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         Amyotrophic Lateral Sclerosis:     more books (100)
  1. Respiratory Management of ALS: Amyotrophic Lateral Sclerosis by LidaGuion, 2010
  2. Les troubles psychopathologiques et les mecanismes adaptatifs dans la sclerose laterale amyotrophique amyotrophic lateral sclerosis [An article from: Pratiques psychologiques] by C. Bungener,
  3. Amyotrophic Lateral Sclerosis: Beyond the Motor Neuron (Neuro-Degenerative Diseases)
  4. ALS drug appears to ease resistant depression.(News)(amyotrophic lateral sclerosis)(Clinical report): An article from: Clinical Psychiatry News by Erik L. Goldman, 2007-02-01
  5. My journey with amyotrophic lateral sclerosis.: An article from: Journal of Neuroscience Nursing by Mary L. Nowotny, 1998-02-01
  6. Monitoring speaking rate by telephone for persons with amyotrophic lateral sclerosis.: An article from: Journal of Medical Speech - Language Pathology by Laura J. Ball, David R. Beukelman, et all 2005-12-01
  7. Amyotrophic Lateral Sclerosis (ALS): Hearing Before a Subcommittee of the Committee on Appropriations, United States Senate, One Hundred Ninth Congres
  8. Gale Encyclopedia of Medicine: Amyotrophic lateral sclerosis by MD, DrPH L. Fleming Fallon Jr., 2002-01-01
  9. International Conference of Amyotrophic Lateral Sclerosis. by Tadao and Yoshiro Yase [eds]. Tsubake, 1987
  10. Amyotrophic Lateral Sclerosis Medical Guide by Qontro Medical Guides, 2008-07-09
  11. Non-neuronal Cells in the Pathogenesis of Amyotrophic Lateral Sclerosis (Acta Biomedical Lovaniensia) by Maarten Dewil, 2007-07-30
  12. Quantitative EEG analysis for assessment to 'plan' a task in amyotrophic lateral sclerosis patients: a study of executive functions (planning) in ALS patients ... [An article from: Cognitive Brain Research] by J. Santhosh, M. Bhatia, et all 2004-12-01
  13. Grandpa inspires couple to strike back at ALS.(FLY ON THE WALL)(Amyotrophic Lateral Sclerosis): An article from: Westchester County Business Journal
  14. Normal chest radiograph in terminal respiratory failure due to amyotrophic lateral sclerosis.(Letter to the editor): An article from: Southern Medical Journal by Christine Won, Dipanjan Banerjee, et all 2006-05-01

61. ALS And Associated Web Sites
Links to sites about amyotrophic lateral sclerosis including chat rooms and message boards.
http://www.geocities.com/sweekes99/ALStitle.html
ALS and Associated Web Sites
Compiled By: Steve Weekes ( sweekes99@yahoo.com SITE INDEX:
ALS INFORMATION WEB SITES

ALS Association Chapter Websites
ALS Related Societies
ALS SOCIETIES AROUND THE WORLD

(Over 40 Countries Represented)
ALS CHAT ROOMS

ALS FORUMS and DISCUSSION GROUPS

CAREGIVER WEBSITES

Travel Assistance Caregiver Chat Rooms, Forums and Discussion Groups PALS / CALS - PERSONAL WEBSITES International PALS / CALS Personal Web Sites Lyme and ALS Associated Diseases Advanced Therapies, Treatments and Research General Health Care and Information ASSISTIVE AIDS, DEVICES, and SOFTWARE General Assistance Sites Communication Assistance and Support Specific Assistance Sites Mind and Spirit Resources Diagnostic Laboratories PRODUCTS, SUPPLIERS, ETC... The intent of this site is to be one of the most complete sources of ALS Web Site Links on the Internet. Note: Due to the extensive content that each page contains, use your Web Browser’s “Edit, Find in this Page” function to search for key words, names, titles, or phrases.

62. Amyotrophic Lateral Sclerosis
Penn State Hershey Medical Center provides world class care and services to patients.
http://www.hmc.psu.edu/healthinfo/a/als.htm

63. Welcome To The Angel Fund
Dedicated to increasing awareness of amyotrophic lateral sclerosis (ALS) and based at Massachusetts General Hospital.
http://www.theangelfund.org
Home About the Angel Fund About ALS Research at MGH ... Resources IMPORTANT INFORMATION Annual Walk of Hope: September 10th, 2005
For more information regarding this event, see the full details here
Download the Walk of Hope 2005 Notice (PDF 72KB)
Download the Walk of Hope 2005 Registration Card(PDF 104KB)
The Angel Fund Family
Words of Inspiration
" With God nothing is impossible. Never give up!"

Ginny DelVecchio Founder of The Angel Fund, The Massachusetts ALS Chapter, ALS Support Groups throughout New England, and an ALS victim. Recent Press Annual Walk of Hope to Benefit ALS - Scheduled for September 10th
Sanders Golf Tournament to Benefit ALS Research
A Night of Entertainment to Benefit ALS Research - a Great Success
Red Sox Pitcher Mike Timlin to visit schools with Little Angels Fifth Annual Dinner Scheduled for March 5th All Press Releases Home What is the Angel Fund?

64. Amyotrophic Lateral Sclerosis (ALS)
The Department of Urology at the Penn State Milton S. Hershey Medical Center provides a full range of services for children and adults with concerns or
http://www.hmc.psu.edu/neurology/aservices/als.htm

65. Index
The personal story of Warren Lee Stickney, who had amyotrophic lateral sclerosis. Also links for further reading.
http://www.geocities.com/HotSprings/4340
View Page 1 Guestbook PICTURESQUE PALS P eople with A myotrophic L ateral S clerosis Honoring PALS Everywhere My dad with some of his grandchildren,1998. My dear father, Warren Lee Stickney, lost his battle with ALS on January 16, 1999.  I wanted to do something to honor his memory and to celebrate his life, so I thought of dedicating a web page to him.  Then I deceided that there were far too many PALS in this world who have loved ones that would like to do the same, so this page is dedicated to all PALS everywhere.  If you have a story and/or pictures of a PALS you would like to honor please e-mail me at wlsals@yahoo.com ALS(also known as Lou Gehrig's Disease) is a neurological disease affecting the nerves that supply all voluntary muscles.  It is one of the most devastating diseases there is.  There is no cure.  ALS affects the muscles of the arms, legs, face, tongue, speech, swallowing and breathing- eventually leading to paralysis. ALS does not affect thinking or intelligence. Feb. 1999 - This is my story of my dad, I will just write what I am thinking at the time so I may sound like I am rambling but please forgive me.  I just want people to know what kind of person the world has lost.  I have heard it said that PALS are the nicest people you could ever meet and this was true of my dad.
A little about him.  Warren Lee Stickney was born in June 1932, he was the youngest of several children.  Grandpa (I started calling him Grandpa almost 20 years ago when my nephew Daniel was born) used to always tell us kids of his adventures as a child (and I am still lucky enough to have his older brother, Bert, come and visit and tell these tales to me and my kids). Grandpa grew up in Michigan and lived on the lake.  He spent his boyhood camping, fishing, swimming,etc.

66. Welcome To The Homepage Of ALS BC
Welcome to the Official Homepage of the amyotrophic lateral sclerosis Society of British Columbia. Mission Statement. The mission of the ALS Society of BC
http://www.alsbc.ca/
Home
Larger Text To Make a Donation Now Accepted
Welcome to the Official Homepage of the
Amyotrophic Lateral Sclerosis Society of British Columbia
Mission Statement
The mission of the ALS Society of BC is to find the cause of and a cure for Amyotrophic Lateral Sclerosis. We are also committed to providing support to ALS patients, their families, and caregivers. The Amyotrophic Lateral Sclerosis Society of BC is an incorporated charitable organization with three principal objectives: To provide direct support to patients, their families, and caregivers To raise funds for patient services and research To increase public awareness and understanding of ALS. The ALS Society of BC was incorporated on December 17, 1981. It was founded by ALS patients, their family members and health care professionals to meet the physical and emotional needs of people with ALS and their caregivers. During the past 20 years, the Society has helped thousands of patients and their families, by providing direct services, information and support. Prince George, West Kootenay

67. PALS (People With Amyotrophic Lateral Sclerosis)
Webring for People with amyotrophic lateral sclerosis (PALS).
http://www.webring.com/hub?ring=pals

68. ALSA - South Texas Chapter
Working to help Texas families touched by amyotrophic lateral sclerosis, also known as Lou Gehrig's disease, by providing support, information, awareness, education, advocacy and hope through research.
http://www.alsa-south-tx.org

Click here for

more information...

The mission of The ALS Association (ALSA) is to discover the cause and cure for Amyotrophic Lateral Sclerosis (Lou Gehrig's disease) through dedicated research while providing patient support, education for health care professionals and the general public, and advocacy for ALS research and health care concerns.
Wanting to know what our chapter has planned for the next few months? Click the link for more information, and be prepared to mark your calendars... more
The South Texas Chapter of The ALSA is working to help Texas families touched by Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, by providing support, information, awareness, education, advocacy and hope through research.
Amyotrophic Lateral Sclerosis (ALS) is a progressive, fatal neuromuscular disease that attacks nerve cells and pathways in the brain and spinal... more
The South Texas Chapter of The ALSA prints a free bi-monthly newsletter.

69. Home Page
Nonprofit organization dedicated to increasing public awareness of amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease)and improving quality of life for the ALS community. Find disease information, events and service details.
http://www.alsfoundation.org
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70. EMedicine Health - Amyotrophic Lateral Sclerosis Overview
amyotrophic lateral sclerosis (ALS) is a progressive disorder of the part of the nervous system that controls voluntary movements.
http://www.emedicinehealth.com/articles/38555-1.asp
Search September 8, 2005 Registration Healthcare Professionals You are in: Brain and Nervous System
Amyotrophic Lateral Sclerosis (Lou Gehrig Disease)
Amyotrophic Lateral Sclerosis Overview
Amyotrophic lateral sclerosis (ALS) is a progressive disorder of the part of the nervous system that controls voluntary movements. It is sometimes called Lou Gehrig disease for the famous baseball player who died of the disease. The muscles become progressively weaker, and the condition eventually leads to paralysis and death.
ALS is one of a group of diseases known as motor neuron diseases. Neurons are nerve cells, and motor neurons are neurons that control movement.
  • Movement occurs when neurons in the brain (upper motor neurons) send messages to neurons in the spinal cord (lower motor neurons). The lower motor neurons relay these messages to the specific muscles that carry out the movement.
    In some motor neuron diseases, only the upper motor neurons are affected, or only the lower motor neurons. In ALS, however, both upper and lower motor neurons are affected.
    The neurons die and stop sending messages to muscles. The muscles are unable to function without these messages and gradually become weaker. They waste away (atrophy) and twitch (fasciculate).

71. HONselect - Amyotrophic Lateral Sclerosis
English, amyotrophic lateral sclerosis, Lou Gehrig Disease - Motor Neuron Disease, amyotrophic lateral sclerosis - ALS (amyotrophic lateral sclerosis)
http://www.hon.ch/HONselect/RareDiseases/C10.228.854.139.html
List of rare diseases: English Deutsch
Language:
MeSH term:
Accepted terms:
English: Amyotrophic Lateral Sclerosis - Lou Gehrig Disease
- Motor Neuron Disease, Amyotrophic Lateral Sclerosis
- ALS (Amyotrophic Lateral Sclerosis)
- Amyotrophic Lateral Sclerosis With Dementia
- Amyotrophic Lateral Sclerosis, Guam Form
- Dementia With Amyotrophic Lateral Sclerosis
Français: Sclérose latérale amyotrophique - Maladie de Charcot Deutsch: Amyotrophische Lateralsklerose - ALS - Gehrig-Krankheit - Myatrophische Lateralsklerose - Lateralsklerose, amyotrophische - Lateralsklerose, myatrophische - Loe-Gehrig-Krankheit Español: Esclerosis Amiotrófica Lateral - Enfermedad de Lou Gehrig - Enfermedad de la Neurona Motora de la Esclerosis Amiotrófica Lateral Português: Esclerose Amiotrófica Lateral - Doença de Lou Gehrig - Doença do Neurônio Motor em Esclerose Lateral Amiotrófica HONselect ressources Definition: Yes Articles: Yes Images: Yes News: No Conferences: No Clinical trials: Yes Web sites: English Yes Français Yes Deutsch No Español No Português No Home About us Site map Search ... Contact http://www.hon.ch/HONselect/RareDiseases/C10.228.854.139.html

72. Amyotrophic Lateral Sclerosis ALS Center At MCP Hahnemann University
The ALS Center of MCP Hahnemann University, Philadelphia, PA, provides compassionate,complete, multidisciplinary, state of the art care and access to the newest, most promising clinical trials in amyotrophic lateral sclerosis ALS, muscular dystrophy MD and neuromuscular disease.
http://www.mcphu.edu/medschool/depts/neurology/alsctr/alshome.htm
Department of Neurology ALS Center of MCP Hahnemann University
Click here to go to new site!

For appointments: 215-762-5035 To speak with the doctor or nurse: 215-762-5186
Clinical trials and research : 215-762-5186 ALS Clinical Services Center
The Hahnemann ALS Center is devoted not only to the clinical care of patients with ALS but to clinical and basic research development. Over the last two years we have made large strides in developing programs in these areas and are in the process of implementing additional strategies to meet these goals. A few of our accomplishments include:
Clinical Research Programs: Clinical Trials: Sanofi SR57746A-Phase III with and without Rilutek BDNF-Phase II and III Myotrophin -Phase III extension, expanded access
Clinical Protocols: Bipap in ALS ALS Care Database Genetic Studies in ALS Tissue Bank Dementia in ALS
Basic Research Glutamate studies in SOD Transgenic mice
We are presently developing additional programs including an educational seminar program. Please call us at 215-762-5186 or email ( Terry.D.Heiman-Patterson@drexel.edu

73. Introduction: Amyotrophic Lateral Sclerosis - WrongDiagnosis.com
Introduction to amyotrophic lateral sclerosis as a medical condition including symptoms, diagnosis, misdiagnosis, treatment, prevention, and prognosis.
http://www.wrongdiagnosis.com/a/amyotrophic_lateral_sclerosis/intro.htm
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Next sections Basic Summary for Amyotrophic lateral sclerosis Prevalence and Incidence of Amyotrophic lateral sclerosis Prognosis of Amyotrophic lateral sclerosis Causes of Amyotrophic lateral sclerosis ... Symptoms of Amyotrophic lateral sclerosis Next chapters: Lichen sclerosis Scleroderma Connective tissue disorders Raynaud's phenomenon ... Feedback
Introduction: Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis: Degenerative disease of the nerves affecting muscles. Amyotrophic lateral sclerosis: Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease, is a progressive, fatal neurological disease affecting as many as 20,000 Americans with 5,000 new cases occurring in the United States each year. The disorder belongs to a class of disorders known as motor neuron diseases. Researching symptoms of Amyotrophic lateral sclerosis: Further information about the symptoms of Amyotrophic lateral sclerosis is available including a list of symptoms of Amyotrophic lateral sclerosis symptom statistics for Amyotrophic lateral sclerosis , other diseases that might have similar symptoms in differential diagnosis of Amyotrophic lateral sclerosis , or alternatively return to research other symptoms in the symptom center Misdiagnosis and Amyotrophic lateral sclerosis:

74. Information On Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) - The Florid
amyotrophic lateral sclerosis (Lou Gehrig s Disease) The most common of a group of disorders known as motor neuron diseases, in which the nerves in the
http://www.floridamedicalnetwork.com/diseases/amyo.htm
Home Today's News What's New Medical Directories ... Associations
***** MEDICAL REFERENCE LIBRARY *****
AMYOTROPHIC LATERAL SCLEROSIS (LOU GEHRIG'S DISEASE) DEFINITION:

The most common of a group of disorders known
as motor neuron diseases, in which the nerves in
the brain that control the movement of muscles
degenerate and muscle function is gradually lost;
commonly called Lou Gehrig's disease.
1. Links to General Information Sites
BACK TO MAIN PAGE Aphco International, Inc.

75. Amyotrophic Lateral Sclerosis
of how it feels to have a fully developed amyotrophic lateral sclerosis. amyotrophic lateral sclerosis (ALS), more commonly known as Lou Gehrig s
http://serendip.brynmawr.edu/bb/neuro/neuro99/web1/Rodrigo.html
Biology 202
1999 First Web Reports

On Serendip
Amyotrophic Lateral Sclerosis
Evelyn Rodrigo
Amyotrophic Lateral Sclerosis (ALS), more commonly known as Lou Gehrig's disease, is a neurological disorder that involves the degeneration of motor neurons. A-myo-trophic is derived from the Greek language. A connotes something negative or none. Myo means it has something to do with the muscles. Trophic translates to "nourishment". The term Lateral is attributed to the parts of the spinal cord that ALS usually affects. The scarring that results from the degeneration of these neurons and nerves in the spinal cord is known as sclerosis. In 1941, Lou Gehrig, a famous baseball player, died of ALS. His name has been associated with this progressive fatal neuromuscular disease ever since. Another person whose name is associated with this disease is the French neurologist, Dr. Jean-Martin Charcot. He was the first to identify that motor neurons from the spinal cord are the main part of the nervous system affected by this disease, in 1869. For that, amyotrophic lateral sclerosis is also known as maladie de Charcot. ALS is progressive and because there is no known cure or way of reversing it's effects, it is also fatal. Death usually ensues between 2 to 5 years after diagnosis. However, advances in research and the increase of support groups make it possible for some to survive longer. Twenty percent of ALS patients live longer than five years and almost ten percent live as long as ten years after diagnosis. Although cases of ALS have been observed among twenty- and thirty-year olds, it generally develops later in life (between the age of 40 and 70). Men and women, as well as different racial groups are equally susceptible in developing ALS although there seems to be a high incidence of this disease in Guam and the Trust Territories of the Pacific. ALS is becoming more and more prevalent in United States. Five thousand new patients are diagnosed with this disease every year as reported by the United States National Institutes of Health.

76. Amyotrophic Lateral Sclerosis: A Challenge For Speech-Language Pathology
amyotrophic lateral sclerosis (ALS), first identified in 1869 by the French Speech deterioration in amyotrophic lateral sclerosis Implications for the
http://www.asha.org/public/speech/disorders/als-amyotrophic-Lateral-Sclerosis.ht
@import url( /styles/importmenuP.css ); Skip to: content navigation Our site's pages are optimized for Web browsing software that supports current Web standards, as established by the World Wide Web Consortium (http://www.w3c.org/) . Content is accessible from older or less standards-compliant technologies, but its presentation will not be identical to visitors with standards-compliant software. Read more on our site's changes and accessiblity. Find a Professional Shop My Account Guest Login Search for: Advanced Search Home Site Location: Home For the Public Disorders and Diseases
Amyotrophic Lateral Sclerosis
A Challenge for Speech-Language Pathology
By Pamela Mathy A myotrophic Lateral Sclerosis (ALS), first identified in 1869 by the French neurologist, Jean-Martin Charcot, is a relentlessly progressive degenerative motor neuron disease that primarily affects the motor neurons of the brain and spinal cord. Lou Gehrig, with whom the disease is often associated, brought international attention to ALS in 1939, when it caused him to retire from baseball. More recently, a variety of public figures from actors (Michael Zaslow) to physicists (Stephen W. Hawking) to retired university professors interviewed on Nightline (Morrie Schwartz) to senators (Jacob Javits) have focused attention on this-devastating disease. Symptoms The early symptoms of ALS are varied. For some it begins with speech slurring, difficulties with swallowing, and/or hoarseness. Others may experience uncharacteristic clumsiness or tripping. Difficulty lifting may be the initial symptom for others. Clinically, the signs and symptoms are divided into two areas-spinal functions and bulbar functions. Three-quarters of people report initial spinal symptoms (weakness in the upper and/or lower extremities) and about one-quarter present with bulbar symptoms (weakness with changes in both speech and swallowing). Both upper and lower motor neurons characteristically become involved as the disease progresses.

77. Amyotrophic Lateral Sclerosis
amyotrophic lateral sclerosis (ALS), sometimes called Lou Gehrig s Disease, amyotrophic lateral sclerosis affects as many as 20000 Americans with 5000
http://www.asha.org/public/speech/disorders/Amyotrophic-lateral-sclerosis.htm
@import url( /styles/importmenuP.css ); Skip to: content navigation Our site's pages are optimized for Web browsing software that supports current Web standards, as established by the World Wide Web Consortium (http://www.w3c.org/) . Content is accessible from older or less standards-compliant technologies, but its presentation will not be identical to visitors with standards-compliant software. Read more on our site's changes and accessiblity. Find a Professional Shop My Account Guest Login Search for: Advanced Search Home Site Location: Home For the Public Disorders and Diseases
Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS), sometimes called Lou Gehrig's Disease, is a progressive neurological disease that attacks the nerve cells (neurons) that control voluntary muscles. This disease belongs to a group of motor neuron disorders (e.g., muscular dystrophy, multiple sclerosis, Parkinson's disease) that are characterized by the gradual degeneration and death of motor neurons. What Are Motor Neurons?

78. Amyotrophic Lateral Sclerosis: Definition And Much More From Answers.com
a·my·o·tro·phic lateral sclerosis ( a mi?-tro fik, -trof ik, a-mi - ) n. ( Abbr. ALS ) A chronic, progressive disease marked by gradual.
http://www.answers.com/topic/motor-neurone-disease
showHide_TellMeAbout2('false'); Business Entertainment Games Health ... More... On this page: Dictionary Diagnosis Encyclopedia Medical WordNet Wikipedia Mentioned In Or search: - The Web - Images - News - Blogs - Shopping amyotrophic lateral sclerosis Dictionary a·my·o·tro·phic lateral sclerosis mī-ə-trō fĭk, -trŏf ĭk, ā-mī
n. Abbr. ALS A chronic, progressive disease marked by gradual degeneration of the nerve cells in the central nervous system that control voluntary muscle movement. The disorder causes muscle weakness and atrophy and usually results in death. Also called Lou Gehrig's disease
Diagnosis
Amyotrophic Lateral Sclerosis What is amyotrophic lateral sclerosis?
Amyotrophic lateral sclerosis (also called ALS or "Lou Gehrig's disease") is a classic motor neuron disease. Motor neuron diseases are progressive chronic diseases of the nerves that come from the spinal cord responsible for supplying electrical stimulation to the muscles. This stimulation is necessary for the movement of body parts. ALS is progressive and fatal. The usual causes of death of patients with motor neuron diseases are not directly related to the disease, but result from simultaneous additional illnesses which ultimately occur because of weakness of the body. These illnesses are often infections.

79. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies:
Search results for amyotrophic lateral sclerosis ALLFIELDS are shown below. Conditions amyotrophic lateral sclerosis; Multiple Sclerosis;
http://www.clinicaltrials.gov/search/term=Amyotrophic Lateral Sclerosis
Home Search Browse Resources ... About Search results for Amyotrophic Lateral Sclerosis [ALL-FIELDS] are shown below.
Include trials that are no longer recruiting patients.
12 studies were found. Recruiting Study of Myobloc in the Treatment of Sialorrhea (Drooling) in Patients with Amyotrophic Lateral Sclerosis (ALS)
Conditions: Amyotrophic Lateral Sclerosis; Sialorrhea Recruiting Early Treatment of Amyotrophic Lateral Sclerosis (ALS) with Nutrition and Non-Invasive Positive Pressure Ventilation (NIPPV)
Condition: Amyotrophic Lateral Sclerosis Recruiting R(+) Pramipexole in Early Amyotrophic Lateral Sclerosis
Condition: Amyotrophic Lateral Sclerosis Recruiting Safety Study of Oral Sodium Phenylbutyrate in Subjects with ALS (Amyotrophic Lateral Sclerosis)
Condition: Amyotrophic Lateral Sclerosis Recruiting Minocycline to Treat Amyotrophic Lateral Sclerosis
Condition: Amyotrophic Lateral Sclerosis Recruiting Familial Amyotrophic Lateral Sclerosis. A Preliminary Study to Identify Subjects Who Might Be Willing to Participate in a Randomized Controlled Trial
Condition: Amyotrophic Lateral Sclerosis Recruiting A Randomised Sequential Trial of Sodium Valproate in Amyotrophic Lateral Sclerosis
Condition: Amyotrophic Lateral Sclerosis (ALS) Recruiting Frontotemporal Dementia and Amytrophic Lateral Sclerosis
Conditions: Frontotemporal dementia; and/or; Lateral amyotrophic sclerosis

80. Clinical Trial: Minocycline To Treat Amyotrophic Lateral Sclerosis
amyotrophic lateral sclerosis, Drug minocycline, Phase III MedlinePlus related topics amyotrophic lateral sclerosis Genetics Home Reference related
http://www.clinicaltrials.gov/ct/gui/show/NCT00047723
Home Search Browse Resources ... About Minocycline to Treat Amyotrophic Lateral Sclerosis This study is currently recruiting patients.
Verified by National Institute of Neurological Disorders and Stroke (NINDS) July 2005 Sponsored by: National Institute of Neurological Disorders and Stroke (NINDS) Information provided by: National Institute of Neurological Disorders and Stroke (NINDS) ClinicalTrials.gov Identifier: Purpose The purpose of this trial is to test the safety, tolerability, and effectiveness of minocycline compared to placebo in patients with amyotrophic lateral sclerosis (ALS). Condition Intervention Phase Amyotrophic Lateral Sclerosis
Drug: minocycline
Phase III

MedlinePlus
related topics: Amyotrophic Lateral Sclerosis
Genetics Home Reference
related topics: amyotrophic lateral sclerosis Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Placebo Control Further Study Details:
Expected Total Enrollment: 400 Study start: January 2003
ALS is a progressive neurodegenerative disorder without cure or known treatment that significantly improves function. Loss of motor neurons in the brain and spinal cord of ALS patients causes the progressive symptoms. Laboratory studies have linked inducible nitric oxide synthase (iNOS) and caspase enzyme activation to motor nerve cell death in ALS. Minocycline-a medication currently approved by the FDA for treatment of bacterial infections-is a tetracycline antibiotic with high central nervous system penetration when taken orally. The drug inhibits the activity of iNOS and caspase enzymes.

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