81. Dr. Koop - Cardiac Amyloidosis Cardiac amyloidosis is a disorder caused by deposits of an abnormal protein inthe heart tissue, resulting in decreased heart function. http://www.drkoop.com/ency/93/000193.html

Home Health Reference Cardiac amyloidosis Jul 29, 2005 Search: Dr.Koop MEDLINE Diseases Symptoms Procedures Natural Medicine ... Drug Library Inside DrKoop News Archive Animations Health Videos Health Tools ... Newsletters Cardiac amyloidosis Injury Disease Nutrition Poison ... Prevention Cardiac amyloidosis Definition: Cardiac amyloidosis is a disorder caused by deposits of an abnormal protein in the heart tissue, resulting in decreased heart function. Alternative Names: Amyloidosis - cardiac; Restrictive cardiomyopathy - amyloidosis; Primary cardiac amyloidosis - AL type; secondary cardiac amyloidosis - AA type; Stiff heart syndrome Causes, incidence, and risk factors: Amyloidosis refers to buildup of a fibril called amyloid in tissues anywhere in the body. Fibrils are proteins produced in excess that are deposited in different organs and slowly replace normal tissue. Different types of amyloidosis are caused by different types of proteins, such as "AL" and "AA." In cardiac amyloidosis there may be associated conduction disturbances (changes in the way the cardiac electrical impulse is transmitted through the heart). Cardiac amyloidosis usually occurs during primary amyloidosis (called AL type amyloidosis). Primary amyloidosis usually accompanies multiple myeloma, a blood disorder in which too much of a certain type of protein is produced. This excess protein is deposited in the heart and in other organs such as the kidney. Deteriorating kidney function also occurs.

82. Dr. Koop - Hereditary Amyloidosis amyloidosis occurs in multiple forms spontaneous, hereditary, and resulting froma cancer of the blood cells called myeloma. Hereditary amyloidosis is an http://www.drkoop.com/ency/93/000368.html

Home Health Reference Hereditary amyloidosis Jul 29, 2005 Search: Dr.Koop MEDLINE Diseases Symptoms Procedures Natural Medicine ... Drug Library Inside DrKoop News Archive Animations Health Videos Health Tools ... Newsletters Hereditary amyloidosis Injury Disease Nutrition Poison ... Prevention Hereditary amyloidosis Definition: Amyloidosis is a type of disease in which an abnormal protein deposits in various tissues. These protein deposits damage the tissues and interfere with the function of the involved organ. The abnormal protein deposits are called amyloid, hence the name of this group of diseases. Amyloidosis occurs in multiple forms: spontaneous, hereditary, and resulting from a cancer of the blood cells called myeloma. Hereditary amyloidosis is an inherited form that is transmitted as an autosomal dominant trait. Alternative Names: Amyloidosis - hereditary New Features Fewer Migraines Skin Cancer Atkins/Low Carb Diets Learn More About Migraines * All Health Centers * Acne Addictions AIDS/HIV Alcohol Abuse Allergies Alternative Medicine Alzheimer's Arthritis Asthma Attention Deficit Disorder (ADHD) Backache Bipolar Affective Disorder Birth Control Blood Blood Pressure Bone/Joint/Tendon Bowel Brain Breast cancer Cancer Cerebral Palsy Cholesterol Cramps Crohn's Disease Cysts Dental/Oral Depression Diabetes Diet, Fitness, Looks

83. DermAtlas: Online Dermatology Image Library Dermatology Image,amyloidosis, Bullo DermAtlas Dermatology Images dermatology image,amyloidosis,amyloidosis,amyloidosis,amyloidosis,amyloidosis,amyloidosis,amyloidosis,amyloidosis,amyloidosis http://dermatlas.med.jhmi.edu/derm/result.cfm?Diagnosis=-609213408

84. Amyloidosis amyloidosis related to plasma cell dyscrasia is not curable. The role ofchemotherpay, and cytokine therapy is discussed. http://www.clevelandclinic.org/myeloma/amyloidosis.htm

Multiple Myeloma Research Center AMYLOIDOSIS Definition Amyloid is a protein-polysaccharide complex substance having starch-like characteristics. Amyloidosis occurs when this substance is deposited into organs or tissues. Cause Amyloidosis is thought to result from many factors. The cause is unknown. PREVALENCE AND INCIDENCE OF AMYLOIDOSIS Amyloidosis is a rare disease. About two-thirds of patients with amyloidosis have primary (where no specific cause or disease is related to the abnormal protein deposits), less than 5% have secondary (associated with another chronic disease, often in multiple myeloma), less than 5% familial (inherited) and less than 5% have senile (occurring secondary to old age) amyloidosis. In patients with primary amyloidosis, 95% are over the age of 40 and 66% are men. Weakness or fatigue Weight loss Heart damage (congestive heart failure) shortness of breath swelling of the feet and legs chest pains irregular heart rhythm lightheadedness (due to lowering of blood pressure during sudden position changes) Abnormal sensations of the arms, feet, or legs

85. Introduction: Amyloidosis - WrongDiagnosis.com Introduction to amyloidosis as a medical condition including symptoms, diagnosis,misdiagnosis, treatment, prevention, and prognosis. http://www.wrongdiagnosis.com/a/amyloidosis/intro.htm

Home Symptoms Diseases Risks ... Diseases Search our medical database Subscribe to our free Newsletter sample Send this page to a friend Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Amyloidosis Next sections Basic Summary for Amyloidosis Prevalence and Incidence of Amyloidosis Prognosis of Amyloidosis Types of Amyloidosis ... Causes of Amyloidosis Next chapters: Testicle disorders Testicular torsion Hydrocele Thymus disorders ... Feedback Introduction: Amyloidosis Amyloidosis: Deposits of proteins causing diseases Amyloidosis: Proteins are important building blocks for all body parts, including muscles, bones, hair, and nails. Proteins circulate throughout the body in the blood and are normally harmless. Occasionally, cells produce abnormal proteins that can settle in body tissue, forming deposits and causing disease. When these deposits of abnormal proteins were first discovered, they were called amyloid , and the disease process amyloidosis Researching symptoms of Amyloidosis: Further information about the symptoms of Amyloidosis is available including a list of symptoms of Amyloidosis , other diseases that might have similar symptoms in differential diagnosis of Amyloidosis , or alternatively return to research other symptoms in the symptom center Misdiagnosis and Amyloidosis: Research more detailed information about misdiagnosis of Amyloidosis underlying causes of Amyloidosis (possibly misdiagnosed), or research

86. Introduction: Dialysis-related Amyloidosis - WrongDiagnosis.com Introduction to Dialysisrelated amyloidosis as a medical condition includingsymptoms, diagnosis, misdiagnosis, treatment, prevention, and prognosis. http://www.wrongdiagnosis.com/d/dialysis_related_amyloidosis/intro.htm

Home Symptoms Diseases Risks ... Diseases Search our medical database Subscribe to our free Newsletter sample Send this page to a friend Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Dialysis-related amyloidosis Next sections Basic Summary for Dialysis-related amyloidosis Causes of Dialysis-related amyloidosis Symptoms of Dialysis-related amyloidosis Complications of Dialysis-related amyloidosis ... Misdiagnosis of Underlying Causes of Dialysis-related amyloidosis Next chapters: Renal Tubular Acidosis Proximal Renal Tubular Acidosis Renal carbuncle Renal osteodystrophy ... Feedback Introduction: Dialysis-related amyloidosis Dialysis-related amyloidosis: Amyloidosis (protein deposits) from kidney dialysis treatment. Dialysis-related amyloidosis: Normal kidneys filter excess proteins from the blood, thus preventing levels from getting too high. When the kidneys don't work properly, as in patients receiving dialysis, another type of protein called beta-2-microglobulin may build up in the blood. When this occurs, beta-2-microglobulin molecules may join together, like the links of a chain, forming a few very large molecules from many smaller ones. These large molecules can form deposits and eventually damage the surrounding tissues and cause great discomfort. This condition is called

87. VASCULITIS, AMYLOIDOSIS, IMMUNODEFICIENCY *amyloidosis as a disease was discovered by Dr. Rokitansky, who called it The name amyloidosis is inappropriate today, because amyloid and starch are http://www.pathguy.com/lectures/imm-iii.htm

VASCULITIS, AMYLOIDOSIS, IMMUNODEFICIENCY (EXCEPT AIDS) Ed Friedlander, M.D., Pathologist scalpel_blade@yahoo.com Cyberfriends: The help you're looking for is probably here. Welcome to Ed's Pathology Notes, placed here originally for the convenience of medical students at my school. You need to check the accuracy of any information, from any source, against other credible sources. I cannot diagnose or treat over the web, I cannot comment on the health care you have already received, and these notes cannot substitute for your own doctor's care. I am good at helping people find resources and answers. If you need me, send me an E-mail at scalpel_blade@yahoo.com Your confidentiality is completely respected. DoctorGeorge.com is a larger, full-time service. There is also a fee site at myphysicians.com , and another at www.afraidtoask.com Translate this page automatically With one of four large boxes of "Pathguy" replies. I'm still doing my best to answer everybody. Sometimes I get backlogged, sometimes my E-mail crashes, and sometimes my literature search software crashes. If you've not heard from me in a week, post me again. I send my most challenging questions to the medical student pathology interest group, minus the name, but with your E-mail where you can receive a reply. Slice of Life videodisk. No medical student should be without access to this wonderful resource. Someday you may be able to access these pictures directly from this page.

88. Amyloidosis The term amyloidosis includes a group of disorders caused by abnormal folding,clumping, (aggregation) http://my.webmd.com/hw/blood_disorders/nord22.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map Health Topics Symptoms ... For a Complete Report Amyloidosis Important It is possible that the main title of the report Amyloidosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Secondary Amyloidosis Transthyretin Methionine-30 Amyloidosis (Type I) Indiana Type Amyloidosis (Type II) Danish Cardiac Type Amyloidosis (Type III) Iowa Type Amyloidosis (Type IV) Finnish Type Amyloidosis (Type V) Icelandic Type Amyloidosis (Type VI) Ohio Type Amyloidosis (Type VII) Familial Visceral Amyloidosis (Type VIII) Familial Lichen Amyloidosis (Type IX) Appalachian Type Amyloidosis Analine 60 Amyloidosis Ashkenazi Type Amyloidosis Isoleucine 33 Amyloidosis Corneal Amyloidosis Amyloid Corneal Dystrophy Familial Cutaneous Amyloidosis Hemodialysis-Related Amyloidosis A Beta-2-Microglobulin Amyloidosis Amyloid Arthropathy of Chronic Hemodialysis Amyloidosis Illinois Type Amyloidosis Prealbumin Tyr-77 Amyloidosis Amyloidosis of Familial Mediterranean Fever Atypical Amyloidosis Cardiopathic Amyloidosis Hereditary Nephropathic Amyloidosis Idiopathic Amyloidosis Lichen Amyloidosis Macular Amyloidosis Neuropathic Amyloidosis

89. BBC - Health - Conditions - Amyloidosis And Abnormal Deposits An uncommon disease, where amyloid accumulates in tissues and organs. http://www.bbc.co.uk/health/conditions/amyloidosis1.shtml

@import url('/includes/tbenh.css') ; Home TV Radio Talk ... A-Z Index THURSDAY 8th September 2005 Text only BBC Homepage Lifestyle Health ... Help Like this page? Send it to a friend! Amyloidosis and abnormal deposits Dr Rob Hicks Amyloidosis is not a common condition. However, since it can damage organs of the body thereby causing them to malfunction, it needs to be considered when things start to go wrong. In this article Abnormally folded proteins Silent accumulation Diagnosis and treatment Abnormally folded proteins Amyloid is the term used to describe a deposit of protein folded in a particular, abnormal way. When these mis-folded proteins deposit in an organ in the body, for example, in the heart, the kidneys or in the nerves, the condition is called amyloidosis. The collection of these abnormal proteins interferes with the normal functioning of the organ affected. Amyloidosis is more common in older people and is also slightly more common in men than it is in women. Since there are many different proteins that may form amyloid, there are also many different types of amyloidosis. The commonest in the UK is AL amyloidosis (also known as primary amyloidosis) where abnormal cells in the bone marrow produce abnormal antibody proteins that form the amyloid. In AA (or secondary amyloidosis), it occurs as a result of an inflammatory condition, most often rheumatoid arthritis, due to the long-term overproduction of an otherwise normal inflammatory protein. There are also some rarer hereditary forms. Silent accumulation

90. Amyloidosis The definitive diagnosis of amyloidosis is made by histological examination Amyloidlike nodules should be distinguished from nodular amyloidosis and, http://www.thedoctorsdoctor.com/diseases/amyloidosis.htm

Background Amyloidosis is a slowly progressive disease which can lead to significant morbidity and death. Amyloid deposits are extracellular and not metabolized or cleared by the body. Thus, the progressive deposits eventually impair the function of the organs where they accumulate. Amyloid is derived from precursor proteins that either have an abnormal structure or are abnormally increased in the serum. About 18 different amyloid precursor proteins have been described. AMYLOID PROTEIN DESIGNATION Immunoglobulin light chain AL Immunoglobulin heavy chain AH Serum amyloid A protein AA Transthyretin ATTR beta-2-microglobulin Apolipoprotein A-I Lysozyme ALys Atrial natriuretic factor AANF Insulin AIns Localized deposits of amyloid may occur in various organs. Probably the most significant finding is the discovery of amyloid in patients with Alzheimer's disease. In this setting, amyloid is postulated to have neurotoxic properties. The definitive diagnosis of amyloidosis is made by histological examination of a biopsy specimen. OUTLINE Disease Associations Pathogenesis Laboratory/Radiologic/Other Diagnostic Testing Gross Appearance and Clinical Variants ... Internet Links DISEASE ASSOCIATIONS CHARACTERIZATION ALOPECIA Progressive generalized alopecia due to systemic amyloidosis Michael E. Lutz, MD

91. Rural Nurse Organization Clinic Digital Library amyloidosis of Kidney, Gross Access document; amyloidosis of Kidney, Additional amyloidosis resources (These sites have not been reviewed. http://ruralnurseorganization-dl.slis.ua.edu/clinical/nephrology/glomerulonephri

Clinical Resources by Topic: Nephrology Amyloidosis Clinical Resources Geriatrics Atlases Radiology Pathology ... Miscellaneous Resources See also: General Nephrology Clinical Resources Amyloidosis Patient/Family Resources The Merck Manual 17th Ed.-1999: Table of contents Chapter 18: Amyloidosis: Table of contents Amyloidosis: Access document Medicine, Ob/Gyn, Psychiatry, and Surgery (eMedicine): Table of contents Amyloidosis, Overview: Access document Amyloidosis, AA (Inflammatory): Access document Amyloidosis, Immunoglobulin-Related: Access document Amyloidosis, Familial Renal: Access document Amyloidosis, Transthyretin-Related: Access document Amyloidosis, Beta2M (Dialysis-related): Access document Dermatology (eMedicine): Table of contents Amyloidosis, Primary Systemic: Access document Amyloidosis, Nodular Localized Cutaneous: Access document Amyloidosis, Lichen: Access document Amyloidosis, Macular: Access document Neurology (eMedicine): Table of contents Amyloid Angiopathy: Access document Neuromuscular Disease Center (WUSTL): Homepage Amyloidosis: Table of contents Geriatrics Resources See also General Geriatrics Resources Merck Manual of Geriatrics: Table of contents Chapter 98. Renal Disorders

92. Amyloidosis amyloidosis is an umbrella term that describes diseases caused by abnormal depositsin the body of the protein amyloid. The symptoms of amyloidosis vary http://www.betterhealth.vic.gov.au/bhcv2/bhcarticles.nsf/pages/Amyloidosis?open

93. BHF Any Questions? - Amyloidosis The British Heart Foundation (BHF) is the leading national charity fighting heartand circulatory disease the UK s biggest killer. The BHF funds research, http://www.bhf.org.uk/questions/index.asp?secondlevel=1161&thirdlevel=1292

94. Immunohistochemistry - In Situ Hybridization - Immunohistochemistry In Amyloidos ProPath Newsletter Immunohistochemistry in amyloidosis. ImmunohistochemistryNewsletter by Rodney T. Miller, MD, Director of Immunohistochemistry, ProPath http://www.immunoportal.com/modules.php?name=News&file=article&sid=9

95. Amyloidosis Similarly, what had been classified as secondary amyloidosis, Most cases ofsenile cardiac amyloidosis or familial amyloid neuropathy have fibrils which http://www.meritcare.com/hwdb/showTopic.asp?pd_hwid=nord22

96. Amyloidosis Support Network - What Is Amyloidosis? amyloidosis is a group of diseases in which one or more organ systems in the The name amyloidosis was first used more than 100 years ago but cases http://amyloidosis.org/whatisit.asp

Search ASN About Us Site Map Tell a Friend Donate to ASN learn more! What is Amyloidosis? Amyloidosis is a group of diseases in which one or more organ systems in the body accumulate deposits of abnormal proteins. The name "amyloidosis" was first used more than 100 years ago but cases were described over 300 years ago. However, only within the past 20 years have physicians understood the specific make-up and structure of amyloid protein. Although amyloidosis is not cancer, it is very serious. It may be disabling or life threatening. However, growing awareness of the condition seems to be leading to substantial new research and treatment alternatives. There are three major types of amyloidosis that are all very different from each other: 1. PRIMARY AMYLOIDOSIS is a plasma cell disorder which originates in the bone marrow and is usually treated with chemotherapy. It is the most common type of amyloidosis in the United States, with estimates of up to 2000 cases diagnosed each year, and occasionally occurs with multiple myeloma. The deposits in this type of the disease are made up of immunoglobulin light chain proteins which may be deposited in any bodily tissues or organs. The disease results when enough amyloid protein builds up in one or more organs to cause the organ(s) to malfunction. The heart, kidneys, nervous system and gastrointestinal tract are most often affected. Normally, bone marrow makes protective antibodies, which are proteins that protect against infection and disease. After they have served their function, these antibodies are broken down and recycled in the body. With amyloidosis, cells in the bone marrow produce antibodies that cannot be broken down. These antibodies then begin to build up in the bloodstream. Ultimately, they leave the bloodstream and can deposit in the tissues or organs as amyloid.

97. Amyloidosis Base de données sur les maladies rares et les médicaments orphelins. http://www.orpha.net/static/GB/amyloidosis.html

Orphanet database access Amyloidosis Direct access to data Alias Amyloid polyneuropathy, transthyretin related Bronchopulmonar amyloidosis Finnish type amyloidosis Ostertag type amyloidosis Portuguese type amyloidosis Summary Full text http://www.orpha.net/data/patho/GB/uk-amyloidosis.pdf Clinical signs Abnormal corneal structure Autosomal dominant inheritance Build/stature/survival anomalies Facial palsy Increased skin pigmentation diffuse Loose skin Prominent / bat ears Protruding lips Puffy eyelids Recurrent infections Renal glomerular defect Skin hypoplasia/atrophy X-linked recessive inheritance Abnormal alimentary tract Cardiac anomalies Eyes anomalies Nephrotic syndrome Neurological structural anomalies Renal failure Hemiparesis/hemiplegia Hyperkeratosis Inguinal hernia Insensitivity to pain Paraparesis/quadraparesis Sparse/absent scalp hair(generalized) Talipes-varus/valgus Ureteric anomalies(reflux/duplex system) Vision anomalies Update : 04/09/2005 Orphanet database access

98. Amyloidosis Online. Interactive support group for persons affected by familial amyloidosispolyneuropathy disease, http://webcenter.health.webmd.netscape.com/hw/blood_disorders/shc29amy.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map Health Topics Symptoms ... Amyloidosis Network International, Inc. Amyloidosis The FAMYL Organization Online. Interactive support group for persons affected by familial amyloidosis polyneuropathy disease, a liver protein disorder, Local meeting in Indiana. CALL: 219-436-5476 E-MAIL: EKoeinig@peoplepc.com WEBSITE: http://www.famy.com VERIFIED: 4/21/2003 Amyloidosis Network International, Inc. International Network. Information and support for persons affected by amyloidosis, an accumulation of abnormal proteins. Networks individuals together for support. Provides education to the public and professionals about the disease. WRITE: Amyloidosis Network Int'l, Inc. 7118 Cole Creek Dr. Houston, TX 77092-1421 CALL: 1-888-269-5643 VERIFIED: 3/24/2004 The above information was "verified" as correct on the date at the end of each entry. Since American Self-Help Group Clearinghouse's database is extensive but staffing is limited and information for these organizations can change, it is not possible to keep every entry in American Self-Help Group Clearinghouse database completely current and accurate. Please check with the organizations listed for the most current information.

99. Amyloidosis amyloidosis Updated May 18, 2004 amyloidosis and Kidney Disease NationalInstitute of Diabetes and Digestive and Kidney Diseases http://www.noah-health.org/en/endocrine/endocrine/amyloidosis.html

Skip navigation About NOAH Help English Spanish Both Advanced NOAH Endocrine Disorders Change text size: Amyloidosis Updated: May 18, 2004 Amyloidosis Merck Manual, 2nd Home Edition Amyloidosis Mayo Clinic Amyloidosis and Kidney Disease National Institute of Diabetes and Digestive and Kidney Diseases Researched by NOAH Contributing Editor: NOAH Team NOAH Endocrine Disorders Specific Endocrine Disorders > Amyloidosis Health Topics Index A to Z Page of the Month Advanced Search ... Feedback

100. Search Result For "Amyloidosis" amyloidosis; amyloidosis; amyloidosis and Kidney Disease http//www.noahhealth.org/en/endocrine/endocrine/amyloidosis.html Information Resources http://www.noah-health.org/search/results.php?lang=1&keyword=Amyloidosis&dtype=1

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