41. UpToDate Patient Information: Acromegaly (somatotroph Adenomas) acromegaly is the clinical syndrome that results from prolonged, acromegaly is uncommon; only three to four cases are diagnosed per million people each http://patients.uptodate.com/topic.asp?file=endo_hor/4528&title=Acromegaly

42. UpToDate Clinical Manifestations Of Acromegaly INTRODUCTION — acromegaly is the clinical syndrome that results from excessive secretion of The most common cause of acromegaly is a somatotroph (growth http://patients.uptodate.com/topic.asp?file=pituitar/6039

43. Acromegaly acromegaly. A hormonal disorder that results when the pituitary gland produces excess growth hormone (GH). Clinical Features. commonly affects middleaged http://www.dental.mu.edu/oralpath/lesions/acromegaly/acromegaly.htm

Acromegaly A hormonal disorder that results when the pituitary gland produces excess growth hormone (GH). Clinical Features: commonly affects middle-aged adults abnormal soft tissue growth of the hands and feet bony changes alter the patient's facial features including the spacing of teeth arthritis thick, coarse, oily skin; skin tags; enlarged lips, nose and tongue; deepening of the voice due to enlarged sinuses and vocal cords; snoring due to upper airway obstruction; excessive sweating and skin odor; fatigue and weakness; headaches; impaired vision; enlargement of body organs, including the liver, spleen, kidneys and heart. Radiographic Features: pituitary gland enlargement Etiology: over production of growth hormone Tissue of Origin: pituitary gland Main Pathologic Process: soft tissue and bone proliferation Treatment: surgical removal of the tumor drug therapy radiation therapy of the pituitary Prognosis: monitored for years for possible recurrence Webmaster © 2001 - Marquette University School of Dentistry - P.O. Box 1881 - Milwaukee, WI 53201-1881

44. Oral Manifestations Of Acromegaly Next Last Index Text. Slide 1 of 22. http://www.dental.mu.edu/oralpath/spresent/acromegaly/sld001.htm

45. Acromegaly.org.uk acromegaly.org.uk The countdown has begun. acromegaly.org.uk. acromegaly.org.uk. contact info@acromegaly.org.uk. http://www.acromegaly.org.uk/

acromegaly.org.uk c o n t a c t info@acromegaly.org.uk

46. Acromegaly Pictures And Understanding Acromegaly acromegaly understanding acromegaly, acromegaly pictures, transsphenoidal surgery, transsphenoidal hypophysectomy, acromegaly symptoms and acromegaly http://www.acromegalyinfo.com/info/understanding/home.jsp

47. Acromegaly acromegaly is an uncommon hormonal disorder that develops when your pituitary The term acromegaly is derived from the Greek words for extremities and http://www.cnn.com/HEALTH/library/DS/00478.html

International Edition MEMBER SERVICES The Web CNN.com Home Page World U.S. Weather ... Autos SERVICES Video E-mail Newsletters Your E-mail Alerts RSS ... Contact Us SEARCH Web CNN.com In association with: DIABETES AND ENDOCRINE SYSTEM Endocrine System Graves' disease Goiter Male hypogonadism Hyperthyroidism ... Pheochromocytoma INFORMATION CENTERS: Pick a category Health Centers Family Health Men's Health Women's Health Children's Health Seniors' Health Working Life Pain Management Condition Centers Immune System Allergy Alzheimer's Arthritis Respiratory System Cancer Endocrine System Digestive System Heart and Blood Infectious Disease Mental Health Note: All links within content go to MayoClinic.com Diseases and Conditions Acromegaly From MayoClinic.com Special to CNN.com Overview Acromegaly is an uncommon hormonal disorder that develops when your pituitary gland produces too much growth hormone during adulthood. When this happens, your bones increase in size, including those of your hands, feet and face. The term acromegaly is derived from the Greek words for "extremities" and "enlargement." In children who are still growing, too much growth hormone can cause a condition called gigantism. These children have exaggerated bone growth and an abnormal increase in height.

48. THE MERCK MANUAL--SECOND HOME EDITION, Acromegaly And Gigantism In Ch. 162, Pitu Increased growth hormone in adults produces acromegaly, in which the In both gigantism and acromegaly, the tongue may enlarge and become more furrowed. http://www.merck.com/mmhe/sec13/ch162/ch162e.html

var externalLinkWarning = "The link you have selected will take you to a site outside Merck and The Merck Manuals.*n*nThe Merck Manuals do not review or control the content of any non-Merck site. The Merck Manuals do not endorse and are not responsible for the accuracy, content, practices, or standards of any non-Merck sources."; Search The Second Home Edition , Online Version Search Index A B C D ... Z Sections Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders ... Women's Health Issues Resources Anatomical Drawings Multimedia Pronunciations Weights and Measures ... , Online Version Section Hormonal Disorders Chapter Pituitary Gland Disorders Topics Introduction Acromegaly and Gigantism Central Diabetes Insipidus Empty Sella Syndrome Enlargement of the Pituitary Gland Galactorrhea ... Hypopituitarism Acromegaly and Gigantism Buy The Book Print This Topic Email This Topic Pronunciations acromegaly adenoma apnea arthritis ... sebaceous Overproduction of growth hormone causes excessive growth. In children, the condition is called gigantism; in adults, it is called acromegaly. Growth hormone stimulates the growth of bones, muscles, and many internal organs. Excessive growth hormone, therefore, leads to abnormally robust growth of all of these tissues. Overproduction of growth hormone is almost always caused by a noncancerous (benign) pituitary tumor (adenoma). Certain rare tumors of the pancreas and lungs also can produce hormones that stimulate the pituitary to produce excessive amounts of growth hormone, with similar consequences.

49. Acromegaly And Acromegaly Symptoms And Sandostatin acromegaly and acromegaly Symptoms acromegaly pictures, acromegaly treatment, pituitary tumor, transsphenoidal surgery, and Sandostatin. http://www.us.sandostatin.com/info/disease/acromegaly/home.jsp

50. Acromegaly And Carcinoid Syndrome And Sandostatin LAR Depot acromegaly and Carcinoid Syndrome Sandostatin LAR Depot, acromegaly symptoms, carcinoid tumor, and controlling hypersecretion. Gain a better understanding http://www.us.sandostatin.com/index.jsp

51. Acromegaly acromegaly is a metabolic disorder caused by the presence of too much growth hormone. It results in gradual enlargement of body tissues including the bones http://www.healthcentral.com/ency/408/000321.html

Dr. Dean TV Specials Newsletters Home ... Health Tools Search Choose a Health Topic * All Health Topics * Acne Addictions AIDS/HIV Alcohol Abuse Allergies Alternative Medicine Alzheimer's Arthritis Asthma Attention Deficit Disorder (ADHD) Backache Bipolar Affective Disorder Birth Control Blood Blood Pressure Bone/Joint/Tendon Bowel Brain Breast cancer Cancer Cerebral Palsy Cholesterol Cramps Crohn's Disease Cysts Dental/Oral Depression Diabetes Diet, Fitness, Looks Disabled/Special Needs Drug Abuse Ear/Nose/Throat Eating/Appetite Eczema Encephalitis Eye/Vision Fatigue Fever Flu Food Poisoning Foot Gallbladder Gastrointestinal Genetic/Congenital GERD/Heartburn Hair Loss Hair/Scalp Headache Hearing Heart Disease, Stroke Heat/Sunstroke Hepatitis Hernia Herpes High Blood Pressure Hormonal Immune Disorders Immunizations/Vaccines Impotence Incontinence/Bladder Infections Injuries Kidney/Urinary Kids Learning Disabilities Liver Lung Cancer Men Menopause, Postmenopause Migraine Mobility/Balance Multiple Sclerosis Muscle Neural Nosebleeds Pain Parasites Pituitary PMS Pregnancy Prostate Cancer Prostate Disorders Psoriasis Psychological Raynaud's Disease Respiratory Reye Syndrome Rheumatoid Arthritis Schizophrenia Seniors Sensory Sexually Transmitted Disease Skin Sleep Speech Disorders Spinal Thyroid Trauma Weight Loss Women Yeast Infections Home Health Encyclopedia Acromegaly Acromegaly Injury Disease Nutrition Poison ... Prevention Acromegaly Definition: Acromegaly is a chronic metabolic disorder caused by the presence of too much growth hormone. It results in gradual enlargement of body tissues including the bones of the face, jaw, hands, feet, and skull.

52. Acromegaly Definition - Medical Dictionary Definitions Of Popular Medical Terms Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=2127

53. The Pituitary Foundation | Disorders | Acromegaly acromegaly is caused when a tumour on the pituitary gland produces too much growth hormone (GH). These tumours are almost always benign (ie not cancerous) http://www.pituitary.org.uk/disorders/acromegaly.htm

Text version Home News Contact Us ... Skip search box SEARCH THIS SITE Advanced search Skip section links DISORDERS Acromegaly Adult GH Deficiency ... Disorders Index LINKS Skip main links The Endocrine System Pituitary Disorders Resources ... About The Pituitary Foundation Acromegaly Acromegaly is caused when a tumour on the pituitary gland produces too much growth hormone (GH). These tumours are almost always benign (i.e. not cancerous) and therefore do not spread to other areas of the body. Acromegaly is a very rare condition and usually develops between the ages of 30 and 50. If the condition develops before a person has stopped growing (which usually occurs between the ages of 15 to 17 years of age), it causes gigantism because growth hormone promotes growth of bones in the body. Typical symptoms coarsening of facial features enlarged hands and feet thickening of the soft tissue in the palms and soles of the feet carpal tunnel syndrome (tingling feeling or pains in the hands) excessive sweating and oily skin headaches vision disturbance sleep apnoea general tiredness irregular periods (oligomenorrhoea) or loss of normal menstrual function (amenorrhoea) - adult females impotence - adult males reduced fertility decrease in sex drive All these symptoms tend to develop gradually and the changes may not be noticed for some time.

54. The Pituitary Foundation | GP Fact File | 3. Acromegaly Sheet No 3 of the GP Fact File produced by The Pituitary Foundation. Also available in pdf format. http://www.pituitary.org.uk/gp-factfile/3-acromegaly.htm

Text version Home News Contact Us ... Skip search box SEARCH THIS SITE Advanced search Skip section links GP FACT SHEETS 1. Introduction 2. Non-Functioning Tumour 3. Acromegaly 5. Hyperprolactinaemia ... GP Fact File Index LINKS Skip main links The Endocrine System Pituitary Disorders Resources ... About The Pituitary Foundation Pituitary Foundation Fact Sheet Incidence: New Cases per million per year Acromegaly Acromegaly is the result of growth hormone (GH) hypersecretion by a pituitary macro- or microadenoma. Presentation before puberty is rare and is the cause of pituitary gigantism. Acromegaly most often occurs in adults aged 30-50 years. Elevated GH levels are associated with changes in appearance, headaches, sweating and tiredness. GH hypersecretion affects a number of body systems and is associated with a two-fold increase in mortality. Presenting symptoms Excessive GH secretion produces a gradual change in appearance (not usually noticed by those living or working with the patient) due to its effects on cartilage and soft tissues. The patient may notice enlargement of the hands and feet and may experience growth of the jaw. Nerve compression symptoms may occur, particularly carpal tunnel syndrome. Premature and widespread osteoarthritis of the weight-bearing joints is also characteristic. Obstructive sleep apnoea may be present, especially in men, leading to daytime sleepiness.

55. Acromegaly Since only the smallest fraction of information dealing with acromegaly is Studies on acromegaly. Overview. The Combined Health Information Database http://www.icongrouponline.com/health/Acromegaly_Ph.html

ICON Health Publications Official Health Sourcebooks Search ICON Health Titles: ACROMEGALY A Bibliography, Medical Dictionary, and Annotated Research Guide to Internet References (acromegalia; eosinophilic adenoma syndrome; gigantism; hyperpituitarism) P A P E R B A C K Paperback Book Paperback Book Order by phone: 800-843-2665 (within USA) 1-201-272-3651 (from outside USA) Paperback Book Shipped in 3 to 5 business days E B O O K Electronic File * E-Book version sent via e-mail in 2 business days Pages Price $34.95(USD) ISBN Published Synopsis In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading." Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing. Since only the smallest fraction of information dealing with acromegaly is indexed in search engines, such as www.google.com or others, a non-systematic approach to Internet research can be not only time consuming, but also incomplete. This book was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so. Related Conditions/Synonyms acromegalia; eosinophilic adenoma syndrome; gigantism; hyperpituitarism

56. Tall Persons Club GB & Ireland · Medical Information · Acromegaly/Gigantism will take on the characteristic appearance of one suffering from acromegaly. acromegaly when normal growth is complete the ends of the long bones fuse, http://www.tallclub.co.uk/medical/acromegaly.asp

Home Bulletin Board (BBS) Chat Room Events ... Member Login Acromegaly/Gigantism back to Medical Information Gigantism: growth hormone is secreted by the anterior lobe of the pituitary gland. It controls the rate of growth of the individual, as well as determining the timing of sexual maturity. It certain cases, usually due to a micro-tumour, the gland continues to secrete growth hormone for much longer, and in greater quantities, than it should. The affected person will continue to grow upwards, as well as outwards, until secretion is stopped, by medical or surgical intervention. If unchecked, the person will take on the characteristic appearance of one suffering from acromegaly. Acromegaly: when normal growth is complete the ends of the long bones fuse, and the person has reached their final height. If the pituitary starts to produce growth hormone again, the person will experience some upwards growth but, due to the fusion of the long bones, many bones, such as the lower jaw, will grow outwards. This leads to a characteristic appearance of the lower jaw and lips, thickening of the fingers and feet, and enlargement of cartilage structures, such as the nose and adams apple, the latter resulting in a deeper than normal voice. The condition is not hereditary, i.e. is not passed on from parent to child via the genetic material, however, some people believe that a set of conditions, or family tendencies, can be passed on, which may make the child more likely than normal to develop the condition. In one case, a man reported that several members of his family have had several pituitary related problems: - diabetes and cryptorchidism (undescended testes), for instance.

57. Neuromuscular + Endocrine Disease acromegaly. Myopathy. Weakness. Proximal; Late in disease course Treatment. Surgery; Octreotide. Hereditary acromegaly http://www.neuro.wustl.edu/neuromuscular/msys/mend.htm

Front Search Index Links ... Adrenal Carcinoid myopathy Corticosteroid Diabetes Gonadal Dysgenesis Gynecomastia Insulinoma Parathyroid ... Hypothyroid From Bramwell : Atlas of Clinical Medicine Myxedema THYROID DISEASE Hyperthyroid Myopathy Ophthalmopathy ... Other associated disorders External link: Testing From Bramwell : Atlas of Clinical Medicine Hypothyroidism Adult History Muscle pain cramps Fatigue Paresthesias Myopathy Weakness Mild (4/5) Symmetric Proximal Occasional: Posterior neck Cramps (40%) Muscle contraction: Slow; Delayed relaxation Muscle enlargement : Occasional (Hoffman's syndrome) Myoedema (33%): Local contracture after muscle tap or pinch Myokymia Associated with Na loss May be associated with ptosis Tendon reflexes: Reduced or Delayed Rhabdomyolysis Course Progression of weakness: Slow over months Resolution of weakness after treatment: Slow over months Neuropathy Carpal tunnel syndrome Cranial nerves : Deafness; Hoarse voice (Local vocal cord lesion) Polyneuropathy (19%): Sensory; Axonal Tendon reflexes: Reduced Ankle reflex Lab Low free thyroxine TSH Primary hypothyroidism: High Pituitary-Hypothalamic disease: Low CK Very High in some patients No correlation with weakness EMG: Normal or mildly myopathic Muscle pathology Usual: Non-specific Pale central regions on NADH Some patients: Accumulation of PAS staining material in muscle fibers Treatment: Thyroid replacement Strength recovers Weakness Slow movements Muscle hypertrophy Growth retardation Hypothyroid: Other associated neuromuscular disorders Myasthenia gravis : Exacerbation of preexisting disease

58. Acromegaly Synonyms. Acromegalia; Eosinophilic adenoma syndrome. ICD9-CM 253.0 acromegaly and gigantism Author(s) Mark R. Dambro, MD http://www.5mcc.com/Assets/SUMMARY/TP0008.html

Acromegaly DESCRIPTION: A disorder due to excessive secretion of pituitary growth hormone, characterized by progressive enlargement of the head and face, hands and feet, and thorax. Usual course - progressive. CAUSES: growth hormone excess from pituitary adenoma Synonyms: Acromegalia Eosinophilic adenoma syndrome ICD-9-CM: 253.0 acromegaly and gigantism Author(s): Mark R. Dambro, MD Illustrations: Acromegaly

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60. UCLA NEUROSURGERY | Pituitary Disorders & Diseases acromegaly is a serious systemic condition caused in over 98% of cases by an The only way to cure pituitary acromegaly is with transsphenoidal surgery http://neurosurgery.ucla.edu/Diagnoses/Pituitary/PituitaryDis_7.html

Acromegaly (Growth Hormone Secreting Adenoma) PITUITARY TUMOR PROGRAM PITUITARY DIAGNOSES INDEX Acromegaly is a serious systemic condition caused in over 98% of cases by an adenoma of the pituitary gland that secretes excessive growth hormone (GH). The clinical features associated with acromegaly include the effects of GH oversecretion, and in some instances by the tumor compressing and injuring the normal pituitary gland, optic nerves and optic chiasm. Untreated acromegaly results in marked bony and soft tissue changes including an altered facial appearance (frontal bossing, prognathism), enlargement of the hands and feet, sleep apnea, and carpal tunnel syndrome. More serious problems may include accelerated cardiovascular disease, hypertension, diabetes mellitus and an increased risk of colon cancer. If the tumor develops before bone growth is completed in adolescence, gigantism is the result. Because of the serious systemic changes resulting from GH excess, treatment is essential, typically with transsphenoidal surgery Symptoms and signs may include: Soft tissue thickening on the palms of the hand Enlargement of hands (ring size), feet (shoe size) and head (hat size)

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