61. Health & Medical > Sickle Cell Disease Child with sickle cell anemia Suffering from Frequent Colds ? Vaccinations after a Splenectomy ? Sickle Beta Thalessemia ? Ensuring that a Child Won t Have http://www.drspock.com/topic/0,1504,467,00.html

September 25, 2005 SEARCH drSpock my account sign in HOT TOPICS Pregnancy Symptoms Read with Your Kids It's Fun! Take Our Quizzes Play with Your Baby TOPICS Parents are talking about their children. Join the discussion. Sickle Cell Disease The Dr. Spock Company and the Discovery Health Channel reveal the human face of a little understood genetic disorder in the television special Sickle Cell: The Forgotten Disease (check your local TV listings for dates and times). Learn more about sickle cell disease in the following articles written by experts in the field. Sickle Cell Disease Topics Sickle Cell: The Forgotten Disease Puts a Human Face on a Little Understood Genetic Disorder Sickle Cell Disease: The Basics The Subtle Differences of Sickle Cell Syndromes ... Treating Sickle Cell Disease with Bone Marrow Transplantation Questions From Other Parents The Lifespan for a Person with Sickle Cell Disease Lack of Emphasis on Sickle Cell Disease How Sickle Cell Disease Is Inherited Treating Children with Sickle Cell Disease ... Ensuring that a Child Won't Have Sickle Cell CONSUMER ALERTS CPSC Warns: Summer Fun Brings More Emergency Room Visits CPSC, K'NEX Industries Announce Recall of Children's Toys

62. Anemia, Sickle Cell 282.60 sickle cell anemia, unspecified REFERENCES; Adams RJ. Lessons from the Stroke Prevention Trial in sickle cell anemia (STOP) study. http://www.5mcc.com/Assets/SUMMARY/TP0056.html

Anemia, sickle cell DESCRIPTION: A chronic hemoglobinopathy transmitted genetically, marked by moderately severe chronic hemolytic anemia, periodic acute episodes of painful "crises," and increased susceptibility to intercurrent infections, especially S. pneumoniae. The heterozygous condition (Hb A/S) is called sickle cell trait and is usually asymptomatic, with no anemia. System(s) affected: Hemic/Lymphatic/Immunologic, Musculoskeletal Genetics: Autosomal recessive, mostly in blacks. Homozygous presence of a variant hemoglobin, HbS or sickle hemoglobin. Heterozygous condition Hb A/S. Incidence/Prevalence in USA: Approximately 1/500 black Americans and 1/1000 Hispanics have sickle cell anemia; 10% black Americans have sickle trait Predominant age: All ages Predominant sex: Male = Female CAUSES: At molecular level: Hb S is produced by substitution of valine for glutamic acid in the sixth amino acid position of the beta chains of the hemoglobin molecule. When deoxygenated, Hb S polymerizes and forms long rods that change RBC from biconcave to sickle shape. At cellular level: Sickle RBCs are inflexible; odd shape and cell rigidity cause increased blood viscosity, stasis, and mechanical obstruction of small arterioles and capillaries, leading to distal ischemia. Sickle RBCs are also more fragile than normal, leading to hemolytic destruction in blood and reticuloendothelial system.

63. Introduction: Sickle Cell Anemia - WrongDiagnosis.com Introduction to sickle cell anemia as a medical condition including symptoms, diagnosis, misdiagnosis, treatment, prevention, and prognosis. http://www.wrongdiagnosis.com/s/sickle_cell_anemia/intro.htm

Home Symptoms Diseases Risks ... Diseases Search our medical database Subscribe to our free Newsletter sample Send this page to a friend Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Sickle Cell Anemia Next sections Basic Summary for Sickle Cell Anemia Prevalence and Incidence of Sickle Cell Anemia Prognosis of Sickle Cell Anemia Risk Factors for Sickle Cell Anemia ... Symptoms of Sickle Cell Anemia Next chapters: Thalassemia Tay Sachs Albinism Galactosemia ... Feedback Introduction: Sickle Cell Anemia Sickle Cell Anemia: Genetic disease causing anemia from improperly formed red blood cells. Researching symptoms of Sickle Cell Anemia: Further information about the symptoms of Sickle Cell Anemia is available including a list of symptoms of Sickle Cell Anemia , other diseases that might have similar symptoms in differential diagnosis of Sickle Cell Anemia , or alternatively return to research other symptoms in the symptom center Misdiagnosis and Sickle Cell Anemia: Research more detailed information about misdiagnosis of Sickle Cell Anemia failure to diagnose Sickle Cell Anemia , or research misdiagnosis of other diseases Treatments for Sickle Cell Anemia: Various information is available about treatments available for Sickle Cell Anemia current research about Sickle Cell Anemia treatments , or research treatments for other diseases.

64. Dr. Koop - Sickle Cell Anemia sickle cell anemia is an inherited disease in which the red blood cells, normally discshaped, become crescent shaped. As a result, they function abnormally http://www.drkoop.com/ency/93/000527.html

Home Health Reference Sickle cell anemia Jul 29, 2005 Search: Dr.Koop MEDLINE Diseases Symptoms Procedures Natural Medicine ... Drug Library Inside DrKoop News Archive Animations Health Videos Health Tools ... Newsletters Sickle cell anemia Injury Disease Nutrition Poison ... Prevention Sickle cell anemia Definition: Sickle cell anemia is an inherited disease in which the red blood cells, normally disc-shaped, become crescent shaped. As a result, they function abnormally and cause small blood clots. These clots give rise to recurrent painful episodes called "sickle cell pain crises." Alternative Names: Anemia - sickle cell; Hemoglobin SS disease (Hb SS); Sickle cell disease Causes, incidence, and risk factors: Sickle cell anemia is caused by an abnormal type of hemoglobin (oxygen carrying molecule) called hemoglobin S. It is inherited as an autosomal recessive trait that is, it occurs in someone who has inherited hemoglobin S from both parents. Someone who inherits hemoglobin S from one parent and normal hemoglobin (A) from the other parent will have sickle cell trait . Approximately 8% of African Americans have sickle cell trait. Someone who inherits hemoglobin S from one parent and another type of abnormal hemoglobin from the other parent will have another form of sickle cell disease, such as sickle cell-b

65. Go Ask Alice!: How Common Is Sickle Cell Anemia? Dear Alice, What percentage of African Americans in the US are diagnosed with sickle cell anemia? http://www.goaskalice.columbia.edu/2061.html

Mac users: please note that our site is optimized for the Safari browser General Health How common is sickle cell anemia? Originally Published: February 08, 2002 Dear Alice, What percentage of African Americans in the U.S. are diagnosed with Sickle Cell Anemia? Dear Reader, Although Sickle Cell Anemia is a relatively rare condition (about one in four thousand Americans have some form of the disease), its significant impact on the African American community and its life-threatening consequences have made it one of the better-known genetic disorders. Approximately 80,000 (or about one in 400) African Americans have some form of Sickle Cell Disease, and another two million (or 1 in 12) African Americans carry the sickle cell trait — a genetic predisposition toward the disease that can be passed down to their children. Even though both sickle cell disease and trait are most common among African Americans, other Americans who trace their ancestry back to the Mediterranean region, South and Central America, Saudi Arabia, and India can also be affected. Sickle cell disease is caused by a defect in the gene that controls the production of hemoglobin. Hemoglobin is the part of red blood cells that is responsible for carrying oxygen in the blood stream throughout the body. Defective hemoglobin produced by the sickle gene become stiff, causing the red blood cells to change from rounded, doughnut-shaped cells that can flow easily through small blood vessels, to pointy sickle-shaped cells. These sickle-shaped cells get stuck in narrow blood vessels and cause traffic jams that interrupt the flow of oxygen to various parts of the body. The body attempts to get rid of these abnormal cells by destroying them, creating sickle cell anemia (anemia is a condition caused by a subnormal level of hemoglobin or red blood cells) that, in turn, can lead to chronic fatigue and decreased resistance to infection.

66. Sickle Cell Disease In Childhood: Part I. Laboratory Diagnosis, Pathophysiology Prophylaxis with oral penicillin in children with sickle cell anemia. The adolescent with sickle cell anemia. Hematol Oncol Clin North Am 1996;10 http://www.aafp.org/afp/20000901/1013.html

Advanced Search AAFP Home Page Journals Vol. 62/No. 5 (September 1, 2000) Sickle Cell Disease in Childhood: Part I. Laboratory Diagnosis, Pathophysiology and Health Maintenance DORIS L. WETHERS, M.D., A patient information handout on sickle cell disease, written by Clarissa Kripke, M.D., assistant editor of AFP, is provided on page 1027. S ickle cell disease is the most common single gene disorder in black Americans, affecting approximately one in 375 persons of African ancestry. Sickling conditions are also common in persons from Mediterranean countries, Turkey, the Arabian peninsula and the Indian subcontinent. Many Spanish-speaking persons in the United States, as well as people from the Caribbean and parts of South and Central America, are affected. The first description of sickle cell disease, published in 1910, was followed by six decades of genetic, hematologic, pathologic, clinical and molecular observations. Since the mid-1970s, two longitudinal prospective studies of children with sickle cell disease have produced a large body of clinical data on the evolution of the disease from birth. The U.S. study followed 3,500 patients with sickle cell disease through sickness and health.

67. Sickle Cell Sickle Cell Disease (SCD) is caused by the malfunction of the red blood cells in sickle cell anemia and Stroke Chest Syndrome With Sickle Cell Disease http://www.savebabies.org/diseasedescriptions/sicklecell.php

Search Our Site! Sickle Cell Disease (SCD) A Hemoglobinopathy Disorder Save Babies Through Screening Foundation is comprised of volunteers. Some have children who were helped by newborn screening, and some have children who have died, or suffered brain damage. For many of the Foundation's volunteers, joy comes from knowing that your child was saved. Many hours of hard work have been done to help children, maybe even yours. Please let us hear from you. What is it? Sickle Cell Disease (SCD) is caused by the malfunction of the red blood cells in affected individuals causing a very severe form of anemia. Inheritance and Frequency The gene defect for sickle cell disease is an autosomal recessive genetic trait and is unknowingly passed down from generation to generation. This faulty gene only emerges when two carriers have children together and pass it to their offspring. For each pregnancy of two such carriers, there is a 25% chance that the child will be born with the disease and a 50% chance the child will be a carrier for the gene defect. It is estimated that on average, sickle cell disease effects 1 of every 1,300 infants in the general population and approximately 1 of every 400 of African descent. It is seemingly more common in individuals of African and Mediterranean ancestry, however, it is not limited to these groups. Ancestor groups should not be a reason to avoid screening for this disorder. It can be found in children of all backgrounds.

68. Sickle Cell Anemia Penn State Hershey Medical Center provides world class care and services to patients. http://www.hmc.psu.edu/healthinfo/s/sicklecell.htm

69. Sickle Cell Anemia - Vitacost Anemia is a deficiency of the oxygencarrying capacity of red blood cells. sickle cell anemia is an inherited chronic anemia in which the red blood cells http://www.vitacost.com/science/hn/Concern/Sickle_Cell_Anemia.htm

My account View cart / Checkout Help Since 1994 Over 1.5 Million Served! Email us Enter keyword or item number Products Health Library Clearance New Products Products Categories ... VitaBlog New! eNewsletter Archives Your Right to Privacy Customer Service Ordering Methods Shipping Information EZShip! 5 Star Guarantee ... Download Order Forms Still have questions? Talk to one of our friendly customer service representatives using Live Chat Science Health Notes Encyclopedia Product Reviews Age Related Macular Degeneration News News Room eNewsletter Archives Vitacost News Releases Additional Resources Physician's Reference Guide and Discount Program Special Discounts walkerdiet.com drkoop.com ... Join our affiliate program! Healthnotes Index: All Healthnotes Indexes Foodnotes Health Concerns Herbal Remedies Homeopathy Recipes Recipes by Course Recipes by Main Ingredient Recipes International Recipes Seasonal Safetychecker Skin Conditions Special Diets Special Recipes Vitamin Guide Weight Control Health Center Search Healthnotes: Sickle Cell Anemia Also indexed as: Crescent Cell Anemia, Sickle Cell Disease

70. Your Child | Pain In Sickle Cell Disease (Sickle Cell Anemia) The pain of sickle cell anemia is very frustrating. You never know when it will strike and it is often For kids Do you know about sickle cell anemia? http://www.med.umich.edu/1libr/yourchild/sicklecell.htm

YOUR CHILD HOME Your Child Topics UMHS HOME Pain in Sickle Cell Disease (Sickle Cell Anemia) What is sickle cell pain? Sickle cell disease if one of the most common inherited diseases worldwide, and pain is the most important symptom of the disease. The pain is often described as deep, gnawing and throbbing. The skin may be tender, red, and warm in the painful areas. Kids with sickle cell disease may experience a wide variety of pain ranging from mild to severe, starting as early as six months old and continuing throughout their lives. The pain of sickle cell anemia is very frustrating. You never know when it will strike and it is often difficult to get it under control. How can you avoid triggering a pain crisis? Most pain episodes do not have an obvious reason for their occurrence. But here are some possible causes and things that your child should avoid: Swimming in cold water Being out in cold weather Getting too hot Getting dehydrated from not drinking enough fluids Colds and infections Overdoing it—not getting enough sleep and rest Drinking alcohol or smoking Menstruation (getting your period) Stress Find out more: Practical Tips for Preventing a Sickle Cell Crisis When should my child see the doctor for sickle cell pain?

71. Adult Health Advisor 2005.2: Sickle Cell Anemia sickle cell anemia is an inherited disease that causes abnormal red blood In the US the frequency of sickle cell anemia among African Americans is about http://www.med.umich.edu/1libr/aha/aha_sicklean_crs.htm

Adult Health Topics All Health Topics Smart Moms, Healthy Babies Find a UMHS Doctor Search Adult Topics Search All Topics This information is approved and/or reviewed by U-M Health System providers but it is not a tool for self-diagnosis or a substitute for medical treatment. You should speak to your physician or make an appointment to be seen if you have questions or concerns about this information or your medical condition. Index Sickle Cell Anemia What is sickle cell anemia? Sickle cell anemia is an inherited disease that causes abnormal red blood cells. It is a lifelong disease. Sickle cell disease is most prevalent among people who are African, African American, Mediterranean (Italian or Greek), Middle Eastern, East Indian, Caribbean, and Central or South American. In the US the frequency of sickle cell anemia among African Americans is about 1 in every 400 births. One of every twelve African American newborns carries the sickle cell trait in his or her genes. How does it occur? Sickle cell anemia is inherited. A baby will have sickle cell anemia if both the mother and the father are carriers of the gene for sickle cell anemia. If someone has just one gene for the disease, they will not have the disease but they are a carrier. If a child inherits a sickle cell gene from each parent, the child has two genes and will have sickle cell anemia.

72. Sickle Cell Anemia sickle cell anemia. Anemia, sickle cell. Hemoglobin S disease Sickle cell disease Peripheral blood smear showing sickle cells admixed with target red http://www.gfmer.ch/genetic_diseases_v2/gendis_detail_list.php?cat3=270

73. Virtual Hospital: University Of Iowa Family Practice Handbook, Fourth Edition: H Hematologic, Electrolyte, and Metabolic Disorders sickle cell anemia Occurs in 40% of patients with sickle cell anemia. http://www.vh.org/adult/provider/familymedicine/FPHandbook/Chapter06/04-6.html

University of Iowa Family Practice Handbook, Fourth Edition, Chapter 6 Hematologic, Electrolyte, and Metabolic Disorders: Sickle Cell Anemia Ke Chen, MD, PhD and Mark A. Graber, MD Immediate Care Center, Iowa Health Physicians and Departments of Family Medicine and Emergency Medicine, University of Iowa College of Medicine Peer Review Status: Externally Peer Reviewed by Mosby Incidence . 0.3% of African Americans are homozygotes (have sickle cell disease); 13% of African Americans are heterozygotes (carriers). Genetics . Autosomal recessive. Abnormal hemoglobin S, leading to sickling of RBCs. Clinical Anemia (see IA and IB under anemia above for clinical symptoms). Sickle crisis : 60% incidence per year. Defined as sickling of cells causing vaso-occlusive disease with bone, lung, renal infarctions, often precipitated by exposure to cold and, importantly, infection . Most common sites of pain are lumbar spine, abdomen, femur, knees, sternum, ribs, shoulder, and elbows. Joint involvement may be symmetric. May be associated with abdominal distension or ileus. May have fever, pulmonary infarctions (see acute chest syndrome below). It may be difficult to differentiate abdominal pain from a sickle crisis from the pain of a surgical acute abdomen. May develop priapism. Fever de facto splenectomized secondary to repeated infarction. Need to treat fever aggressively because encapsulated organisms such as pneumo- cocci and

74. African American Women: Sickle Cell Anemia sickle cell anemia (sihkul sell uh-nee-mee-uh) is a blood disorder, passed down from parents to sickle cell anemia can cause serious health problems http://www.4woman.gov/minority/aasickle.cfm

Skip navigation Health Problems in African American Women: Sickle Cell Anemia Sickle cell anemia (sih-kul sell uh-nee-mee-uh) is a blood disorder, passed down from parents to children. It involves problems the red blood cells. Normal red blood cells are round and smooth and move through blood vessels easily. Sickle cells are hard and have a curved edge. These cells cannot squeeze through small blood vessels. They block the organs from getting blood. Your body destroys sickle red cells quickly, but it can't make new red blood cells fast enough a condition called anemia. Sickle cell anemia can cause serious health problems: pain and swelling the hands and feet fatigue shortness of breath pain in any organ or joint eye damage yellow color in skin and eyes slow to grow hard to fight infections stroke chest pain fever Every year, about 1 in 600 African Americans are born with sickle cell disease. This means that they got the sickle gene from both parents. People who have only one gene are carriers of the sickle cell, but won't get sickle cell anemia themselves. They can pass the gene to their children. It is estimated that one in 12 African Americans have one sickle cell gene. Last updated: January 2005 E-mail this page to a friend Publications - This booklet is a review of pain prevention, home treatment, emergency treatment, and inpatient treatment in the hospital. The more one knows about the causes, prevention and treatment of pain, the better the chances of an early recovery. There are different types and different causes of pain requiring a clinician’s help and advice about treatment.

75. Sickle Cell Anemia CHC Wausau Hospital s Medical Library and Patient Education Center provides research services and healthcare information to physicians, http://www.chclibrary.org/micromed/00065190.html

Main Search Index Definition Description Causes ... Resources Sickle cell anemia Definition Sickle cell anemia is an inherited blood disorder that arises from a single amino acid substitution in one of the component proteins of hemoglobin. The component protein, or globin, that contains the substitution is defective. Hemoglobin molecules constructed with such proteins have a tendency to stick to one another, forming strands of hemoglobin within the red blood cells. The cells that contain these strands become stiff and elongatedthat is, sickle shaped. Description Sickle-shaped cellsalso called sickle cellsdie much more rapidly than normal red blood cells, and the body cannot create replacements fast enough. Anemia develops due to the chronic shortage of red blood cells. Further complications arise because sickle cells do not fit well through small blood vessels, and can become trapped. The trapped sickle cells form blockages that prevent oxygenated blood from reaching associated tissues and organs. Considerable pain results in addition to damage to the tissues and organs. This damage can lead to serious complications, including

76. Sickle Cell Anemia: Definition And Much More From Answers.com sickle cell anemia n. A chronic, usually fatal anemia marked by sickleshaped red blood cells, occurring almost exclusively in Black people of Africa. http://www.answers.com/topic/sickle-cell-anemia

showHide_TellMeAbout2('false'); Business Entertainment Games Health ... More... On this page: Dictionary Health Medical WordNet Wikipedia Mentioned In Or search: - The Web - Images - News - Blogs - Shopping sickle cell anemia Dictionary sickle cell anemia n. A chronic, usually fatal anemia marked by sickle-shaped red blood cells, occurring almost exclusively in Black people of Africa or of African descent, and characterized by episodic pain in the joints, fever, leg ulcers, and jaundice. The disease occurs in individuals who are homozygous for a mutant hemoglobin gene. Also called sickle cell disease var tcdacmd="cc=hlt;dt"; Health sickle cell anemia A hereditary form of anemia in which the red blood cells become sickle-shaped (shaped like a crescent) and less able to carry oxygen Sickle cell anemia is a chronic disease and occurs most frequently in people of African descent. Medical sickle cell anemia n. A chronic, usually fatal inherited form of anemia marked by crescent-shaped red blood cells, occurring almost exclusively in Blacks, and characterized by fever, leg ulcers, jaundice, and episodic pain in the joints. Also called crescent cell anemia drepanocytic anemia drepanocytosis meniscocytosis sickle cell disease sickle cell syndrome WordNet Note: click on a word meaning below to see its connections and related words.

77. Sickle Cell Disease: Information From Answers.com Sickle Cell Disease (sickle cell anemia) What is sickle cell anemia? sickle cell anemia (sickle cell disease) is a disorder of the blood caused by an. http://www.answers.com/topic/sickle-cell-anaemia

showHide_TellMeAbout2('false'); Business Entertainment Games Health ... More... On this page: Diagnosis Encyclopedia WordNet Best of Web Mentioned In Or search: - The Web - Images - News - Blogs - Shopping sickle cell disease Diagnosis Sickle Cell Disease (Sickle Cell Anemia) What is sickle cell anemia? Sickle cell anemia (sickle cell disease) is a disorder of the blood caused by an inherited abnormal hemoglobin (an oxygen-carrying protein within the red blood cells). The abnormal hemoglobin causes distorted (sickled) red blood cells. The sickled red blood cells are fragile and prone to rupture. When the number of red blood cells decreases from rupture (hemolysis), anemia is the result. This condition is referred to as sickle cell anemia. The irregular sickled cells can also block blood vessels causing tissue and organ damage and pain. Sickle cell anemia is one of the most common inherited blood anemias. The disease primarily affects Africans and African Americans. It is estimated that in the United States, some 50,000 African Americans are afflicted with the most severe form of sickle cell anemia. Overall, current estimates are that one in 1,875 U.S. African American is affected with sickle cell anemia. How is sickle cell anemia inherited?

78. Discovery Health :: Diseases & Conditions :: Sickle Cell Anemia sickle cell anemia is an inherited blood disease. It causes serious health problems among African Americans or individuals of African descent. http://health.discovery.com/encyclopedias/illnesses.html?article=1767&page=1

79. LII - Results For "sickle Cell Anemia" Results for sickle cell anemia 1 of 1 Subject sickle cell anemia Created by cl last updated Jun 27, 2004 - comment on this record http://www.lii.org/search?searchtype=subject;query=Sickle cell anemia;subsearch=

80. Autosomal Recessive: Cystic Fibrosis, Sickle Cell Anemia, Tay Sachs Disease Detailed information on autosomal recessive inheritance, including cystic fibrosis, sickle cell anemia, and Tay Sachs disease. http://www.healthsystem.virginia.edu/uvahealth/peds_genetics/recessive.cfm

[ Skip Navigation ] Health System Home For Health Answers Healthcare Professionals ... Advanced Search Health System Search Search for Information People UVa Home Health System News Health System Events (all) Health System Publications ... Making a Gift Topics Adolescent Medicine Allergy/Asthma/Immunology Blood Disorders Burns Cancer Common Injuries/Poison Tips Craniofacial Anomalies Dermatology Diabetes/Endo/Metabolism Eye Care Genitourinary/Kidney High-Risk Newborn High-Risk Pregnancy Infectious Diseases Medical Genetics Mental Health Nervous System Disorders Normal Newborns Oral Health Orthopaedics Pediatric Surgery Respiratory Disorders Terminal Illness in Children Transplantation UVa Health Topics A to Z FIND A DOCTOR High-Risk Obstetrics Medical Genetics Reproductive Genetics ... CLINICAL TRIALS Search This Site Autosomal Recessive: Cystic Fibrosis, Sickle Cell Anemia, Tay Sachs Disease Genes are inherited from our biological parents in specific ways. One of the basic patterns of inheritance of our genes is called autosomal recessive inheritance. What is autosomal recessive inheritance?

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