41. Sickle Cell Anemia - DrGreene.com Read an article discussing a genetic condition which destroys blood cells leading to anemia. http://www.drgreene.com/21_1186.html

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42. Sickle Cell Anemia sickle cell anemia national and international resources, clinics with genetic counselors and geneticists. http://www.kumc.edu/gec/support/sickle_c.html

Sickle Cell Anemia American Sickle Cell Anemia Association P.O. Box 1971, 10300 Carnegie Ave, Cleveland, OH 44106, Phone: 216.229.8600, Fax: 216.229.4500 URL: www.ascaa.org/ E-mail: ashc@cybernex.net Support Groups Online video Sickle Cell Disease Association of America, Inc. (SCDAA), formerly know as the National Association for Sickle Cell Disease (NASCD) 200 Corporate Pointe, Suite 495, Culver City California 90230-8727, Phone: 310.216.6363 or 800.421.8453, Fax: 310.215.3722, E-mail: scdaa@sicklecelldisease.org What is Sickle Cell Disease? Education materials on Alpha Thalassemia, Beta Thalassemia, Hemoglobin C Trait (AC), Sickle Cell Trait (AS), Hemoglobin E Trait (AE) Map of United States with links to state organizations Uriel Owens Chapter SCDAA, PO BOX 171371, 650 Minnesota Ave., 2nd Floor, Kansas City, KS 66117, 913.621.1713, owens@sicklecellkck.org Sickle Cell Disease Association of Piedmont , NC Sickle Cell Anemia Research Foundation (SCARF), 2625 Third Street, P.O. Box 206, Alexandria, Louisiana 71309, 877.722.7370, e-mail: scarf@sicklecelldisease.org Regional Organizations, Clinics, Groups

43. It's In The Blood! A Documentary History Of Linus Pauling, Hemoglobin And Sickle Other Sites About sickle cell anemia and Hemoglobin. Except where noted, all items are courtesy of the Ava Helen and Linus Pauling Papers, Oregon State http://osulibrary.oregonstate.edu/specialcollections/coll/pauling/blood/

Start by reading our Introduction , or choose one of the three sections: Narrative All Documents and Media Linus Pauling Day-By-Day An illustrated, forty-six page account of Linus Pauling's research of how blood works at the molecular level. Read Narrative A wealth of primary sources - over three hundred letters, manuscripts, photographs, published papers, audio-visual snippets and more - provide an important scholarly perspective on the relationship between blood biochemistry and molecular disease. View All Documents and Media Alternate View: Image Catalogue A detailed, illustrated look at all of Linus Pauling's personal and professional communications and activities for each day of the years 1940 through 1949. Presented in user-friendly calendar form. (Available June 2005) More Information General and Scientific Bibliographies Chronological List of Documents Credits and Acknowledgements Other Sites About Sickle Cell Anemia and Hemoglobin Except where noted, all items are courtesy of the Ava Helen and Linus Pauling Papers Oregon State University Libraries Special Collections The Valley Library ... Oregon State University Corvallis, Oregon 97331-4501

44. It's In The Blood!: A Documentary History Of Linus Pauling, Hemoglobin And Sickl Linus Pauling and Hemoglobin and sickle cell anemia A Documentary History, Narrative They found that blood samples from sickle cell anemia patients and http://osulibrary.oregonstate.edu/specialcollections/coll/pauling/blood/narrativ

Narrative Home Search All Documents and Media Linus Pauling Day-By-Day ... Conclusions Science Previous Next Audio Clip: Itano, Singer and Wells' work on sickle cell anemia. Molecular Disease lectures given at SUNY, New York. November 1970. (Linus Pauling) 2:36 Click images to enlarge Longsworth scanning diagrams of carbonmonoxyhemoglobin, 1949. Two mobility curve graphs from Harvey Itano's dissertation, 1949. Sickle cell anemia, a molecular disease. Science 110 (November 1949): 543-548, November 1949. Geneticist L. C. Dunn, "Old and New in Genetics," May 1964 Home Search All Documents and Media Linus Pauling Day-By-Day ... Oregon State University

45. Sickle Cell Disease / Family Village American sickle cell anemia Association Chat Room The Sickle Cell Forum Discussion forum for those living with or who know someone with sickle cell anemia http://www.familyvillage.wisc.edu/lib_scd.htm

Sickle Cell Disease Who to Contact Where to Go to Chat with Others Learn More About It Web Sites ... Search Google for "Sickle Cell" Who to Contact Sickle Cell Disease Association of America 16 S. Calvert Street, Suite 600 Baltimore, Maryland 21202 410.528.1555 Office 410.528.1495 Fax 800.421.8453 General Public E-Mail: scdaa@sicklecelldisease.org Website: http://sicklecelldisease.org/ The Sickle Cell Disease Association of America, Inc. (SCDAA), formerly know as the National Association for Sickle Cell Disease (NASCD) was founded in 1971 to provide an effective coordinated community-based approach to developing and implementing strategies to resolve issues surrounding sickle cell disease. Through three decades, SCDAA and its Member Organizations have demonstrated how community-based organizations can work with local and state government agencies in furtherance of national health care objectives. Sickle Cell Disease Association of America, Inc. is helping to promote finding a universal cure for sickle cell disease, and helping to improve the quality of life for individuals and families where sickle cell disease related conditions exist. The American Sickle Cell Anemia Association 10300 Carnegie Avenue Cleveland Clinic / East Office Building (EEb18) Cleveland, Ohio 44106

46. AllRefer Health - Sickle Cell Anemia (Anemia - Sickle Cell, Hemoglobin SS Diseas sickle cell anemia (Anemia Sickle Cell, Hemoglobin SS Disease (Hb SS), Sickle Cell Disease) information center covers causes, prevention, symptoms, http://health.allrefer.com/health/sickle-cell-anemia-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Sickle Cell Anemia Sickle Cell Anemia Definition Prevention Treatment Expectations or Prognosis ... Go To Main Page Alternate Names : Anemia - Sickle Cell, Hemoglobin SS Disease (Hb SS), Sickle Cell Disease Definition Sickle cell anemia is an inherited disease in which the red blood cells, normally disc-shaped, become crescent shaped. As a result, they function abnormally and cause small blood clots. These clots give rise to recurrent painful episodes called "sickle cell pain crises." Red Blood Cells, Sickle Cell Red Blood Cells, Normal

47. Sickle Cell Anemia, Cincinnati Children's Hospital Medical Center Cincinnati Children s Hospital Medical Center treats sickle cell anemia an inherited disorder of the hemoglobin in red cells. http://www.cincinnatichildrens.org/health/info/blood/diagnose/sickle-cell-anemia

Home Contact Us Site Map Go to Advanced Search ... Hemophilia Sickle Cell Anemia von Willebrand Disease Home Care Overview Tests and Procedures Conditions and Diagnoses Sickle Cell Anemia Related Services Sickle Cell Center Blood Disease Center Sickle Cell Anemia is an inherited disorder of hemoglobin, the chemical substance which gives red blood cells their red color and carries oxygen to the tissues. In sickle cell anemia the abnormal hemoglobin (Hgb SS) makes the red cells rigid and distorted from the usual round shape into sickle shapes. At times, these stiff, crescent-shaped sickled red blood cells can plug up small blood vessels and decrease blood flow to various parts of the body. This leads to anemia and to periodic painful episodes. A painful episode can sometimes be referred to as a "crisis" we prefer not to use this unduly frightening word. Cause This genetic disorder is a result of both parents passing a sickle gene to their child. The parents are said to be carriers or to have sickle trait. Sickle trait is not a disease by itself. Symptoms Pain is the hallmark of sickle cell disease. Because of the nature of the disease, signs and symptoms may vary in frequency and severity. This disease can effect every major organ in the body (lungs, liver, kidneys, spleen, heart, brain, intestines, bones, etc.). Symptoms such as painful swelling of the hands and/or feet (Dactylitis) can be seen as early as 4 months of age. Sometimes more serious complications develop, such as, strokes, difficulty breathing, or orthopedic problems.

48. Overview, Cincinnati Children's Hospital Medical Center Pediatric sickle cell anemia Director Clinton Joiner, MD, PhD, and Clinical Director Patrick Kelly, MD, are physicians in the Hematology / Oncology Division http://www.cincinnatichildrens.org/svc/alpha/b/blood/programs/sickle-cell/

Home Contact Us Site Map Go to Advanced Search ... Sickle Cell Center Overview Newsletter Related Links Faculty Related Research ... News Releases Sickle Cell Center Overview Sickle cell anemia is an inherited disorder of hemoglobin, the protein that gives red blood cells their red color and carries oxygen to the tissues. With sickle cell anemia, the abnormal hemoglobin makes the usually round red blood cells rigid and distorted into sickle, or crescent, shapes. At times, these stiff, crescent-shaped red blood cells can plug up small blood vessels and decrease blood flow to various parts of the body. This leads to anemia, unpredictable pain episodes, and sometimes, other serious medical complications. The experts at the Cincinnati Children's Comprehensive Sickle Cell Center provide care for all the routine problems and complications of sickle cell disease. In partnership with families and the community, we try to maximize the growth and development of each patient. Our Mission Through medical treatment, psychological evaluation, social services, education, counseling, research and working collaboratively with families, we are dedicated to prolonging and improving the lives of our patients. Our History Dr. Marilyn Gaston, the Sickle Cell Awareness Group, concerned parents and hospital administration established the Comprehensive Sickle Cell Center (CSCC) at Cincinnati Children's in 1971. The center created one of the first newborn screening programs for sickle cell in the United States. Doctors at Cincinnati Children's performed the first bone marrow transplant to cure sickle cell disease. To prevent the complication of acute chest syndrome, researchers at Cincinnati Children's developed incentive spirometry, which is the standard of care across the country. The CSCC provides important leadership in the National Sickle Cell Disease Program and plays a significant role in advancing sickle cell disease research and patient care.

49. Sickle-cell Disease - Wikipedia, The Free Encyclopedia Sicklecell anemia or anaemia (also sickle-cell disease) is a genetic disorder in sickle cell anemia is caused by a mutation in the ß-globin chain of http://en.wikipedia.org/wiki/Sickle-cell_anemia

Sickle-cell disease From Wikipedia, the free encyclopedia. (Redirected from Sickle-cell anemia Sickle-cell disease Sickle-shaped red blood cells Sickle-cell disease is a genetic disorder in which red blood cells may change shape under certain circumstances. This causes the cells to become stuck in capillaries which deprives the downstream tissues of oxygen and causes ischemia and infarction . The disease usually occurs in periodic painful attacks, eventually leading to damage of internal organs, stroke , or anemia , and usually resulting in decreased lifespan. It is common in people from countries with a high incidence of malaria , and especially in West Africa , or in descendents from those people. The disease was originally called sickle-cell anemia but this name has fallen out of favor in medical contexts because anemia is not the only symptom of the disease. Contents Signs and symptoms Vasoocclusive crises Other sickle-cell crises Complications ... edit Signs and symptoms Patients have baseline anemia that varies in severity, with hemoglobin levels of 7-9 mg/dl typical. Often white blood cell counts are elevated simply due to marrow hyperactivity. Reticulocyte counts are elevated, reflecting new red blood cells replacing the rapidly cleared older cells - red blood cell life span is markedly reduced in this disease. edit Vasoocclusive crises Vasoocclusive crises are caused by sickled red blood cells that obstruct capillaries and restrict bloodflow to an organ, resulting in

50. Sickle Cell Anemia: Bone Manifestations a CHORUS notecard document about sickle cell anemia bone manifestations. http://chorus.rad.mcw.edu/doc/01069.html

CHORUS Collaborative Hypertext of Radiology Musculoskeletal system About CHORUS Search Feedback sickle cell anemia: bone manifestations 8-13% of blacks carry sickling factor symptoms: chronic ulcers, pain crises, many infections, priapism xray findings: deossification due to marrow hyperplasia decreased bone density in skull with widened diploic space "H-shaped vertebrae" or "fish vertebrae" rib notching thrombosis and infarction AVN , esp. femoral head periosteal rxn (" bone within bone secondary osteomyelitis Staph. aureus Salmonella dactylitis = hand foot syndrome growth effects bone shortening secondary to diminished blood supply death Brian Funaki, MD - 6 February 1995 Last updated 26 May 2004 Related CHORUS documents: avascular necrosis (AVN) bone within a bone gallstones progeria (Hutchinson-Gilford) syndrome ... pancreatitis Search for related articles: AJR American Journal of Roentgenology PubMed : index to biomedical literature ... Medical College of Wisconsin

51. New Hope For People With Sickle Cell Anemia (FDA Consumer Reprint) A recent clinical trial found that the drug Hydrea (hydroxyurea) significantly reduced painful episodes in adults with a severe form of sickle cell anemia. http://www.pueblo.gsa.gov/cic_text/health/sicklecell/496_sick.html

Return to Federal Citizen Information Center Home Page This article originally appeared in the May 1996 FDA Consumer The version below is from a reprint of the original article and contains revisions made in December 1997 and February 1999. New Hope for People with Sickle Cell Anemia by Eleanor Mayfield In tropical regions of the world where the parasite-borne disease malaria is prevalent, people with a single copy of a particular genetic mutation have a survival advantage. Over time, people from these regions have migrated, had children, and in some cases married each other. Some of their children inherit two copies of the mutation. While inheriting one copy of the mutation confers a benefit, inheriting two copies is a tragedy. Children born with two copies of the genetic mutation have sickle cell anemia, a painful disease that affects the red blood cells and is curable only in rare instances. In February 1998, the Food and Drug Administration approved the drug Droxia (hydroxyurea) for reducing painful episodes in adults with a severe form of sickle cell anemia. The drug doesn't cure the disease. Hydroxyurea also is approved under the name Hydrea for treating certain cancers. Genetic Defect Changes Cel Shape The genetic defect that causes sickle cell anemia affects hemoglobin, a component of red blood cells. Hemoglobin's job is to carry oxygen to all the cells and tissues of the body. Red blood cells that contain normal hemoglobin (such as the one pictured top right) are soft and round. Their soft texture enables them to squeeze through the body's small blood vessels.

52. Sickle Cell Anemia And Thalassemias To Begin The Lecture, Click sickle cell anemia and thalassemias. To begin the lecture, click the START button above. If you are the first time visitor, you might want to know How to http://www.pitt.edu/~super1/lecture/lec10781/

Lists of Lectures Front Page Sickle cell anemia and thalassemias To begin the lecture, click the START button above. If you are the first time visitor, you might want to know [ How to navigate within and outside the lecture This is a beta version. Uploading date: July 13, 2003 Your comments to this version would be highly appreciated as well. Submit Your comments

53. Hardin MD : Sickle Cell Anemia From the University of Iowa, the *best* lists of Internet sources in sickle cell anemia. http://www.lib.uiowa.edu/hardin/md/sicklecellanemia.html

Sickle Cell Anemia A service of the University of Iowa Site Map Diseases Home ... Diseases Search Hardin MD See also: Home Blood Diseases Genetic Disorders Popular Women's Health Dermatology Nursing Pharm Infect Disease Anemia +Pictures Blood Diseases Brain Pictures Child Diseases +Pictures Chlamydia +Pictures Genetic Disorders +Pictures Heart Pictures High Blood Pressure +Pictures Kidney Diseases Lungs Pictures Malaria +Pictures Medical Pictures Skin Pictures Strep Infection +Pictures Stroke +Pictures Tooth Decay Pictures Sickle Cell Anemia Pictures MEDLINE plus Sickle cell anemia National Library of Medicine ClinicalTrials.gov : Anemia, Sickle cell National Library of Medicine, National Institutes of Health Open Directory Project : Health : ... : Blood disorders : Sickle cell (Other versions: Google Yahoo : Sickle cell disease LookSmart : Sickle cell anemia Sickle cell anemia US Government Librarians' Index to the Internet : Sickle cell anemia Carole Leita, California State Library Sickle Cell Anemia Pictures MEDLINEplus Health Encyclopedia : Sickle cell anemia Symptoms A.D.A.M. / National Library of Medicine

54. What Is Sickle Cell Anemia? sickle cell anemia is an inherited blood disease. sickle cell anemia affects the red blood cells. Normal red blood cells are smooth and round like http://www.nhlbi.nih.gov/health/dci/Diseases/Sca/SCA_WhatIs.html

DCI Home Blood Diseases Sickle Cell Anemia : What Is ... What Is ... Other Names Causes Who Is At Risk ... Links What Is Sickle Cell Anemia? Sickle cell anemia is an inherited blood disease. That means you are born with it and it lasts a lifetime. Sickle cell anemia affects the red blood cells . Normal red blood cells are smooth and round like doughnuts. They move easily through blood vessels to carry oxygen to all parts of the body. In sickle cell anemia, the red blood cells become hard, sticky, and shaped like sickles or crescents. When these hard and pointed red cells go through the small blood vessels, they tend to get stuck and block the flow of blood. This can cause pain, damage, and a low blood count or anemia. The sickle-shaped red blood cells tend to get stuck in narrow blood vessels, blocking the flow of blood. Anemia is a shortage of red blood cells in your blood. In sickle cell anemia, this shortage of red blood cells occurs because sickle cells do not last very long. It is hard for your body to make new red blood cells fast enough to keep up. Normal red blood cells last about 120 days in the bloodstream. Sickle cells die after only about 10 to 20 days. Sickle cell trait is different from sickle cell anemia. A person with sickle cell trait does not have the disease but carries the gene that causes the disease. Persons with sickle cell trait can pass the gene to their children. For more information on sickle cell trait, see the section on "

55. Hematopathology This is sickle cell anemia in sickle cell crisis. The abnormal hemoglobin SS is prone to crystallization when oxygen tension is low, and the RBC s change http://www-medlib.med.utah.edu/WebPath/HEMEHTML/HEME015.html

This is sickle cell anemia in sickle cell crisis. The abnormal hemoglobin SS is prone to crystallization when oxygen tension is low, and the RBC's change shape to long, thin sickle forms that sludge in capillaries, further decreasing blood flow and oxygen tension. Persons with sickle cell trait (Hemoglobin AS) are much less likely to have this happen.

56. Treatments For Sickle Cell Anemia Article explains sickle cell anemia treatments being investigated through research. http://rarediseases.about.com/cs/sicklecell/a/110602.htm

var zLb=12; var zIoa1 = new Array('Suggested Reading','What is Sickle Cell Anemia?','http://rarediseases.about.com/library/weekly/aa110202a.htm','Internet links on sickle cell','http://rarediseases.about.com/cs/sicklecell/'); var zIoa2 = new Array('Elsewhere on the Web','American Sickle Cell Anemia Association','http://www.ascaa.org/','NHLBI: Facts About Sickle Cell Anemia','http://www.nhlbi.nih.gov/health/public/blood/sickle/sca_fact.htm'); zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a70' About Rare / Orphan Diseases Information by Disease Type Blood Disorders Treatments for Sickle Cell Anemia Rare Diseases Essentials Rare Diseases: Basic Information Rare Diseases Support Groups ... Help w(' ');zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/7.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the Rare / Orphan Diseases newsletter! See Online Courses Search Rare / Orphan Diseases Stay up to date! Email to a friend Print this page Suggested Reading What is Sickle Cell Anemia?

57. Sickle Cell - Health And Medical Information Produced By Doctors - MedicineNet.c What are the symptoms and treatments of sickle cell anemia? sickle cell anemia (sickle cell disease) is a disorder of the blood caused by an inherited http://www.medicinenet.com/sickle_cell/article.htm

document.writeln(''); About Us MedicineNet Home > Sickle Cell search help Printer-Friendly Format FREE Newsletters Email to a Friend ... Next Sickle Cell Disease (Sickle Cell Anemia) Medical Author: William C. Shiel Jr., MD, FACP, FACR What is sickle cell anemia? How is sickle cell anemia inherited? What conditions promote the sickling (distortion) of the red blood cells in sickle cell anemia? ... Sickle Cell Anemia At A Glance What is sickle cell anemia? Sickle cell anemia (sickle cell disease) is a disorder of the blood caused by an inherited abnormal hemoglobin (an oxygen-carrying protein within the red blood cells). The abnormal hemoglobin causes distorted (sickled) red blood cells. The sickled red blood cells are fragile and prone to rupture. When the number of red blood cells decreases from rupture (hemolysis), anemia is the result. This condition is referred to as sickle cell anemia. The irregular sickled cells can also block blood vessels causing tissue and organ damage and pain. Sickle cell anemia is one of the most common inherited blood anemias. The disease primarily affects Africans and African Americans. It is estimated that in the United States, some 50,000 African Americans are afflicted with the most severe form of sickle cell anemia. Overall, current estimates are that one in 1,875 U.S. African American is affected with sickle cell anemia.

58. InteliHealth: Sickle Cell Anemia InteliHealth Featuring Harvard Medical School s consumer health information. For more than 550 diseases and conditions, learn What Is It?, Symptoms, http://www.intelihealth.com/IH/ihtIH/WSIHW000/9339/9453.html

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59. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies: Conditions Graft Versus Host Disease; sickle cell anemia; Thalassemia Conditions Pulmonary Hypertension; sickle cell anemia http://www.clinicaltrials.gov/ct/gui/action/FindCondition?ui=D000755&recruiting=

60. Clinical Trial: Natural History Of Sickle Cell Disease And Other Hemolytic Disor Hemoglobin SC Disease Hematologic Diseases sickle cell anemia Hemolytic Anemia Prophylaxis with oral penicillin in children with sickle cell anemia. http://www.clinicaltrials.gov/ct/gui/show/NCT00081523

Home Search Browse Resources ... About Natural History of Sickle Cell Disease and Other Hemolytic Disorders This study is currently recruiting patients. Verified by National Institutes of Health Clinical Center (CC) February 17, 2005 Sponsored by: National Heart, Lung, and Blood Institute (NHLBI) Information provided by: National Institutes of Health Clinical Center (CC) ClinicalTrials.gov Identifier: Purpose Under this study, NIH physicians will evaluate and treat patients with sickle cell disease and other hemolytic disorders (diseases involving damage to red blood cells) in order to learn more about the diseases and the painful attacks and lung complications that are often associated with them. Patients in this study will not receive experimental therapy, but will be given standard medical care. Patients who meet the medical criteria for another NIH protocol may be offered participation in that study, but are not obligated to enroll in it. Patients 5 years of age and older with known or suspected sickle cell disease, sickle cell trait or another anemia or red blood cell disorder such as thalassemia may be eligible for this study. Participants will be admitted to the NIH Clinical Center as an inpatient or outpatient for evaluation and treatment. In addition to a physical examination, evaluation may include the following types of tests and procedures: - Routine blood and urine tests, including a 24-hour urine collection

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