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         Alpha-1 Antitrypsin Deficiency:     more books (16)
  1. Alpha 1 - Antitrypsin Deficiency (Lung Biology in Health and Disease) by Crystal, 1995-10-26
  2. Alpha-1-Antitrypsin Deficiency: Pathophysiology, Diagnosis and Treatment by Bals, 2010-03
  3. Alpha-1 Antitrypsin Deficiency - Clinical Aspects and Management (Uni-Med Science) by Thomas Kohnlein, 2007-02-15
  4. Best practices in: diagnosis and management of alpha-1 antitrypsin deficiency.(Disease/Disorder overview)(Report): An article from: Family Practice News by Leonard Fromer, 2009-04-01
  5. Best practices in: diagnosis and management of alpha-1 antitrypsin deficiency.: An article from: Internal Medicine News by Gale Reference Team, 2009-04-01
  6. Alpha-1 Antitrypsin Deficiency - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers by Philip M. Parker, 2007-07-19
  7. Pharmacological treatment of alpha 1 antitrypsin deficiency.(RESPIRATORY PHARMACOLOGY): An article from: FOCUS: Journal for Respiratory Care & Sleep Medicine by Doug Gardenhire, 2010-01-01
  8. Alpha 1-antitrypsin deficiency
  9. Alpha 1-Antitrypsin Deficiency: Biology, Pathogenesis, Clinical Manifestations, Therapy by Marcel Dekker, 1996-01-01
  10. [Alpha.sub.1]-antitrypsin deficiency is often overlooked, and can lead to COPD.(Pulmonary Medicine)(chronic obstructive pulmonary disease ): An article from: Family Practice News by Debra Wood, 2004-08-01
  11. Alpha-1 Antitrypsin Deficiency: A History Through the Medical Literature
  12. Understanding alpha-1 antitrypsin deficiency (SuDoc HE 20.3002:AN 8/6) by U.S. Dept of Health and Human Services, 1994
  13. COPD: alph[a.sub.1]-antitrypsin deficiency often overlooked.(chronic obstructive pulmonary disease): An article from: Internal Medicine News
  14. Alpha-1 antitrypsin: An entry from Thomson Gale's <i>Gale Encyclopedia of Genetic Disorders, 2nd ed.</i> by Michelle, MS, CGC Bosworth, 2005

41. Alpha-1 Antitrypsin Deficiency
alpha1 antitrypsin deficiency is a disease caused by reduced or abnormal The liver is also damaged by alpha-1 antitrypsin deficiency, as are the lungs.
http://www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive
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Alpha-1 antitrypsin deficiency
Written by Dr David Maxton, gastroenterologist
What is alpha-1 antitrypsin deficiency?
Alpha-1 antitrypsin deficiency is a disease caused by reduced or abnormal production in the body of the enzyme inhibitor alpha-1 antitrypsin. Body tissues and blood normally contain powerful enzymes - known as proteases - that can attack foreign substances within the body that may be harmful, such as tobacco smoke. However, these protease enzymes must be carefully regulated as they could attack and damage normal tissues rather than the intended target resulting in local tissue damage. Blood and tissues have a protease inhibitor that binds the enzyme to prevent unrestricted and potentially harmful protease activity. The commonest protease inhibitor in the blood is alpha-1 antitrypsin and its role is to protect the tissues from protease attack. Alpha-1 antitrypsin is one of a family of proteins with similar functions known as the serine proteinase inhibitor (or serpin) superfamily. These proteins play an important role in controlling inflammation, coagulation and repair mechanisms in the body. Most alpha-1 antitrypsin in the body is produced by the liver. The liver is also damaged by alpha-1 antitrypsin deficiency, as are the lungs.

42. Alpha-1 Antitrypsin Deficiency
The symptoms of liver disease due to alpha1 antitrypsin deficiency in adults are alpha-1 antitrypsin deficiency is associated with an increased risk of
http://www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive
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Alpha-1 antitrypsin deficiency (Contd)
Written by Dr David Maxton, gastroenterologist
Adult liver disease
The symptoms of liver disease due to alpha-1 antitrypsin deficiency in adults are similar to those in older children. But the disease may not become apparent for years. The symptoms are the same as with any other liver cirrhosis: jaundice, abdominal swelling, bleeding into the gut and, ultimately, coma. Alpha-1 antitrypsin deficiency is associated with an increased risk of hepato-cellular carcinoma or primary liver cancer. This cancer may be the first sign of disease. Disease in alpha-1 antitrypsin carriers
It is unclear whether heterozygous carriers, eg those with one abnormal gene, are more prone to develop liver disease. Some liver disease currently of unknown cause may be due to alpha-1 antitrypsin deficiency. Alternatively, reduced alpha-1 antitrypsin may worsen or increase susceptibility to liver disease due to other causes such as infection or alcohol. How is alpha-1 antitrypsin deficiency diagnosed?

43. Alpha2Alpha Home Page
alpha1 antitrypsin deficiency Support Group Logo to people having emphysema and other health disorders related to alpha-1 antitrypsin deficiency.
http://alpha2alpha.net/
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This site is d edicated to Claude Baril: founder of the Alpha-1 Internet Mailing List linking Alphas all over the world for educational purposes only Alpha-1 Antitrypsin Deficiency
is a genetic disease that can affect the liver
(cirrhosis), lungs (emphysema), and skin
(panniculitis). Our mission is to provide peer-to-peer support and information to people having emphysema and other health disorders related to Alpha-1 Antitrypsin Deficiency. Top
Updated July 18, 2005 What is Alpha1? Links General Lung-affected , and Liver-affected information. The remaining navigation buttons link to specific support areas in this site. Note all For questions about Social Security
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44. Alpha-1 Antitrypsin Deficiency - Patient UK
alpha1 antitrypsin deficiency Information or supportSearch further.
http://www.patient.co.uk/showdoc/90/
Alpha-1 Antitrypsin Deficiency
Information or support Search further
UK sources of information and / or support
Alpha 1 Antitrypsin Alliance
Aims to raise the profile of A1AD amongst the medical profession and to assist in the early identification / diagnosis of individuals with the disorder.
Alpha-1 UK
Offers support and advice to those with Alpha-1 Antitrypsin Deficiency in the UK.
Alpha-1-antitrypsin deficiency
Article on Alpha-1-antitrypsin deficiency from the Children's Liver Disease Foundation
British Liver Trust
Provides support to people with liver conditions.
Children's Liver Disease Foundation
Provides support to children and families affected by childhood liver diseases.
Further sources / More detailed information
Some non-UK sites
The following list popular non-UK health information sites, mainly from the US. They have not been checked to see if alpha-1-antitrypsin deficiency is included but these large sites are comprehensive.
Evidence Based Medicine
For sites and information on Evidence Based Medicine.

45. Alpha-1 Antitrypsin Deficiency (AATD), Cincinnati Children's Hospital Medical Ce
alpha1 antitrypsin deficiency (AATD) causes, signs, symptoms, diagnosis, treatment and prognosis information by the Pediatric Liver Care Center at
http://www.cincinnatichildrens.org/svc/alpha/l/liver/diseases/alpha-1-antitrypsi
Home Contact Us Site Map Go to Advanced Search ... Alagille Syndrome Alpha-1 Antitrypsin Deficiency Autoimmune Hepatitis Biliary Atresia Gylcogen Storage Disease (GSD) Hepatocellular Carcinoma (Hepatoma) ... Contact Us
Liver Diseases and Treatments
Alpha-1 Antitrypsin Deficiency (AATD)
Related Services Liver Care Center
Explanation
Causes Symptoms l Diagnosis l Treatment l Prognosis
What is alpha-1 antitrypsin deficiency (AATD)?
Alpha-1 antitrypsin deficiency (AATD) is a common, serious disease that is passed down from parents to children. It can cause liver and lung disease. In some cases, it can cause a rare skin condition in children and adults called panniculitis (rare form of skin disease that is an inflammation of fat just beneath the skin, causing the skin to harden and form lumps). The liver makes a protein called alpha-1 antitrypsin that goes into the bloodstream. This protein protects the lungs and allows them to work normally. If there is not enough alpha-1 antitrypsin, it is called alpha-1 antitrypsin deficiency (AATD). Alpha-1 antitrypsin deficiency is the most common genetic cause of liver disease in children and is the most common genetic disease for which liver transplantation is done.

46. Department Of Medicine: Pulmonary & Critical Care
alpha1 antitrypsin deficiency (Alpha-1) is one of the most common serious hereditary disorders in the world and can result in life-threatening lung or
http://www.med.miami.edu/med/pulmonarymed/alpha.asp
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ALPHA-1 ANTITRYPSIN DEFICIENCY
Para Espanol presione aqui
Alpha-1 Antitrypsin Deficiency (Alpha-1) is one of the most common serious hereditary disorders in the world and can result in life-threatening lung or liver disease in children and adults.
Alpha-1 can lead to lung destruction and is often misdiagnosed as asthma or smoking-related emphysema, chronic bronchitis or Chronic Obstructive Pulmonary Disease (COPD). Lung disease is the most frequent cause of disability and early death among affected persons and a major reason for lung transplantation. Alpha-1 can also lead to liver failure in childhood (a major cause of liver transplantation in children) and may cause progressive liver damage in adults.
Our group includes both clinicians and scientists who have a special interest in the study and management of Alpha-1. We are collaborating in clinical trials with the Alpha-1 Foundation and have a special interest in studying why individuals with this disorder develop airway disease. Our strong commitment to care and research in Alpha-1 has established us as a referral center for patients suffering from this disease in South Florida.

47. University Of Miami School Of Medicine - Glossary - Alpha 1 Antitrypsin Deficien
What are the signs and symptoms of the alpha1 antitrypsin deficiency? alpha-1 antitrypsin deficiency is an inherited (passed down from parents)
http://www.med.miami.edu/glossary/art.asp?articlekey=278

48. Alpha-1 Antitrypsin Deficiency Medical Information
alpha1 antitrypsin deficiency Information from Drugs.com.
http://www.drugs.com/enc/alpha_1_antitrypsin_deficiency.html

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Alpha-1 antitrypsin deficiency
Injury Disease Nutrition Poison ... Liver anatomy
Alpha-1 antitrypsin deficiency
Definition
Alpha-1 antitrypsin deficiency is a lack of a liver protein that blocks the destructive effects of certain enzymes. The condition may lead to emphysema and liver disease
Alternative Names
AAT deficiency
Causes
Alpha-1 antitrypsin deficiency results from a genetic defect. The mechanism that causes associated liver disease and emphysema in some people with this deficiency is not known. However some evidence suggests that it may be related to inflammation. Approximately 75% of adults with severe deficiency will develop emphysema, which often begins before 40 years of age. Smoking can increase risk.
Symptoms
Additional symptoms that may be associated with emphysema or cirrhosis include the following:

49. Alpha-1 Antitrypsin Deficiency
Liver Patholgy Digital Lab Alpha1-Antitrypsin Deficiency III alpha-1 antitrypsin deficiency WEB Alpha 1 National Association (antitrypsin deficiency
http://www.ability.org.uk/alpha1_antitrypsin_deficiency.html
Our Aims Services Stats ... Z Alpha-1 Antitrypsin Deficiency Alpha-1 Antitrypsin Deficiency Alpha-1-antitrypsin Deficiency Patient UK - Alpha-1-antitrypsin deficiency Alpha-1-Antitrypsin Deficiency (AAT ... Webmaster . Site Design by Ability "see the ability, not the disability" Acknowledgments

50. Alpha-1 Antitrypsin Deficiency - Medco.com
Research diseases and conditions or browse detailed drug information. Features include interactive tools and related news.
http://www.medcohealth.com/medco/consumer/ehealth/ehskeywordsearch.jsp?topicID=A

51. Alpha-1 Advocacy Alliance - What Is Alpha-1 Antitrypsin Deficiency...
Alpha1 Advocacy Alliance mission is to improve the health and well being of those affected by Alpha-1 through support to patients, educating healthcare
http://www.alpha1advocacy.org/wialpha.html
Home Mission Statement What is Alpha-1 Need Help Now ! ... Alpha-1 Advocacy Summary
Won't you sign up for membership? Simply click HERE
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Read our and be assured we are here to help. Let us know what we can do for YOU!
What is Alpha-1 Antitrypsin Deficiency...
Alpha-1 antitrypsin is a protein produced by the liver to protect the human body from damage caused by neutrophil elastase. Neutrophil elastase is an enzyme released by white blood cells during times of inflammation and infection and is necessary in digesting damaged cells and bacteria.  When A1AD is not available to neutralize this enzyme, the body tissues are damaged.
(AAT) is a "protein" (also called "alpha-1 proteinase inhibitor") , which circulates in the blood. AAT protects the human tissues from being damaged by other chemicals that are contained in white blood cells.
White blood cells contain chemicals ("enzymes")

52. ALPHA-1 ANTITRYPSIN DEFICIENCY - HEREDITARY EMPHYSEMA
alpha1 antitrypsin deficiency alias Genetic or Hereditary Emphysema Alpha1-antitrypsin deficiency is a hereditary defect in body chemistry.
http://www.cheshire-med.com/programs/pulrehab/forum/messages/6834.html
ALPHA-1 ANTITRYPSIN DEFICIENCY - HEREDITARY EMPHYSEMA
Follow Ups Post Followup TCMC Chronic Lung Disease Forum FAQ Posted by PeterD on July 11, 1998 at 16:11:47: Alpha-1 Antitrypsin Deficiency alias Genetic or Hereditary Emphysema My name is PeterD. You can get information about Alpha-1 from a toll free number listed at: 1-800 425-7421 and/or if you have access to the web there are three (3) great pages about Alpha-1 produced by real live Alpha folks. Those pages are as follows: http://www.alpha1.org http://www.alphalink.org http://www.alphaone.org These are great sources for information and research. Please let me know if I can help you anymore. For a starter here is a general article on Alpha-1 Antitrypsin Deficiency. Take care and holler if you need to. PeterD
Information for Patients with Alpha1-Antitrypsin Deficiency This information is being provided to help you understand alpha1-antitrypsin deficiency. This information is not a substitute for your doctor. Some of the terms may be confusing at first; if you have questions about this information, don't hesitate to ask your doctor. Alpha1-antitrypsin deficiency is a hereditary defect in body chemistry. Less than 100,000 Americans have it.

53. University Of Florida - Alpha-1 Antitrypsin Deficiency Detection Laboratory
The alpha1 antitrypsin deficiency Detection Laboratory at the University of Florida is an international reference laboratory for Alpha-1 Antitrypsin levels
http://www.alphaone.ufl.edu/a1dlab.php
The Alpha-1 Antitrypsin Deficiency Detection Laboratory at the University of Florida is an international reference laboratory for Alpha-1 Antitrypsin levels and phenotype and genotype analysis. Currently three Alpha-1 detection programs are utilizing the services of the UF Alpha-1 Antitrypsin Deficiency Detection Laboratory. Through these programs, testing is provided free of charge to patients. State of Florida Alpha-1 Detection Program The State of Florida and the Alpha-1 Foundation have sponsored this detection program since 1999. The program focuses on targeted population screening, patient and physician education, and treatment programs for AAT Deficiency. For more information on the State of Florida Alpha-1 Detection Program or to order a free test kit, please call the University of Florida Alpha-1 Research Program toll-free at 1-800-559-5706. Talecris Biotherapeutics Alpha-1 Detection Program Talecris Biotherapeutics is supporting a nationwide targeted detection program for Alpha-1. Test kits and laboratory processing are provided to pulmonary clinics and at-risk patients free of charge. For more information or to obtain a Talecris Alpha-1 test kit, please call 1-800-562-7222. Alpha-1 Coded Testing (ACT) Trial The Medical University of South Carolina (MUSC) is currently conducting a research study which evaluates perceived risks and benefits of genetic testing. The

54. Alpha-1 Antitrypsin Deficiency
alpha1 antitrypsin deficiency alleles and severe cystic fibrosis lung disease. Augmentation therapy for severe alpha 1-antitrypsin deficiency is the
http://www.umdnj.edu/rspthweb/bibs/antitryp.htm
Alpha-1 Antitrypsin Deficiency
Belai Y, Hernandez-Juviel JM, Bruni R. Addition of alpha1-antitrypsin to surfactant improves oxygenation in surfactant-deficient rats. Am J Respir Crit Care Med. Piitulainen E, Eriksson S. Decline in FEV1 related to smoking status in individuals with severe alpha1-antitrypsin deficiency (PiZZ). Eur Respir J. Alpha-1-Antitrypsin Deficiency Registry Study Group. Survival and FEV1 decline in individuals with severe deficiency of alpha1-antitrypsin. Am J Respir Crit Care Med. Cassina PC, Teschler H, Konietzko N, et al. Two-year results after lung volume reduction surgery in alpha1- antitrypsin deficiency versus smoker's emphysema. Eur Respir J. Mahadeva R, Lomas DA. Genetics and respiratory disease. 2. Alpha 1-antitrypsin deficiency, cirrhosis and emphysema. Thorax. Mahadeva R, Stewart S, Bilton D, Lomas DA. Alpha-1 antitrypsin deficiency alleles and severe cystic fibrosis lung disease. Thorax. Paone G, Brantly M. alpha 1-antitrypsin deficiency. Monaldi Arch Chest Dis.

55. Alpha1-antitrypsin Deficiency Alleles And The Taq-I G-->A Allele In Cystic Fibro
Alpha1antitrypsin deficiency phenotypes were detected in 20 (16 MS, alpha-1 antitrypsin deficiency alleles and severe cystic fibrosis lung disease
http://erj.ersjournals.com/cgi/content/abstract/11/4/873
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Alpha1-antitrypsin deficiency alleles and the Taq-I G>A allele in cystic fibrosis lung disease
R Mahadeva, RC Westerbeek, DJ Perry, JU Lovegrove, DB Whitehouse, NR Carroll, RI Ross-Russell, AK Webb, D Bilton, and DA Lomas
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Am. J. Respir. Cell Mol. Biol., September 1, 2003; 29(3): 390 - 396.

56. Childrens Liver Disease Foundation
Alpha 1 Antitrypsin Deficiency Posted 4 February 2004. alpha1 antitrypsin deficiency, which is often written as Alpha-1 ATD, was first identified in 1968.
http://www.childliverdisease.org/diseases/alpha1
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About this section
Alpha 1 Antitrypsin Deficiency
Alpha 1 Antitrypsin Deficiency
Posted: 4 February 2004 Alpha-1 antitrypsin deficiency, which is often written as Alpha-1 ATD, was first identified in 1968. Individuals with Alpha-1 ATD produce a slightly different form of Alpha-1 antitrypsin protein in the liver. This abnormal Alpha-1 AT becomes trapped in the liver. This also means that it is not carried to other parts of the body so individuals usually, but not always, have low concentrations of Alpha-1 AT in their blood. Click here to order a leaflet Click here to contact a member of the support team To speak to a member of the support team call 0121 212 6008/6009 Related Links: Literature Order Form This site uses scripts to create a rollover effect on the navigation, but dont worry if you have got them disabled, you can access all the content by clicking on the main button, and navigating your way through using the links at the bottom of each content page.

57. Environmental Health Perspectives: Alpha-1 Antitrypsin Deficiency Is Not A Rare
Full text of the article, alpha1 antitrypsin deficiency is not a rare disease but a disease that is rarely diagnosed - Commentary from Environmental
http://www.findarticles.com/p/articles/mi_m0CYP/is_16_111/ai_112983153
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ABNF Journal, The AIDS Treatment News AMAA Journal ... View all titles in this topic Hot New Articles by Topic Automotive Sports Top Articles Ever by Topic Automotive Sports Alpha-1 antitrypsin deficiency is not a rare disease but a disease that is rarely diagnosed - Commentary Environmental Health Perspectives Dec, 2003 by Frederick J. de Serres
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There are no data on genetic epidemiologic studies of AAT deficiency in countries in the Caribbean such as Puerto Rico or countries in Central and South America where the numbers of immigrants from countries in southern Europe is high (de Serres 2002). Therefore, the numbers at risk for AAT deficiency worldwide are expected to be much higher. Furthermore, this database demonstrates that AAT deficiency is found in various populations of African blacks; Arabs and Jews in the Middle East; and Central, Far East, and Southeast Asians; as well as whites in northern Europe and their descendents in Australia, New Zealand, and North America. In addition, these new data indicate that there are marked racial and ethnic differences in the gene frequencies and prevalence of the PiS and PiZ alleles worldwide (de Serres 2002).

58. Alpha-1 Antitrypsin Deficiency Panniculitis Rajagopal R, Malik AK, Murthy PS, Ne
be an underlying cause such as proteinase inhibitor deficiency. Herein a case of alpha1 antitrypsin deficiency leading to panniculitis is described.
http://www.ijdvl.com/article.asp?issn=0378-6323;year=2002;volume=68;issue=6;spag

59. The Federal Air Surgeon's Medical Bulletin, Summer 2002: An Airman With Alpha-1
alpha1 antitrypsin deficiency, caused by a rare genetic defect, may manifest in adults as early-onset chronic obstructive pulmonary disease (COPD).
http://www.cami.jccbi.gov/AAM-400A/FASMB/FAS200202/alpha.htm
An Airman with Alpha-1 Antitrypsin Deficiency
Case Report, by Luis A. Moreno, MD, and Alex M. Wolbrink, MD
Alpha-1 antitrypsin deficiency, caused by a rare genetic defect, may manifest in adults as early-onset chronic obstructive pulmonary disease (COPD). Clinical suspicion for this disorder may be derived from history and physical examination alone and the diagnosis may be confirmed by appropriate testing. Confirmation of the diagnosis does not necessarily lead to revocation of medical certification, especially for those airmen who can demonstrate stable conditions.
Background
A 49-year-old, nonsmoker, Caucasian male with 725 total hours of flight time applied for renewal of his third-class FAA airman medical certificate. His medical history was significant for chronic obstructive pulmonary disease secondary to hereditary alpha-1 antitrypsin (AAT) deficiency (ZZ type). His outpatient management included daily bronchodilator therapy with ipratropuim bromide (Atrovent) and beclomethasone dipropionate (Beclovent), as well as biweekly intravenous AAT replacement therapy (Prolastin). On physical examination, distant sounds were not heard during lung auscultation and hepatomegaly was not evident from abdominal palpation. Inspection of the thorax, however, revealed a "slight increase" in anterior-posterior diameter of the chest. The remainder of the exam was described as unremarkable.
The airman was initially diagnosed six years earlier with AAT deficiency. Mild dyspnea with exertion characterized his major symptom at the time of presentation. Clinically, the patient did not report worsening conditions since the time of diagnosis. However, his most recent pulmonary function tests (PFTs) indicated severe airway obstruction with hyperinflation. Diffusing capacity demonstrated a significant decrease compared with that from the previous two years (DLCO 70% vs. 55% of predicted). Although not significant, flow rates also revealed a decrease compared with that from the previous two years (FEV1/FVC ratio of 35% vs. 32% of predicted).

60. Alpha-1 Antitrypsin Deficiency - National Institutes Of Health (NIH)
alpha1 antitrypsin deficiency - Health Information from National Institutes of Health (NIH)
http://health.nih.gov/result.asp/1089

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