101. IMF (UK) - AL Amyloidosis Address http//www.myeloma.org.uk/frmsets/fsal.htm Title IMF (UK) ALamyloidosis • Size 1261 • Last Modified Fri, 04 Oct 2002 123150 GMT http://www.myeloma.org.uk/frmsets/fsal.htm

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102. ESynopsis Of Amyloidosis Of The Kidney eSynopsis of amyloidosis of Kidney From the Electonic Synopsis of Pathology, theUniversity of Connecticut School of Medicine, Department of Pathology. http://esynopsis.uchc.edu/S264.htm

Prev GU Menu PathWeb Home Feed Back ... Next Renal Amyloidosis Etiology Production of abnormal proteins that form non-branching fibrils approximately 10 nm in diameter that have a cross beta-pleated sheet configuration on X-ray crystallography. The etiologies of amyloidosis are many, including lymphoproliferative disorders such as myeloma/lymphoma, chronic longstanding inflammation such as rheumatoid arthritis, tuberculosis and osteomyelitis, familial/genetic, chronic hemodialysis and of course idiopathic. Pathogenesis The amyloid fibrils deposit in extracellular regions such as the glomerular mesangia and glomerular basement membranes rendering the glomerular filter leaky to plasma proteins, e.g. albumin., Epidemiology Being of diverse etiology, amyloidosis will be epedimiologically diverse. Amyloidosis may be related to multiple myeloma, chronic long standing inflammatory processes such as rheumatoid arthritis and chronic osteomyelitis, chronic renal hemodialysis or be hereditary. General Gross Description The kidneys are usually normal size or larger than normal.

103. NEJM -- Sign In Correspondence from The New England Journal of Medicine Molecular Mechanismsof amyloidosis. http://content.nejm.org/cgi/content/full/349/19/1872

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Access to this article requires sign-in. Subscribers have access to all content. Other registered users have access to research articles six months old and older. If you're a registered user or an activated subscriber SIGN IN User Name Password Forgot your Password? Click here and we'll e-mail it to you. If you do not use cookies, sign in here. Remember my User Name and Password. Log in via Athens. PURCHASE THIS ARTICLE Purchase a single article and get immediate online access for just $10. If you're a subscriber but have not yet activated your full online access If you'd like to purchase a subscription to NEJM If you're not a subscriber and want FREE limited access... ACTIVATE YOUR SUBSCRIPTION Subscribers to NEJM are entitled to full access to all online content and features, including 20 FREE online CME exams. OR Receive full access to ALL current content and online features including Personal Archives, PDF article downloads, PDA access, E-mail alerts and 20 FREE online CME exams. OR Receive FREE online access to NEJM Original and Special Articles 6 months after publication and choose to receive the Table of Contents and notification of early release articles via e-mail.

104. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies: Conditions Drug Toxicity; primary systemic amyloidosis. 8. Recruiting, Study ofSystemic amyloidosis Presentation and Prognosis Condition amyloidosis http://www.clinicaltrials.gov/ct/gui/c/a1b/action/SearchAction?JServSessionIdzon

105. UpToDate Renal Amyloidosis involvement usually occurs only in primary or secondary amyloidosis 1,35.There are also rare hereditary forms of renal amyloidosis (see below); http://patients.uptodate.com/topic.asp?file=glomrdis/9989

106. It Is Generally Considered That The Amyloidoses Share Common Pathogenic Mechanis Immunoglobulin (primary) amyloidosis, while the most common form of amyloidosis, Primary amyloidosis is a disease caused by the abnormal accumulation of http://www.iupui.edu/~amyloid/primary.htm

I Primary Amyloidosis What is Primary Amyloidosis? Primary amyloidosis is a disease caused by the abnormal accumulation of protein molecules in body tissues. These proteins are fragments of immunoglobulin (antibody) molecules which are normally present in the blood to give protection against bacteria and other infectious agents. Normally, antibody molecules are constantly being synthesized by cells of the immune system and then, after a finite life span, degraded so that there is a balance between production and degradation. In this way our active immune system protects our bodies from a constantly changing array of infectious bacteria and viruses. In primary amyloidosis a defect occurs in the immune system. Excessive amounts of certain antibody molecules are produced and fragments of these molecules get deposited in tissues. These tissue deposits, as they enlarge, damage normal tissues and cause the disease that we know as primary amyloidosis. What causes primary amyloidosis? The cause of primary amyloidosis is unknown. Since the amyloid protein comes from immunoglobulin molecules, it is possible that some response of the immune system to an infectious bacteria, virus or other foreign substance may trigger the overproduction of antibody protein. So far this is only speculation, because amyloid has not been known to be associated with any particular infection. Indeed, there are no epidemiological data to suggest that amyloid occurs as result of infection. More is known about how the antibody molecules are deposited in tissue and lead to the disease. It is known that antibody molecules are made only by certain cells in the immune system called plasma cells. It is known that plasma cells can synthesize large amounts of antibody molecules but are usually under regulatory mechanisms that maintain a balance.

107. Amyloidosis - Macular - 1 Dept. of Dermatology University of Iowa College of Medicine. amyloidosis -Macular - Left Infrascapular Back. Return to Image Index page. http://tray.dermatology.uiowa.edu/Amyloid-mac001.htm

Dept. of Dermatology - University of Iowa College of Medicine Amyloidosis - Macular - Left Infrascapular Back Return to Image Index page. Return to Image Index page. Return to Dermatology's Home page. September, 1995

108. Amyloidosis And Waldenstrom's Macroglobulinemia -- Gertz Et Al. 2004 (1): 257 -- Waldenström macroglobulinemia (WM) is rarer than amyloidosis (1500 per year WMversus The two keys to effective treatment of AL amyloidosis are early http://www.asheducationbook.org/cgi/content/full/2004/1/257

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Abstract Full Text (PDF) Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager PubMed PubMed Citation Articles by Gertz, M. A. Articles by Treon, S. P. Hematology 2004 The American Society of Hematology Morie A. Gertz Giampaolo Merlini and Steven P. Treon Abstract Primary systemic amyloidosis is an immunoglobulin light chain disorder that is 1/5th as common as multiple myeloma. Amyloidosis is regularly seen in the practice of a hematologist and has recently undergone major advances in terms of the ability to evaluate responses as well as new therapeutic options that were not available when this topic was covered as an education session macroglobulinemia (WM) is rarer than amyloidosis (1500 per year WM versus 3000 per year amyloid in the US), and recent consensus panels have established the definition of the disease, the diagnostic

109. Epilepsy Ontario :: Amyloidosis Epilepsy Ontario amyloidosis. amyloidosis Menu, (NeuroWebForum). Please e-mailinfo@epilepsyontario.org if you have any links that you feel we should http://epilepsyontario.org/client/EO/EOWeb.nsf/web/Amyloidosis

Sections Epilepsy Ontario Contact EO The Organization Our Resource Centre Epilepsy NEWS Announcements 'Sharing' News Epilepsy Information About Epilepsy Seizures Medications First Aid ... WWW Links Get Involved Local Chapters Provincial Programs Funding Volunteer Opportunities ... Direct Donation Products Helmets Epilepsy Monitoring Systems Glad Cards More... ... Site Map WWW Links :: Other Conditions (Links) WWW Links Other Conditions (Links) Acoustic Neuroma Aicardi Syndrome ... Williams Syndrome Amyloidosis Amyloidosis Menu (NeuroWebForum) Please e-mail info@epilepsyontario.org if you have any links that you feel we should have on our site. To submit questions, comments, or suggestions please click here Last Modified: 01/28/2004 03:05:48 PM

110. FIRSTConsult - Sdfdsf FIRSTConsult, amyloidosis (Medical Condition File). Published for medical studentsand primary healthcare providers by Elsevier. http://www.firstconsult.com/?action=view_article&id=1014717&type=101&bref=1

111. Amyloidosis The term amyloidosis includes a group of disorders caused by abnormal folding,clumping, (aggregation) and/or accumulation of particular proteins (amyloids, http://www.bchealthguide.org/kbase/nord/nord22.htm

var hwPrint=1;var hwDocHWID="nord22";var hwDocTitle="Amyloidosis";var hwRank="1";var hwSectionHWID="nord22-Header";var hwSource="en-caQ2_05";var hwDocType="Nord"; National Organization for Rare Disorders, Inc. Amyloidosis Important It is possible that the main title of the report Amyloidosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Secondary Amyloidosis Transthyretin Methionine-30 Amyloidosis (Type I) Indiana Type Amyloidosis (Type II) Danish Cardiac Type Amyloidosis (Type III) Iowa Type Amyloidosis (Type IV) Finnish Type Amyloidosis (Type V) Icelandic Type Amyloidosis (Type VI) Ohio Type Amyloidosis (Type VII) Familial Visceral Amyloidosis (Type VIII) Familial Lichen Amyloidosis (Type IX) Appalachian Type Amyloidosis Analine 60 Amyloidosis Ashkenazi Type Amyloidosis Isoleucine 33 Amyloidosis Corneal Amyloidosis Amyloid Corneal Dystrophy Familial Cutaneous Amyloidosis Hemodialysis-Related Amyloidosis A Beta-2-Microglobulin Amyloidosis Amyloid Arthropathy of Chronic Hemodialysis Amyloidosis Illinois Type Amyloidosis Prealbumin Tyr-77 Amyloidosis Amyloidosis of Familial Mediterranean Fever Atypical Amyloidosis Cardiopathic Amyloidosis Hereditary Nephropathic Amyloidosis Idiopathic Amyloidosis Lichen Amyloidosis Macular Amyloidosis Neuropathic Amyloidosis Paramyeloidosis Pericollagen Amyloidosis Portuguese Type Amyloidosis Primary Amyloidosis Primary Cutaneous Amyloidosis Primary Nonhereditary Amyloidosis

112. Department Of Health - Amyloidosis Although amyloidosis is not cancer, it is very serious. Familial (or Hereditary)amyloidosis is the only type of amyloidosis that is inherited. http://www.doh.state.fl.us/amyloidosis.html

Skip left hand navigation and go to main body of page. Link to Sitemap directory contact us ... Tobacco Prevention Program Amyloidosis Links Ask an Oncologist about Amyloidosis Ask a Board Certified Oncologist questions about Amyloidosis. Communicate privately and confidentially with doctors about cancer affecting you, your family or friends. http://www.oncli.com/ Primary Amyloidosis Explains what causes the abnormal protein build-up that leads to bone marrow disease. Gives symptoms, diagnosis, and treatment options. http://www.mayoclinic.org/amyloidosis-rst/ Amyloidosis Support Network Amyloidosis Support Network - The Network's primary function is to link those affected by amyloidosis, to further support resources, and to educate the public and professionals so that the disease can be recognized earlier and appropriately treated. http://www.amyloidosis.org Information Amyloidosis is a group of diseases in which one or more organ systems in the body accumulate deposits of abnormal proteins. Although amyloidosis is not cancer, it is very serious. It is disabling or life threatening. However, growing awareness of the condition seems to be leading to substantial new research and treatment alternatives.

113. Medical Science 520, Inflammation & Amyloidosis JPG (146811 bytes), Slide 26 Renal amyloidosis, H E stain. i27.jpg (94357 bytes),Slide 27 Renal amyloidosis, congored stain, polarized light http://www.vetmed.wsu.edu/medsci520/inflamm.htm

Inflammation and Amyloidosis (I) Click on a small image to view a larger version. Click the back arrow on your browser to return to the list of images for each topic. Slide 1: Acute purulent conjunctivitis Slide 2: Acute appendicitis Slide 3: Acute suppurative meningitis Slide 4: Acute suppurative meningitis, (neutrophilic meningitis) Slide 5: Acute fibrinous pericarditis Slide 6: Multifocal, suppurative, hepatitis Slide 7: Pulmonary abscess (liquefactive necrosis) Slide 8: Acute fibrinous pneumonia and pleuritis, (Lobar pneumonia), bovine Slide 9: Acute, suppurative, pneumonia. Note congestion, edema, and neutrophils. Slide 10: Infective endocarditis (bovine) Slide 11: Chronic cystitis Slide 12: Chronic cystitis (lymphocytic cystitis) canine Slide 13: Renal tuberculosis Slide 14: Granulomatous pneumonia (tuberculosis) Slide 15: Granulomatous pneumonia (tuberculosis), area of central necrosis, Langhans-type giant cells, fibrosis, epithelioid cells Slide 16: Granulomatous pneumonia, Langhans-type giant cell, epithelioid cells, lymphocytes, and fibrosis Slide 17: Granulomatous lymphadenitis (Histoplasmosis) Slide 18: Ulcerative dermatitis Slide 19: Rheumatoid arthritis, hands

114. POEMS Syndrome Treatment Options At Mayo Clinic POEMS syndrome treatment options at Mayo Clinic include bone marrow transplants. http://www.mayoclinic.org/poems/

Home About Mayo Clinic Jobs Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services POEMS Syndrome POEMS Syndrome Overview Symptoms Diagnosis Treatment Options ... Medical Services Treatment of POEMS Syndrome at Mayo Clinic (Synonyms: Crow-Fukase syndrome, PEP syndrome, Shimpo syndrome and Takatsuki syndrome) Patients with POEMS syndrome experience an integrated approach to diagnosis and treatment at Mayo Clinic. Working together, Mayo specialists develop a treatment plan based on the patient's needs and health issues. In some cases, patients with POEMS syndrome can receive a bone marrow transplant through Mayo Clinic's Transplant Center. Mayo is active in research on this disorder. Diagnosis POEMS syndrome is so rare that physicians who do not have experience with the disease may miss the diagnosis. Physicians at Mayo Clinic have the skills and experience necessary to diagnose this rare condition. The overgrowth of plasma cells can often be detected by finding an abnormal protein in the blood or urine, by an abnormality on a bone X-ray and/or a bone marrow biopsy. Read more about diagnosis of POEMS Syndrome Treatment Options Because POEMS syndrome is a multisystem disease, hematologists at Mayo Clinic gather neurologists, endocrinologists, radiation oncologists, physical therapists and other specialists to develop a comprehensive treatment approach. Treatment options include radiation therapy, corticosteroids, chemotherapy, a bone marrow transplant, hormone replacement therapy and physical therapy. Read more about

115. Amyloidpage This site has moved to. http//amyloid.bu.edu/amyloid/Amyloid1.htm. http://medicine.bu.edu/amyloid/amyloid1.htm

This site has moved to http://amyloid.bu.edu/amyloid/Amyloid1.htm

116. Renal Biopsy Case History July, 1995 A 64 year old man with a 15 year history of coronary artery disease andhypertension (treated with Hygroton 50mg/day), and a 5 year history of diabetes http://www.gamewood.net/pathcase/795/795-case.htm

Renal Biopsy Case History July, 1995 Clinical Summary A 64 year old man with a 15 year history of coronary artery disease and hypertension (treated with Hygroton 50mg/day), and a 5 year history of diabetes mellitus (treated with 25 units NPH insulin/day) was found to have 3+ proteinuria during a routine physical examination. Follow-up laboratory evaluation revealed: 9 g/day proteinuria, 2-3 RBC/hpf in the urine, serum creatinine 1.2 mg/dL (106 umol/L), creatinine clearance 77 mL/min (128 mL/s), BUN 20 mg/dL (7.0 mmol/L), cholesterol 300 mg/dL (7.76 mmol/L), albumin 3.1 g/dL (31 g/L), calcium 9.2 mg/dL (2.30 mmol/L), phosphorus 4.3 mg/dL (1.39 mmol/L), glucose 189 mg/dL (10.5 mmol/L), uric acid 9.5 mg/dL (565 umol/L), and normal LFTs. He was referred to a nephrologist for evaluation and treatment. Physical examination revealed weight 81.2 kg, blood pressure 100/72 mm Hg, no retinopathy and 1+ pitting edema in the lower extremities. Laboratory data included: 12 g/day proteinuria, 8-10 RBC/hpf in the urine

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