41. PharmGKB: Activated Protein C Resistance activated protein c resistance. Alternate Names, APC Resistance; Resistance, APC. PharmGKB Primary Data. Phenotype Datasets. None. Pathways. None http://www.pharmgkb.org/do/serve?objId=PA446880&objCls=Disease

42. Antiphospholipid Antibodies And Activated Protein C Resistance - Chapter 3: Hype Activated protein C cleaves (divides) and inactivates coagulation factors Va causes factor V to be resistant to protein C and can result in clotting. http://www.venous-info.com/handbook/hbk03f.html

Phospholipids are fats that contain phosphorus. Antiphospholipid (APL) antibodies are acquired antibodies to phospholipid-bound protein and prothrombin. These antibodies can prolong coagulation times. APL antibodies occur in about 5% of the population, including healthy persons and are common in people with lupus erythematosus (10–30%) other connective tissue disorders, cancer, HIV, drug and possibly estrogen intake, pulmonary embolism, intravenous catheter thrombosis, or thrombosis in the liver, portal vein, kidney, or retina. A person with APL antibodies who has symptoms needs to take heparin for the acute event, then long-term warfarin. Some physicians prescribe steroids also. A person with APL antibodies who has lupus (lupus anticoagulant) and no symptoms and is having vascular reconstruction should take antiplatelet therapy such as aspirin preoperatively, heparin therapy during the operation, and warfarin postoperatively. Activated protein C cleaves (divides) and inactivates coagulation factors Va and VIIIa in the presence of protein S. This system allows blood to clot while maintaining fluidity. A genetic change in factor V, called

43. Activated Protein C Resistance And Factor V Leiden In Patients With Hemolysis, E Another 38% of the women had subnormal activated protein C ratios (2.02.3). Only 57% of the women with an activated protein c resistance were identified as http://www.greenjournal.org/cgi/content/abstract/92/3/457

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45. Activated Protein C Resistance (APCR) Van Cott EM, Soderberg BL, Laposata M. activated protein c resistance, the factor V Leiden mutation, and a laboratory testing algorithm. http://www.labcorp.com/datasets/labcorp/html/chapter/mono/cf003300.htm

Activated Protein C Resistance (APCR) Number CPT Related Information Factor V Leiden Mutation Analysis Synonyms APCR Specimen Plasma, frozen Volume 2 mL Minimum Volume 1 mL Container Blue-stopper (sodium citrate plasma) tube Collection Blood should be collected in a blue-stopper tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio. The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples. When noncitrate tubes are collected for other tests, collect sterile and nonadditive(red-stopper) tubes prior to citrate (blue-stopper) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-stopper tube. Serum gel separator tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge and carefully remove the plasma without disturbing the cells using a plastic transfer pipette. Transfer the plasma into a LabCorp plastic purple tube with cap (LabCorp ID 9566589372). The specimen should be frozen immediately and maintained frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

46. Biochem. J. (1996) 313, 467-472 - C. Aparicio And B. Dahlba~Dck - Factor V:Q506 Molecular mechanisms of activated protein c resistance Resistance to activated protein C (APC), which is the most prevalent pathogenetic risk factor of http://www.biochemj.org/bj/313/bj3130467.htm

About the journal Subscriptions Authors Users ... Download to Citation Matcher Biochem. J. (1996) Molecular mechanisms of activated protein C resistance Properties of factor V isolated from an individual with homozygosity for the Arg to Gln mutation in the factor V gene Abbreviations used: APC, activated protein C; FV, factor V; FVa, activated factor V; FV:Q , factor V with glutamine (Q) at position 506 ; FV:R , factor V with arginine (R) at position 506; FXa, activated factor X; mAb, monoclonal antibody; HPC4, mAb against protein C; HPS54, mAb against protein S; HFV30, mAb against factor V; EGF, epidermal growth factor; PPACK, D -phenylalanyl- L -prolyl- L -arginine chloromethyl ketone; PEG, polyethylene glycol; APTT, activated partial thromboplastin time. * To whom correspondence should be addressed. Resistance to activated protein C (APC), which is the most prevalent pathogenetic risk factor of thrombosis, is linked to a single point-mutation in the factor V (FV) gene, which predicts replacement of Arg (R) at position 506 with a Gln (Q). This mutation modifies one of three APC-cleavage sites in the heavy chain of activated FV (FVa), suggesting that mutated FVa (FVa:Q ) is at least partially resistant to APC-mediated degradation. To elucidate the molecular mechanisms of APC-resistance and to investigate the functional properties of FV in APC resistance, FV:Q

47. Blackwell Synergy - Cookie Absent Mechanisms for acquired activated protein c resistance in cancer patients. G. SARIG, Y. MICHAELI*, N. LANIR, B. BRENNER and N. HAIM* http://www.blackwell-synergy.com/doi/abs/10.1111/j.1538-7836.2005.01168.x

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48. Cutaneous Necrosis In Pregnancy Secondary To Activated Protein C Resistance In H function protein S activity with evidence of activated protein c resistance. has not been reported in associated with activated protein c resistance http://www.jrsm.org/cgi/content/abstract/88/4/229

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager PubMed Articles by Perkins, W. Articles by Chisholm, M. ORIGINAL ARTICLES Cutaneous necrosis in pregnancy secondary to activated protein C resistance in hereditary angioedema W Perkins, I Downie, M Keefe and M Chisholm Department of Dermatology, Royal South Hants Hospital, Southampton, UK. A 26-year-old woman with hereditary angineurotic oedema (HAE) presented at 22 weeks gestation with severe cutaneous necrosis similar to that seen in coumarin skin necrosis. Protein S deficiency secondary to HAE and pregnancy was postulated. Treatment with heparin, C1-inhibitor concentrates, systemic steroids and surgical debridement resulted in a successful outcome for both mother and child. Subsequent investigations revealed normal levels of protein C, antithrombin III, total protein S, free protein S but reduced function protein S activity with evidence of activated protein C resistance. Cutaneous necrosis has not been reported in associated with

49. IngentaConnect Clinical Significance Of Acquired Activated Protein C Resistance Keywords acquired activated protein c resistance factor vl; antiphospholipid antibodies; systemic lupus erythematosus; thrombosis http://www.ingentaconnect.com/content/arn/lu/2002/00000011/00000011/art00005

Home About Ingenta Ingenta Labs Help For Publishers Why go online? Why choose IngentaConnect? Why choose CustomConnect? Access and authentication ... Contact us For Researchers About IngentaConnect Search and browse Publications available Accessing articles ... Register For Librarians Why choose IngentaConnect? Why choose IngentaConnect Premium? Activating Subscriptions Purchasing articles ... Browse Publications Clinical significance of acquired activated protein C resistance in patients with systemic lupus erythematosus Authors: ; Reverter J-C. ; Font J. ; Espinosa G. ; Cervera R. ; Carmona F. ; Balasch J. ; Ingelmo M. ; Ordinas A. Source: Lupus , Volume 11, Number 11, 1 November 2002, pp. 730-735(6) Publisher: Hodder Arnold Journals View Table of Contents full text options Abstract: Antiphospholipid antibodies (aPL) may induce acquired activated protein C resistance (acquired APCR). The role of acquired APCR in patients with systemic lupus erythematosus (SLE) is not well known. To evaluate the prevalence of acquired APCR and its association with clinical manifestations we studied 103 consecutive SLE patients and 103 matched controls. APCR in the undiluted test and after dilution in factor V deficient plasma, factor V Leiden, protein C and S, lupus anticoagulant, and anti-cardiolipin, anti- vs P =0.007; and 33

50. Activated Protein C Resistance - Alegent Health Serving Eastern Nebraska And Sou activated protein c resistance Alegent Health serving eastern Nebraska and southwest Iowa - Council Bluffs, Iowa - Corning, Iowa - Missouri Valley, http://www.alegent.com/112938.cfm

>> Lab Tests @import url(module.css); Print This Page Activated Protein C Resistance Please Refer to APC Resistance Profile WELLNESS CENTERS PHARMACY TRIALS ... Alegent Health Clinic � 2004 Alegent Health

51. Specialty Laboratories ::: We Help Doctors Help Patients Factor V Leiden and activated protein c resistance Comparison of functional testing for resistance to activated protein C and molecular biological http://www.specialtylabs.com/books/display.asp?id=1068

52. ACTIVATED PROTEIN C RESISTANCE V (APCRV), PLASMA activated protein c resistance V (APCRV), PLASMA Marquette General Health System Freeze specimen immediately at or = 40 degrees C, if possible. http://www.mgh.org/lab/CATALOG/TESTS/5096.HTM

ACTIVATED PROTEIN C RESISTANCE V (APCRV), PLASMA Marquette General Health System General Info Alpha Code APCR MGH LIS Test No Schedule Monday through Friday Testing Time 1 day/1 hour Testing Lab Mayo Labs Specimen Info Type Light blue-top Volume 1.0 mL Temperature Frozen Preservative Collection Info 1. Draw blood in a light blue-top (citrate) tube(s). Spin down, remove plasma, spin plasma again, and place 1.0 mL of citrate platelet- poor plasma in plastic vial. (Glass vials cannot be accepted.) Note: Double-centrifuged specimens are critical for accurate results as platelet contamination may cause spurious results. 3. Send specimen frozen. 4. If priority specimen, mark requisition, give reason, and request a call-back. Note: 1. Each coagulation assay requested should have its own vial. Methods Clot-Based Assay Clinical Utilities CPT Codes Reference Range BASELINE ACTIVATED PARTIAL THROMBOPLASTIN TIME V(APTT V) 35-43 seconds APTT V WITH APC 100-130 seconds APCRV RATIO Pediatric reference range: Pediatric reference range has neither been established nor is available in scientific literature. The adult reference

53. ARUP Activated Protein C Resistance Certifications Internet Services Login. ARUP s User s Guide. 0030127 activated protein c resistance. Test Mnemonic APC RST. See APC Resistance Profile http://www.aruplab.com/guides/ug/tests/0030127activated_20protein_20c_20resistan

54. THE MERCK MANUAL OF GERIATRICS, Ch. 70, Hypercoagulability And activated protein c resistance increases the risk of venous thromboembolism activated protein c resistance is an important defect to be aware of when http://www.merck.com/mrkshared/mmg/sec9/ch70/ch70b.jsp

55. HighWire -- Browse Journals - Activated Protein C Resistance Journals focusing on activated protein c resistance (in order by highest focus). Radiology info free ISSUES Nephrology Dialysis Transplantation info http://highwire.stanford.edu/lists/topic_dir/608683/608684/613947/613948/614082/

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56. Activated Protein C Resistance, The Factor V Leiden Mutation, And A Laboratory T Individuals with activated protein c resistance have a mutated factor V, The original test for activated protein c resistance that was offered for use http://arpa.allenpress.com/arpaonline/?request=get-document&doi=10.1043/0003-998

57. Activated Protein C Resistance In Antiphospholipid Thrombosis Syndrome Bokarewa MI, Blomback M. Combination of activated protein c resistance and antibodies to phospholipid in the development of thrombosis. http://www.cmj.org/information/full.asp?id=1288

58. Activated Protein C Resistance In Antiphospholipid Thrombosis Syndrome activated protein c resistance in antiphospholipid thrombosis syndrome. WU Jingsheng ?, ZHOU Zhizhong ?, LI Xiangpei ?, LI Xiaomei ?, http://www.cmj.org/information/abstract.asp?id=1288

59. Turkish Journal Of Haematology Keywords activated protein c resistance, FV Leiden, Prevalence in healthy Activated protein C (APC) resistance has been found to be an important cause http://www.tjh.com.tr/text.php3?id=207

60. Activated Protein C Resistance Topic - Unified Search Environment most common cause of APC resistance. Synonyms and Source Vocabularies activated protein c resistance MSH/MH/D020016 LNC/CN/NOCODE MTHICD9/ET/289.81 http://www.use.hcn.com.au/portals/shared/subject.`Activated Protein C Resistance

Activated Protein C Resistance Topic Tree Definition: A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance. Synonyms and Source Vocabularies: Activated Protein C Resistance APC Resistance Hematologic Diseases Anemia Blood Coagulation Disorders Blood Group Incompatibility ... Hematologic Neoplasms Thrombophilia Disseminated Intravascular Coagulation Purpura, Thrombotic Thrombocytopenic Protein S Deficiency Antithrombin III Deficiency ... Activated Protein C Resistance

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