21. Alpha-1 Antitrypsin Deficiency alpha1 antitrypsin deficiency is a disease caused by reduced or abnormal production in the body of the enzyme inhibitor alpha-1 antitrypsin. http://www.netdoctor.co.uk/diseases/facts/alpha1def.htm

Search: All NetDoctor Diseases Medicines NetDoctor.co.uk Home News and features News News archive Newsletter Features Encyclopaedia Diseases Examinations Medicines Premium services SMS services StayQuit thediet Health centres ADHD Allergy and asthma Children's health Depression ... All health centres Discussion and support Discussion forums Support groups Services Ask the doctor Find a hospital Search Medline Test yourself Information About NetDoctor Commercial opportunities NetDoctor.com Alpha-1 antitrypsin deficiency Written by Dr David Maxton , gastroenterologist What is alpha-1 antitrypsin deficiency? Alpha-1 antitrypsin deficiency is a disease caused by reduced or abnormal production in the body of the enzyme inhibitor alpha-1 antitrypsin. Body tissues and blood normally contain powerful enzymes - known as proteases - that can attack foreign substances within the body that may be harmful, such as tobacco smoke. However, these protease enzymes must be carefully regulated as they could attack and damage normal tissues rather than the intended target resulting in local tissue damage. Blood and tissues have a protease inhibitor that binds the enzyme to prevent unrestricted and potentially harmful protease activity. The commonest protease inhibitor in the blood is alpha-1 antitrypsin and its role is to protect the tissues from protease attack.

22. Alpha-1 Antitrypsin Deficiency : Virtual Hospital - Health Topics A-Z For Adult Providers. The International Thoracic Teaching Resource alpha1 antitrypsin deficiency. For Adult Patients. Health Prose AAT Deficiency A http://www.vh.org/navigation/vh/topics/adult_provider_alpha-1_antitrypsin_defici

Health Topics A-Z Alpha-1 Antitrypsin Deficiency All Topics Adult Patient Topics Adult Provider Topics Pediatric Patient Topics ... Pediatric Provider Topics For Adult Providers The International Thoracic Teaching Resource: Alpha-1 Antitrypsin Deficiency For Adult Patients Health Prose: AAT Deficiency: A Serious Disorder Largely Unknown All Topics Adult Patient Topics Adult Provider Topics ... University of Iowa http://www.vh.org/navigation/vh/topics/adult_provider_alpha-1_antitrypsin_deficiency.html

23. Alpha-1 Antitrypsin Deficiency - Signs, Symptoms, Treatment Options And Preventi alpha1 antitrypsin deficiency is a lung disease that can be genetic or self-caused by smoking. Alpha Antitrypsin Deficiency is caused by a deficiency in http://lungdiseases.about.com/od/antitrypsindeficiency/

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a79' About Lung Diseases Locate a Lung Disease Genetic Lung Diseases A1 Antitrypsin Deficiency Lung Diseases Essentials Locate a Lung Disease - START HERE Are You At Risk for Getting Lung Cancer? ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the Lung Diseases newsletter! See Online Courses Search Lung Diseases Alpha-1 Antitrypsin Deficiency Alpha-1 Antitrypsin Deficiency is a lung disease that can be genetic or self-caused by smoking. Alpha Antitrypsin Deficiency is caused by a deficiency in the alpha-1 antitrypsin protein. This protein helps to protect the lungs from destructive illnesses and the harmful effects of smoking. Learn more the signs, symptoms, treatment options and prevention of Alpha Antitrypsin Deficiency. Alphabetical Recent Alpha-1 Antitrypsin Deficiency - Emphysema - Genetic Lung Diseases - Inherited Lung Diseases What is Alpha-1 Antitrypsin Deficiency? What are its signs and symptoms? How is it diagnosed? Find out the answers to these and other questions you may have about Alpha-1 Antitrypsin Deficiency. General Information About Alpha-1 Antitrypsin Deficiency General information, such as causes, risk factors and treatment of Alpha-1 Antitrypsin Deficiency are provided.

24. Alpha-1 Antitrypsin Deficiency - Emphysema - Genetic Lung Diseases - Inherited L What is alpha1 antitrypsin deficiency? What are its signs and symptoms? How is it diagnosed? Find out the answers to these and other questions you may have http://lungdiseases.about.com/od/antitrypsindeficiency/a/alpha1antitryp.htm

var zLb=0; zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a79' About Lung Diseases Locate a Lung Disease Genetic Lung Diseases ... A1 Antitrypsin Deficiency Alpha-1 Antitrypsin Deficiency - Emphysema - Genetic Lung Diseases - Inherited Lung Diseases Lung Diseases Essentials Locate a Lung Disease - START HERE Are You At Risk for Getting Lung Cancer? ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the Lung Diseases newsletter! See Online Courses Search Lung Diseases Stay up to date! Compare Prices Email to a friend ... Print this page Most Popular Do You Have Lung Cancer? Quiz - Are You At Risk for Developing Lung Cancer? Testing For Tuberculosis Signs of Tuberculosis ... Write A Condolence Letter What's Hot Write A Condolence Letter Pneumothorax - Do You Have A Collapsed Lung? Occupational Lung Disease Screening Quiz Do You Have Lung Cancer? ... Tour the Respiratory System adunitCM(150,100,'x55') Alpha-1 Antitrypsin Deficiency Explained From Stacey Lloyd Your Guide to Lung Diseases FREE Newsletter.

25. Alpha-1 Antitrypsin Deficiency alpha1 antitrypsin deficiency Genetic Testing. Testing is simple, painless and easy with DNA Direct s confidential testing services. http://www.dnadirect.com/tests/Asthma_alpha1/index.jsp

26. Alpha-1 Antitrypsin Deficiency alpha1 antitrypsin deficiency, also called Alpha-1, is a progressive condition that can lead to lung and liver disease and other problems. http://www.dnadirect.com/resource/conditions/alpha_1/index.jsp

27. Understanding Alpha-1 Antitrypsin Deficiency alpha1 antitrypsin deficiency is an inherited (passed down from parents) Smokers with alpha-1 antitrypsin deficiency have a faster rate of lung damage. http://www.clevelandclinic.org/health/health-info/docs/1100/1138.asp?index=5731&

28. Alpha-1 Antitrypsin alpha1 antitrypsin deficiency (A1AD) is an autosomal recessive disorder marked The deficiency of alpha-1 antitrypsin leads to tissue damage due to the http://www.brown.edu/Courses/Digital_Path/Liver/alpha_1_antitrypsin.htm

Alpha-1-antitrypsin deficiency General description A lpha-1 antitrypsin deficiency (A1AD) is an autosomal recessive disorder marked by abnormally low or no serum levels of alpha-1 antitrypsin in the blood. It is the most common genetic cause of liver disease in children and of emphysema in adults. Alpha-1 antitrypsin is a major protease inhibitor synthesized in the liver. It is involved in inhibition neutrophil elastase, a protease released by white blood cells at inflammatory sites. The deficiency of alpha-1 antitrypsin leads to tissue damage due to the body's inability to inhibit tissue-destructive enzymes. Incidence Approximately 1 in 2500 births. Symptoms Fatigue due to lung damage. Difficulty breathing. Jaundice (if liver is affected). May lead to hepatitis and cirrhosis. Pathophysiology Alpha-1 antitrypsin level rises sharply after tissue injury and inflammation. Genotype of normal alpha-1 antitrypsin is "MM"; person with MM genotype is not affected. Genotype of abnormal alpha-1 antitrypsin is "ZZ"; person with ZZ genotype is affected.

29. Alpha-1 Related Emphysema - American Lung Association Site A person has alpha1 antitrypsin deficiency only if he or she inherits two People who have alpha-1 antitrypsin deficiency will pass on one abnormal gene http://www.lungusa.org/site/pp.asp?c=dvLUK9O0E&b=35014

30. Alpha-1 Antitrypsin Deficiency alpha1 antitrypsin deficiency International Support Mailing List Alpha1 National Association Alpha1-Antitrypsin Deficiency National Association http://www.cannylink.com/diseasealpha1.htm

Web www.CannyLink.com Alpha-1 Antitrypsin Deficiency Alpha-1 Antitrypsin Deficiency International Support Mailing List Alpha1 National Association Alpha1-Antitrypsin Deficiency National Association AlphaChat - chat room for those who have A1AD. AlphaNet Online AlphaOne Community Internet Guide - resource and support guide for persons afflicted with this genetic liver and lung disease which causes emphysema and cirrosis. Texas Alpha-1 Resource Support Group - dedicated to identifying, educating and providing emotional support for all individuals and families with alpha-1 antitrypsin deficiency. Back to The Cannylink home page You can e-mail us at Webmaster@cannylink

31. Dr. Koop - Alpha-1 Antitrypsin Deficiency alpha1 antitrypsin deficiency is a lack of a liver protein that blocks the destructive effects of certain enzymes. The condition may lead to and . http://www.drkoop.com/ency/93/000120.html

Home Health Reference Alpha-1 antitrypsin deficiency Jul 29, 2005 Search: Dr.Koop MEDLINE Diseases Symptoms Procedures Natural Medicine ... Drug Library Inside DrKoop News Archive Animations Health Videos Health Tools ... Newsletters Alpha-1 antitrypsin deficiency Injury Disease Nutrition Poison ... Prevention Alpha-1 antitrypsin deficiency Definition: Alpha-1 antitrypsin deficiency is a lack of a liver protein that blocks the destructive effects of certain enzymes. The condition may lead to emphysema and liver disease Alternative Names: AAT deficiency Causes, incidence, and risk factors: Alpha-1 antitrypsin deficiency results from a genetic defect. The mechanism that causes associated liver disease and emphysema in some people with this deficiency is not known, however some evidence suggests that it may be related to inflammation. Approximately 75% of adults with severe deficiency will develop emphysema, which often begins before 40 years of age. Smoking can increase risk. New Features Fewer Migraines Skin Cancer Atkins/Low Carb Diets Learn More About Migraines * All Health Centers * Acne Addictions AIDS/HIV Alcohol Abuse Allergies Alternative Medicine Alzheimer's Arthritis Asthma Attention Deficit Disorder (ADHD) Backache Bipolar Affective Disorder Birth Control Blood Blood Pressure Bone/Joint/Tendon Bowel Brain Breast cancer Cancer Cerebral Palsy Cholesterol Cramps Crohn's Disease Cysts Dental/Oral Depression Diabetes Diet, Fitness, Looks

32. Alpha-1 Antitrypsin Deficiency Definition - Asthma Symptoms, Relief Therapies, T Medical information about asthma symptoms and relief therapies doctor produced and written for patients experiencing asthma related conditions to make http://www.medterms.com/script/main/art.asp?articlekey=2208

33. AllRefer Health - Alpha-1 Antitrypsin Deficiency (AAT Deficiency) alpha1 antitrypsin deficiency (AAT Deficiency) information center covers causes, prevention, symptoms, diagnosis, treatment, incidence, risk factors, http://health.allrefer.com/health/alpha-1-antitrypsin-deficiency-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Alpha-1 Antitrypsin Deficiency Alpha-1 Antitrypsin Deficiency Definition Treatment Expectations or Prognosis Complications ... Go To Main Page Alternate Names : AAT Deficiency Definition Alpha-1 antitrypsin deficiency is a lack of a liver protein that blocks the destructive effects of certain enzymes. The condition may lead to emphysema and liver disease Lungs Liver Anatomy Alpha-1 antitrypsin deficiency results from a genetic defect. The mechanism that causes associated liver disease and emphysema in some people with this deficiency is not known, however some evidence suggests that it may be related to inflammation. Approximately 75% of adults with severe deficiency will develop emphysema, which often begins before 40 years of age. Smoking can increase risk. Previous Top Next Jump to another section Definition Treatment Prognosis Complications ... Calling Your Health Care Provider Topics that might be of interest to you Cirrhosis Emphysema Liver Disease Lung Disease ... Chest X-Ray Other Topics Abdomen - Swollen Agitation Auscultation Bloody or Tarry Stools ... Foot, Leg, and Ankle Swelling

34. ► Alpha-1 Antitrypsin Deficiency A medical encycopedia article on the topic alpha-1 antitrypsin deficiency. http://www.umm.edu/ency/article/000120.htm

var MenuLinkedBy='AllWebMenus [2]', awmBN='530'; awmAltUrl=''; Disease Nutrition Surgery Symptoms Injury ... Encyclopedia (English) Toggle English Spanish Alpha-1 antitrypsin deficiency Overview Symptoms Treatment Prevention Definition: A deficiency of a protein produced in the liver that blocks the destructive effects of certain enzymes. The condition may lead to emphysema and liver disease Alternative Names: AAT deficiency Causes, incidence, and risk factors: Alpha-1 antitrypsin deficiency results from a genetic defect. The mechanism that causes associated liver disease and emphysema in some people with this deficiency is not known, however some evidence suggests that it may be related to inflammation. Approximately 75% of adults with severe deficiency will develop emphysema, which often begins before 40 years of age. Smoking can increase risk. Lungs Liver anatomy Review Date: 12/2/2001 Reviewed By: Steven Kawut, M.D., Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York City, NY. Review provided by VeriMed Healthcare Network.

35. Alpha-1 Antitrypsin Deficiency alpha1 antitrypsin deficiency Updated January 26, 2005. The Basics What Is alpha-1 antitrypsin deficiency? Should I Be Tested? Alpha-One Foundation (also http://www.noah-health.org/en/kidver/liver/diseases/alpha1/

Skip navigation About NOAH Help English Spanish Both Advanced NOAH Kidney and Liver Change text size: Alpha-1 Antitrypsin Deficiency Updated: January 26, 2005 The Basics What Is Alpha-1 Antitrypsin Deficiency? Should I Be Tested? Alpha-One Foundation (also in Spanish Living with Alpha-1 Antitrypsin Deficiency A Guide for the Recently Diagnosed Alpha-One Carrier Alpha-One Foundation (also in Spanish Information Resources Alpha-One Association Researched by NOAH Contributing Editor: NOAH Team NOAH Kidney and Liver Liver, Gallbladder and Bile Duct Diseases Specific Diseases > Alpha-1 Antitrypsin Deficiency Health Topics Index A to Z Page of the Month Advanced Search ... Feedback

36. Search Result For "Alpha-1 Antitrypsin Deficiency" NOAH pages containing alpha1 antitrypsin deficiency . alpha-1 antitrypsin deficiency Featured Link http://www.noah-health.org/search/results.php?lang=1&keyword=Alpha-1 Antitrypsin

37. Alpha-1 Antitrypsin Deficiency Symptom Signs And Treatment At Mayo Clinic you are here, alpha1 antitrypsin deficiency Treatment in Jacksonville Treatment in Rochester Treatment in Arizona Appointments Clinical Trials http://www.mayoclinic.org/copd/alpha1.html

Home About Mayo Clinic Jobs Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Chronic Obstructive Pulmonary Disease (COPD) Chronic Obstructive Pulmonary Disease Overview Treatment Alpha-1 Antitrypsin Deficiency Treatment in Jacksonville ... Medical Services Alpha-1 Antitrypsin Deficiency AAT Not Uncommon AAT is more common than most people realize. It affects one in 3,000 to 5,000 individuals. The two other most common fatal genetic defects are cystic fibrosis and Down syndrome. Mayo Clinic is a leading center for treatment of and research on Alpha-1 antitrypsin (AAT) deficiency, the genetic form of emphysema. AAT, a protein predominantly made in the liver and secreted into the blood stream, helps protect the lungs. Its deficiency may cause lung disease, especially in smokers. Lung disease is the most frequent cause of disability and early death among those affected by the disease. It is also a major reason that patients undergo lung transplants. AAT deficiency can lead to lung destruction and is often misdiagnosed as another form of Chronic Obstructive Pulmonary Disease (COPD) or asthma. The World Health Organization (WHO) recommends that all individuals with COPD, as well as adults and adolescents with asthma (an estimated 30 million Americans), be tested for AAT deficiency. The abnormal protein can also accumulate in the liver and lead to liver failure. It is the leading genetic cause of liver transplantation in children liver transplantation is the only cure so far for this manifestation of AAT deficiency.

38. Diseases - Alpha1-Antitrypsin Deficiency Or Inherited Emphysema - National Jewis The inherited form of emphysema is called alpha1 antitrypsin deficiency or Alpha - 1 for short. People with this disorder don t have enough of a major http://www.nationaljewish.org/disease-info/diseases/copd/about/alpha1-antitrypsi

Skip to Content About National Jewish Disease Information Patient Information ... Contact Us You are here: National Jewish Home Disease Information Diseases We Treat Chronic Obstructive Pulmonary Disease ... About COPD Alpha1-Antitrypsin Deficiency More About: About COPD COPD FAQs Signs and Symptoms of COPD What is Chronic Bronchitis What is Emphysema Questions? Talk to a LUNG LINE nurse at 1-800-222-LUNG or e-mail us Alpha -Antitrypsin Deficiency or Inherited Emphysema What is COPD? C hronic o bstructive p ulmonary d isease or COPD for short, is a lung disease that affects millions of people each year. COPD is a general term used to describe diseases such as emphysema and chronic bronchitis. In emphysema there is damage to the walls of the air sacs (alveoli) in the lungs. The earliest symptom of emphysema is shortness of breath during activity. Later the shortness of breath can occur at rest also. What is Inherited Emphysema? What Does the Alpha1 Protein do in the Body? How is the Diagnosis Made? How is Inherited Emphysema Managed? ... What Does the Future Hold? What is Inherited Emphysema? Most cases of emphysema are caused by smoking or other environmental factors. There is growing evidence that genetics can also increase the risk of developing emphysema. In about one out of every 50 cases of emphysema, there is a specific hereditary basis for the disease.

39. ALPHA-1 ANTITRYPSIN DEFICIENCY Pediatric Oncall Offers a description of alpha–l antitrypsin, including the affects on the liver and how it presents. http://www.pediatriconcall.com/fordoctor/diseasesandcondition/alpha1deficiency.a

DOCTOR CORNER Search GO Home Back Ask Doctor Post Query Education Image Gallery Teaching Files Question of the day Specialist Answers Latest Updates Conference Journal Search Original Articles Clinical Trials Search For Pediatricians Hospitals Special Schools Drug Index ... Sign Out ALPHA-1 – ANTITRYPSIN DEFICIENCY UserName Password New Register Forgot password Dr Ira Shah M.D, DCH(GoldMedalist), FCPS , DNB Q: What is alpha – l-antitrypsin ? A: Alpha –1- antitrypsin is a glycoprotein produced by the liver. Its primary function is to protect the lungs from neutrophil elastase, which is an enzyme that digests the phagocyte cells and bacteria to promote healing. However, it requires alpha-l – antitrypsin to prevent it from damaging the lung tissue. Alpha-l- antitrypsin is an acute- phase reactant. Its level increases to 3 or 4 times the normal amount at times of infection, pregnancy or any conditions that cause an increase in neutrophil elastase. Q: What happens where there is deficiency of alpha-l- antitrypsin?

40. Alpha 1-antitrypsin Deficiency - Wikipedia, The Free Encyclopedia Alpha 1antitrypsin deficiency (A1AD or Alpha-1) is a genetic disorder caused by Symptoms of alpha-1 antitrypsin deficiency include shortness of breath, http://en.wikipedia.org/wiki/Alpha_1-antitrypsin_deficiency

Wikimedia needs your help in the final days of its fund drive. See our fundraising page Over US$225,000 has been donated since the drive began on 19 August. Thank you for your generosity! Alpha 1-antitrypsin deficiency From Wikipedia, the free encyclopedia. Alpha 1-antitrypsin deficiency or Alpha-1 ) is a genetic disorder caused by reduced levels of alpha 1-antitrypsin in the blood . It can lead to emphysema and, in some cases, to liver disease. Contents Signs and symptoms Pathophysiology Treatment Epidemiology ... edit Signs and symptoms Symptoms of alpha-1 antitrypsin deficiency include shortness of breath , recurring respiratory infections, or obstructive asthma that does not respond to treatment. Individuals with alpha-1 may develop emphysema during their thirties or forties, without a history of significant smoking (although smoking greatly increases the risk for emphysema). A1AD also causes impaired liver function in some patients and may lead to cirrhosis and liver failure (15%). It is the leading cause of liver transplantation in newborns. edit Pathophysiology Please see alpha 1-antitrypsin for a discussion of the various genotypes and phenotypes associated with A1AD.

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