61. Search Result For "Adrenoleukodystrophy" adrenoleukodystrophy; adrenoleukodystrophy; adrenoleukodystrophy adrenoleukodystrophy Information Page; Aicardi Syndrome Information Page; http://www.noah-health.org/search/results.php?lang=1&keyword=Adrenoleukodystroph

62. Adrenoleukodystrophy adrenoleukodystrophy is a rare genetic disease characterized by a loss of myelin surrounding nerve cells in the brain and progressive adrenal gland http://www.healthatoz.com/healthatoz/Atoz/ency/adrenoleukodystrophy.jsp

63. GeneReviews: Adrenoleukodystrophy, X-Linked adrenoleukodystrophy Wikipedia, the free encyclopediaadrenoleukodystrophy (ALD) is a degenerative disorder of the sheath covering nerve Retrieved from http//en.wikipedia.org/wiki/adrenoleukodystrophy http://www.genetests.org/query?dz=x-ald

64. Mississippi River Challenge For Rett Syndrome & Adrenoleukodystrophy (ALD) adrenoleukodystrophy (ALD). What Is adrenoleukodystrophy (ALD)? ALD is one of a group of genetic disorders called the leukodystrophies that cause damage to http://www.mississippichallenge.org/ald.html

2003 World Record Set: 18 days, 4 hours, 51 minutes! The Mississippi River Challenge for - May 10, 2003 6 AM to May 28, 10:51 AM 2003- A 2,348 Mile Marathon to Support a Marathon of Research! Please see Justin Bradford's Website and sign his guestbook - he loves to hear from everyone (Justin is Bob Bradford's grandson)! Home Team Mission Route Map ... Contact Us Adrenoleukodystrophy (ALD) What Is Adrenoleukodystrophy (ALD)? ALD is one of a group of genetic disorders called the leukodystrophies that cause damage to the myelin sheath, the fatty covering, on nerve fibers in the brain and leads to progressive neurological disability and death. It is probably best know to Americans as the disease that afflicts the young boy Lorenzo Odone, whose story is told in the 1993 film 'Lorenzo's oil'. Who Gets ALD?

65. Adrenoleukodystrophy NINDS adrenoleukodystrophy information page. This Web resource on adrenoleukodystrophy (a rare genetic disorder) is produced by the National Institute of http://omni.ac.uk/browse/mesh/D000326.html

low graphics Adrenoleukodystrophy Adrenoleukodystrophy Adrenoleukodystrophy / genetics other: Addison Disease Adrenoleukodystrophy Bandolier extra : Lorenzo's oil (systematic review) "Lorenzo's oil" is one in a series of evidence-based Internet essays focusing on specific health-related issues and topics, taken from the Bandolier Extra collection. Published in November 2002, this essay describes a systematic review carried out on the use of Lorenzo's oil in adrenoleukodystrophy (ALD) and in adrenomyeloneuropathy (AMN), its adult-onset form. This condition is one of a group of genetic disorders called the leukodystrophies, that results in damage to the myelin sheath (the fatty covering on the nerve cells in the brain) which Lorenzo's oil, a mixture of glyceryl trioleate and glyceryl trierucate, attempts to reduce. This document is in PDF, which requires Adobe Acrobat Reader. Review [Publication Type] Myelin Sheath Fatty Acids Essays [Publication Type] ... Adrenoleukodystrophy Adrenoleukodystrophy / genetics GeneReviews : X-linked adrenoleukodystrophy Notes for physicians on X-linked adrenoleukodystrophy (X-ALD). This document includes diagnosis, a clinical description, differential diagnosis, management, genetic counselling, and molecular genetics. Posted in March 1999 (updated February 2002), this resource forms part of GeneReviews (formerly GeneClinics profile), a peer-reviewed clinical genetic information resource that is funded by the US National Institutes of Health (NIH) and produced by the University of Washington, Seattle. This resource contains a summary and bibliographical references of the review. Last updated in April 2004.

66. Kid Squared: Adrenoleukodystrophy adrenoleukodystrophy. Did you ever see the movie Lorenzo s oil it s a terrific movie abour the power of two parents love for their son? It s that disease. http://65.254.88.134/archives/000153.html

Kid Squared Adding Gabriel to Jonas, Mieke and Jefferson. Main October 20, 2004 Adrenoleukodystrophy Did you ever see the movie Lorenzo's oil- it's a terrific movie abour the power of two parents' love for their son? It's that disease. (ALD): A rapidly progressive X-linked genetic disorder marked by the accumulation of saturated very long chain fatty acids (VLCFA) in all tissues and body fluids, with a preference for the brain and the adrenal glands. This buildup leads to inflammation of the brain and erosion of the white matter of the central nervous system and the adrenal glands. It affects only boys; while there is a neonatal form, it typically strikes between the ages of 6 and 10. I found out today that a friend of mine's very close friends were told last week that their son Harry (7) has six months to live. This is all very sudden. He was a normal boy until about a month ago, he suddenly started to have problems concentrating, he would talk in circles, and became very clumsy. Four weeks later they are told he is not going to live more than six months and that he will deteriorate quickly. Already there are times he doesn't recognize Deb, one of his mother's best friends. This is so painful. We spent Christmas with them at our friends' house a few years ago, played with the boys, and have kept up on their lives through out the years. There are so many layers to this tragedy. The condition is genetic, passed down from the mother. Can you imagine how that would feel? What's worse their older son Sam (10) may also have the gene. They are reeling from the news of their baby and now they are faced with the brutal reality that they must discover Sam's fate as soon as they can, so they can start treatment. There is no cure.

67. Rural Nurse Organization Clinic Digital Library adrenoleukodystrophy Access document; Neonatal adrenoleukodystrophy Access document. Merck Manual Second Home Edition Table of contents. Section 6. http://ruralnurseorganization-dl.slis.ua.edu/patientinfo/metabolism/inborn/perox

Patient/Family Resources by Topic: Metabolic Disorders Adrenoleukodystrophy Patient/Family Resources Miscellaneous See also: Hypofunction of the Adrenal Cortex Patient/Family Resources Mental Retardation Patient/Family Resources Genetic Testing Patient/Family Resources General Genetic Disorders Patient/Family Resources ... Adrenoleukodystrophy Clinical Resources National Institute of Neurological Disorders and Stroke: Homepage Disorders Information: List of documents Adrenoleukodystrophy: Access document United Leukodystrophy Foundation: Homepage Introductions to the Leukodystrophies: Access document Adrenoleukodystrophy: Access document Neonatal Adrenoleukodystrophy: Access document Merck Manual - Second Home Edition Table of contents Section 6. Brain, Spinal Cord, and Nerve Disorders: Table of contents Chapter 92. Multiple Sclerosis and Related Diseases: Table of contents Introduction: Access document Other Primary Demyelinating Diseases: Access document Miscellaneous Adrenoleukodystrophy Patient/Family Resources The Family Village Library - Specific Diagnoses Card Catalog Table of contents Leukodystrophy: Access document Healthfinder (US DHHS): Homepage Genetics: List of documents MedlinePlus (National Library of Medicine) Health Topics: Index Genetic Testing: List of documents Prenatal Testing: List of documents Genetic Counseling: List of documents Genetic Disorders: List of documents Birth Defects: List of documents YAHOO - Health:Diseases and Conditions:Metabolic Diseases Additional Metabolic Diseases resources ( These sites have not been reviewed.

68. Rural Nurse Organization Clinic Digital Library adrenoleukodystrophy Access document. Pediatrics Resources See also General Pediatrics adrenoleukodystrophy (Keyword search) List of documents http://ruralnurseorganization-dl.slis.ua.edu/clinical/metabolism/inborn/peroxiso

Clinical Resources by Topic: Metabolic Disorders Adrenoleukodystrophy Clinical Resources Pediatrics Radiology Genetics Clinical Guidelines ... Miscellaneous Resources See also: Hypofunction of the Adrenal Cortex Clinical Resources Mental Retardation Clinical Resources Genetic Testing Clinical Resources General Genetic Disorders Clinical Resources ... Adrenoleukodystrophy Patient/Family Resources Neurology (eMedicine): Table of contents Inherited Metabolic Disorders: Access document Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes: List of documents Adrenoleukodystrophy: Access document Pediatrics Resources See also General Pediatrics Resources Neurology (eMedicine): Table of contents Peroxisomal Disorders: Access document Radiology Resources See also General Radiology Resources CHORUS-Collaborative Hypertext of Radiology: Homepage Musculoskeletal System: List of documents Adrenoleukodystrophy: Access document Genetics Resources See also General Genetics Resources GeneClinics: Homepage Adrenoleukodystrophy (X-linked): Access document Online Mendelian Inheritance in Man: Homepage Adrenoleukodystrophy: Access document Adrenoleukodystrophy, Autosomal Neonate Form:

69. X-linked Adrenoleukodystrophy NeuroLearn NeuroHelp Metabolic Summary Xlinked adrenoleukodystrophy is a peroxisomal disease with Such inflammatory response is not seen in neonatal adrenoleukodystrophy (NALD). http://moon.ouhsc.edu/kfung/JTY1/NeuroHelp/ZNF3IE01.htm

X-linked Adrenoleukodystrophy NeuroLearn NeuroHelp Metabolic Peroxisomal disorders, classification ... Reference BACKGROUND AND CLINICAL INFORMATION Head Summary: X-linked adrenoleukodystrophy is a peroxisomal disease with combined involvement of the CNS and the adrenal glands. Progressive childhood onset is the most common presentation but clinical presentation is quite variable. Pathologically, X-ALD is characterized by lipid accumulation (birefrigent striations, also seen in other peroxisomal diseases) in the adrenal gland and testicular interstitial glands and inflammatory "three-zone" demyelinating lesions in the brain. Clinical features: Over half of the patients present with the childhood form, about 25% have a late-onset presentation with adrenomyeloneuropathy, and 10% have isolated Addison disease. Childhood onset type: Usually between 4 and 8 years of age, with progressive disturbances of gait and subtle cognitive decline. Only about 10% of the caes will develop features of adrenal cortical insufficiency. Symptoms of Addison's disease commonly appear before the neurologic symptoms, but may follow mental deterioration. Skin pigmentation is very uncommon.

70. Neonatal Adrenoleukodystrophy (NALD) NeuroLearn NeuroHelp Neonatal adrenoleukodystrophy (NALD). NeuroLearn NeuroHelp Metabolic @ Peroxisomal disorders, Differential diagnosis from Xlinked adrenoleukodystrophy. http://moon.ouhsc.edu/kfung/JTY1/NeuroHelp/ZNF3IE04.htm

Neonatal adrenoleukodystrophy (NALD) NeuroLearn NeuroHelp Metabolic Peroxisomal disorders, classification Clincial: This is a condition that is distinctly different from X-ALD. It is a peroxisomal disease with assembly deficiency. Presentation is early and involves both sexes. Clinical features include hypotonia, seizures and failure to thrive. There is also dysmorphic facial features similar to Zellweger’s syndrome but is less severe. Pathology: The major change in the CNS is demyelination, perivascular lymphocytic infiltration, macrophages containing PAS-(+) material, and neuronal migration disorder (less impressive that that in Zellweger’s syndrome). Adrenal glands are severely atrophic and contains ballooned and striated birefrigent cortical cells with trilaminar inclusions common to peroxisomal diseases with assembly deficiency. Hepatic peroxisomes are rare or absent. Differential diagnosis from X-linked adrenoleukodystrophy. NeuroLearn NeuroHelp Metabolic F or Comment: KarMing-Fung@ouhsc.edu

71. Lorenzo's Oil For AMN And ALD Lorenzo s oil for adrenoleukodystrophy and adrenomyeloneuropathy. adrenoleukodystrophy magnetic resonance follow up after Lorenzo s oil therapy. http://www.jr2.ox.ac.uk/bandolier/booth/neurol/lorenz.html

@import "../../styles/advanced.css"; Skip navigation Lorenzo's oil for adrenoleukodystrophy and adrenomyeloneuropathy Clinical bottom line Lorenzo's oil has no value in patients with established symptoms. It may be of value of asymptomatic patients, and may delay onset of symptoms, but the extent of any effect is unclear. The problem is that the fatty acids in Lorenzo's oil do not replace the very long chain fatty acids in the brain because they do not cross the blood-brain barrier. Background There are several forms of ALD. Onset of the classic childhood form, which is the most severe and affects only boys, may occur between ages 4 and 10. Features of this form may include visual loss, learning disabilities, seizures, dysarthria (poorly articulated speech), dysphagia (difficulty swallowing), deafness, disturbances of gait and coordination, fatigue, intermittent vomiting, melanoderma (increased skin pigmentation), and progressive dementia. The most common symptoms are usually behavioral changes such as abnormal withdrawal or aggression, poor memory, and poor school performance. In the milder adult-onset form (also called adrenomyeloneuropathy, or AMN), which typically begins between ages 21 and 35, symptoms may include leg stiffness, progressive spastic paraparesis (stiffness, weakness and/or paralysis) of the lower extremities, and ataxia. Although adult-onset ALD progresses more slowly than the classic childhood form, it can also result in deterioration of brain function.

72. MyDNA.com - Adrenoleukodystrophy myDNA is a consumer focused health, genetics, and genomics information provider offering disease condition information, health wellness tips, http://www.mydna.com/genes/genetics/disorders/disease/nutritional/ald.html

@import url(http://www.mydna.com/plone.css); @import url(http://www.mydna.com/ploneCustom.css); myDNA.com Search Yellow Pages News ... Diets Search For In Entire Site Articles News Images Advanced Search Home Genetics Center ... Nutritional and Metabolic Adrenoleukodystrophy Page Tools Print This Page E-Mail This Page Add to Favorites Genetics Genetics News Ask Dr. DNA Top Tens Genetics 101 Genetic Testing Genetic Disorders Genes and Disease Blood Diseases Cancer Digestive System Ear, Nose and Throat Female-Specific Disease Glands and Hormones Heart and Blood Vessels Immune System Male Specific Disease Muscle and Bone Neonatal Diseases Nervous System Nutritional and Metabolic Respiratory Diseases Skin, Connective Tissue

73. Adrenoleukodystrophy - Swedish Medical Center, Seattle, Washington adrenoleukodystrophy Swedish Medical Center, Seattle, Washington. http://www.swedish.org/14127.cfm

PDF Version Search Send-to-Friend Health Library Home ... Conditions InBrief Adrenoleukodystrophy by Rick Alan Definition Causes Risk Factors ... Organizations Definition Adrenoleukodystrophy (ALD) is a rare inherited genetic disorder. ALD results in degeneration of: The fatty insulation covering on nerve fibers in the brain (myelin sheath) The adrenal gland There are several types of ALD. The two most common types are: X-linked (also called child-onset ALD) and neonatal. Causes ALD is caused by an inherited defective gene on the X chromosome, and is therefore called a sex-linked inherited disorder. In people with ALD, the body's enzymes do not properly break down fatty acids. This results in an accumulation of high levels of saturated fatty acids in the brain and the adrenal cortex, which causes degeneration of the myelin sheath (which covers the nerves) and the adrenal gland. Risk Factors A risk factor is something that increases your chances of getting a disease or condition. Risk factors for ALD include: Having a mother who carries the defective ALD gene Age: Childhood Sex: Male Symptoms Symptoms can vary within the types of ALD.

74. Adrenoleukodystrophy adrenoleukodystrophy (ALD) is a rare inherited genetic disorder. ALD results in degeneration of. The fatty insulation covering on nerve fibers in the brain http://healthgate.partners.org/browsing/browseContent.asp?fileName=22566.xml&tit

75. Adrenoleukodystrophy - St. Joseph Mercy, Ann Arbor Michigan adrenoleukodystrophy St. Joseph Mercy Health System Hospitals serving Ann Arbor, SE Michigan, Washtenaw County, Livingston County, Wayne County, http://www.sjmercyhealth.org/12353.cfm

@import url(default.css); Online Health Information Health Information - Rare Diseases and Disorders Back to Health Library Print This Page Email to a Friend National Organization for Rare Disorders, Inc. Adrenoleukodystrophy Synonyms Disorder Subdivisions General Discussion Resources ... For a Complete Report Important It is possible that the main title of the report Adrenoleukodystrophy is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Adult Onset ALD Addison Disease with Cerebral Sclerosis Addison-Schilder Disease Adrenomyeloneuropathy ALD AMN Bronze Schilder's Disease Encephalitis Periaxialis Diffusa Flatau-Schilder Disease Melanodermic Leukodystrophy Myelinoclastic Diffuse Sclerosis Schilder Disease Schilder Encephalitis Siewerling-Creutzfeldt Disease Sudanophilic Leukodystrophy, ADL Disorder Subdivisions Childhood Adrenoleukodystrophy Neonatal Adrenoleukodystrophy General Discussion Adrenoleukodystrophy is a rare inherited metabolic disorder characterized by the loss of the fatty covering (myelin sheath) on nerve fibers within the brain (cerebral demyelination) and the progressive degeneration of the adrenal gland (adrenal atrophy). Adrenoleukodystrophy that is inherited as an X-linked genetic trait may begin in childhood or adulthood. However, Adrenoleukodystrophy that is inherited as an autosomal recessive genetic trait typically begins during infancy (neonatal period). Resources

76. Adrenoleukodystrophy adrenoleukodystrophy is a rare inherited metabolic disorder characterized by the loss of the fatty covering http://my.webmd.com/hw/raising_a_family/nord43.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map Health Topics Symptoms ... For a Complete Report Adrenoleukodystrophy Important It is possible that the main title of the report Adrenoleukodystrophy is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Adult Onset ALD Addison Disease with Cerebral Sclerosis Addison-Schilder Disease Adrenomyeloneuropathy ALD AMN Bronze Schilder's Disease Encephalitis Periaxialis Diffusa Flatau-Schilder Disease Melanodermic Leukodystrophy Myelinoclastic Diffuse Sclerosis Schilder Disease Schilder Encephalitis Siewerling-Creutzfeldt Disease Sudanophilic Leukodystrophy, ADL Disorder Subdivisions Childhood Adrenoleukodystrophy Neonatal Adrenoleukodystrophy General Discussion Adrenoleukodystrophy is a rare inherited metabolic disorder characterized by the loss of the fatty covering (myelin sheath) on nerve fibers within the brain (cerebral demyelination) and the progressive degeneration of the adrenal gland (adrenal atrophy). Adrenoleukodystrophy that is inherited as an X-linked genetic trait may begin in childhood or adulthood. However, Adrenoleukodystrophy that is inherited as an autosomal recessive genetic trait typically begins during infancy (neonatal period).

77. CCR: NIGMS HGCR: Phenotypic Overview-Adrenoleukodystrophy Collection Pseudoneonatal adrenoleukodystrophy (PNALD OMIM 264470) is caused by a Our collection of adrenoleukodystrophy cell lines comprises a total of http://locus.umdnj.edu/nigms/phenotype/ald.html

CCR NIGMS NIA NINDS ... LMS Quickfind... Animals Characterized Mutations Cell Types CEPH Families Chromosome Aberrations Controls Dysmorphology Gene Pathways HapMap Resource Human Variation Hybrids Inherited Disorders Extended Families Phenotypic Overviews Polymorphism Resource SNP500 Resource Special Collections Search NIGMS Catalog Search Help Quickfind... Animals Char. Mutations Cell Types CEPH Families Chrom. Aberrations Controls Dysmorphology Gene Pathways HapMap Resource Human Variation Hybrids Inherited Disorders Extended Families Phenotypic Overviews Polymorphism Res. SNP500 Resource Special Collections Repository Overview About NIGMS Diseases and Gene Variants Controls Search ... Site Map Adrenoleukodystrophy Collection The leukodystrophies encompass several genetic disorders in which damage to the myelin sheath occurs. Adrenoleukodystrophy (ALD OMIM # ) is an X-linked recessive disorder that is caused by mutations in the gene (OMIM # plays a role in peroxisomal beta-oxidation and mutations in this gene lead to the accumulation of the saturated very long chain fatty acids in all tissues of the body. ALD has three main phenotypes including a childhood cerebral form, an adult form known as Adrenomyeloneuropathy (AMN), and Addison disease only. Unlike ALD, Neonatal Adrenoleukodystrophy (NALD OMIM # ) is an autosomal recessive disorder caused by dysfunction of peroxisomal enzymes. Mutations in several different genes have been associated with NALD. Pseudoneonatal Adrenoleukodystrophy (PNALD OMIM #

78. Arch Neurol -- Abstract: Follow-up Of 89 Asymptomatic Patients With Adrenoleukod Followup of 89 Asymptomatic Patients With adrenoleukodystrophy Treated With Lorenzo’s Oil. Hugo W. Moser, MD ; Gerald V. Raymond, MD ; Shou-En Lu, http://archneur.ama-assn.org/cgi/content/abstract/62/7/1073

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 62 No. 7, July 2005 Featured Link E-mail Alerts Original Contribution Article Options Full text PDF Send to a Friend Readers Reply Submit a reply Related articles in this issue Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Moser HW Odone A ISI Web of Science (1) Contact me when this article is cited Topic Collections Radiologic Imaging Pediatric Neurology Magnetic Resonance Imaging Topic Collection Alerts Hugo W. Moser, MD Gerald V. Raymond, MD Shou-En Lu, PhD Larry R. Muenz, PhD Ann B. Moser, BA Jiahong Xu, MS Richard O. Jones, PhD Daniel J. Loes, MD Elias R. Melhem, MD Prachi Dubey, MD, MPH Lena Bezman, MD, MPH N. Hong Brereton, MS, RD Augusto Odone Arch Neurol. To identify asymptomatic boys with X-linked adrenoleukodystrophy who have a normal magnetic resonance image were identified by a plasma very long-chain fatty acids assay oil and moderate fat restriction. Plasma fatty acids and clinical

79. Adrenoleukodystrophy → Department Of Neurogenetis, Max Planck Institute Of Xlinked adrenoleukodystrophy (ALD) is the most frequent inherited CNS myelin Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice. http://nave.em.mpg.de/adrenoleukodystrophy/

Neurogenetics Projects Adrenoleukodystrophy Fullscreen Login ... Links Celia Kassmann Phone: Fax: E-mail: Mouse models of X-linked adrenoleukodystrophy (ALD) Celia Kassmann, Hauke Werner in collaboration with S. Forss-Petter (Wien), J. Berger (Wien) and M. Baes (Leuven) X-linked adrenoleukodystrophy (ALD) is the most frequent inherited CNS myelin disease (leukodystrophy) in children. This neurological disorder is caused by mutations of the X chromosome-linked adrenoleukodystrophy protein gene (Abcd1). Severely affected ALD patients are young males with a rapidly progressing, lethal CNS demyelination. The underlying disease mechanism is not understood, but appears to involve disturbed peroxisome function. Some patients with mutations of the same gene have no demyelination but a slowly progressing non-inflammatory degeneration of spinal cord axons (Adrenomyeloneuropathy, AMN). Both ALD and AMN patients suffer from adrenocortical insufficiency (Addison's disease). The responsible Abcd1 gene encodes an ABC transporter (ALDP) specific for peroxisomes. Accumulation of very long chain fatty acids (VLCFA) is typical for this and other peroxisomal disorders, but whether this biochemical defect is the cause of demyelination or merely a biochemical marker is not known.

80. Adrenoleukodystrophy Cerebral adrenoleukodystrophy Int. Storage Dis. Collaborative Study Grp adrenoleukodystrophy Symptoms and SelfAssessment Test adrenoleukodystrophy http://www.ability.org.uk/Adrenoleukodystrophy.html

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