41. TIGC - The Antiphospholipid Syndrome The antiphospholipid syndrome. Principal Developer C. Carter The antiphospholipid syndrome (APS) is increasingly recognized as an important clinical http://www.tigc.org/eguidelines/antiphoslipid04.htm

June 2004 The Antiphospholipid Syndrome Principal Developer: C. Carter Secondary Developers: D. Houston, L. Vickers 1. DEFINITION The antiphospholipid syndrome (APS) is increasingly recognized as an important clinical disorder, but one which has engendered confusion in both its clinical and laboratory aspects. A diagnosis of APS requires the presence of both clinical and laboratory criteria (1,2). Clinical Criteria: Thrombosis arterial venous small vessels Obstetrical complications fetal loss at 10 weeks or later, without apparent fetal abnormalities premature birth (³ 34 weeks) due to pre-eclampsia or placental insufficiency 3 or more consecutive unexplained spontaneous abortions (less than 10 weeks) The manifestations of APS are similar whether the condition is primary, or whether it occurs in the setting of underlying connective tissue disease (e.g. lupus erythematosus) in which case it is referred to as 'secondary' APS. The clinical manifestations associated with APS can be caused by many different underlying disorders. Laboratory evaluation is critical to determine whether a clinical event is attributable to APS in a given patient. Laboratory criteria: Many laboratory tests have been used to detect antiphospholipid antibodies. These fall in two general categories: coagulation assays and antibody binding assays.

42. Elsevier.com - The Antiphospholipid Syndrome II I. History and Epidemiology of the antiphospholipid syndrome (RA Asherson) Management of Thrombosis in the antiphospholipid syndrome (RHWM Derksen et al http://www.elsevier.com/wps/product/cws_home/627679

Home Site map Regional Sites Advanced Product Search ... The Antiphospholipid Syndrome II Book information Product description Author information and services Ordering information Bibliographic and ordering information Conditions of sale Book related information Submit your book proposal Other books in same subject area About Elsevier Select your view THE ANTIPHOSPHOLIPID SYNDROME II Autoimmune Thrombosis http://books.elsevier.com/elsevier/?isbn=0444509879 Edited by R.A. Asherson , Groote Schuur Hospital, Rheumatic Diseases Unit, University of Cape Town School of Medicine, Cape Town, South Africa R. Cervera , Systemic Autoimmune Diseases Unit, Hospital Clinic, Villaroel 170, Barcelona 08036, Spain J.C. Piette Y. Shoenfeld , Chaim Sheba Medical Center, Department of Medicine B, Research Unit of Autoimmune Diseases, Tel-Hashomer 52621, Israel Description This book provides the reader with a comprehensive overview of the Antiphospholipid syndrome. One of the most important advances in rheumatology and connective tissue diseases of the last decade. It provides an explanation for many previously undefined conditions with no clear pathogenesis encompassing all subspeculations in internal medicine as well as obstetrics. Clotting problems leading to strokes and myocardial infarctions (in younger people) as well as a large variety of other syndromes such as chorea, hyproadrenalism, pulmonary problems are now being understood. Contents Preface. Editor biography. List of Contributors.

43. THE CATASTROPHIC ANTIPHOSPHOLIPID SYNDROME (CAPS) Asherson RA, Cervera R. The antiphospholipid syndrome a syndrome in evolution. Catastrophic antiphospholipid syndrome Clinical and laboratory http://www.rheuma21st.com/archives/cutting_asherson_caps.html

Here is the fourth in our "clinical" series of cutting-edge articles which are appearing in Rheuma21st.com in advance of their dissemination in print journals or meetings. THE CATASTROPHIC ANTIPHOSPHOLIPID SYNDROME (CAPS) A Review of 115 Patients and Possible Clues to Pathogenesis and Treatment Reported by RA Asherson, MD, FACP, FCP(SA), FRCP, FACR, Rheumatic Diseases Unit, University of Cape Town School of Medicine and The Groote Schuur Hospital, Cape Town, South Africa Y Shoenfeld, MD, Department of Medicine "B", Chaim Sheba Medical Center, Tel Hashomer, Israel published 27. February 2001 Download As A PDF File : To read and print PDF files, you will need free Adobe Acrobat Reader INTRODUCTION Initial observations of thrombosis occurring in the presence of the lupus anticoagulant (LA) were reported by Bowie et al ( ) in 1963. Two years later, they reported the myriad vascular complications affecting both veins and arteries seen in patients with SLE, including the presence of LA and even a biological false-positive test for syphilis ( ). Many papers published in the 1970s and 1980s have confirmed this association. The occurrence of recurrent miscarriages and the LA had also been documented (

44. BBC - Health - Conditions - Antiphospholipid Syndrome The effects this bloodclotting disorder can have on your health. http://www.bbc.co.uk/health/conditions/antiphospholipid1.shtml

@import url('/includes/tbenh.css') ; Home TV Radio Talk ... A-Z Index THURSDAY 8th September 2005 Text only BBC Homepage Lifestyle Health ... Help Like this page? Send it to a friend! Hughes syndrome (sticky blood or antiphospholipid syndrome) Dr Trisha Macnair We look in detail at the condition that could be responsible for as many as one in five cases of recurrent miscarriage. In this article What is it? Symptoms Causes Who's affected? ... Treatment What is it? Hughes syndrome (or sticky blood syndrome or, more technically, antiphospholipid syndrome) is an important cause of blood clotting problems and accounts for as many as one in five cases of recurrent miscarriage. Hughes syndrome may be to blame in some cases of economy class syndrome It is linked to an increased risk of vein thrombosis, including blood clots in the legs such as deep vein thrombosis (DVT). Hughes syndrome may be to blame in some cases of economy class syndrome, which has lead to the deaths of young people travelling on long-haul flights. There is also a great risk of more dangerous arterial thrombosis, including strokes and heart attacks. One in five cases of stroke in young people (under 45) is associated with Hughes syndrome. (For more information on stroke, contact The Stroke Association ). Others are misdiagnosed as having multiple sclerosis because of similar brain symptoms.

45. Antiphospholipid Syndrome (APS) Disorders often associated with scleroderma include antiphospholipid syndrome. http://www.sclero.org/medical/symptoms/associated/antiphospholipid/a-to-z.html

www.sclero.org So you'd like to learn more about scleroderma? an Amazon guide by Shelley Ensz, ISN President Our site menu requires pop-ups and javascript enabled. About the ISN Join/Donate Languages Medical Scleroderma Experts Symptoms Newsroom Message Board Support Stories Support Groups SWA Sites to Surf!

46. Arthritis Research Campaign | Antiphospholipid Syndrome antiphospholipid syndrome (APS) is a disorder in which the blood has a tendency to clot too quickly ( sticky blood syndrome). http://www.arc.org.uk/about_arth/booklets/6059/6059.htm

scotland + n. ireland north wales + midlands east + southeast ... south + southwest What is antiphospholipid syndrome (APS)? Antiphospholipid syndrome (APS) is a disorder in which the blood has a tendency to clot too quickly ('sticky blood' syndrome). The clotting can affect any vein or artery in the body, resulting in a wide range of symptoms. These are described below. (The medical words in italics are explained in more detail in the Glossary at the end of the booklet.) History of APS Most of the early work leading to the detailed description of APS was carried out in the early 1980s by Dr Graham Hughes and his colleagues while studying a disease called lupus (see arc booklet ' Lupus '). In lupus the immune system goes into 'overdrive' and produces a huge variety of excess antibodies . While studying lupus it became clear that some patients had a tendency to form blood clots in arteries and veins. This clotting was associated with a particular antibody which 'attacks' phospholipids antiphospholipid antibodies . It was discovered that the syndrome could exist in people without lupus. This is now known as APS or primary antiphospholipid syndrome. What are the main signs and symptoms?

47. Antiphospholipid Syndrome Some autoantibodies in the antiphospholipid syndrome also interfere with The spectrum of the antiphospholipid syndrome allows for the stratification of http://www.medical-journals.com/r03239.htm

UK Europe Asia Editorials Online™ ... Home NEJM Editorial Volume 349:1177-1179 September 18, 2003 Number 12 Treatment of the Antiphospholipid Syndrome Michael D. Lockshin, M.D., and Doruk Erkan, M.D. Two decades after the presence of anticardiolipin antibodies and a syndrome of spontaneous thrombosis and fetal death were linked, and after the publication of approximately 3500 reports in which the term "antiphospholipid syndrome" has been used, we still lack scientifically robust, evidence-based rules for the treatment of the antiphospholipid syndrome. This failure is due in part to a lack of well-designed prospective studies and in part to the clinical complexity of the syndrome. The complexity stems in part from the fact that the antiphospholipid syndrome actually comprises two syndromes, one that is not associated with another illness (primary antiphospholipid syndrome), and another that entails the additional burden of systemic lupus erythematosus or other rheumatic disease (secondary antiphospholipid syndrome; in up to one third of patients with lupus, the antiphospholipid

48. New Registry Will Benefit Patients With Antiphospholipid Syndrome (APS) Patients with antiphospholipid syndrome (APS) will benefit from a new national registry and tissue repository sponsored by the National Institute of http://www.niams.nih.gov/ne/press/2001/04_19.htm

En español Highlights Osteoarthritis Initiative Press Releases ... Reports Press Releases By Year NATIONAL INSTITUTES OF HEALTH National Institute of Arthritis and Musculoskeletal and Skin Diseases FOR IMMEDIATE RELEASE Thursday, April 19, 2001 Contact: Judith Wortman Office of Communications and Public Liaison niamsinfo@mail.nih.gov New Registry Will Benefit Patients with Antiphospholipid Syndrome (APS) Patients with antiphospholipid syndrome (APS) will benefit from a new national registry and tissue repository sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the National Center on Minority Health and Health Disparities (NCMHD). The coordinating center will reside at the University of North Carolina, Chapel Hill (UNC). APS is an autoimmune disorder in which the body appears to recognize certain phospholipids (fatty molecules that are important components of a cell's membrane) as foreign substances and produces antibodies against them. People with APS may experience blood clots leading to heart attack, stroke or loss of the fetus during pregnancy. APS may occur in patients with lupus and related autoimmune diseases or as a primary syndrome in otherwise healthy individuals. Biomedical researchers at eight medical centers will collect and update clinical, demographic and laboratory information from patients with APS and make it available to researchers and to medical practitioners concerned with the diagnosis and treatment of this syndrome. According to Stephen I. Katz, M.D., Ph.D., NIAMS director, "The availability of this information will permit better comparisons among clinical research projects and help rheumatologists, obstetricians and other physicians resolve problems associated with the many manifestations of the syndrome."

49. Virtual Hospital: University Of Iowa Family Practice Handbook, Fourth Edition: R antiphospholipid syndrome (APS) is a disorder characterized by recurrent venous or arterial thrombosis, recurrent fetal loss, and thrombocytopenia http://www.vh.org/adult/provider/familymedicine/FPHandbook/Chapter07/14-7.html

University of Iowa Family Practice Handbook, Fourth Edition, Chapter 7 Rheumatology: Antiphospholipid Syndrome David C. Krupp, MD and Mark A. Graber, MD Departments of Family Medicine and Emergency Medicine University of Iowa Hospitals and Clinics and College of Medicine Peer Review Status: Externally Peer Reviewed by Mosby General . Antiphospholipid syndrome (APS) is a disorder characterized by recurrent venous or arterial thrombosis, recurrent fetal loss, and thrombocytopenia associated with the presence of lupus anticoagulant or anticardiolipin antibody, or both. The female-to-male ratio is 2:1. May occur as a manifestation of lupus or may occur as an isolated, discrete syndrome. Anticardiolipin and antiphospholipid are essentially interchangeable terms. Depending on the assay used to detect them, they cross-react. Several subtypes that do not cross-react have been identified but are currently of little clinical significance. Clinical Features Pregnancy loss . Obstetric complications include recurrent fetal loss, often but not always in the late second or third trimester, severe pre-eclampsia, premature delivery, chorea gravidarum, and intrauterine growth retardation. Patients may also have "postpartum syndrome," which is manifested by pleuropericarditis and fever.

50. Antiphospholipid Syndrome: Information From Answers.com antiphospholipid syndrome What is the antiphospholipid syndrome? The antiphospholipid syndrome is a disorder of the immune system that is. http://www.answers.com/topic/antiphospholipid-syndrome

showHide_TellMeAbout2('false'); Business Entertainment Games Health ... More... On this page: Diagnosis Wikipedia Mentioned In Or search: - The Web - Images - News - Blogs - Shopping antiphospholipid syndrome Diagnosis Antiphospholipid Syndrome What is the antiphospholipid syndrome? The antiphospholipid syndrome is a disorder of the immune system that is characterized by excessive clotting of blood and/or certain complications of pregnancy (premature miscarriages, unexplained fetal death, or premature birth) and antiphospholipid antibodies (cardiolipin or lupus anticoagulant antibodies). Patients with antiphospholipid syndrome have developed abnormal symptoms while having antiphospholipid antibodies detectable in the blood. Antiphospholipid syndrome is also called the phospholipid antibody syndrome. Antiphospholipid syndrome has been referred to as Hughes syndrome in honor of the doctor who first described it. It is important to note that antiphospholipid antibodies can also be found in the blood of individuals without any disease process. In fact, antiphospholipid antibodies have been reported in approximately 2 percent of the normal population. Harmless antiphospholipid antibodies can be detected in the blood for a brief period occasionally in association with a wide variety of conditions, including bacterial, viral (hepatitis, HIV), and parasite (malaria) infections. Certain drugs can cause antiphospholipid antibodies to be produced in the blood, including antibiotics, cocaine, hydralazine

51. Arthritis: Catastrophic Antiphospholipid Syndrome (CAPS) Catastrophic antiphospholipid syndrome clinical and laboratory features of 50 patients. Catastrophic antiphospholipid syndrome Response to repeated http://www.thedoctorwillseeyounow.com/articles/arthritis/caps_9/

IN THIS ARTICLE What is it? Symptoms Treatment Too much Vitamin A from meat and dairy products can weaken the bones of the elderly. more... OTHER TOPICS SLE Fibromyalgia Sepsis Catastrophic Antiphospholipid Syndrome (CAPS) Juan Javier Lichauco, M.D., Jayashree Sinha, M.D., , and Peter Barland, M.D. Drs. Lichauco and Sinha are Fellows in Rheumatology, Department of Medicine, Montefiore Medical Center and the Albert Einstein College of Medicine, New York. Drs. Lichauco, Sinha and Barland report no commercial conflicts of interest. A young woman is brought to the hospital with a frightening array of problems, any one of which could be fatal. Her kidneys and heart are barely functioning. She is having difficulty breathing and her skin is covered with purplish blotches. On top of all this, she seems mentally confused and may have had a stroke. At first, the doctors are stumped. Fearing some kind of virulent infection or poisoning, which might have caused these symptoms, they give the young woman antibiotics and dialysis treatment to aid her failing kidneys. Unfortunately, in this woman's case, the cause was neither infection nor poisoning but, instead, a rare and mysterious illness called CAPS, catastrophic antiphospholipid antibody syndrome. What Is It?

52. Antiphospholipid Syndrome,Antiphospholipid Antibody Syndrome,APLS antiphospholipid syndrome,Antiphospholipid Antibody Syndrome,APLS,APS,antiphospholipid syndrome,Antiphospholipid Antibody Syndrome,APLS,APS. http://www.icomm.ca/geneinfo/antiphos.htm

53. Antiphospholipid Syndrome & MS The antiphospholipid syndrome and Multiple Sclerosis (MS) or atypical MS in the clinical spectrum covered by the antiphospholipid syndrome (APS). http://www.infotech.demon.co.uk/MS.htm

The Antiphospholipid Syndrome and "Multiple Sclerosis" Dr. Graham R.V. Hughes, MD FRCP Head of Lupus Research Unit The Rayne Institute St. Thomas' Hospital, London SE1 7EH (First printed in: LUPUS (1999), Volume 8 Number 2 (Full references have been omitted and the reader should refer to the above journal or to Stockton Press The issue of "Lupus" includes a further study embracing "multiple sclerosis" (MS) or "atypical MS" in the clinical spectrum covered by the antiphospholipid syndrome (APS). As IJdo et al (1998) pointed out in their paper, "with increasing utilisation of MRI studies, there has been a marked increased incidence in the misdiagnosis of MS in the American population". An observation which can probably be applied elsewhere. One of the different diagnosis of MS is APS. from the first clinical descriptions, it was obvious that neurological features were both frequent and protean. Spinal cord involvement has included Guillain-Barre syndrome and transverse myelitis. Anecdotally, most clinicians dealing with APS or lupus with APS have seen patients initally labelled as "probable MS". Certainly the ischaemic changes produced by the APS in the white matter may be indistinguishable on MRI from those of MS. Conversely, it may be that some patients with "true" MS occasionally exhibit anticardiolipin (aCL) antibodies. Fukazawa et al (1993) found that 2 out of 38 patients with definite MS had positive aCL titres. Both of these patients had optic neuritis and transverse myelitis. A subsequent study reported positive aCL (IgG 9% and IgM 44%) in 32 MS patients. Another study from Japan reviewed 20 cases of MS, all of whom had optic neuritis. No less that 9 had transverse mylelitis. Four patients (all of whom had optic neuritis and myelitis) were positive for aCL. In a small study in our department, sera from 36 MS patients were studied. Five were aPL positive and of these, two had transverse myelitis (unpublished observations).

54. Antiphospholipid Syndrome The antiphospholipid syndrome (APLS) is defined by antiphospholipid antibodies and antiphospholipid syndrome Antiphospholipid antibodies are a group of http://www.edae.gr/antiphospholipid.html

HELLENIC ASSOCIATION DERMATOLOGY-VENEREOLOGY ANTIPHOSPHOLIPID SYNDROME G. Karakatsanis, Dermatologist. 1-12 ANTIPHOSPHOLIPID (HUGHES') SYNDROME A treatable cause of recurrent pregnancy loss. This syndrome was first described by Hughes in 1983. It is an important cause of thrombotic disease, both venous and arterial (especially recurrent cerebral ischemic attacks). Other features include mild thrombocytopenia, chorea, heart valve disease, livedo reticularis, and most commonly, recurrent pregnancy loss. AARDA - Antiphospholipid Syndrome Acquired Thrombophilia Antiphospholipid Antibody Syndrome Immune Problems. Alan E Beer, MD Joanne Kwak-Kim, MD , Joanne Kwak-Kim, MD, Evangelos Ntrivalas, MD , Hee Soo Chung MD American Autoimmune Related Diseases Association 1999 the American Autoimmune Related Diseases Association, Anti-[beta]2-glycoprotein I : a useful marker for the antiphospholipid syndrome ANTIBODY ASSOCIATED WITH AUTOIMMUNE DISORDERS FOUND TO "CLUSTER" IN FAMILIES Anticardiolipin antibodies David Tanne, MD Department of Neurology Chaim Sheba Medical Center. Tel Hashomer, Israel Anti-Phosphatidylserine (aPS) Antibodies ANTIPHOSPHOLIPID (HUGHES') SYNDROME A treatable cause of recurrent pregnancy loss.

55. Antiphospholipid Syndrome This document explains what antiphospholipid syndrome is, the incidence of the syndrome, the problems it can cause, and possible prevention of these http://omni.ac.uk/browse/mesh/D016736.html

low graphics Antiphospholipid Syndrome broader: Autoimmune Diseases other: Addison Disease Arthritis, Rheumatoid Dermatitis Herpetiformis Diabetes Mellitus, Type 1 ... Thyroiditis, Autoimmune This is one of a series of pregnancy-related information leaflets produced by Dr. Danny Tucker, a UK-based Specialist Registrar in Obstetrics and Gynaecology. This document explains what Antiphospholipid syndrome is, the incidence of the syndrome, the problems it can cause, and possible prevention of these problems. Pregnancy Complications Patient Education Handout [Publication Type] Antiphospholipid Syndrome NHS direct online health encyclopaedia : Hughes syndrome Patient information about Hughes syndrome from the NHS direct online service. The pages contain comprehensive, clearly and simply written information covering different aspects of the condition. These include an introduction to Hughes syndrome, followed by separate sections on symptoms, causes, diagnosis and treatment. NHS direct online is a Web site providing health information and advice for people in England. Patient Education Antiphospholipid Syndrome Last modified: 02 Sep 2005

56. Antiphospholipid Syndrome - Information News Australian researchers at University of New South Wales have identified a mechanism than can cause blood clots a discovery with implications for those http://www.news-medical.net/?keyword=Antiphospholipid syndrome

57. Log In Problems An example of how the body´s best intentions sometimes fail, this syndrome can underlie a multitude of disorders, ranging from multiple fetal loss to early http://www.medscape.com/viewarticle/408839

Unable to Deliver Requested Page In order to use Medscape, your browser must be set to accept cookies delivered by the Medscape site. To find out how to adjust your browser settings to accept cookies, please click here Medscape uses cookies to customize the site based on the information we collect at registration. The cookies contain no personally identifiable information and have no effect once you leave the Medscape site. You can read more about our use of cookies in our About Medscape Help WebMD Health

58. Antiphospholipid Syndrome antiphospholipid syndrome. In the 1950 s it was discovered that approximately 10% of patients with systemic lupus erythematosus had circulating lupus http://medinfo.ufl.edu/year2/coag/antiphos.html

Antiphospholipid Syndrome I. Anticardiolipin antibodies A. This is a distinct entity from lupus anticoagulants. B. Clinical Features 1. Thrombosis and Thromboembolus The first hypercoagulable process we've discussed to clearly have increased arterial events Recurrent DVT (intracranial veins, retinal veins, upper extremities, hepatic veins, portal veins, renal veins, inferior vena cava, lower extremities) Pulmonary embolism Arterial thrombosis (coronary arteries, retinal arteries, brachial arteries, mesenteric arteries, peripheral arteries, aorta). 2. First thrombotic often occurs in early-mid teenage years. 3. Women may experience recurrent fetal loss, usually in second or third trimester. 4. Migraine headaches, transient ischemic attacks, or Guillain-Barre syndrome is often seen. 5. Mild thrombocytopenia is often seen. 6. There is often a dermatologic condition known as livido reticularis in which the skin appears mottled. This is usually most notable in the lower extremities. 7. There is often a postpartum syndrome, which occurs 2-10 weeks after delivery and consists of fevers, dyspnea, pleuritic chest pain, pulmonary infiltrates, pleural effusions, cardiomyopathy, and arrhythmias. C. Possible mechanisms for anticardiolipin mediated disease.

59. Antiphospholipid Syndrome antiphospholipid syndrome (APLS) is a rare autoimmune disorder characterized by recurring blood clots http://my.webmd.com/hw/stroke/nord985.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Choose a Topic All Conditions ADD/ADHD Allergies Alzheimer's Arthritis Asthma Back Pain Bipolar Disorder Breast Cancer Cancer Cholesterol Management Dental Depression Diabetes Epilepsy Eye Health Heart Disease Hepatitis HIV/AIDS Hypertension Men's Conditions Mental Health Migraines/Headaches Multiple Sclerosis Osteoporosis Parkinson's Sexual Conditions Stroke Weight Control Women's Conditions Health Topics Symptoms Medical Tests Medications ... For a Complete Report Antiphospholipid Syndrome Important It is possible that the main title of the report Antiphospholipid Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Antiphospholipid Antibody Syndrome APLS APS Disorder Subdivisions None General Discussion Antiphospholipid Syndrome (APLS) is a rare autoimmune disorder characterized by recurring blood clots that usually appear before 45 years of age. It may also be associated with repeated spontaneous abortions for no apparent reason in young women. There may be a family history of blood clotting disorders in some cases. APS may occur in individuals with lupus or related autoimmune diseases or as a primary syndrome in otherwise healthy individuals.

60. Health/Women's Health - Chronic Illness: Postive Options For Antiphospholipid Sy Book on Postive Options for antiphospholipid syndrome , buy online at Hunter In APS, antiphospholipid antibodies attack the platelets in the blood, http://www.hunterhouse.com/showbook.asp?bid=199

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