21. Sickle Cell Information Center Home Page The Mission of the Sickle Cell Information Center www.SCInfo.org http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

22. Welcome To The Nevada Childhood Cancer Foundation Organization provides social, emotional, psychological and educational support for families of children with critical illnesses including HIV/AIDS, hemophilia, sickle cell anemia, cancer, and immunological and renal diseases. http://nvccf.org

The Nevada Childhood Cancer Foundation, working side-by-side with the medical team, provides social, emotional, educational and psychological support services to families of all children who are diagnosed with life threatening or critical illnesses such as cancer, HIV/AIDS, sickle cell anemia and other immunological diseases. 12th Annual ‘Profiles Of Courage’ Dinner and Auction will be held on October 29, 2005 at the Mirage Hotel Casino Ballroom. Call now and reserve your table 702-735-8434. MORE DETAILS CLICK HERE Home Board of Directors Camp Cartwheel ... Bravery Hearts Profiles of Courage Beads NCCF is A Non-Profit 501 (C) 3 Corporation © 2004 NCCF Site Maintained by Original Design and Hosting by Bizwala Amazing photography courtesy of ModePhoto High quality photos available for purchase from ModePhoto by clicking here Sales of photos benefit the Nevada Childhood Cancer Foundation.

23. Sickle Cell Society Sickle Cell Society UK based charity which provides care and information on sickle cell anaemia (anemia) and other sickle cell disorders to http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

24. Sickle Cell Anemia You may also want to visit the sickle cell anemia Slide Show. Search for information about Treatment of sickle cell anemia Click Here http://radlinux1.usuf1.usuhs.mil/rad/home/cases/sickle.html

The Department of Radiology and Nuclear Medicine of the Uniformed Services University of the Health Sciences Bethesda, Maryland Sickle Cell Anemia MS-1 ANATOMY MS-2 RADIOLOGY MS-4 ELECTIVE TROPICAL MEDICINE ... Visit The Main Radiology Website! Sickle Cell Anemia Introduction Ironically, the sickle cell trait (the heterozygous HgbSA - not the homozygous HgbSS) seems to have a protective effect against the malaria parasite. By the time many patients reach adulthood, there is often objective evidence of anatomic and/or functional damage to various tissues due to the cumulative effects of recurrent vasoocclusive (clotting) episodes. However, the course of the disease is variable from patient to patient. Learn More About Sickle Cell Anemia - 1 Learn More About Sickle Cell Anemia - 2 Learn More About Sickle Cell Anemia - 3 You may also want to visit the Sickle Cell Anemia Slide Show. Bone Changes Sickle Cell Anemia and its variants produce roentgenographically similar bone changes. These have been divided conveniently into four groups; Deossification due to marrow hyperplasia Thrombosis and infarction Secondary osteomyelitis Growth defects The first is most commonly seen only in sickle cell anemia. Marrow hyperplasia crowds and thins the bone trabeculae which results in bone weakness and osteoporosis. Bone softening at the centra of the vertebral bodies of the spine occurs in 70% of patients; a biconcave shape results as the intervertebral disks push into the softened bone. Infarction on the vertebral bodies may also result in partial or complete collapse of the central portion as well. The biconcave, or "fish mouth" vertebrae (due to compression of the vertebral endplates above and below the disk space) are virtually pathognomonic of sickle cell disease. Such changes are evident on the enclosed chest X-rays.

25. CNN - Boy Receives First Cord Blood Transplant For Sickle Cell Anemia - December CNN http://www.cnn.com/HEALTH/9812/14/cord.blood.sickle.cell/index.html

MAIN PAGE WORLD ASIANOW U.S. ... news quiz CNN WEB SITES: TIME INC. SITES: Go To ... Time.com People Money Fortune EW MORE SERVICES: video on demand video archive audio on demand news email services ... pagenet DISCUSSION: message boards chat feedback SITE GUIDES: help contents search FASTER ACCESS: europe japan WEB SERVICES: Boy receives first cord blood transplant for sickle cell anemia Keone is the first sickle cell patient to receive a cord blood transfusion from an unrelated donor. December 14, 1998 Web posted at: 2:09 p.m. EDT (1809 GMT) From Medical Correspondent Rhonda Rowland ATLANTA (CNN) Researchers say children who might have died from inherited immune disorders or leukemia may be cured with umbilical cord blood transplants. Now scientists at Emory University Hospital have done the world's first "unrelated donor" cord blood transplant in a child with sickle cell anemia. Keone Penn of Snellville, Georgia, looks like a typical 12-year-old. But he has a severe cased of sickle cell anemia, an inherited disorder where red blood cells are abnormally shaped. "He had a stroke when he was 5 and he's been getting chronic blood transfusions ever since he had the stroke lots of fevers, infections, seizures," said his mother, Leslie Penn.

26. What Is Sickle Cell Disease The most common are sickle cell anemia (SS), SickleHemoglobin C Disease (SC) If one parent has sickle cell anemia and the other is Normal, http://www.sicklecelldisease.org/about_scd/index.phtml

About Sickle Cell Disease SCDAA Home About SCDAA Member Organizations About Sickle Cell Disease ... Search What is Sickle Cell Disease? Sickle cell disease is an inherited blood disorder that affects red blood cells. People with sickle cell disease have red blood cells that contain mostly hemoglobin* S, an abnormal type of hemoglobin. Sometimes these red blood cells become sickle-shaped (crescent shaped) and have difficulty passing through small blood vessels. Normal red blood cell Sickle-shaped red blood cell When sickle-shaped cells block small blood vessels, less blood can reach that part of the body. Tissue that does not receive a normal blood flow eventually becomes damaged. This is what causes the complications of sickle cell disease. There is currently no universal cure for sickle cell disease. Hemoglobin – is the main substance of the red blood cell. It helps red blood cells carry oxygen from the air in our lungs to all parts of the body. Normal red blood cells contain hemoglobin A. Hemoglobin S and hemoglobin C are abnormal types of hemoglobin. Normal red blood cells are soft and round and can squeeze through tiny blood tubes (vessels). Normally, red blood cells live for about 120 days before new ones replace them. People with sickle cell conditions make a different form of hemoglobin A called hemoglobin S (S stands for sickle). Red blood cells containing mostly hemoglobin S do not live as long as normal red blood cells (normally about 16 days). They also become stiff, distorted in shape and have difficulty passing through the body’s small blood vessels. When sickle-shaped cells block small blood vessels, less blood can reach that part of the body. Tissue that does not receive a normal blood flow eventually becomes damaged. This is what causes the complications of sickle cell disease.

27. Sickle Cell Anemia - MayoClinic.com sickle cell anemia is an inherited blood disease that causes pain, organ damage and other problems. Treatments may reduce pain and prevent complications. http://www.mayoclinic.com/invoke.cfm?id=DS00324

28. SickleCellNew3 Provides a first hand look at sickle cell anemia, built by a person suffering from the disease. Frequently asked questions and a personal diary of the owner's own battle with this disease. http://www.geocities.com/HotSprings/Spa/3194/

Glad You Stopped By! My initial intention for building this site was in response to the numerous sites that seemed targeted for the medical profession. After viewing several of these sites, I wondered where the Sicklers were and why hadn't they built any sites? Then it dawned on me... I'm a Sickler and I haven't built a site!  Although I'm not a medical professional, I hope this site can shed some light on Sickle Cell Anemia from a personal view. Page descriptions are below and I invite you  to browse the entire site. Hopefully, we'll both learn something in the end! The Sickle Cell Forum Been looking for people, living with Sickle Cell anemia like you? The Sickle Cell Forum is the place to be! The input has been lively and there's a definite community forming. To join our growing family, simply click on the link below. See you there, Charles Click to Join The Sickle Cell Forum For information about me, be sure to read the "About Me" page. The "Sickle Cell Diaries" is my personal account of life with Sickle Cell.

29. Sickle Cell Anemia Disease Profile Images of all 24 human chromosomes and different genes that have been mapped to them. Free wall poster available from Web site. http://www.ornl.gov/sci/techresources/Human_Genome/posters/chromosome/sca.shtml

Human Genome Project Information Genomics:GTL Microbial Genome Program home The U.S. Department of Energy Biological and Environmental Research program funds this site. Genetic Disease Profile: Sickle Cell Anemia For more about the gene that causes sickle cell anemia, see the HBB Gene Profile . The following was adapted from NIH Publication No. 96-4057. Sickle Cell Timeline - Herrick provides the first formal description of sickle cell anemia when he reports that the blood smear of a dental student at the Chicago College of Dental Surgery contains "pear-shaped and elongated forms." - Hahn and Gillespie associate the sickling of red blood cells with low oxygen conditions. - Sherman reports that the sickling of red blood cells in the absence of oxygen is caused by a change in the hemoglobin molecule structure. - Watson suggests that the presence of fetal hemoglobin in the red blood cells of sickle cell newborns is the reason they do not show disease symptoms. - Noted physical chemist Linus Pauling and associates publish "Sickle Cell Anemia, a Molecular Disease" in

30. Sickle Cell Anemia Gene Images of all 24 human chromosomes and different genes that have been mapped to them. Free wall poster available from Web site. http://www.ornl.gov/sci/techresources/Human_Genome/posters/chromosome/hbb.shtml

Human Genome Project Information Genomics:GTL Microbial Genome Program home The U.S. Department of Energy Biological and Environmental Research program funds this site. HBB: The Gene Associated with Sickle Cell Anemia Approximate gene location is based on Chromosome 11 map from NCBI Entrez Map Viewer. Official Gene Symbol: HBB Name of Gene Product: hemoglobin, beta Alternate Name of Gene Product: beta globin Locus: 11p15.5 - The HBB gene is found in region 15.5 on the short (p) arm of human chromosome 11. Gene Structure: The normal allelic variant for this gene is 1600 base pairs (bp) long and contains three exons. mRNA: The intron-free mRNA transcript for the HBB gene is 626 base pairs long. See the NCBI sequence record to access the mRNA sequence data. Coding Sequence (CDS): 444 base pairs within the mRNA code for the amino acid sequence of the gene's protein product. Protein Size: The HBB protein is 146 amino acids long and has a molecular weight of 15,867 Da. See the annotated HBB protein sequence

31. EMedicine - Anemia, Sickle Cell : Article By Ali Taher, MD Anemia, Sickle Cell sickle cell anemia is a common reason patients of African descent seek emergency medical care. Although knowledge of the http://www.emedicine.com/emerg/topic26.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Emergency Medicine Hematology And Oncology Anemia, Sickle Cell Last Updated: January 5, 2005 Rate this Article Email to a Colleague Synonyms and related keywords: crescent cell anemia sickle cell disease , autosomal recessive genetic disease, hemoglobin S HbS sickle cell anemia vasoocclusive crisis ... avascular necrosis , hand and foot syndrome, dactylitis, isosthenuria , acute chest syndrome, hypertransfusion programs, hematologic crises aplastic crisis Parvovirus B 19 infection infectious crises ... syncope AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Ali Taher, MD , Associate Professor, Department of Internal Medicine, Division of Hematology-Oncology, American University of Beirut Medical Center Coauthor(s): Ziad Kazzi, MD , Assistant Professor, Department of Emergency Medicine, University of Alabama in Birmingham Editor(s): Roy Alson, MD, PhD, FACEP, FAAEM

32. EMedicine - Sickle Cell Anemia : Article By Ariel Distenfeld, MD sickle cell anemia Sickle cell disease (SCD) and its variants are genetic disorders of mutant hemoglobins (Hb). The most common form found in North http://www.emedicine.com/med/topic2126.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Hematology Sickle Cell Anemia Last Updated: May 2, 2005 Rate this Article Email to a Colleague Synonyms and related keywords: hemoglobin SS disease, homozygous hemoglobin S disease, sickle cell disease, SCD, mutant hemoglobins, Hb S, Hb SS, Hb A, Hb SA, anemia, red blood cells, RBC, sickle shaped, vasoocclusive crisis, sickle cell crisis AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Ariel Distenfeld, MD , Clinical Associate Professor, Department of Medicine, New York University School of Medicine; Fellowship Director, Division of Hematology, Department of Internal Medicine, Cabrini Medical Center Coauthor(s): Ulrich Woermann, MD , Consulting Staff, Division of Instructional Media, Institute for Medical Education, University of Bern, Switzerland Ariel Distenfeld, MD, is a member of the following medical societies:

33. Massachusetts General Hospital Cancer Center Schwannomas, sickle cell anemia, Skin Cancer, Small Cell Lung, Small Intestine Cancer, Soft Tissue Sarcoma, Stomach (Gastric) Cancer, Synovial Sarcoma http://www.massgeneral.org/cancer/

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34. New Hope For People With Sickle Cell Anemia (FDA Consumer Reprint) A recent clinical trial found that the drug Hydrea (hydroxyurea) significantly reduced painful episodes in adults with a severe form of sickle cell anemia. http://www.fda.gov/fdac/features/496_sick.html

This article originally appeared in the May 1996 FDA Consumer and contains revisions made in December 1997 and February 1999. The article is no longer being updated. New Hope for People with Sickle Cell Anemia by Eleanor Mayfield In tropical regions of the world where the parasite-borne disease malaria is prevalent, people with a single copy of a particular genetic mutation have a survival advantage. Over time, people from these regions have migrated, had children, and in some cases married each other. Some of their children inherit two copies of the mutation. While inheriting one copy of the mutation confers a benefit, inheriting two copies is a tragedy. Children born with two copies of the genetic mutation have sickle cell anemia, a painful disease that affects the red blood cells and is curable only in rare instances. In February 1998, the Food and Drug Administration approved the drug Droxia (hydroxyurea) for reducing painful episodes in adults with a severe form of sickle cell anemia. The drug doesn't cure the disease. Hydroxyurea also is approved under the name Hydrea for treating certain cancers. Genetic Defect Changes Cell Shape The genetic defect that causes sickle cell anemia affects hemoglobin, a component of red blood cells. Hemoglobin's job is to carry oxygen to all the cells and tissues of the body. Red blood cells that contain normal hemoglobin (such as the one pictured top right) are soft and round. Their soft texture enables them to squeeze through the body's small blood vessels.

35. Sickle Cell Anemia-Blood Diseases & Disorders Overview of sickle cell anemia. anemia the most common symptom of all the sickle cell diseases. In sickle cell disease, red blood cells are produced http://www.umm.edu/blood/sickle.htm

var MenuLinkedBy='AllWebMenus [2]', awmBN='530'; awmAltUrl=''; Donations / Banking Blood Diseases Blood Disorders... Anemias... ... Site Map Related Resources Within UMM Hematology Pediatric Oncology Translate using Google to Spanish German French Italian Portuguese Blood Diseases Sickle Cell Disease What is sickle cell disease? Sickle cell disease is an inherited blood disorder characterized by defective hemoglobin. It affects millions of people throughout the world and approximately 72,000 people in the US. It is present in one in every 500 African-American births. Normal hemoglobin cells are smooth and round, allowing for ease in moving through blood vessels. Sickle cell hemoglobin molecules are stiff and form into the shape of a sickle or a scythe. They tend to cluster together, and cannot easily move through blood vessels. The cluster causes a blockage and stops the movement of oxygen-carrying blood. Sickle cells die after about 10 to 20 days, unlike normal hemoglobin cells, which live for up to 120 days. This results in a chronic short supply of red blood cells, which causes anemia. The most common variations of the sickle cell gene include the following: Sickle cell trait The person is carrying the defective gene, HbS, but also has some normal hemoglobin, HbA. This is referred to as HbAS. Persons with sickle cell trait are usually without symptoms of the disease. Mild anemia may occur. Under intense, stressful conditions, exhaustion, hypoxia (low oxygen), and/or severe infection, the sickling of the defective hemoglobin may occur and result in some complications associated with the sickle cell disease.

36. Sickle Cell And African-Americans sickle cell anemia sickle cell anemia Community Based Health Programs Community These disorders include sickle cell anemia, the sickle beta thalassemia http://www.blackhealthcare.com/BHC/SickleCell/Description.asp

Home Diabetes Hypertension Coronary Heart Disease ... Healthy Lifestyles Category Description Epidemiology Prevention Diagnosis and Evaluation ... End Stage Organ Disease Disease Center Diabetes Hypertension Coronary Heart Disease Stroke ... Healthy Lifestyles Community Issues The Problem Closing the Gap Initiatives Healthy Lifestyles Healthy Lifestyle library Community Resources Closing the Gap Initiatives About Us General Information Press Releases Corporate Profile Become a Sponsor ... Privacy Statement Sickle Cell Anemia - Description Sickle cell disease is a generic term for a group of genetic disorders characterized by the predominance of hemoglobin S (Hb S). These disorders include sickle cell anemia, the sickle beta thalassemia syndromes, and hemoglobinopathies in which Hb S is in association with another abnormal hemoglobin that not only can participate in the formation of hemoglobin polymers but also is present in sufficient concentration to enable the red cells to sickle. Examples of the latter disorders include hemoglobin SC disease, hemoglobin SD disease, and hemoglobin S O Arab disease. The sickle cell disorders are found in people of African, Mediterranean, Indian, and Middle Eastern heritage. In the United States, these disorders are most commonly observed in African Americans and Hispanics from the Caribbean, Central America, and parts of South America. In contrast to these diseases is sickle cell trait. Individuals with sickle cell trait (Hb AS) have a normal beta globin gene (bA) and a bS globin gene, resulting in the production of both normal hemoglobin A and hemoglobin S, with a predominance of Hb A. Their red blood cells sickle only under unusual circumstances such as marked hypoxia and the hyperosmolar environment of the renal medulla (resulting in hyposthenuria).

37. Sickle Cell Anemia sickle cell anemia Updated February 2, 2005 NOAH Heart and Blood sickle cell anemia. NOAH Logo, Health Topics Index A to Z Page of the Month http://www.noah-health.org/en/blood/sicklecell/

Skip navigation About NOAH Help English Spanish Both Advanced NOAH Heart and Blood Change text size: Sickle Cell Anemia Updated: February 2, 2005 What is Sickle Cell Disease? The Basics Causes/Genetics Screening/Prevention Sickle Cell Trait ... Types of Sickle Cell Disease Information Resources Organizations Research Facilities Care and Treatment Clinical Trials Hydroxyurea Management of Acute Chest Syndrome Pain Management ... Umbilical Cord and Bone Marrow Transplants Special Groups Especially For Children Especially for Teens For Families For Teachers and Employers ... For Women Researched by NOAH Contributing Editor: NOAH Team NOAH Heart and Blood > Sickle Cell Anemia Health Topics Index A to Z Page of the Month Advanced Search ... Feedback

38. Sickle Cell Anemia Genes and disease provides short descriptions of inherited disorders. It is hosted by the National Center for Biotechnology Information (NCBI), http://www.ncbi.nlm.nih.gov/disease/sickle.html

This Genes and Disease page has been moved to: Please update your bookmarks. If you are not automatically transported to the new page after 15 seconds, click on this link Genome View HBB on chromosome 11 Databases PubMed the literature Key Papers Recent literature LocusLink collection of gene-related information OMIM catalog of human genes and disorders Information Fact Sheet from the National Heart, Lung and Blood Institute, NIH SCDAA Sickle Cell Disease Association of America SICKLE CELL ANEMIA (SCA) is the most common inherited blood disorder in the United States, affecting about 72,000 Americans or 1 in 500 African Americans. SCA is characterized by episodes of pain, chronic hemolytic anemia and severe infections, usually beginning in early childhood. SCA is an autosomal recessive disease caused by a point mutation in the hemoglobin beta gene ( HBB ) found on chromosome 11p15.4. Carrier frequency of HBB varies significantly around the world, with high rates associated with zones of high malaria incidence, since carriers are somewhat protected against malaria. About 8% of the African American population are carriers. A mutation in HBB results in the production of a structurally abnormal hemoglobin (Hb), called HbS. Hb is an oxygen carrying protein that gives red blood cells (RBC) their characteristic color. Under certain conditions, like low oxygen levels or high hemoglobin concentrations, in individuals who are homozygous for HbS, the abnormal HbS clusters together, distorting the RBCs into sickled shapes. These deformed and rigid RBCs become trapped within small blood vessels and block them, producing pain and eventually damaging organs.

39. OMIM - SICKLE CELL ANEMIA http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603903

40. Sickle Cell Anemia sickle cell anemia, hereditary conditions. In sickle cell anemia, the shape of hemoglobin is altered, and the red blood cells can become rigid, pointy, http://www.labtestsonline.org/understanding/conditions/sickle.html

TESTS Test not listed? A/G Ratio ACE ACT ACTH AFB Culture AFP Maternal AFP Tumor Marker Albumin Aldolase Aldosterone Allergies ALP Alpha-1 Antitrypsin ALT Ammonia Amylase ANA Antibody Tests Antiglobulin, Direct Antiglobulin, Indirect Antiphospholipids Antithrombin Apo A Apo B ApoE Genotyping aPTT AST Autoantibodies Bicarbonate Bilirubin Blood Culture Blood Gases Blood Smear BMP BNP Bone Markers BRCA BUN C-peptide CA-125 CA 15-3 CA 19-9 Calcitonin Calcium Cardiac Biomarkers Cardiac Risk Cardiolipin Antibodies Catecholamines CBC CCP C. diff CEA Celiac Disease Tests CF Gene Mutation Chemistry Panels Chlamydia Chloride Cholesterol CK CK-MB CMP CMV Coagulation Factors Complement Levels Cortisol Creatinine Creatinine Clearance CRP CRP, high-sensitivity

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