1. Acromegaly Describes this hormonal condition, how common it is and how it s diagnosed, treatment, and resources. http://www.niddk.nih.gov/health/endo/pubs/acro/acro.htm

What Causes Acromegaly? How Common is Acromegaly? How is Acromegaly Diagnosed? How is Acromegaly Treated? ... Other Resources Acromegaly is a hormonal disorder that results when the pituitary gland produces excess growth hormone (GH). It most commonly affects middle-aged adults and can result in serious illness and premature death. Once recognized, acromegaly is treatable in most patients, but because of its slow and often insidious onset, it frequently is not diagnosed correctly. The name acromegaly comes from the Greek words for "extremities" and "enlargement" and reflects one of its most common symptoms, the abnormal growth of the hands and feet. Soft tissue swelling of the hands and feet is often an early feature, with patients noticing a change in ring or shoe size. Gradually, bony changes alter the patient's facial features: the brow and lower jaw protrude, the nasal bone enlarges, and spacing of the teeth increases. Overgrowth of bone and cartilage often leads to arthritis. When tissue thickens, it may trap nerves, causing carpal tunnel syndrome, characterized by numbness and weakness of the hands. Other symptoms of acromegaly include thick, coarse, oily skin; skin tags; enlarged lips, nose and tongue; deepening of the voice due to enlarged sinuses and vocal cords; snoring due to upper airway obstruction; excessive sweating and skin odor; fatigue and weakness; headaches; impaired vision; abnormalities of the menstrual cycle and sometimes breast discharge in women; and impotence in men. There may be enlargement of body organs, including the liver, spleen, kidneys and heart.

2. Acromegaly - Endocrinology Health Guide This health guide deals with acromegaly, a pituitary disorder caused by excess growth hormones. Symptoms and treatments are discussed. http://www.umm.edu/endocrin/acromegaly.htm

var MenuLinkedBy='AllWebMenus [2]', awmBN='530'; awmAltUrl=''; Endocrinology Health Guide... Pituitary Gland Disorders... Pituitary Tumors Acromegaly ... Glossary Related Resources Within UMM Endocrinology Joslin Diabetes Center School of Medicine Endocrinology Site Translate using Google to Spanish German French Italian Portuguese Endocrinology Health Guide Acromegaly What is acromegaly? Acromegaly is the Greek word for "extremities" and "enlargement." When the pituitary gland produces excess growth hormones, this results in excessive growth called acromegaly. The excessive growth occurs first in the hands and feet, as soft tissue begins to swell. Acromegaly affects mostly middle-aged adults. Untreated, the disease can lead to severe illness and death. What are the symptoms of acromegaly? Symptoms of acromegaly vary depending on how long the patient has had the disease. The following are the most common symptoms. However, each individual may experience symptoms differently: swelling of the hands and feet facial features become coarse as bones grow body hair becomes coarse as the skin thickens and/or darkens increased perspiration accompanied with body odor protruding jaw voice deepening enlarged lip, nose, and tongue

3. Acromegaly & Gigantism - Endocrinology - Medstudents A review of acromegaly Gigantism with focus on etiology, pathogenesis and treatment. http://www.medstudents.com.br/endoc/endoc8.htm

Endocrinology Karina Naomi Une Medstudents' Homepage Introduction Acromegaly/Gigantism is a very rare disease (annual incidence: 3/1.000.000). The syndrome results from a chronic exposure to GH (Growth Hormone) leading to the classic clinical features that the diagnosis seems to be easy. High exposure to GH produces gigantism in youths prior to epiphyseal fusion and acromegaly in adults. The early diagnosis and intervention may prevent irreversible changes associated with chronic overproduction of GH (as well IGF-1) and may also normalize life expectancy. These patients have an increased mortality rate from systemic sequela of hypersomatotrophism in 2-4 times that of the healthy population. Etiology Acromegaly/Gigantism is the second in frequency of Pituitary Adenomas, accounting for about 17% of them. It is often caused by a pituitary adenoma GH secreting (99%), but other causes has been described such as: A rare form caused by hypersecretion of GHRH from an ectopic source (pancreatic islet or carcinoid tumors) or from within the central nervous system such as ganglyoneuroma (called eutopic ). Even more rare form is a

4. EMedicine - Acromegaly Article By Hasnain M Khandwala, MD acromegaly Increased and unregulated growth hormone (GH) production, usually caused by a GH-secreting pituitary tumor (somatotroph tumor), http://www.emedicine.com/med/topic27.htm

5. Acromegaly - EMedicine Health Consumer health resource center providing an overview of acromegaly and its causes, symptoms, and treatment. From eMedicine Health. http://www.emedicinehealth.com/Articles/38312-1.asp

Search September 8, 2005 Registration Healthcare Professionals You are in: Acromegaly Acromegaly Acromegaly Overview Acromegaly is a serious condition that occurs when the body produces too much of the hormones that control growth. The hormone most often affected is called growth hormone, or GH. It is produced by the pituitary gland, a tiny organ at the base of the brain. Growth hormone promotes growth of bone, cartilage, muscle, organs, and other tissues. When there is too much growth hormone in the body, these tissues grow larger than normal. This excessive growth can cause serious disease and even premature death. Other effects include enlargement of jaw and other facial bones; overgrowth of bone and cartilage in the joints, causing arthritis, back pain, and curvature of the spine (kyphosis); swelling of the face, lips, and tongue; breathing problems during sleep (sleep apnea); thickening of the skin; carpal tunnel and other nerve entrapment syndromes; and enlargement of body organs such as the heart, thyroid gland (goiter), liver, and kidneys. Untreated, acromegaly is linked to early heart disease, high blood pressure, heart rhythm disorders, diabetes, and colonic polyps, a precursor of colon cancer.

6. OHSU Pituitary Unit - Acromegaly Provides signs and symptoms, diagnosis, treatment options, and complications. From OHSU Health. http://www.ohsupituitary.com/patients/acromeg.asp

Introduction About The Pituitary Diseases Of The Pituitary Prolactinoma ... Cushing's Disease Acromegaly Hormone Deficiency And Replacement Streaming Video: Doctor/Patient Discussions (coming soon) How Do I Work With My Doctor To Find Out If I Have A Pituitary Disorder Diagnosed With A Pituitary Tumor - What Should I Do Next? ... I Have A Question Acromegaly Approximately 10% of pituitary adenomas secrete excess growth hormone (GH) which in adults causes a disease called acromegaly. The word "acromegaly" is of Greek derivation and literally means, "enlarged extremities". The vast majority of cases of acromegaly are caused by pituitary adenomas but other causes include tumors of the pancreas, lungs or adrenal glands. This section will focus on acromegaly caused by pituitary tumors. Acromegaly Quick Link to topics below Diagnosis Treatment New Treatment Options Assessment of Cure or Adequacy of Treatment ... Long-term Course and Potential Complications Signs and Symptoms Due to the slow growth of GH secreting pituitary tumors, the physical characteristics of acromegaly typically develop very slowly over several decades. Acromegaly is particularly characterized by skeletal changes including enlarging hands and feet. For example, patients often recall having to resize their rings several times over a 15 to 20 year period and/or having to increase shoe size several times over the same time frame. Other skeletal changes include enlarging jaw and brow (frontal bossing). Despite the characteristic features of acromegaly, the gradual onset of physical changes often result in the disease being clinically missed for years. In fact, these tumors are often detected because of a mass effect (e.g., headaches, visual changes, other pituitary hormone deficiencies) rather than the physical changes caused by GH excess. Common features of acromegaly are listed in Table 1.

7. Acromegaly Information And Living With Acromegaly Learn about this condition, how it's diagnosed, and treated. Features an animated tutorial from Novartis. http://www.acromegalyinfo.com

Acromegaly Home Understanding Acromegaly Causes Signs and Symptoms Diagnosis ... Glossary Check out Ask Your Doctor, with questions to take with you on your next doctor visit. View the questions Gradual enlargement of the hands and feet Swelling of soft tissue Skin tags Menstrual cycle disturbances / impotence Sweating Headaches Vision problems Carpal tunnel syndrome Muscle weakness/fatigue Joint pain Learn more about symptoms Knowledge is power. We'll keep you informed with disease information and resources for further learning. Sign up Normalize GH and IGF-1 levels Control tumor mass without harming normal pituitary function Relieve signs and symptoms Restore life expectancy to that of the general population Learn about the goals of treatment Getting your GH and IGF-1 levels under control can help you feel better. That's one reason why it's important to begin your treatment soon after diagnosis. Learn more about taking control Learn about adapting to life with acromegaly Contact Us Site Map ... Find a Physician A Novartis Program. For U.S. Residents Only. Use of website is governed by the and Privacy Statement www.acromegalyinfo.com

8. AcromegalySupport.Org Home Support network for people living with acromegaly. Provides patient information, events, and news. http://acromegalysupport.org

About the Site The Acromegaly Outreach Program, a support network for people living with Acromegaly, was founded in 2002 at Cedars-Sinai Medical Center , Los Angeles, California. This program now operates in conjunction with the endocrinology centers at New York University Medical Center and Massachusetts General Hospital . Recognizing that the pituitary disorder, Acromegaly, is relatively unknown to the general public, we have committed ourselves to establishing increased awareness through education and support. Each medical center offers patients and their families an array of support services including excellent, specialized medical treatments, monthly Pituitary Support Group meetings for emotional well-being, and education through this web site and through our quarterly Acromegaly Newsletter In addition, each center will have annual Educational Symposia for patients, families and friends where information on all the current and most innovative treatment options for Acromegaly will be provided. This website serves to provide information on all aspects of living with Acromegaly. Resources you will find here include updates on current news and events for each center, how to get involved in ongoing clinical studies, learn more about your medical condition and feel empowered on how to make the best choices for your medical care by locating knowledgeable endocrinologists and surgeons. You can also find solace and relate to others by reading our

9. Acromegaly acromegaly is a hormonal disorder that results when the pituitary gland produces excess growth hormone (GH). It most commonly affects middleaged http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

10. NIDDK Health Information Endocrine Metabolic Diseases Topics. acromegaly. Addison's Disease. Cushing's Syndrome. Human Growth Hormone and CreutzfeldtJakob Disease http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

11. ► Acromegaly A medical encycopedia article on the topic acromegaly. http://www.umm.edu/ency/article/000321.htm

var MenuLinkedBy='AllWebMenus [2]', awmBN='530'; awmAltUrl=''; Disease Nutrition Surgery Symptoms Injury ... Encyclopedia (English) Toggle English Spanish Acromegaly Overview Symptoms Treatment Prevention Definition: Acromegaly is a chronic metabolic disorder caused by the presence of too much growth hormone. It results in gradual enlargement of body tissues including the bones of the face, jaw, hands, feet, and skull. Alternative Names: Somatotroph adenoma; Growth hormone excess Causes, incidence, and risk factors: Acromegaly occurs in about 6 of every 100,000 adults. It is caused by abnormal production of growth hormone after normal growth of the skeleton and other organs is complete. Excessive production of growth hormone in children causes gigantism rather than acromegaly. The cause of the increased hormone secretion is usually a benign tumor of the pituitary gland. The pituitary gland, which is located just below the brain, controls the production and release of several different hormones including growth hormone. There are no known risk factors for acromegaly other than a prior history of a pituitary tumor.

12. OHSU Pituitary Unit - Pituitary Tumor And Disease Treatment Center Comprehensive treatment center specializing in pituitary tumors and diseases including cushing's, acromegaly, and prolactinomas. http://www.ohsupituitary.com/

A comprehensive treatment center for the management of pituitary tumors and diseases of the pituitary gland Click on the title above to read about the role of the pituitary gland and the characteristics of pituitary disease. Learn how to determine if you have a pituitary tumor or disorder. Utilize multiple patient support resources including the ability to ask general questions of an OHSU neuroendocrinologist. Click on the title above to get valuable information to help you recognize patients with a pituitary tumor or disorder. Review case studies and utilize other educational tools. Gain rapid clinical access to an OHSU neuroendocrinologist for questions and referrals. Click on the title above to learn about the outstanding faculty and resources of the OHSU Pituitary Unit. Services include neurosurgical treatment of pituitary tumors utilizing intraoperative MRI, interventional neuroradiology and radiation-oncology. See recent news releases and other updates about the OHSU Pituitary Unit. Site Map Contact OHSU Pituitary Unit Make A Gift Terms and Conditions ... Disclosure OHSU is an equal opportunity, affirmative action institution.

13. Acromegaly - Endocrinology Health Guide This health guide deals with acromegaly, a pituitary disorder caused by excess growth hormones. Symptoms and treatments are discussed. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

14. Acromegaly.org acromegaly is a hormonal disorder that most commonly occurs in middleaged men and women. The prevalence of acromegaly is approximately 60 cases per million http://www.acromegaly.org/index.php

What is Acromegaly? Acromegaly is a hormonal disorder that most commonly occurs in middle-aged men and women. The prevalence of acromegaly is approximately 60 cases per million population, and the incidence is 3.3 new cases per million per year. The name "acromegaly" comes from the Greek words for "extremities" (acro) and "great" (megaly), because one of the most common symptoms of this condition is abnormal growth of the hands and feet. The symptoms of acromegaly can vary and they develop gradually over time; therefore, a diagnosis of this condition may be difficult. Early detection is a goal in the management of acromegaly because the pathologic effects of increased growth hormone (GH) production are progressive. Current government trials on Acromegaly Current clinical trials for Acromegaly patients from National Institutes of Health. More... One Woman's Opinion May I say thank you for the obvious hard work etc.. that went in to the creation of this very informative web site. I, personally , have read everything on here and more than once. I used this site along with many other resourses in my search to find knowledge and care. I'm sure nobody can argue that this site is the best !!! and nobody can argue about seeking knowledge... and, being a former teacher, I agree completely "read, learn, explore!" Multimedia Library PNA has introduced a multimedia library featuring information about acromegaly and other health topics.

15. Sandostatin.com Global For Healthcare Professionals - Sandostatin LAR Home International site for this medication used for acromegaly. Includes information on acromegaly, GEP tumors, case studies, physicians roster, journal articles, and slide library. http://www.sandostatin.com

generateButtons(0,6,"images/","tnav",false); What's New New data from ASCO 2005 more September 3-8, 2005, Goteborg, Sweden 7th European Congress of Endocrinology more What matters most in treating Acromegaly About Acromegaly Acromegaly is a rare and complex disease caused by overproduction of growth hormone. Diagnosing Acromegaly Treating Acromegaly What matters most in treating GEP NE Tumours About GEP NE Tumours Gastro-entero-pancreatic neuroendocrine (GEP NE) tumours are tumours that are located in the digestive tract. Diagnosing GEP NE Tumours Treating GEP NE Tumours Search Recently Published Data The latest clinical research on: Acromegaly Endocrine GEP NE Tumours Pancreatic Surgery Complications ... Clinical Trials of Sandostatin® LAR® Learn More Resources for Patients Our Newsletter PubMed [database online]. National Center for Biotechnology Information. Available at: www.ncbi.nih.gov/gquery/gquery.fcgi?CMD. Accessed May 2003. LAR Depot (octreotide/IM Injection) and is intended for healthcare professionals outside the US. If you are a US resident, please click on the US Residents link at the top of this page. The information on this site is not country-specific and may contain information that is outside the approved indications where you practice. Privacy Information Site Map

16. Acromegaly Gigantism - Endocrinology - Medstudents A review of acromegaly Gigantism with focus on etiology, pathogenesis and treatment. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

17. Pituitary Network Association Recent Clinical Review Abstract The Antitumoral Effects of Somatostatin Analog Therapy in acromegaly. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

18. Acromegaly - Interesting Images - Medstudents acromegaly An image from Medstudents the brazilian virtual medical journal. This section contains a lot of original images. http://www.medstudents.com.br/image/endoc/imgend9.htm

Images in Endocrinology A patient with acromegaly If you have suggestions or comments send an e-mail to images@medstudents.com.br Back to Images in Endocrinology Back to Medstudents' Homepage

19. Acromegaly And Carcinoid Syndrome And Sandostatin LAR Depot Information Both patient and professional information about acromegaly and GEP tumors and treatment with Sandostatin LAR Depot. Directed towards US residents. http://www.us.sandostatin.com

Sandostatin Home About Sandostatin How Does It Work? Taking Sandostatin Starting Therapy ... For Healthcare Professionals The information in this section is intended for U.S. Healthcare Professionals Only Check out Ask Your Doctor , with questions you can take on your next doctor visit. Questions for patients with acromegaly Questions for patients with carcinoid syndrome Get exclusive disease information, treatment updates, and resources for further learning. Sign Up Learn More Only treats the 'Critical 4': controlling hypersecretion at the site of the tumor, controlling hypersecretion of GH, normalizing IGF-1 levels, and controlling the symptoms of acromegaly. targets the underlying causes of your symptoms , rather than simply masking them. Site Map Contact Us AcromegalyInfo.com Carcinoid.com Use of website is governed by the and Privacy Statement www.us.sandostatin.com Novartis Pharmaceuticals Corporation

20. Systemic Complications Of Acromegaly Epidemiology, Pathogenesis Systemic Complications of acromegaly Epidemiology, Pathogenesis, and Management Annamaria Colao , Diego Ferone , Paolo Marzullo and http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

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