121. Scleroderma In autoimmune diseases like scleroderma, normal molecules of the body are scleroderma can range from a localized disease that primarily affects the skin http://www.fhcrc.org/research/diseases/scleroderma/

@import "/wrapper/global.css"; @import "/wrapper/wrapper.css"; Scleroderma Disease Background Description of Disease Who is at Risk? National Cancer Institute Dictionary Our Research Overview of Fred Hutchinson Research Research Highlights Innovative new treatments for autoimmune diseases Uncovering the genetic secrets of autoimmune disease Relevant Articles Fred Hutchinson Publications Disease Background Description of the Disease Scleroderma is a chronic autoimmune disease. Its hallmark feature is fibrosis, which means hardening of the skin (derived from "sklero" or hard and "derma" referring to skin). In autoimmune diseases, a person's immune system attacks the body, resulting in inflammation of various organs or tissues. The components of the immune system responsible for this effect are antibodies and cells. Antibodies are proteins produced by white blood cells typically made in response to infection caused by pathogens like bacteria and viruses. In autoimmune diseases like scleroderma, normal molecules of the body are mistakenly recognized by immune-system cells and antibodies, and are targeted for destruction. Scleroderma can range from a localized disease that primarily affects the skin to a more serious illness known as systemic sclerosis, causing damage to multiple parts of the body. Tissues that can be affected include the skin, joints, digestive tract, lung and kidney.

122. Scleroderma - Lucile Packard Children's Hospital There are two forms of scleroderma localized scleroderma and systemic sclerosis.Localized scleroderma can be seen more frequently in children than the http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/arthritis/sclero.html

Day Hospital Rheumatology Rheumatologists Scleroderma CREST Syndrome A less severe form of is called CREST . The CREST syndrome represents the following symptoms: C alcium skin deposits R aynaud's phenomenon (a condition in which the blood vessels of the fingers and toes go into spasm when triggered by factors such as cold, stress, or illness; the result is cold, painful, or numb fingers and toes which in severe cases may become gangrenous) E sophageal dysfunction (problems with the esophagus, the tube between the mouth and the stomach) S clerodactyly (skin damage on fingers) T elangiectasia (spider veins), limits skin damage to the fingers. However, this disease, when coupled with pulmonary hypertension (elevated blood pressures within the lungs), can lead to heart and respiratory failure. What is scleroderma? There are two forms of scleroderma: localized scleroderma and systemic sclerosis. Localized scleroderma can be seen more frequently in children than the systemic form. It may involve patches of the skin on the trunk, arms, legs, or head. Other names for the localized form are morphea and linear scleroderma. Systemic sclerosis is a chronic, degenerative disease that affects the joints, skin, and internal organs. Scleroderma is also associated with blood vessel abnormalities. Systemic sclerosis occurs only rarely in children.

123. Atlas Of Dermatology Localized scleroderma affecting the tongue and perioral skin scleroderma, Clinicalpicture (1081). Linear scleroderma scleroderma, Clinical picture (1085) http://atlases.muni.cz/atl_en/main nenadory vazregr.html

124. Log In Problems scleroderma is an autoimmune disease afflicting the skin and viscera. Two expertsdiscuss its prevalence, prognosis, issues surrounding diagnosis, http://www.medscape.com/viewarticle/501603

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125. Scleroderma Women are about four times more likely than men to be afflicted with scleroderma,a chronic disease that most often strikes women during middle age. http://www.healthywomen.org/content.cfm?L1=3&L2=69

126. Scleroderma - Children's Hospital Boston CREST Syndrome A less severe form of scleroderma is called CREST. There aretwo forms of scleroderma localized scleroderma and systemic sclerosis. http://www.childrenshospital.org/az/Site1565/mainpageS1565P0.html

or find by letter: A-F G-L M-R S-Z My Child Has... Home Scleroderma Scleroderma Programs that treat this condition or perform this procedure Rheumatology Program Samara Jan Turkel Clinical Center CREST Syndrome A less severe form of scleroderma is called CREST . The CREST syndrome represents the following symptoms: Calcium skin deposits Raynaud phenomenon (a condition in which the blood vessels of the fingers and toes go into spasm when triggered by factors such as cold, stress, or illness; the result is cold, painful, or numb fingers and toes which in severe cases may become gangrenous) Esophageal dysfunction (problems with the esophagus, the tube between the mouth and the stomach) Sclerodactyly (skin damage on fingers) Telangiectasia (spider veins), limits skin damage to the fingers. However, this disease, when coupled with pulmonary hypertension (elevated blood pressures within the lungs), can lead to heart and respiratory failure. What is scleroderma? There are two forms of scleroderma: localized scleroderma and systemic sclerosis. Localized scleroderma can be seen more frequently in children than the systemic form. It may involve patches of the skin on the trunk, arms, legs, or head. Other names for the localized form are morphea and linear scleroderma. Systemic sclerosis is a chronic, degenerative disease that affects the joints, skin, and internal organs. Scleroderma is also associated with blood vessel abnormalities. Systemic sclerosis occurs only rarely in children.

127. OBGYN.net - Scleroderma & Pregnancy - A. Iqbal, MD OBGYN.net Medical Professionals page, contains daily news, events calendar,clinical information, and links to featured sections, articles, http://www.obgyn.net/displayppt.asp?page=/english/pubs/features/presentations/iq

128. FIRSTConsult - Sdfdsf FIRSTConsult, scleroderma (Patient Education File). Published for medical studentsand primary healthcare providers by Elsevier. http://www.firstconsult.com/?action=view_article&id=1037518&type=103&bref=1

129. NewYork-Presbyterian Hospital Vascular Care Scleroderma Health information about scleroderma from NewYorkPresbyterian. The UniversityHospitals of Columbia and Cornell. http://wo-pub2.med.cornell.edu/cgi-bin/WebObjects/PublicA.woa/4/wa/viewHContent?

130. Untitled Document http://www.srfcure.org/home/

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