61. Introduction antiphospholipid syndrome is characterized by the presence of venous and/or Longterm anticoagulation is recommended for antiphospholipid syndrome http://www.arthritis.org/research/Bulletin/Vol52No3/Introduction.asp

Welcome! Log In Create Profile Search Arthritis.org Keyword advanced search Español Bulletin on the Rheumatic Diseases Research Update ... 2003 Research Conference Summary This publication is made possible by an educational grant from Amgen Inc. and Wyeth Pharmaceuticals. Introduction Epidemiology Immunologic Aspects and Pathogenesis Clinical Manifestations Diagnosis ... Archives Volume 52, Number 3 Antiphospholipid Syndrome Doruk Erkan, MD Michael D. Lockshin, MD Division of Rheumatology Hospital for Special Surgery, Weill Medical College of Cornell University New York, NY Summary Points Antiphospholipid syndrome is characterized by the presence of venous and/or arterial thrombosis and/or pregnancy morbidity and the presence of antiphospholipid antibodies. Long-term anticoagulation is recommended for antiphospholipid syndrome patients with recurrent vascular events. For antiphospholipid syndrome patients with recurrent pregnancy events, aspirin plus heparin is recommended during pregnancy. Introduction Antiphospholipid syndrome (APS) is characterized by vascular thrombosis and/or pregnancy morbidity in the presence of circulating antiphospholipid antibodies (aPL), most commonly anticardiolipin antibodies (aCL), and a positive lupus-anticoagulant test (LAC) (

62. Antiphospholipid Syndrome (aPL) Detailed information on antiphospholipid syndrome in pregnancy. http://www.healthsystem.virginia.edu/uvahealth/peds_hrpregnant/autoapl.cfm

[ Skip Navigation ] Health System Home For Health Answers Healthcare Professionals ... Advanced Search Health System Search Search for Information People UVa Home Health System News Health System Events (all) Health System Publications ... Making a Gift Topics Adolescent Medicine Allergy/Asthma/Immunology Blood Disorders Burns Cancer Common Injuries/Poison Tips Craniofacial Anomalies Dermatology Diabetes/Endo/Metabolism Eye Care Genitourinary/Kidney High-Risk Newborn High-Risk Pregnancy Infectious Diseases Medical Genetics Mental Health Nervous System Disorders Normal Newborns Oral Health Orthopaedics Pediatric Surgery Respiratory Disorders Terminal Illness in Children Transplantation UVa Health Topics A to Z FIND A DOCTOR Adult Congenital Heart and Pregnancy Diabetes and Pregnancy High-Risk Obstetrics ... WHY CHOOSE UVA Search This Site Antiphospholipid Syndrome (aPL) What is antiphospholipid syndrome (aPL)? Antiphospholipid syndrome is an autoimmune disease in which the body produces large amounts of antiphospholipid antibodies. Phospholipids are a special type of fat containing phosphate that makes up the outer walls of the body's cells. Antiphospholipid antibodies attack the phospholipids. This causes many different problems including increased blood clotting. Cardiolipin is one type of phospholipid and specific anticardiolipin antibodies may develop. This disease is about two times more common in women than men. It is generally characterized by the following:

63. The Antiphospholipid Syndrome (Hughes' Syndrome) The antiphospholipid syndrome (APS) is sometimes called sticky blood syndrome . The result is an autoimmune disease, eg antiphospholipid syndrome. http://www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive

// Show bread crumbs navigation path. breadcrumbs('five'); //> From: www.tiscali.co.uk/lifestyle/ Calculators Calorie Counter Diseases Examinations ... Medicines Frames not supported Frames not supported HOTLINKS Health shop Health forum Health amd Nutrition Diseases ... A What is the cause of the antiphospholipid syndrome? What types of antiphospholipid syndrome exist? When only the symptoms of the antiphospholipid syndrome occur, this is known as primary antiphospholipid syndrome. The secondary form occurs in association with another autoimmune disease, usually systemic lupus erythematosus. Both types are more common in women. What are the symptoms of antiphospholipid syndrome? The symptoms relate to abnormal clotting. Most commonly clots can develop in the veins of the legs (deep vein thrombosis), resulting in a swollen, painful leg, with the swelling usually starting in the calf. These clots in the leg may happen once, or several times. Clots may also occur in the lung (pulmonary embolus), sometimes following a clot in the leg, which breaks off and travels in the circulation until it lodges in part of the blood supply to the lung. A clot in the lung may lead to shortness of breath, chest pain made worse by breathing in, or coughing up a small amount of blood. Some clots occur in patients soon after starting on the oral contraceptive pill (oestrogen-containing types).

64. High-Risk Pregnancy - Antiphospholipid Syndrome (aPL) antiphospholipid syndrome (aPL). What is antiphospholipid syndrome (aPL)? antiphospholipid syndrome is an autoimmune disease in which the body produces http://www.musckids.com/health_library/hrpregnant/autoapl.htm

Home About Us Departments Send an e-Card ... Your Hospital Visit 171 Ashley Ave. Charleston, SC 29425 800-424-MUSC Print Version High-Risk Pregnancy Antiphospholipid Syndrome (aPL) What is antiphospholipid syndrome (aPL)? Antiphospholipid syndrome is an autoimmune disease in which the body produces large amounts of antiphospholipid antibodies. Phospholipids are a special type of fat containing phosphate that makes up the outer walls of the body's cells. Antiphospholipid antibodies attack the phospholipids. This causes many different problems including increased blood clotting. Cardiolipin is one type of phospholipid and specific anticardiolipin antibodies may develop. This disease is about two times more common in women than men. It is generally characterized by the following: thrombosis - blood clots in arteries or veins (especially in the legs). Clots in vessels of the central nervous system (brain and spinal cord) can result in stroke. thrombocytopenia - low platelets (cells important in blood clotting).

65. Entrez PubMed antiphospholipid syndrome in pregnancy a randomized, controlled trial of treatment. Farquharson RG, Quenby S, Greaves M. http://www.jexpclinassistreprod.com/pubmed/12220757

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66. MSN Encarta - Dictionary - Antiphospholipid Syndrome antiphospholipid syndrome. an·ti·phos·pho·lip·id syn·drome. noun. Definitions. med Same as Hughes syndrome. Encarta® World English Dictionary North http://encarta.msn.com/dictionary_561536654/antiphospholipid_syndrome.html

MSN Home My MSN Hotmail Shopping ... Sign In Web Search: Encarta Subscriber Sign In Help Home ... > > Click here to search all of MSN Encarta Dictionary Find in Click here to search all of MSN Encarta Dictionary Thesaurus Translations A B ... Print Preview Search for " antiphos... syndrome " in all of MSN Encarta Download the MSN Encarta Right-Click Dictionary antiphospholipid syndrome an·ti·phos·pho·lip·id syn·drome noun Definitions: med Same as Hughes' syndrome More Links from Our Advertisers SAT Prep Distance Learning Education Online Tutoring ... Worldwide Advertisement document.write(' Also on Encarta Compare online degrees Train for a better career College life Encarta word of the day Our Partners Book bargains on MSN Shopping ClassesUSA.com: Compare online degrees CollegeBound Network: ReadySetGo Kaplan Test Prep and Admissions ... The Princeton Review Also on MSN Going Tribal, on Discovery Back-to-school bargains on MSN Shopping Job search guide on MSN Careers MSN Shopping var fSucceed = false; © 2005 Microsoft MSN Privacy Legal Advertise Feedback ... Help

67. HSS - Conditions & Treatments : Antiphospholipid Syndrome Conditions Treatments antiphospholipid syndrome. http://www.hss.edu/Conditions/Antiphospholipid-Syndrome

var pgName = 'Condition Article'; var pgType = 'conditions'; Find a Physician Conditions and Treatments Departments and Services Research Education Giving to HSS About HSS Home / Antiphospholipid Syndrome Antiphospholipid Syndrome Antiphospholipid Syndrome Text Audio Video Clinical Trials PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE) document.write(textIcon('Conditions/Antiphospholipid-Syndrome/Clinical-Trial-22122')); document.write(audioIcon('Conditions/Antiphospholipid-Syndrome/Clinical-Trial-22122','0')); document.write(videoIcon('Conditions/Antiphospholipid-Syndrome/Clinical-Trial-22122','0')); Overview Antiphospholipid Antibody Syndrome - In-Depth Overview document.write(textIcon('Conditions/Antiphospholipid-Syndrome/Antiphospholipid-Antibody-Syndrome')); document.write(audioIcon('Conditions/Antiphospholipid-Syndrome/Antiphospholipid-Antibody-Syndrome','0')); document.write(videoIcon('Conditions/Antiphospholipid-Syndrome/Antiphospholipid-Antibody-Syndrome','0')); Maps and Directions Notice of Privacy Practices HSS Staff Login Contact HSS

68. Antiphospholipid Syndrome (aPL) - Mountain View Bay Area Sunnyvale Cupertino Pal antiphospholipid syndrome (aPL) El Camino Hospital is located in the heart of Silicon Valley at Mountain View, California ,serving Mountain View Bay Area http://www.elcaminohospital.org/12374.cfm

@import url(default.css); @import url(module.css); Home Hospital News Find A Doctor Health Information A-Z ... Back to Search Antiphospholipid Syndrome (aPL) What is antiphospholipid syndrome (aPL)? Antiphospholipid syndrome is an autoimmune disease in which the body produces large amounts of antiphospholipid antibodies. Phospholipids are a special type of fat containing phosphate that makes up the outer walls of the body's cells. Antiphospholipid antibodies attack the phospholipids. This causes many different problems including increased blood clotting. Cardiolipin is one type of phospholipid and specific anticardiolipin antibodies may develop. This disease is about two times more common in women than men. It is generally characterized by the following: thrombosis - blood clots in arteries or veins (especially in the legs). Clots in vessels of the central nervous system (brain and spinal cord) can result in stroke. thrombocytopenia - low platelets (cells important in blood clotting). pregnancy loss (especially repeated losses) Antiphospholipid syndrome was only defined in recent years and is sometimes called Hughes syndrome, or sticky blood syndrome. The disease may occur along with other autoimmune diseases such as systemic lupus erythematosus (SLE, or lupus).

69. Florida State University College Of Medicine Digital Library Chapter 77 Antiphospholipid Antibody Syndrome Access document Additional antiphospholipid syndrome resources (These sites have not been reviewed. http://fsumed-dl.slis.ua.edu/clinical/immunology/autoimmune/antiphospholipid-syn

Clinical Resources by Topic: Immunology Antiphospholipid Syndrome Clinical Resources Emergency Pediatrics Geriatrics Pathology ... Miscellaneous Resources See also: General Immunology Clinical Resources Antiphospholipid Syndrome Patient/Family Resources Hoffman: Hematology: Basic Principles and Practice 4th Ed.-2005 (MD Consult): Table of contents Medical Library subscription INFO Part VIII - Hemostasis and Thrombosis: Access document Chapter 112 - Clinical Evaluation of Hemorrhagic Disorders: The Bleeding History and Differential Diagnosis of Purpura: Access document Introduction: Access document The Bleeding History: Access document Differential Diagnosis of Hemorrhagic Dermatologic Lesions: Access document Nonpurpuric Disorders Simulating Purpura: Access document References: Access document References: Access document Chapter 127 - Hypercoagulable States: Access document Introduction: Access document Clinical Approach: Access document Acquired Thrombotic Disorders: Access document Management: Access document References: Access document References: Access document References: Access document Part X - Consultative Hematology: Access document Chapter 152 - Hematologic Manifestations of Systemic Disease: Infection, Chronic Inflammation, and Cancer:

70. Clinical Trial: Antiphospholipid Syndrome Collaborative Registry (APSCORE) antiphospholipid syndrome (APS) is an autoimmune disorder in which the body The antiphospholipid syndrome Collaborative Registry (APSCORE) is a national http://www.clinicaltrials.gov/ct/show/NCT00076713

Home Search Browse Resources ... About Antiphospholipid Syndrome Collaborative Registry (APSCORE) This study is currently recruiting patients. Verified by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) March 2005 Sponsors and Collaborators: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Center on Minority Health and Health Disparities (NCMHD) Information provided by: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) ClinicalTrials.gov Identifier: Purpose Antiphospholipid Syndrome (APS) is an autoimmune disorder in which the body recognizes certain normal components of blood and/or cell membranes as foreign substances and produces antibodies against them. Patients with these antibodies may experience miscarriages and blood clotting disorders, including heart attacks and strokes. APS may occur in people with systemic lupus erythematosus and other autoimmune diseases, or in otherwise healthy individuals. The Antiphospholipid Syndrome Collaborative Registry (APSCORE) is a national registry and tissue repository for patients with APS. This registry will collect clinical information and blood samples from people with APS.

71. JN 2002; Vol.15 N°4 342-348 ABSTRACT antiphospholipid syndrome is defined by recurrent thrombotic events and antiphospholipid syndrome (APS) is now widely accepted as a systemic http://www.sin-italy.org/jnonline/Vol15N4/342.html

72. Antiphospholipid Syndrome - Patient UK antiphospholipid syndrome Patient UK. A directory of UK health, disease, illness and related medical websites that provide patient information. http://www.patient.co.uk/showdoc/40024537/

PatientPlus articles are written for doctors and so the language can be technical. However, some people find that they add depth to the articles found in the other sections of this website which are written for non-medical people. Antiphospholipid syndrome Synonyms: APS, Lupus anticoagulant, Hughes' syndrome, sticky blood The antiphospholipid syndrome is a disorder with recurrent arterial and venous thrombosis, pregnancy loss and possibly thrombocytopenia . There is lupus anticoagulant (LA), moderate to high levels of anticardiolipin (aCL) or both. It is called primary if there is no clinical or serological evidence of autoimmune disorders. In patients with recognised autoimmune disorders, usually systemic lupus erythematosus, it is called secondary. There is remarkably little clinical or biochemical difference between the two except that those with secondary disease are more likely to have endocarditis, valve disease and haemolytic anaemia Despite the lupus anticoagulant and thrombocytopenia the risk is of thrombosis rather than haemorrhage. Epidemiology Incidence In SLE 35 to 40% have anti-phospholipid antibodies (aPL) but they are found in 1-5% of the healthy population. Anti-cardiolipin antibodies (aCL) occur more frequently in the elderly.

73. Autoimmunity / What Is Autoimmunity? / Autoimmune Diseases / > Antiphospholipid The antiphospholipid syndrome (APS) was first described in the early 1950s Definite antiphospholipid antibody syndrome is considered to be present if at http://www.diagnostics.com/templates/Page____2175.asp

Choose your destination Diagnostics Brazil Diagnostics France Diagnostics Italy Diagnostics Netherlands Diagnostics Norway Diagnostics Spain Diagnostics Sweden Diagnostics Taiwan Diagnostics UK Diagnostics US What is extranet? Company Info Website Info Allergy ... Scientific Services The antiphospholipid syndrome (APS) was first described in the early 1950s in women who were noted to have prolonged bleeding times that were not correctable by addition of normal plasma, history of hypercoagulability, false-positive VDRL, and a history of recurrent pregnancy loss. The lupus anticoagluant and the anticardiolipin antibody were characterized as acquired antibodies. Clinical and serologic criteria for the classification of APS have been proposed on the basis of a study of 667 SLE patients: Classification of Antiphospholipid Syndrome Clinical manifestations: Vascular thrombosis (one or more clinical episodes of arterial, venous, or small vessel thrombosis) Pregnancy morbidity (one or more unexplained deaths of a morphologically normal fetus at or beyond the 10th week of gestation / one or more premature births at or before the 34th week of gestation / three or more unexplained consecutive spontaneous abortion before the 10th week of gestation) Laboratory criteria: Anticardiolipin antibodies (IgG and/or IgM) Lupus anticoagulant Definite antiphospholipid antibody syndrome is considered to be present if at least 1 of the clinical criteria and 1 of the laboratory criteria are met.

74. SupportPath.com: Antiphospholipid Syndrome SupportPath.com leads you to Internet resources for supportrelated information on hundreds of health, personal, and relationship topics. http://www.supportpath.com/sl_a/antiphospholipid_syndrome.htm

Antiphospholipid Syndrome Also called: Hughes Syndrome About Us Add-A-Link Email Gallery ... here Online Communities / Message Boards... None Listed Online Chats... Note: Regularly scheduled chats are listed on our NEW Online Events Calendar Links in this section are primarily to chat rooms open 24/7 which may or may not be moderated. None Listed Usenet Groups... Note: Your browser must be properly configured to access Usenet groups from this site. None Listed Mailing Lists... None Listed National / International Organizations... UNITED KINGDOM Hughes Syndrome Foundation Website: http://www.hughes-syndrome.org/ Description: The aims of this registered charity: To offer understanding and support to sufferers of Hughes Syndrome; To offer information and education on Hughes Syndrome; To support research into the condition; To raise funds to provide information, education and research. Website includes information about Hughes Syndrome (Antiphospholipid Syndrome), research, and information on support groups. Date Added: 08/08/2002 Note: Groups are listed alphabetically by U.S. state and then country.

75. Antiphospholipid Syndrome to be part of the clinical spectrum of SLE but while the 2 syndromes often coexist, SLE is not necessary for the diagnosis of antiphospholipid syndrome http://www.aic.cuhk.edu.hk/web8/anti-phospholipid syndrome.htm

All these topics are covered in the Not so BASIC course. Click here for details Anti-phospholipid syndrome Used to be considered to be part of the clinical spectrum of SLE but while the 2 syndromes often co-exist, SLE is not necessary for the diagnosis of antiphospholipid syndrome Definition There is as yet no agreed definition of APS but the consensus opinion seems to be that the following are required, although they need not be present simultaneously: recurrent thromboembolic events recurrent fetal loss livedo reticularis high titre sustained IgG anticardiolipin antibody or lupus anticoagulant with abnormal PTT . (NB a number of infections can induce anti-phospholipid antibodies eg syphilis, Lyme disease, HIV-1) Clinical syndromes Arterial occlusion syndromes arterial occlusion occurs as discrete episodes usually occurs in single rather than multiple vessels can affect any size of vessel in individual patients the size of vessel and the body area affected is usually consistent from episode to episode eg patients who have had a stroke tend to have recurrent strokes no recognised triggers Brain recurrence rate almost 20% per year small vessel occlusion leading to confusion Kidney modest proteinuria most common clinical manifestation hypertension haematuria and hypocomplementaemia not features renal insufficiency Catastrophic occlusion syndrome rare multiple widespread infarctions over days to weeks may be precipitated by viral infection or allergic reaction leukocytosis

76. UpToDate Antiphospholipid Syndrome And The Kidney INTRODUCTION — The antiphospholipid antibody syndrome (APS) is characterized by antibodies directed against either phospholipids or plasma proteins bound to http://patients.uptodate.com/topic.asp?file=glomrdis/20963

77. UpToDate Patient Information: Blood Clotting Problems Due To Antibodies (antipho In others, a syndrome called the antiphospholipid syndrome (APS) develops. In patients with APS, Pathogenesis of the antiphospholipid antibody syndrome http://patients.uptodate.com/topic.asp?file=arth_rhe/4811

78. Antiphospholipid Syndrome Avcin, T. et al. Recent Advances in antiphospholipid syndrome. Lupus 2002; 114 Blood 1995; 863685; Levine, LS, et al. The antiphospholipid syndrome. http://www.amc.edu/amr/archives/200210/review02.html

Contents Director One Two ... Topic 1 Topic 2 EKG Rad 1 Rad 2 AMR - October Review - Antiphospholipid Syndrome Timothy P. Collins, MD The lupus anticoagulants, anticardiolipin antibodies and anti-beta2 glycoprotein I antibodies are autoimmune antibodies against phospholipids or plasma proteins bound to anionic phospholipids and comprise a clinical paradox of thromboembolic disease called the antiphospholipid syndrome (APS). Classically, it is a reflex lab test ordered as a part of any hypercoagulable work-up. In this review, I hope to simplify this complex autoimmune phenomenon to the basic epidemiology, clinical manifestations, treatment and the diagnostic criteria as recently proposed by the International Consensus and American College of Hematology. It has been reported that antiphospholipid antibodies are found among young, apparently healthy individuals at a prevalence of 1 to 5% for both anticardiolipin antibodies and the lupus anticoagulant (Petri et al.). As with other autoimmune phenomenon, the presence of antiphospholipid antibodies increases with age and with coexistent chronic disease. Not surprisingly, the prevalence of antiphospholipid antibodies is considerably higher in patients with systemic lupus erythematosus (SLE) (Avcin et al.).

79. Men With Lupus And Phospholipid Syndrome although the figure may be higher for antiphospholipid syndrome. Antiphospholipid antibody syndrome consists of recurrent blood clots (such as strokes, http://www.lupusmn.org/Education/Articles/MenwithLupusandPhospholipidSyndrome.ht

Donate Volunteer Press Lupus Foundation of Minnesota The Atrium Suite 135 2626 East 82nd Street Bloomington, MN 55425 Phone Number Email us Proud member of: Support Services Research Education Events About Us Education Back to Education Page Back to Lupus Articles Listing Men With Lupus and Antiphospholipid Syndrome “Why don't they ever write about me?” I have heard that question so often that it might have occurred to me to volunteer to write something myself, but it did not, so Henrietta Aladjem, editor of Lupus World , volunteered me instead. The reasons “they don't write about men are, I think, basically two: 1) thoughtlessness on the part of my colleagues and myself, and 2) there is not a whole lot to say. For the first, I apologize. Sexism, it seems, works in both directions. For the second, most of what is known about male-female differences in lupus or in antiphospholipid syndrome is fairly soft and not very dramatic information. Only about 10% of lupus patients are men, although the figure may be higher for antiphospholipid syndrome. Antiphospholipid antibody syndrome consists of recurrent blood clots (such as strokes, or clots in the veins of the legs) and, in women, recurrent miscarriages, associated with anticardiolipin antibody or lupus anticoagulant. (Together these antibodies are called antiphospholipid antibodies.) The syndrome can occur either by itself (primary) or in patients with lupus (secondary). About one-third of patients with lupus have the antibody, but only one-tenth to one-fifth have the syndrome.

80. Disease Category Listing (542): Antiphospholipid Syndrome CenterWatch Listing of Clinical Research Trials for antiphospholipid syndrome. http://www.centerwatch.com/patient/studies/cat542.html

Clinical Trials: Antiphospholipid Syndrome Illinois Chicago; University of Chicago - Section of Reproductive Endocrinology and Infertility Research study for Antiphospholipid Antibody Syndrome (APS). Chicago; University of Chicago - Section of Reproductive Endocrinology and Infertility The PROMISSE Study New York New York; NYU-Hospital for Joint Diseases The Registry for the Antiphospholipid syndrome Back to Clinical Trials by Medical Areas Research centers specializing in this illness area Additional resources ... in this illness area This site is run by CenterWatch, a publishing company that focuses on the clinical trials industry. The information provided in this service is designed to help patients find clinical trials that may be of interest to them, and to help patients contact the centers conducting the research. CenterWatch is neither promoting this research nor involved in conducting any of these trials. Trial listing updated: September 7, 2005 at 2:44:43 PM Patient Resources: [ Trial Listing Notification Services Drug Directories About Clinical Research ... Patient Bookstore Professional Resources: [ Research Center Profiles Industry Provider Profiles Industry News Professional Resources ... Professional Bookstore General: [ Search Site Map Your Privacy CW World ... Home This site was developed in association with Illumina Interactive , Boston, MA

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