -- The Antiphospholipid Syndrome
Review Article from The New England Journal of Medicine The antiphospholipid syndrome.
http://content.nejm.org/cgi/content/short/346/10/752
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Previous Volume 346:752-763 March 7, 2002 Number 10 Next The Antiphospholipid Syndrome
Jerrold S. Levine, M.D., D. Ware Branch, M.D., and Joyce Rauch, Ph.D. Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.
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Antiphospholipid antibodies are a family of autoantibodies that exhibit a broad range of target specificities and affinities, all recognizing various combinations of phospholipids, phospholipid-binding proteins, or both. The term "antiphospholipid syndrome" was first coined to denote the clinical association between antiphospholipid antibodies and a syndrome of hypercoagulability. Revision of the criteria for diagnosis of the antiphospholipid syndrome and the terminology used to describe the disease is an ongoing process (Table 1). View this table:
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Table 1.

94. OB-GYN-L Messages For December, 1995: Antiphospholipid Syndrome?
Maybe reply Danny Tucker Re antiphospholipid syndrome? Maybe reply dahmd@gate.net Re antiphospholipid syndrome?
http://forums.obgyn.net/ob-gyn-l/OBGYNL.9512/0436.html
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Antiphospholipid Syndrome?
From: Gary Kaufman gkaufman@bu.edu
Thu Dec 28 21:12:45 1995
Given the positive ACL, fetal losses, thrombocytopenia and thrombosis it seems like antiphospholipid sydrome is a safe bet. Recommendations regarding long term therapy - SQ heparin at 12,000 units bid? Role of low molecular weight heparin, prednisone, asa? Thanks, - Gary Kaufman MD Boston City Hospital, Boston MA gkaufman@bu.edu GKAUFMAN@BU.EDU

95. 5th Tübinger Seminar: SLE And Lupus-Nephritis
W. Habscheid The antiphospholipid syndrome. (Nieren Hochdruckkrh 1995 (24) 672 677). Antiphospholipid antibodies can be detected in laboratory by
http://www.uni-tuebingen.de/uni/kmp/tusem5_e.htm
SLE and Lupus-Nephritis
T. Witte, R.E. Schmidt: Pathophysiology and immunology of SLE
(Nieren Hochdruckkrh 1995 (24) 666 - 667). The cause of SLE is unclear. Twin studies showed a genetical influence on the pathogenesis of the disease. Rare defects of several complement components leading ton a prolonged clearance of immune complexes can cause SLE-like syndromes. Fcgamma receptors, that also participate in the clearance of immune complexes, may play a role in the pathogenesis of SLE. The rate of CD32-"high responders" is increased among SLE patients. The Fcgamma receptor III (CD16) is expressed on activated mesangial cells of the kidney. It mediates release of cytokines after binding of immune complexes and may therefore participate to the pathogenesis of lupus nephritis. A recently published family study on the pathogenesis of lupus could mark HLA-B7-DR2 and HLA-B8-DR3 as risk haplotypes, however, no "SLE gene" was defined.
Keywords: SLE - lupus - pathogenesis - Fc receptors.
J. G. Saal, S. Koch, F.P. Fischer: Joint, tendon and bone manifestations of systemic lupus erythematosus
(Nieren Hochdruckkrh 1995 (24) 668 - 671). Involvement of joints in systemic lupus erythematosus (SLE) is one of the earliest and most frequent manifestations of the disease. This has been shown by retrospective analysis of 71 consecutive SLE patients at our institution where 61 % or 78 % of the patients presented with arthritis at onset or during the course of the disease. respectively. These figures correspond quite well with similar studies reported in the literature.

96. Antiphospholipid Syndrome Profile
antiphospholipid syndrome Profile. Number. 250555. CPT. 85613; 85732; 86147 (x2). Test Includes. Anticardiolipin antibodies, IgG, quantitative;
http://www.labcorp.com/datasets/labcorp/html/chapter/mono/se032300.htm
Antiphospholipid Syndrome Profile Number CPT Test Includes Anticardiolipin antibodies, IgG, quantitative; anticardiolipin antibodies, IgM, quantitative; lupus anticoagulant Specimen Serum and frozen plasma Volume 1 mL serum and one plasma tube Container Red-stopper tube or serum-separator tube and blue-stopper (sodium citrate plasma) tube Collection When specimen is collected for multiple tests, the order of draw is 1) sterile culture tubes, 2) nonadditive (red-stopper) tubes, 3) coagulation (sodium citrate [blue-stopper] tubes), 4) serum-separator tubes, and 5) other additive (EDTA [lavender-stopper], heparin [green-stopper], etc) tubes. If only coagulation tests are being drawn, draw 5 mL into another tube, discard, and then collect coagulation tests. This collection procedure eliminates contamination of the specimen with tissue thromboplastins and cross-contamination from additives such as heparin and EDTA. Collect nine parts whole blood to one part 3.2% sodium citrate using plastic collection material, or draw one blue-stopper (sodium citrate) tube until the vacuum is depleted to ensure a 9:1 ratio. Centrifuge immediately at 3500 rpm for 15 minutes. Carefully remove the plasma, aliquot 2 mL of plasma into a plastic transport tube, and freeze immediately. If hematocrit (Hct) is >55%, use the following formula to calculate the volume of anticoagulant required for 5 mL of anticoagulated blood: X = (100-Hct) / (595-Hct). X is the volume of anticoagulant required to prepare unit volume of anticoagulated blood. Carefully remove the plasma from cells without disturbing the cells. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

97. Sao Paulo Medical Journal -
CONTEXT Patients with antiphospholipid syndrome and alloimmunity have poor After antiphospholipid syndrome and alloimmune failure were diagnosed,
http://www.scielo.br/scielo.php?pid=S1516-31802003000600006&script=sci_arttext&t

98. Immune System Diseases
Agammaglobulinemia Anaphylaxis - antiphospholipid syndrome - Ataxia Telangiectasia About Antiphospholipid Antibody Syndrome - Univ of Illinois
http://www.mic.ki.se/Diseases/C20.html
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Diseases and Disorders Links pertaining to Immune System Diseases Alert! Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider. Start Page Contents: Agammaglobulinemia Anaphylaxis Antiphospholipid Syndrome Ataxia Telangiectasia ... Wiskott-Aldrich Syndrome
Immune System Diseases Immonology [Bowers et al.; educ.] - Univ of South Carolina (US) A 4-pages introduction to The Immune System - Nobel Foundation Understanding the Immune System - NCI/NIH (US) The Anatomy of the Immune System , and an Immunology Glossary - Univ of Leicester (UK) The Immune System P Bugl ] -Univ of Hartford (US) Basic Immunology [G Heath] - Optometry Today, Feb 2002 (UK) Understanding the Immune System [Schindler et al.] - Cancer.gov (US) Immunobiology. 5th ed. [Janeway et al., 2001; online book] - via PubMed, NLM (US) The Lymphatic System and Immunity [MJ Farabee] An Immunology Study Sheet - Medical Study Guides, Univ of Kansas (US)

99. HighWire -- Browse Journals - Antiphospholipid Syndrome
Browse Journals publishing on antiphospholipid syndrome, (return to Topic Journals focusing on antiphospholipid syndrome (in order by highest focus)
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100. OMIM - ANTIPHOSPHOLIPID SYNDROME

http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=107320

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