1. Alexander Disease alexander disease is a rare, genetic, degenerative disorder of the nervous system. http://healthlink.mcw.edu/article/921383447.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Neurology By keywords: Receive Health Link via email! Subscribe now >> Alexander Disease Alexander disease is a rare, genetic, degenerative disorder of the nervous system. It is one of a group of genetic disorders called the leukodystrophies that affect growth of the myelin sheath, the fatty coveringwhich acts as an insulatoron nerve fibers in the brain. Alexander disease, which affects mostly males, usually begins at about 6 months of age. Symptoms may include mental and physical retardation, dementia, enlargement of the brain and head, spasticity (stiffness of arms and/or legs), and seizures. In addition to the infantile form, juvenile and adult onset forms of the disorder have been reported. These forms occur less frequently and have a longer course of progression. Is there any treatment? There is no cure for Alexander disease, nor is there a standard course of treatment. Treatment of Alexander disease is symptomatic and supportive.

2. The Family Village / Library / Leukodystrophy Resources on Adrenoleukodystrophy, alexander disease, Canavan Disease, Krabbes Disease, Metachromatic Leukodystrophy, and Refsum's Disease. http://www.familyvillage.wisc.edu/lib_leukodystrophy.html

Leukodystrophy Types of Leukodystophy: Adrenoleukodystrophy, Alexander Disease, Canavan Disease, Krabbes Disease, Metachromatic Leukodystrophy, and Refsum's Disease Who to Contact Where to Go to Chat with Others Learn More About It Web Sites ... Search Google for "Leukodystrophy" Who to Contact United Leukodystrophy Foundation (ULF) 2304 Highland Drive Sycamore IL 60718 (815) 895-2432 (fax) E-mail: ulf@tbcnet.com Website: http://www.ulf.org/ This is a nonprofit, voluntary health organization dedicated to providing patients and their families with information about their disease. In addition, it provides assistance in identifying sources of medical care, social services, and genetic counseling; establishing a communication network among families; increasing public awareness; acting as an information source for health care providers; and promoting and supporting research into causes, treatments, and prevention of the leukodystrophies. The ULF is supported solely by donations. Where to Go to Chat with Others Yahoo list of leukodystrophy discussion groups Krabbes E-mail Contacts Inborn Errors of Metabolism Discussion Group MLD Support Learn More About It Alexander Disease From Online Mendelian Inheritance in Man (OMIM) Canavan Disease From Online Mendelian Inheritance in Man (OMIM) Krabbe Disease From Online Mendelian Inheritance in Man (OMIM) Krabbes Disease: Basic Information From the Krabbes Disease Homepage Metachromatic Leukodystrophy, Late Infantile

3. NINDS Forwarding Page Information sheet compiled by NINDS, the National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/health_and_medical/disorders/alexand_doc.htm

NINDS has redesigned its website and the URL for the page you were seeking has changed. The new URL for this page is /disorders/alexander_disease/alexander_disease.htm . Please update your bookmark to this page. You will be automatically taken to this page in 5 seconds, or you can click the link to go there now.

4. Alexander Disease Information Page National Institute Of alexander disease information sheet compiled by NINDS. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

5. Alexander Disease Information Page: National Institute Of Neurological Disorders alexander disease information sheet compiled by NINDS. http://www.ninds.nih.gov/disorders/alexander_disease/alexander_disease.htm

Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system More about Alexander Disease Studies with patients Research literature Press releases Search NINDS... (help) Contact Us My Privacy NINDS is part of the National Institutes of Health You are here: Home Disorders Alexander Disease NINDS Alexander Disease Information Page Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Alexander Disease? Is there any treatment? What is the prognosis? What research is being done? ... Organizations What is Alexander Disease? Is there any treatment? There is no cure for Alexander disease, nor is there a standard course of treatment. Treatment of Alexander disease is symptomatic and supportive. What is the prognosis? The prognosis for individuals with Alexander disease is generally poor. Most children with the infantile form do not survive past the age of 6. Juvenile and adult onset forms of the disorder have a slower, more lengthy course. What research is being done?

6. Alexander Disease alexander disease What is alexander disease? DESCRIPTION alexander disease is a rare, genetic, degenerative disorder of the nervous system. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

7. Alexander Disease Press Releases: National Institute Of Neurological Disorders A alexander disease information sheet compiled by NINDS. http://www.ninds.nih.gov/disorders/alexander_disease/press_alexander_disease.htm

Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system More about Alexander Disease Studies with patients Research literature Press releases Search NINDS... (help) Contact Us My Privacy NINDS is part of the National Institutes of Health You are here: Home Disorders Alexander Disease Sorry! There are no press releases for: Alexander Disease. Use your browser's Back button to return to your previous activity. National Institute of Neurological Disorders and Stroke Home About NINDS Disorders Funding ... Accessibility

8. Alexander Disease alexander disease is a rare, genetic, degenerative disorder of the nervous system. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

9. GeneReviews: Alexander Disease Your browser does not support HTML frames so you must view alexander disease in a slightly less readable form. Please follow this link to do so. http://www.geneclinics.org/profiles/alexander/

Your browser does not support HTML frames so you must view Alexander Disease in a slightly less readable form. Please follow this link to do so.

10. ALEXANDER DISEASE Contact A Family - For Families With Disabled printer friendly alexander disease search this site home how we can help medical information index of conditions about the http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

11. Alexander Disease alexander disease is an extremely rare, progressive, neurological disorder that usually becomes apparent http://my.webmd.com/hw/health_guide_atoz/nord56.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report Alexander Disease Important It is possible that the main title of the report Alexander Disease is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Dysmyelogenic Leukodystrophy Dysmyelogenic Leukodystrophy-Megalobare Fibrinoid Degeneration of Astrocytes Fibrinoid Leukodystrophy Hyaline Panneuropathy Leukodystrophy with Rosenthal Fibers Megalencephaly with Hyaline Inclusion Megalencephaly with Hyaline Panneuropathy Disorder Subdivisions None General Discussion In infants and young children affected by Alexander Disease, associated symptoms and findings include a failure to grow and gain weight at the expected rate (failure to thrive); delays in the development of certain physical, mental, and behavioral skills that are typically acquired at particular stages (psychomotor retardation); and progressive enlargement of the head (macrocephaly). Additional features typically include sudden episodes of uncontrolled electrical activity in the brain (seizures); abnormally increased muscle stiffness and restriction of movement (spasticity); and progressive neurological deterioration. In some cases, there is hydrocephalus. In most cases, Alexander Disease appears to occur randomly for unknown reasons (sporadically), with no family history of the disease. In an extremely small number of cases, it is thought that the disorder may have affected more than one family member.

12. Alexander Disease a CHORUS notecard document about alexander disease http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

13. Alexander S Disease NeuroLearn NeuroHelp Leukodystrophy Summary Alexander s disease is a leukodystrophy that is seen most commonly alexander disease is the first disease that is known to be associated with http://moon.ouhsc.edu/kfung/JTY1/NeuroHelp/ZNE2IE01.htm

Alexander's Disease NeuroLearn NeuroHelp Leukodystrophy Background ... Differential Diagnosis BACKGROUND AND CLINICAL INFORMATION Head Summary: Alexander's disease is a leukodystrophy that is seen most commonly in infants or later childhood and is clinically a progressive, sometimes very slow, process with dementia, seizures and spasticity. Pathologically, it is a degenerative disorder of the CNS characterized by diffuse demyelination and rarefaction of the white matter, with little or no sparing of the arcuate fibers, and widespread accumulation of Rosenthal fibers. Generalized changes are most frequently seen but localized forms are also reported. Genetics: Probably a genetically inherited disease but the pattern of inheritance has not been established. Sequence analysis of DNA samples from patients representing different Alexander disease phenotypes revealed that most cases are with non-conservative mutations in the coding region of GFAP. Alexander disease is the first disease that is known to be associated with GFAP mutations [ Bren n er M , et al., 2001

14. Alexander Disease Diagnosis With MR Imaging Van Der Knaap Et alexander disease Diagnosis with MR Imaging Marjo S. van der Knaapa , Sakkubai Naidua , Steven N. Breitera , Susan Blasera , Hans Stroinka http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

15. NORD - National Organization For Rare Disorders, Inc. alexander disease belongs to a group of rare disorders known as More specifically, in alexander disease there is a lack of normal amounts of the http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Alexander Dis

16. Alexander Disease Diagnosis With MR Imaging Van Der Knaap Et Al. alexander disease Diagnosis with MR Imaging Marjo S. van der Knaapa , Sakkubai Naidua , Steven N. Breitera , Susan Blasera , Hans Stroinka http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

17. Alexander Disease - Genetics Home Reference Where can I find additional information about alexander disease? What if I still have specific questions about alexander disease? http://ghr.nlm.nih.gov/condition=alexanderdisease

Home What's New Browse Handbook ... Search Alexander disease Related Gene(s) Quick links to this topic NIH Publications National Institutes of Health MedlinePlus Health Information Educational resources Information pages Patient support For patients and families Gene Reviews Clinical summary Gene Tests DNA test labs PubMed Recent literature OMIM Genetic disorder catalog References Alexander disease On this page: What is Alexander disease? How common is Alexander disease? ... help with understanding Alexander disease? What is Alexander disease? Alexander disease is a rare disorder of the nervous system that usually begins before 2 years of age (infantile form). Onset can also occur, although less commonly, later in childhood (juvenile form) or adulthood. Alexander disease is considered one of the leukodystrophies, a group of disorders in which the primary abnormality is the inability to maintain the fatty covering (myelin) that insulates nerve fibers in the brain. Signs and symptoms of the infantile form of Alexander disease usually include an enlarged brain and head (megalencephaly), stiffness in the arms and/or legs (spasticity), seizures, and mental and physical retardation. If disease onset occurs later in childhood, common problems include speech abnormalities, swallowing difficulties, and poor coordination (ataxia). Alexander disease is also characterized by abnormal deposits of proteins, called Rosenthal fibers, in specialized brain cells (astrocytes). How common is Alexander disease?

18. BBC NEWS Health Fish To Help Stem Severe Bleeding It is used to treat a rare form of haemophilia, sometimes known as Alexander's disease, and for people with the more common haemophilia A and http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

19. Alexander Disease - References - Genetics Home Reference Gene Review alexander disease This link leads to a site outside Genetics Home Reference. alexander disease a review and the gene. Int J Dev Neurosci. http://ghr.nlm.nih.gov/condition=alexanderdisease/show/References

Home What's New Browse Handbook ... Search Alexander disease Back to condition summary Alexander disease References These sources were used to develop the Genetics Home Reference condition summary on Alexander disease. Gene Review: Alexander Disease Johnson AB. Alexander disease: a review and the gene. Int J Dev Neurosci. 2002 Jun-Aug; 20(3-5): 391-4. Review. PubMed citation ... PubMed citation Last Comprehensive Review: May 2005 Published: September 6, 2005 Contact NLM Customer Service Lister Hill National Center for Biomedical Communications ... Selection Criteria for Web Links Indicates a page outside Genetics Home Reference.

20. Alexander Disease - Genetics Home Reference What is alexander disease? alexander disease is a rare disorder of the nervous system that usually begins during infancy or early childhood. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

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