1. Amyloidosis Detailed information about this disease by Robert C. Mellors, MD, Ph.D. of theCornell University Medical College. http://edcenter.med.cornell.edu/CUMC_PathNotes/Immunopathology/Immuno_04.html

Immunopathology by Robert C. Mellors, M.D., Ph.D. Amyloidosis General Considerations (Note: Amyloid can be studied in the context of cell injury or immunological diseases. For this reason, we have included the same material in both Cell Injury and Immunopathology.) A myloidosis is not a single disease entity but rather a diverse group of disease processes characterized by extracellular tissue deposits, in one or many organs, of protein materials which are generically termed amyloid. Amyloid is distinguished grossly by a starch-like staining reaction with iodine (thus the term amyloid), microscopically by its extracellular distribution and tinctorial and optical properties when stained with Congo red, and by its protein fibril structure as shown by electron microscopy and x-ray crystallography (see Table-1). Table-1 Amyloid deposition may be either a primary (idiopathic) process without known antecedent or secondary to some other condition and may be localized to one specific site or generalized throughout the body (systemic), usually with fatal consequences. Although considerable overlap is seen in the organ distribution of various forms of amyloid, primary amyloidosis tends to involve mesodermal tissues, most frequently affecting peripheral nerves, skin, tongue, joints, heart, and liver while secondary amyloidosis mainly affects parenchymatous organs, such as spleen, kidneys, liver, and adrenals. Amyloid deposits typically contain three components. Amyloid protein fibrils account for about 90% of the amyloid material and comprise one of several different types of proteins with the capacity to fold into what are called "beta-pleated" sheet fibrils, a unique protein configuration with binding sites for Congo red. In addition, amyloid deposits are intimately associated with the amyloid P (pentagonal) component (AP), a glycoprotein related to normal serum amyloid P (SAP), and are closely associated with sulfated glycosaminoglycans (GAG), complex carbohydrates of connective tissue.

2. Symptoms Of Amyloidosis Ask the doctor medical forum for patients hosted by Med Help. A brief look at this disease and the symptoms. http://www.medhelp.org/perl6/neuro/archive/4773.html

Questions in The Neurology Forum are being answered by doctors from The Cleveland Clinic , consistently ranked one of the best hospitals in America. Forum: The Neurology and Neurosurgery Forum Topic: Amyloidosis Subject: Symptoms of Amyloidosis I understand that amyloidosis is a neurological condition and that an enlarged tongue can be a symptom. What are the other symptoms of this disease and is the onset of the disease slow or does it advance rapidly? Are fasciculations a common symptom? Muscle weakness? Thank you for your help. Amyloidosis is in fact a multisystem disease which sometimes may effect the nervous system. It involves the deposition of protein aggregates in various tissues and can be either a genetic condition or may occurr in response to another pathological condition,for example chronic inflammation. The age of onset and progression of amyloidosis is largely dependent on the underlying cause with more rapid evolution in the familial (inherited) types. The neurological manifestations usually declare themselves in the form of peripheral neuropathy, with numbness and weakness of the peripheries.

3. Amyloidosis Join a support group for this disease and links to other sites. http://www.sblupus.org/amyloid.html

Amyloidosis Amyloidosis Information Page Amyloidosis Medical Links Amyloidosis Network International Amyloidosis Web Forum and Links ... Boston University Amyloid Treatment and Medical Center Guide for Patients Healthlink USA Mayo Clinic Patient InformationAmyloidosis Neuromuscular Disease Center Amyloidosis NORD Amyloidosis ... Yahoo! Amyloidosis We have started an email discussion list for anyone with an interest in amyloidosis. Try it out! To subscribe, click on the link below: Click to subscribe to amyloidosis Return to the Resource List Go to Did you come to this page first? Check out our features on the Resource List and the Main Menu ! Also, visit our bookstore ! And please post on our Message Board Share your favorite links with us so we can add them to this page! E-mail us at sblc@silcom.com Tell us what you liked and didn't like about any links or our page in general. Fill out a Comment Card or e-mail us Find any BUGS on our pages? Something go to the wrong place, misspelled, out-of-date, or otherwise need fixing? Please let us know! Fill out a

4. Peripheral Neuropathy And Amyloidosis Ask the doctor medical forum for patients hosted by Med Help. http://www.medhelp.org/perl6/neuro/archive/10656.html

Questions in The Neurology Forum are being answered by doctors from The Cleveland Clinic , consistently ranked one of the best hospitals in America. Forum: The Neurology and Neurosurgery Forum Topic: Amyloidosis Subject: Peripheral Neuropathy and Amyloidosis You may have come up with something which explains your problems and it is VERY important that you share this information with bothof your physicians. Amyloidosis is a disease in which abnormal protein polymers or aggregates are laid dowm in multiple organs, it usually occurrs in response to chronic infection or inflammation and given your history of chronic hepatitis you would be a likely candidate. Amyloid is laid dowm as I mentioned in multiple organs,including skin, spleen, kidneys and peripheral nerves. In solid organs it can cause enlargement,in peripheral nerves it can cause neuropathy. The diagnosis can be made by a biopsy of a peripheral nerve or any other involved tissue, I would bring this to the attention of your neurologist as it is obviously very relevant ot your subsequent evaluation and treatment.

5. NORD - National Organization For Rare Disorders, Inc. A list of alternative names and a general discussion about this disease. http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Amyloidosis

6. Head And Neck Manifestations Of Amyloidosis Written by J. Cary Moorhead, MD for the Baylor College of Medicine. http://www.bcm.edu/oto/grand/4992.html

Grand Rounds Archives The information contained within the Grand Rounds Archive is intended for use by doctors and other health care professionals. These documents were prepared by resident physicians for presentation and discussion at a conference held at The Baylor College of Medicine in Houston, Texas. No guarantees are made with respect to accuracy or timeliness of this material. This material should not be used as a basis for treatment decisions, and is not a substitute for professional consultation and/or peer-reviewed medical literature. HEAD AND NECK MANIFESTATIONS OF AMYLOIDOSIS J. Cary Moorhead, MD April 9, 1992 Amyloidosis is not a specific disease per se, but rather is the result of a number of unrelated disease processes leading to deposition of extracellular protein in tissues throughout the body. This disease frequently presents with head and neck manifestations. Amyloidosis is typified by extracellular deposition of insoluble proteinaceous material which has typical staining properties and electron microscopic appearance. Its hallmark is an apple green birefringence under polarized microscopy. Under the electron microscope, amyloid appears as a mass of rigid, nonbranching fibrils. X-ray crystallography reveals that these fibrils have a regular, antiparallel, beta-pleated sheet configuration. Amyloidosis can affect virtually any organ or tissue in the body. The most common presenting symptoms are fatigue or weakness, weight loss, ankle edema, dyspnea, paresthesias, and light-headedness or syncope. The most common physical findings are hepatosplenomegaly, edema, macroglossia, orthostatic hypotension and purpura. A number of associated syndromes are frequently seen, including carpal tunnel syndrome, peripheral neuropathy, nephrotic syndrome, congestive heart failure and sprue. The most significantly involved organ systems are the kidneys and heart. Failure of these two systems also constitutes the two leading causes of death.

7. Amyloidosis Support Network amyloidosis Support Network The Network s primary function is to link thoseaffected by amyloidosis, to further support resources, and to educate the http://www.amyloidosis.org/

Search ASN About Us Site Map Tell a Friend Donate to ASN learn more! ASN Mission Statement The Amyloidosis Support Network's primary function is to "link those affected by amyloidosis to further support resources" and increase public and professional awareness so that the disease can be detected earlier and properly treated. Learn more about The Amyloidosis Support Network (A 501c3 Non-Profit Organization). What is Amyloidosis or Amyloid? Amyloidosis is a group of diseases in which one or more organ systems in the body accumulate deposits of abnormal proteins known as amyloid. The name "amyloidosis" was first used more than 100 years ago, but cases were described over 300 years ago. However, only within the past 25 years have physicians understood the specific make-up and structure of amyloid proteins. Although amyloidosis is not cancer, it is very serious. It is disabling or life threatening. However, growing awareness of the condition seems to be leading to substantial new research and treatment alternatives. Learn more about amyloidosis or amyloid.

8. Amyloidosis Support Network Provide complete, integrated, easyto-reach support and information to existing information and referrals for other sources of help. Primarily for patients and their families struggling with the disease. http://amyloidosis.org/

Search ASN About Us Site Map Tell a Friend Donate to ASN learn more! ASN Mission Statement The Amyloidosis Support Network's primary function is to "link those affected by amyloidosis to further support resources" and increase public and professional awareness so that the disease can be detected earlier and properly treated. Learn more about The Amyloidosis Support Network (A 501c3 Non-Profit Organization). What is Amyloidosis or Amyloid? Amyloidosis is a group of diseases in which one or more organ systems in the body accumulate deposits of abnormal proteins known as amyloid. The name "amyloidosis" was first used more than 100 years ago, but cases were described over 300 years ago. However, only within the past 25 years have physicians understood the specific make-up and structure of amyloid proteins. Although amyloidosis is not cancer, it is very serious. It is disabling or life threatening. However, growing awareness of the condition seems to be leading to substantial new research and treatment alternatives. Learn more about amyloidosis or amyloid.

9. Amyloidosis Support Network amyloidosis Support Network The Network's primary function is to link those affected by amyloidosis, to further support resources, and to educate http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

10. MedlinePlus Medical Encyclopedia: Primary Amyloidosis Primary amyloidosis is a disorder in which insoluble protein fibers are deposited in The cause of primary amyloidosis is unknown, but the condition is http://www.nlm.nih.gov/medlineplus/ency/article/000533.htm

@import url(/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Primary amyloidosis Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Amyloidosis on the fingers Amyloidosis on the face Alternative names Return to top Amyloid - primary Definition Return to top Primary amyloidosis is a disorder in which insoluble protein fibers are deposited in tissues and organs, impairing their function. Causes, incidence, and risk factors Return to top The cause of primary amyloidosis is unknown, but the condition is related to abnormal production of immunoglobulins by a type of immune cell called plasma cells. The symptoms depend on the organs affected by the deposits, which can include the tongue, intestines, skeletal and smooth muscles, nerves, skin, ligaments, heart, liver, spleen, and kidneys. This can result in the following conditions: Cardiomyopathy (poor heart function) Kidney failure Carpal tunnel syndrome (painful swelling of nerves in the wrist) Malabsorption (inadequate absorption of nutrients from the intestinal tract) Gastrointestinal reflux (GERD) Other conditions The deposits infiltrate the affected organs, causing them to lose resilience and become stiff, which decreases their ability to function. Secondary amyloidosis can be caused by infection, inflammatory diseases, and sometimes cancer.

11. Atlas Of Pathology A picture of group of proteins arranged in a Bpleated sheet affecting a blood vessel. http://www.med.uiuc.edu/PathAtlasf/CVAtlas020.html

Back to Previous Image URBANA ATLAS OF PATHOLOGY Cardiovascular Volume Image Number 020 - Amyloidosis, blood vessel Click for image Go to next image in this volume Back to Master Atlas contents

12. Amyloidosis Treatment At Mayo Clinic amyloidosis treatment for abnormal protein deposited in the body's tissues or organs at Mayo Clinic. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

13. MedlinePlus Medical Encyclopedia: Cardiac Amyloidosis Senile cardiac amyloidosis is becoming more common as the average age of the Cardiac amyloidosis is the most typical restrictive cardiomyopathy, http://www.nlm.nih.gov/medlineplus/ency/article/000193.htm

@import url(/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Cardiac amyloidosis Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Calling your health care provider Illustrations Heart, section through the middle Dilated cardiomyopathy Alternative names Return to top Amyloidosis - cardiac; Restrictive cardiomyopathy - amyloidosis; Primary cardiac amyloidosis - AL type; secondary cardiac amyloidosis - AA type; Stiff heart syndrome Definition Return to top Cardiac amyloidosis is a disorder caused by deposits of an abnormal protein in the heart tissue, resulting in decreased heart function. Causes, incidence, and risk factors Return to top Amyloidosis refers to buildup of a fibril called amyloid in tissues anywhere in the body. Fibrils are proteins produced in excess that are deposited in different organs and slowly replace normal tissue. Different types of amyloidosis are caused by different types of proteins, such as "AL" and "AA." In cardiac amyloidosis there may be associated conduction disturbances (changes in the way the cardiac electrical impulse is transmitted through the heart). Cardiac amyloidosis usually occurs during primary amyloidosis (called AL type amyloidosis). Primary amyloidosis usually accompanies multiple myeloma, a blood disorder in which too much of a certain type of protein is produced. This excess protein is deposited in the heart and in other organs such as the kidney. Deteriorating kidney function also occurs.

14. The Merck Manual Endocrine And Metabolic Disorders Chapters on a variety of endocrine problems such as hyperlipidemia, polyglandular deficiency syndromes, the porphyrias, amyloidosis, and others. http://www.merck.com/mrkshared/mmanual/section2/sec2.jsp

15. Amyloidosis Symptoms, Diagnosis And Treatment Explains how amyloidosis results from protein antibodies accumulating on an organ causing diseases such as multiple myeloma and mad cow disease. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

16. Health And Medical Information Produced By Doctors - MedicineNet.com MedicineNet.com With its definition, symptoms, diagnosis, and treatment. http://www.medicinenet.com/Script/Main/Art.asp?li=MNI&d=51&cu=16583&

17. THE MERCK MANUAL, Sec. 2, Ch. 18, Amyloidosis Chapter 18. amyloidosis Topics General amyloidosis Accumulation in the tissues of various insoluble fibrillar proteins (amyloid) in http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

18. THE MERCK MANUAL, Sec. 2, Ch. 18, Amyloidosis amyloidosis Accumulation in the tissues of various insoluble fibrillar In the different biochemical types of amyloidosis, etiologic mechanisms may vary http://www.merck.com/mrkshared/mmanual/section2/chapter18/18a.jsp

19. Amyloidosis Table2 Classifications of amyloidosis amyloidosis and Alzheimer's disease. Pathogenesis of amyloidosis. amyloidosis is not one disease but a http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

20. THE MERCK MANUAL--SECOND HOME EDITION, Ch. 304, Amyloidosis amyloidosis is twice as common in men as in women and is more common People with amyloidosis who develop heart failure have a poor prognosis as well. http://www.merck.com/mmhe/sec25/ch304/ch304a.html

var externalLinkWarning = "The link you have selected will take you to a site outside Merck and The Merck Manuals.*n*nThe Merck Manuals do not review or control the content of any non-Merck site. The Merck Manuals do not endorse and are not responsible for the accuracy, content, practices, or standards of any non-Merck sources."; Search The Second Home Edition , Online Version Search Index A B C D ... Z Sections Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders ... Women's Health Issues Resources Anatomical Drawings Multimedia Pronunciations Weights and Measures ... , Online Version Section Special Subjects Chapter Amyloidosis Topics Amyloidosis Amyloidosis Buy The Book Print This Topic Email This Topic Pronunciations amyloidosis arrhythmia arthritis colchicine ... prednisone Amyloidosis is a rare disease in which a protein called amyloid accumulates in various tissues and organs, impairing normal function. Amyloidosis causes few or no symptoms in some people, while producing severe symptoms and fatal complications in other people. The severity of the disease depends on which organs are affected by amyloid deposits. Amyloidosis is twice as common in men as in women and is more common among older people. Many forms of amyloidosis exist, and the disease can be classified into four groups: primary amyloidosis, secondary amyloidosis, hereditary amyloidosis, and amyloidosis associated with normal aging.

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