21. Alexander Disease / Library / The Family Village From the alexander disease Project at the Waisman Center, University of Wisconsin. alexander disease From Online Mendelian Inheritance in Man (OMIM) http://www.familyvillage.wisc.edu/lib_alex.html

Alexander Disease Who to Contact Learn More About It Research Web Sites ... Search Google for "Alexander Disease" Who to Contact United Leukodystrophy Foundation 2304 Highland Drive Sycamore, IL 60178 E-mail: ulf@tbcnet.com Web: http://www.ulf.org/ The United Leukodystrophy Foundation (ULF), incorporated in 1982, is a nonprofit, voluntary health organization dedicated to providing patients and their families with information about their disease and assistance in identifying sources of medical care, social services, and genetic counseling; establishing a communication network among families; increasing public awareness and acting as an information source for health care providers; and promoting and supporting research into causes, treatments, and prevention of the leukodystrophies. Leukodystrophies are a group of genetic nervous system disorders affecting the myelin sheath, which insulates the axon through which nerve impulses are conducted. Learn More About It Alexander Disease - Summary for Parents From the Alexander Disease Project at the Waisman Center, University of Wisconsin Alexander Disease From Online Mendelian Inheritance in Man (OMIM) About Alexander Disease - Partners Leukodystrophy Service at MGH Research Alexander Disease Project Waisman Center, University of Wisconsin

22. Alexander Disease Patient/Family Resources alexander disease Patient/Family Resources http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

23. OMIM - ALEXANDER DISEASE http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=203450

24. Entrez PubMed alexander disease diagnosis with MR imaging. van der Knaap MS, Naidu S, cases of alexander disease to assess the possibility of an MRbased diagnosis. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

25. Medical Dictionary: Alexander Disease - WrongDiagnosis.com Medical dictionary definition of alexander disease as a medical term including diseases, symptoms, treatments, and other medical and health issues. http://www.wrongdiagnosis.com/medical/alexander_disease.htm

Home Symptoms Diseases Risks ... Dictionary Search our medical database Subscribe to our free Newsletter sample Send this page to a friend Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Alexander Disease Next chapters: ALL Allergen Allergic Allergic diseases ... Feedback Medical Dictionary: Alexander Disease Medical dictionaries: Medical dictionary Medical malpractice dictionary Medical Acronymns/Abbreviations Alexander Disease : Another name for Alexander Syndrome (or close medical condition association). Alexander Disease : Alexander Disease is listed as a type of (or associated with) the following medical conditions in our database: leukodystrophy Brain conditions Genetic Disease Alexander Disease (medical condition): Brain myelin disorder causing mental degeneration. Alexander Disease : Alexander disease is a rare, genetic, degenerative disorder of the nervous system. It is one of a group of genetic disorders called the leukodystrophies that affect growth of the myelin sheath — the fatty covering which acts as an insulator — on nerve fibers in the brain. More information on medical condition: Alexander Syndrome Introduction: Alexander Syndrome Basic Summary for Alexander Syndrome Types of Alexander Syndrome Symptoms of Alexander Syndrome Treatments for Alexander Syndrome Footnotes: 1. excerpt from

26. Introduction: Alexander Syndrome - WrongDiagnosis.com Alexander Syndrome alexander disease is a rare, genetic, degenerative disorder of the 1. excerpt from NINDS alexander disease Information Page NINDS http://www.wrongdiagnosis.com/a/alexander_syndrome/intro.htm

Home Symptoms Diseases Risks ... Diseases Search our medical database Subscribe to our free Newsletter sample Send this page to a friend Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Alexander Syndrome Next sections Basic Summary for Alexander Syndrome Prevalence and Incidence of Alexander Syndrome Prognosis of Alexander Syndrome Types of Alexander Syndrome ... Symptoms of Alexander Syndrome Next chapters: Alternating Hemiplegia Anoxia Aphasia Apraxia ... Feedback Introduction: Alexander Syndrome Alexander Syndrome: Brain myelin disorder causing mental degeneration. Alexander Syndrome: Alexander disease is a rare, genetic, degenerative disorder of the nervous system. It is one of a group of genetic disorders called the leukodystrophies that affect growth of the myelin sheath — the fatty covering which acts as an insulator — on nerve fibers in the brain. Researching symptoms of Alexander Syndrome: Further information about the symptoms of Alexander Syndrome is available including a list of symptoms of Alexander Syndrome , or alternatively return to research other symptoms in the symptom center Treatments for Alexander Syndrome: Various information is available about treatments available for Alexander Syndrome , or research treatments for other diseases.

27. Alexander Disease Definition - Medical Dictionary Definitions Of Popular Medical Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=13493

28. GFAP Definition - Medical Dictionary Definitions Of Popular Medical Terms The degenerative brain condition called alexander disease is caused by More than 20 GFAP mutations that cause alexander disease have been identified. http://www.medterms.com/script/main/art.asp?articlekey=33140

29. CCHS Clinical Digital Library Alexanders Disease Access document. Miscellaneous alexander disease Patient/Family Resources. The Family Village Library Specific Diagnoses Card Catalog http://cchs-dl.slis.ua.edu/patientinfo/metabolism/inborn/lipid/leukodystrophies/

Patient/Family Resources by Topic: Metabolic Disorders Alexander Disease Patient/Family Resources Miscellaneous See also: Mental Retardation Patient/Family Resources Genetic Testing Patient/Family Resources General Genetic Disorders Patient/Family Resources General Metabolic Disorders Patient/Family Resources ... Alexander Disease Clinical Resources Na tional Institute of Neurological Disorders and Stroke: Homepage Disorders Information: List of documents Alexander Disease: Access document United Leukodystrophy Foundation: Homepage Introductions to the Leukodystrophies: Access document Alexanders Disease: Access document Miscellaneous Alexander Disease Patient/Family Resources The Family Village Library - Specific Diagnoses Card Catalog Table of contents Leukodystrophy: Access document Healthfinder (US DHHS): Homepage Genetics: List of documents MedlinePlus (National Library of Medicine) Health Topics: Index Genetic Testing: List of documents Prenatal Testing: List of documents Genetic Counseling: List of documents Genetic Disorders: List of documents Birth Defects: List of documents YAHOO - Health:Diseases and Conditions:Genetic Disorders Additional Genetic Disorders resources ( These sites have not been reviewed.

30. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies: Search results for alexander disease ALLFIELDS are shown below. Condition Coronary Artery Disease. 8. Recruiting, Satraplatin in Hormone Refractory http://www.clinicaltrials.gov/search/term=Alexander Disease

Home Search Browse Resources ... About Search results for Alexander Disease [ALL-FIELDS] are shown below. Include trials that are no longer recruiting patients. 15 studies were found. Recruiting Study of 18F-Fluorodeoxyglucose (FluGlucoScan) in Patients with Cancer or Suspected Cancer Conditions: Brain Neoplasms; Lung Neoplasms; Thyroid Neoplasms; Colorectal Neoplasms; Lymphoma Recruiting Study of F-Fluorodeoxyglucose (FluGlucoScan) in Patients with Known or Suspected Cancers of Low Incidence Conditions: Sarcoma; Multiple Myeloma; Testicular Neoplasms; Ovarian Neoplasms; Kidney Neoplasms Recruiting A Study of Preoperative Radiation Therapy and Capecitabine in Locally Advanced Rectal Cancer Conditions: Rectal Cancer; Neoplasm Metastasis Recruiting Study of Fluorodeoxyglucose (FluGlucoScan) in Patients with Breast Cancer: Correlation with Histologic Findings of Sentinel Node Biopsies and Axillary Dissection Condition: Breast Neoplasms Not yet recruiting Study of 18F-Fluorodeoxyglucose (FluGlucoScan) in Patients Receiving a Treatment Planning Study of 3 Dimensional Conformal Radiation Therapy Guided by Breath Held CT and PET Imaging for Patients with Non-Small Cell Lung Cancer Condition: Lung Neoplasms Not yet recruiting Study of 18F-Fluorodeoxyglucose (FluGlucoScan) in Patients with Known or Suspected Soft Tissue Sarcoma Condition: Sarcoma Recruiting Satraplatin in Hormone Refractory Prostate Cancer Patients Previously Treated with One Cytotoxic Chemotherapy Regimen Conditions: Prostate Cancer; Hormone Refractory Prostate Cancer; One Prior Cytotoxic Chemotherapy Regimen

31. Alexander Disease: Information From Answers.com alexander disease alexander disease is a slowly progressing fatal neurodegenerative disease . Synonyms Dysmyelogenic Leukodystrophy Dysmyelogenic. http://www.answers.com/topic/alexander-disease

showHide_TellMeAbout2('false'); Business Entertainment Games Health ... More... On this page: Wikipedia Mentioned In Or search: - The Web - Images - News - Blogs - Shopping Alexander disease Wikipedia Alexander disease Alexander disease is a slowly progressing fatal neurodegenerative disease Synonyms Dysmyelogenic Leukodystrophy Dysmyelogenic Leukodystrophy-Megalobare Fibrinoid Degeneration of Astrocytes Fibrinoid Leukodystrophy Hyaline Panneuropathy Leukodystrophy with Rosenthal Fibers Megalencephaly with Hyaline Inclusion Megalencephaly with Hyaline Panneuropathy Clinical features Delays in development of some physical, psychical and behavioral skills, progressive enlargement of the head ( macrocephaly seizures spasticity , in some cases also hydrocephalus dementia , clumsy movements. Pathology This genetically based condition, affecting the central nervous system ( mid brain and cerebellum )is caused by mutations in the gene for glial fibrillary acidic protein ( GFAP ) that maps to chromosome . It´s inherited in an autosomal dominant manner. Alexander disease belongs to

32. Alexander Disease alexander disease Updated May 18, 2004. alexander disease United Leukodystropy Foundation; alexander disease Gene Clinics.org; alexander disease National http://www.noah-health.org/en/bns/disorders/other/alex.html

Skip navigation About NOAH Help English Spanish Both Advanced NOAH Brain and Nervous System Change text size: Alexander Disease Updated: August 16, 2005 Alexander Disease United Leukodystropy Foundation Alexander Disease Gene Clinics.org Alexander Disease National Organization of Rare Disorders Alexander Disease Genetics Home Reference Alexander Disease Information Page National Institute of Neurological Disorders and Stroke Researched by NOAH Contributing Editor: NOAH Team NOAH Brain and Nervous System Specific Nervous System Disorders Other Neurological Problems > Alexander Disease Health Topics Index A to Z Page of the Month Advanced Search ... Feedback

33. Search Result For "Alexander Technique" alexander disease; alexander disease; alexander disease; alexander disease; alexander disease Information Page http://www.noah-health.org/search/results.php?lang=1&keyword=Alexander Technique

34. Partners Leukodystrophy Service At MGH alexander disease is a slowly progressive disease that primarily affects children. This observation adds alexander disease to a growing list of http://fisher.mgh.harvard.edu/leuko/alexander.html

Home Staff Services Leukodystrophy categories Contact us Links Radiological Classification (Neonatal) Adrenoleukodystrophy and (Pseudoneonatal) Adrenoleukodystrophy ... Epidemiology Clinical Features Broad Overview Clinical Subtypes Testing Radiology ... Hypotheses Prognosis Natural History and complications Treatment Drugs Symptomatic Introduction Alexander disease is a slowly progressive disease that primarily affects children. First described by Alexander in 1949, it is characterized by the finding of Rosenthal fibers in brain specimens(Harding 1990). It is genetically determined, by sporadic gain of function mutations in the GFAP gene (Brenner, Johnson et al. 2001). This observation adds Alexander disease to a growing list of intermediate filament diseases, which includes Emery-Dreifuss muscular dystrophy (lamin A/C), cardiac and skeletal desmin myopathy (Desmin). To date all cases have been sporadic and more recent mutational analysis has not found mutations in either parent. There have been case reports, not genetically confirmed, of more than one child being affected (Johnson, Personal Communication, United Leukodystrophy Foundation Annual Meeting, 2002). Return to top Epidemiology The incidence of more than one affected person in any kindred is exceptional.

35. Partners Leukodystrophy Service At MGH Neurophysiological investigations in two cases of Alexander s disease with alexander disease and intermediate filaments in astrocytes a fatal gain of http://fisher.mgh.harvard.edu/leuko/refs.html

Partners Leukodystrophy Service at Massachusetts General Hospital Home Staff Frequently Asked Questions Services ... CACH References Contact us Links Leukodystrophy Service, Massachusetts General Hospital, #3125, Building 114, 16th Street, Charlestown, MA 02129. Ph: 617-726-5750 Fx: 617-726-8543 Directions to Massachusetts General Hospital Tuesday, October 1, 2002 REFERENCES: Antoku, Y. (1988). "Adrenoleukodystrophy: VLCFAs in erythrocytes." Neurology Aubourg, P., C. Adamsbaum, et al. (1993). "A two-year trial of oleic and erucic acids ("Lorenzo's oil") as treatment for adrenomyeloneuropathy." N Engl J Med 329 (11): 745-52. Barinaga, M. (1999). "Mutant fruit flies respond to Lorenzo's oil." Science 284 (5422): 1899, 1901. Barkovich, A. J., D. M. Ferriero, et al. (1997). "Involvement of the pontomedullary corticospinal tracts: a useful finding in the diagnosis of X-linked adrenoleukodystrophy." AJNR Am J Neuroradiol 18 (1): 95-100. Baslow, M. H. (2000). "Canavan's spongiform leukodystrophy: a clinical anatomy of a genetic metabolic CNS disease." J Mol Neurosci 15 (2): 61-9.

36. Alexander Disease a CHORUS notecard document about alexander disease. http://chorus.rad.mcw.edu/doc/00017.html

CHORUS Collaborative Hypertext of Radiology Nervous system About CHORUS Search Feedback Alexander disease dysmyelinating disease rare, sporadic usually presents in 1st year megalencephaly: gradual enlargement of head retardation, convulsion, spasticity CT findings: decreased density of white matter frontal lobe predominance +/- dilated lateral ventricles Dx: brain bx Charles E. Kahn, Jr., MD - 2 February 1995 Last updated 26 May 2004 Related CHORUS documents: leukodystrophy dysmyelinating disease adrenoleukodystrophy Pelizaeus-Merzbacher syndrome ... spongy degeneration (Canavan disease) Search for related articles: AJR American Journal of Roentgenology PubMed : index to biomedical literature ... Medical College of Wisconsin

37. Alexander Disease alexander disease. dysmyelinating disease; rare, sporadic; usually presents in 1st year; megalencephaly gradual enlargement of head; retardation, http://chorus.rad.mcw.edu/to-go/00017.html

Alexander disease dysmyelinating disease rare, sporadic usually presents in 1st year megalencephaly: gradual enlargement of head retardation, convulsion, spasticity CT findings: decreased density of white matter frontal lobe predominance +/- dilated lateral ventricles Dx: brain bx Home Nervous system

38. Alexander Disease - Quest Diagnostics Patient Health Library alexander disease is an extremely rare, progressive, neurological disorder that usually becomes apparent during infancy or early childhood. http://www.questdiagnostics.com/kbase/nord/nord56.htm

var hwPrint=1;var hwDocHWID="nord56";var hwDocTitle="Alexander Disease";var hwRank="1";var hwSectionHWID="nord56-Header";var hwSource="en-usQ2_05";var hwDocType="Nord"; National Organization for Rare Disorders, Inc. Alexander Disease Important It is possible that the main title of the report Alexander Disease is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Dysmyelogenic Leukodystrophy Dysmyelogenic Leukodystrophy-Megalobare Fibrinoid Degeneration of Astrocytes Fibrinoid Leukodystrophy Hyaline Panneuropathy Leukodystrophy with Rosenthal Fibers Megalencephaly with Hyaline Inclusion Megalencephaly with Hyaline Panneuropathy Disorder Subdivisions None General Discussion In infants and young children affected by Alexander Disease, associated symptoms and findings include a failure to grow and gain weight at the expected rate (failure to thrive); delays in the development of certain physical, mental, and behavioral skills that are typically acquired at particular stages (psychomotor retardation); and progressive enlargement of the head (macrocephaly). Additional features typically include sudden episodes of uncontrolled electrical activity in the brain (seizures); abnormally increased muscle stiffness and restriction of movement (spasticity); and progressive neurological deterioration. In some cases, there is hydrocephalus. In most cases, Alexander Disease appears to occur randomly for unknown reasons (sporadically), with no family history of the disease. In an extremely small number of cases, it is thought that the disorder may have affected more than one family member.

39. Alexander Disease DESCRIPTION alexander disease is a rare, genetic, degenerative disorder of the alexander disease, which affects mostly males, usually begins at about 6 http://www.healthieryou.com/alexander.html

Select One Contact CME? Order? Register? Place an Ad? Print Pages? More... ADD/ADHD Alcoholism Alzheimer's Anorexia Anxiety Bipolar Disorder Borderline Bulimia Children Compulsive Dementia Depression Dissociation Drug Abuse Eating Disorders Fear Forgetfulness Hyperactivity Mania Manic-Dep Mood Disorder Narcissistic Neurology Obsessive OCD Panic Paraphilias Phobia Personality Psychosis PTSD Schizophrenia Seasonal Mood Sexual Issues Social Phobia Suicidal Tic Disorders Violence Alexander Disease What is Alexander Disease? DESCRIPTION: Alexander disease is a rare, genetic, degenerative disorder of the nervous system. It is one of a group of genetic disorders called the leukodystrophies that affect growth of the myelin sheath, the fatty coveringwhich acts as an insulatoron nerve fibers in the brain. Alexander disease, which affects mostly males, usually begins at about 6 months of age. Symptoms may include mental and physical retardation, dementia, enlargement of the brain and head, spasticity (stiffness of arms and/or legs), and seizures. In addition to the infantile form, juvenile and adult onset forms of the disorder have been reported. These forms occur less frequently and have a longer course of progression. Is there any treatment?

40. ALEXANDER DISEASE: Contact A Family - For Families With Disabled Children: Infor Contact a Family is a UK charity for families with disabled children. We offer information on specific conditions and rare disorders. http://www.cafamily.org.uk/Direct/a31.html

printer friendly ALEXANDER DISEASE home how we can help medical information index of conditions ... how you can help Did you find this page helpful? yes no Alexander disease is a rare genetic, degenerative disorder of the nervous system with effects on the mid brain and cerebellum; in the most common infantile form of the disease, the frontal white matter is involved. It is one of a group of genetic disorders called the leukodystrophies. The term leukodystrophy comes from the Greek words, 'leuko' meaning white and referring to the 'white matter' of the nervous system and 'dystrophy' meaning imperfect growth or development. In Alexander disease, the growth of the white matter of the brain, or myelin sheath, is affected. The brain stem may be particularly involved; in rare adult forms of the condition resulting in unusual signs such as flapping movement of the palate (palatal myoclonus), limb paralysis and clumsy movements. Cerebellar disease also occurs. The disease is due principally to mutations in a gene for glial fibrillary acidic protein (GFAP) that maps to chromosome 17q21; all mutations to date have been heterozygous. Mutations suspected in another gene, NADH-ubiquinone flavoprotein-1, have not been detected in the majority of Alexander disease patients. The onset of Alexander disease may occur at any time during infancy or adulthood. For many individuals onset is between birth and two years, with the average being six months. This infantile form of the disease affects boys and girls and leads to delayed development and dementia. The condition is characterised by an enlarged brain and head (megalencephaly), progressive spasticity (stiffness of the arms and/or legs)

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