61. Acromegaly And Gigantism CHC Wausau Hospital s Medical Library and Patient Education Center provides research services and healthcare information to physicians, http://www.chclibrary.org/micromed/00036000.html

Main Search Index Definition Description Causes ... Resources Acromegaly and gigantism Definition Acromegaly is a disorder in which the abnormal release of a particular chemical from the pituitary gland in the brain causes increased growth in bone and soft tissue, as well as a variety of other disturbances throughout the body. This chemical released from the pituitary gland is called growth hormone (GH). The body's ability to process and use nutrients like fats and sugars is also altered. In children whose bony growth plates have not closed, the chemical changes of acromegaly result in exceptional growth of long bones. This variant is called gigantism, with the additional bone growth causing unusual height. When the abnormality occurs after bone growth stops, the disorder is called acromegaly. Description Acromegaly is a relatively rare disorder, occurring in approximately 50 out of every 1 million people (50/1,000,000). Both men and women are affected. Because the symptoms of acromegaly occur so gradually, diagnosis is often delayed. The majority of patients are not identified until they are middle aged. The pituitary is a small gland located at the base of the brain. A gland is a collection of cells that releases certain chemicals, or hormones, which are important to the functioning of other organs or body systems. The pituitary hormones travel throughout the body and are involved in a large number of activities, including the regulation of growth and reproductive functions. The cause of acromegaly can be traced to the pituitary's production of GH.

62. Acromegaly Feature article describes acromegaly, its diagnosis, and treatment. http://rarediseases.about.com/library/weekly/aa121302a.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a70' About Rare / Orphan Diseases Rare Diseases A - B Rare Diseases: A Acromegaly Rare Diseases Essentials Rare Diseases: Basic Information Rare Diseases Support Groups ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the Rare / Orphan Diseases newsletter! See Online Courses Search Rare / Orphan Diseases Acromegaly Hormonal disorder Related Resources Internet links on acromegaly From Other Guides Senior Health: Acromegaly Sleep Disorders: Sleep Apnea Elsewhere on the Web NIDDK: Acromegaly Andre the Giant Internet site Mary Kugler, MSN, RN,BC Guide to Rare/Orphan Diseases What is it? Acromegaly is a hormonal disorder in which there is overproduction of growth hormone. If the disorder begins in puberty, it is called gigantism. What causes it? Most cases of acromegaly are caused by a non-cancerous tumor of the pituitary gland in the brain. The tumor produces excess growth hormone, and as it grows it presses on the brain tissue around it. Most of these tumors occur spontaneously and are not genetically inherited. In a few cases, acromegaly is caused by a tumor somewhere else in the body, such as in the lungs, pancreas, or adrenal glands.

63. Introduction: Acromegaly - WrongDiagnosis.com Introduction to acromegaly as a medical condition including symptoms, diagnosis, misdiagnosis, treatment, prevention, and prognosis. http://www.wrongdiagnosis.com/a/acromegaly/intro.htm

Home Symptoms Diseases Risks ... Diseases Search our medical database Subscribe to our free Newsletter sample Send this page to a friend Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Acromegaly Next sections Basic Summary for Acromegaly Prevalence and Incidence of Acromegaly Types of Acromegaly Causes of Acromegaly ... Symptoms of Acromegaly Next chapters: Gigantism Rheumatic conditions Ankle conditions Hip conditions ... Feedback Introduction: Acromegaly Acromegaly: Rare hormone disorder causing excessive growth. Researching symptoms of Acromegaly: Further information about the symptoms of Acromegaly is available including a list of symptoms of Acromegaly , other diseases that might have similar symptoms in differential diagnosis of Acromegaly , or alternatively return to research other symptoms in the symptom center Misdiagnosis and Acromegaly: Research more detailed information about misdiagnosis of Acromegaly underlying causes of Acromegaly (possibly misdiagnosed), or research misdiagnosis of other diseases Treatments for Acromegaly: Various information is available about treatments available for Acromegaly , or research treatments for other diseases.

64. Endocrinology - Acromegaly acromegaly affects mostly middleaged adults. Untreated, the disease can lead Symptoms of acromegaly vary depending on how long the patient has had the http://uuhsc.utah.edu/healthinfo/adult/endocrine/acromegaly.htm

Acromegaly What is acromegaly? Acromegaly is the Greek word for "extremities" and "enlargement." When the pituitary gland produces excess growth hormones, this results in excessive growth called acromegaly. The excessive growth occurs first in the hands and feet, as soft tissue begins to swell. Acromegaly affects mostly middle-aged adults. Untreated, the disease can lead to severe illness and death. What are the symptoms of acromegaly? Symptoms of acromegaly vary depending on how long the patient has had the disease. The following are the most common symptoms. However, each individual may experience symptoms differently: swelling of the hands and feet facial features become course as bones grow body hair becomes course as the skin thickens and/or darkens increased perspiration accompanied with body odor protruding jaw voice deepening enlarged lip, nose, and tongue thickened ribs (creating a barrel chest) joint pain degenerative arthritis enlarged heart enlargement of other organs strange sensations and weakness in arms and legs snoring fatigue and weakness headaches loss of vision irregular menstrual cycles in women breast milk production in women impotence in men The symptoms of acromegaly may resemble other conditions or medical problems. Consult a physician for diagnosis.

65. Acromegaly And Gigantism acromegaly and gigantism Growth Hormone Excess acromegaly and Gigantism. Jaffe, CA acromegaly Recognition and Treatment. Drugs 47, no. http://www.healthatoz.com/healthatoz/Atoz/ency/acromegaly_and_gigantism.jsp

66. NORD - National Organization For Rare Disorders, Inc. Synonyms of acromegaly. Marie Disease. Disorder Subdivisions. General Discussion acromegaly is a rare, slowly progressive chronic disorder that affects http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Acromegaly

67. Neuroendocrine Research Studies In Pituitary Disorders the Food and Drug Administration), SOM 230, in patients with active acromegaly. All patients who have active acromegaly and are not controlled on their http://www.massgeneral.org/pituitary/acromegaly_studies.htm

Acromegaly 005: A Study to Evaluate Treatment with a Combination of Pegvisomant Plus Sandostatin LAR, Pegvisomant (alone) and Sandostatin (alone) in Patients with Acromegaly Two classes of medications are currently approved for the medical treatment of acromegaly: somatostatin analogues (Sandostatin LAR) and growth hormone antagonist (Pegvisomant). The aim of this 40-week study is to evaluate treatment with Sandostatin LAR plus pegvisomant and pegvisomant alone in those patients who have not responded to Sandostatin LAR alone. All adult patients who have undergone surgery and/or radiation therapy for the acromegaly and have been taking Sandostatin LAR for at least six months may be eligible for this study. Eligible subjects who are not controlled on their current dose of Sandostatin LAR will be randomly assigned to two groups: (1) will continue on the current dose of Sandostatin LAR in addition to Pegvisomant, or (2) will be asked to stop the Sandostatin LAR and be started on Pegvisomant alone. There are 12 visits occurring approximately once a month. Medication is provided at no cost during study participation. Travel expenses are reimbursed. This study is currently closed to further enrollment.

68. Acromegaly Base de données sur les maladies rares et les médicaments orphelins. http://www.orpha.net/static/GB/acromegaly.html

Orphanet database access Acromegaly Direct access to data Alias Gigantism (acromegaly, infantile and juvenile forms) Somatotrophinoma, familial Clinical signs Autosomal dominant inheritance Coarse face Enlarged diaphysis Hypothal.hypoph. axis abn. function Large hand Long face Long foot/arachnodactyly of toes Long/large ear Long/large/bulbous nose Macroglossia Macropenis/large penis Muscular build Prognathism Tall stature Tapered fingers Thick lips Abnormal dental position Adenoma Increased body hair Kiphosis Synophris Update : 04/09/2005 Orphanet database access

69. Novartis Pharmaceutical- A Through Z - Acromegaly acromegaly (akro-MEG-aly) is a rare disease. How is acromegaly treated? Where can I learn about living with acromegaly? http://www.pharma.us.novartis.com/conditions/az/acromegaly.jsp

70. AllRefer Health - Acromegaly (Growth Hormone Excess, Somatotroph Adenoma) acromegaly (Growth Hormone Excess, Somatotroph Adenoma) information center covers causes, prevention, symptoms, diagnosis, treatment, incidence, http://health.allrefer.com/health/acromegaly-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Acromegaly Acromegaly Definition Prevention Treatment Expectations or Prognosis ... Go To Main Page Alternate Names : Growth Hormone Excess, Somatotroph Adenoma Definition Acromegaly is a chronic metabolic disorder caused by the presence of too much growth hormone. It results in gradual enlargement of body tissues including the bones of the face, jaw, hands, feet, and skull. Endocrine Glands Acromegaly occurs in about 6 of every 100,000 adults. It is caused by abnormal production of growth hormone after normal growth of the skeleton and other organs is complete. Excessive production of growth hormone in children causes gigantism rather than acromegaly. The cause of the increased hormone secretion is usually a benign tumor of the pituitary gland. The pituitary gland, which is located just below the brain, controls the production and release of several different hormones including growth hormone.

71. Acromegaly - Patient Tree - Part Of TELEPLEXUS® acromegaly Patient Tree - Patient To Patient Support Information - Part of TELEPLEXUS® http://www.teleplexus.com/Acromegaly.html

My TELEPLEXUS About TELEPLEXUS TELEPLEXUS Mail TELEPLEXUS network: Addison's Disease Patient Tree Cyber Apostle Jersey Spin ... Home Acromegaly Acromegaly is a hormonal disorder that results when the pituitary gland produces excess growth hormone (GH). It most commonly affects middle-aged adults and can result in serious illness and premature death. Once recognized, acromegaly is treatable in most patients, but because of its slow and often insidious onset, it frequently is not diagnosed correctly. The name acromegaly comes from the Greek words for "extremities" and "enlargement" and reflects one of its most common symptoms, the abnormal growth of the hands and feet. Soft tissue swelling of the hands and feet is often an early feature, with patients noticing a change in ring or shoe size. Gradually, bony changes alter the patient's facial features: the brow and lower jaw protrude, the nasal bone enlarges, and spacing of the teeth increases. Overgrowth of bone and cartilage often leads to arthritis. When tissue thickens, it may trap nerves, causing carpal tunnel syndrome, characterized by numbness and weakness of the hands. Other symptoms of acromegaly include thick, coarse, oily skin; skin tags; enlarged lips, nose and tongue; deepening of the voice due to enlarged sinuses and vocal cords; snoring due to upper airway obstruction; excessive sweating and skin odor; fatigue and weakness; headaches; impaired vision; abnormalities of the menstrual cycle and sometimes breast discharge in women; and impotence in men. There may be enlargement of body organs, including the liver, spleen, kidneys and heart.

72. Acromegaly http://www.lumen.luc.edu/lumen/MedEd/medicine/endonew/acromegaly/acromegaly.htm

73. Discovery Health :: Diseases & Conditions :: Acromegaly acromegaly is excessive bone growth. It results when a person s body produces too much growth hormone. The condition causes gradual enlargement of the bones http://health.discovery.com/encyclopedias/illnesses.html?article=480&page=1

74. Pharmaceutical Research And Manufacturers Of America acromegaly. Complete a new search Acne, acromegaly, Actinic Keratosis, Acute gouty arthritis, Acute Respiratory Distress Syndrome, adenovirises http://www.phrma.org/newmedicines/newmedsdb/drugs.cfm?indicationcode=Acromegaly|

75. Stanford Cancer Center - Acromegaly Cancer Types Stanford acromegaly is a rare disorder; it results from a pituitary tumor that overproduces growth The onset of acromegaly is insidious and seemingly benign, http://cancer.stanfordhospital.com/cancerTypes/endocrine/pituitary/acromegaly/

76. Acromegaly - Patient UK acromegaly is a condition where you make too much growth hormone. This causes various symptoms which slowly develop over several years. http://www.patient.co.uk/showdoc/27000264/

Acromegaly Acromegaly is a condition where you make too much growth hormone. This causes various symptoms which slowly develop over several years. The most noticeable symptoms are hands and feet that become larger, and features of the face become more prominent. The cause is usually a small non-cancerous tumour in the pituitary gland. Treatment options include surgery to remove the tumour, and medicines to block the release or effects of growth hormone. Understanding the pituitary gland and growth hormone The pituitary gland gland lies just below the brain. It makes several hormones, including growth hormone. (A hormone is a chemical which is made in one part of the body, but passes into the bloodstream and has effects on other parts of the body.) The amount of growth hormone that you make is partly controlled by other hormones which come from a small part of the brain called the hypothalamus. This is just above the pituitary. It makes growth hormone releasing hormone (GHRH) which stimulates the pituitary to make growth hormone when the blood level of growth hormone is low. It also makes somatostatin which prevents the pituitary from making growth hormone when the level of growth hormone is high. Growth hormone helps to stimulate growth and repair or various body tissues. It is needed in childhood to help you to grow. Growth hormone acts on some tissues directly. But, it also stimulates the liver to make another hormone called insulin-like growth factor-1 (IGF-1). Many of the effects of growth hormone are actually due to IGF-1 which acts on various cells on the body.

77. Society For Endocrinology - UK Acromegaly Registry acromegaly is a rare disease with a prevalence estimated at 40 per million To gather prospective and retrospective data on acromegaly in the UK with a http://www.endocrinology.org/SFE/acromegaly.htm

Contents Home About Journals ... Links Society for Endocrinology UK Acromegaly Registry Background and purpose of the UK Acromegaly Registry Methodology Ethics Recent developments and links to other projects ... Support information Background and purpose of the UK Acromegaly Registry Acromegaly is a rare disease with a prevalence estimated at 40 per million populations. It is apparent that the condition is associated with increased morbidity and mortality, but the results of studies carried out by individual centres have been limited due to the lack of sufficient patient numbers. It was proposed that a UK national database should be established for the collection of both prospective and retrospective data. The core dataset collected by individual centres throughout the country is combined nationally, providing sufficient patient numbers to address key epidemiological and therapeutic issues. The objective of this project is therefore to gather data to investigate the links between acromegaly and increased morbidity and mortality, as follows: - To gather prospective and retrospective data on acromegaly in the UK with a view to obtaining a large series so that the database will be able to generate more significant data than has been possible previously.

78. BBC - Health - Conditions - Acromegaly And Growth Hormone A feature on growth hormones and acromegaly. Other characteristic changes that occur in acromegaly include deepening of the voice, excess sweating and http://www.bbc.co.uk/health/conditions/acromegaly1.shtml

@import url('/includes/tbenh.css') ; Home TV Radio Talk ... A-Z Index THURSDAY 8th September 2005 Text only BBC Homepage Lifestyle Health ... Help Like this page? Send it to a friend! Acromegaly and growth hormone Dr Rob Hicks Many people say they would like parts of their body to be bigger. But there are times when enlargement of certain body parts is not desired. In this article Growth hormone does what it says Overproduction of growth hormone Rampant growth Characteristics ... Overcoming the problem Growth hormone does what it says The pituitary gland is responsible for producing many different hormones. Some of these hormones act directly on parts of the body, while some trigger other glands to release their own hormones One hormone produced by the pituitary gland that acts directly is called growth hormone (GH) and it doesn't take a genius to figure out what it does. Growth hormone stimulates the growth of muscle, cartilage and bone. Overproduction of growth hormone In rare circumstances, the pituitary gland may produce excessive amounts of GH. Invariably this is the result of the presence of a pituitary tumour, which in most cases is non-cancerous. Occasionally these tumours appear as part of an inherited condition called multiple endocrine neoplasia, in which tumours develop in several different hormone-producing glands around the body. However, why these tumours in the pituitary gland occur in the first place remains a mystery. Since the pituitary gland is located just below the brain, as it grows it may press on the brain, causing headaches. It may also affect vision, which is usually noticed as a reduction in a person's field of vision.

79. Acromegaly acromegaly is a hormonal disorder that results when the pituitary gland produces excess growth hormone (hGH). http://endocrine-disorders.health-cares.net/acromegaly.php

80. OMIM - ACROMEGALY http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=102200

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