21. International Scleroderma Network The major worldwide resource for top notch scleroderma medical and support information, with over 1200 pages in 19 languages, from the nonprofit http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

22. MedlinePlus: Scleroderma scleroderma. From the National Institutes of Health; Handout on Healthscleroderma (National Institute of Arthritis and Musculoskeletal and Skin http://www.nlm.nih.gov/medlineplus/scleroderma.html

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Other health topics: A B C D ... List of All Topics Scleroderma Contents of this page: From the NIH Overviews Diagnosis/Symptoms Treatment ... Children Search MEDLINE/PubMed for recent research articles on Scleroderma You may also be interested in these MedlinePlus related pages: Raynaud's Disease Immune System/AIDS Skin, Hair and Nails From the National Institutes of Health Handout on Health: Scleroderma (National Institute of Arthritis and Musculoskeletal and Skin Diseases) Overviews Scleroderma (Mayo Foundation for Medical Education and Research) Scleroderma Scleroderma (American College of Rheumatology) Diagnosis/Symptoms ANA (Antinuclear Antibody Test) (American Association for Clinical Chemistry) Treatment Treatment Information (Scleroderma Research Foundation) Specific Conditions CREST Syndrome (Mayo Foundation for Medical Education and Research) Localized Scleroderma (Morphea) (Scleroderma Foundation) - Links to PDF Clinical Trials ClinicalTrials.gov: Scleroderma, Localized

23. What Is Scleroderma? Information About Scleroderma And Scleroderma scleroderma is a rare, chronic autoimmune disease. This page includes and overview of scleroderma, information about scleroderma and scleroderma http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

24. Scleroderma Society Of Canada - Home Page A nonprofit society raising awareness of and funding for research and a cure. Good factual information about this disease. http://www.scleroderma.ca/

Scleroderma.ca Welcome to our website This website offers information about scleroderma, a connective tissue disease that is characterized by fibrosis (thickening and hardening) of the skin and other organs. Information about the Scleroderma Society of Canada and other support organizations is also available on this website. Donations Click Here For Donation Information Latest News Golf Tournament Fundraiser... Click Here For More... AGM and Conference details... Click Here For More... June Awareness... Click Here For More... Scleroderma Patient Medical Survey... Click Here For More... Poster Campaign... Click Here For More... Canada Represented at European Conf... Click Here For More... Click here to view more... We gratefully acknowledge the generous donation from The Calgary Foundation that has helped make this project possible. Site Designed by Webstylers Technologies Inc.

25. MedlinePlus Medical Encyclopedia: Systemic Sclerosis (scleroderma) CREST syndrome; Progressive systemic sclerosis; scleroderma. Definition Returnto top. scleroderma is a diffuse connective tissue disease characterized by http://www.nlm.nih.gov/medlineplus/ency/article/000429.htm

@import url(/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Systemic sclerosis (scleroderma) Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Raynaud's phenomenon CREST syndrome Sclerodactyly Telangiectasia Alternative names Return to top CREST syndrome; Progressive systemic sclerosis; Scleroderma Definition Return to top Scleroderma is a diffuse connective tissue disease characterized by changes in the skin, blood vessels, skeletal muscles, and internal organs. Causes, incidence, and risk factors Return to top The cause of scleroderma is unknown. The disease may produce local or systemic symptoms. The course and severity of the disease varies widely in those affected. Excess collagen deposits in the skin and other organs produce the symptoms. Damage to small blood vessels within the skin and affected organs also occurs. In the skin, ulceration, calcification, and changes in pigmentation may occur. Systemic features may include fibrosis and degeneration of the heart, lungs, kidneys and gastrointestinal tract.

26. Scleroderma Read the posts or post a message for those who have or who are interested in this disorder. http://pub59.ezboard.com/fsclerodermadiscussionboardfrm1

"); else document.write(""); // > Scleroderma Discussion Board > Scleroderma Login Register Your Free Account (Required) Search Help ... Need help logging in? 1 visitor in the last 15 minutes: Members - 1 Guest - Anonymous Topic Replies Last Comment Started By what happened here? 7/12/05 9:51 pm by: Hanson Hottie Hanson Hottie icon legend: Closed Topics New messages Contact Administrator Register An Account Home Scleroderma Discussion Board Powered By ezboard® Ver. 7.32

27. I HAVE SCLERODERMA Stories of real people who have scleroderma. Living and coping with scleroderma. A site by people with scleroderma, for people with scleroderma . http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

28. International Scleroderma Network The major worldwide resource for top notch scleroderma medical and supportinformation, with over 1200 pages in 19 languages, from the nonprofit http://www.sclero.org/

www.sclero.org So you'd like to learn more about scleroderma? an Amazon guide by Shelley Ensz, ISN President Our site menu requires pop-ups and javascript enabled. About the ISN Join/Donate Languages Medical Scleroderma Experts Symptoms Newsroom Message Board Support Stories Support Groups SWA Sites to Surf! Hope on Horizon ISN Gift Shop Email ISN ISN Medical

29. Juvenile Rheumatic Disease Group Website Online support for parents of children with a JRD, including juvenile rheumatoid arthritis, juvenile scleroderma, juvenile dermatomyositis, juvenile systemic lupus, and other rheumatic disorders. Includes resources. http://www.geocities.com/beegal68/JRD-Website.html

Welcome to the Juvenile Rheumatic Disease (JRD) Website ~Click the picture above to enter~ Graphic's provided by www.graphicgarden.com You are visitor number since October 2001 A Free Online Support Group Script's provided by Dynamic Drive This page was created with the help of the Meta Tag Analyzer Please, help save a child's life and read the above "Amber Alert". If you would like an Amber Alert ticker for your website, please, click the ticker! © 2005 JRD

30. Scleroderma Research Foundation There is currently no cure for scleroderma but, in many cases, it can be managed. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

31. What Is Scleroderma? Information About Scleroderma And Scleroderma Symptoms. scleroderma is a rare, chronic autoimmune disease. This page includes and overviewof scleroderma, information about scleroderma and scleroderma symptoms. http://www.sclero.org/medical/about-sd/a-to-z.html

www.sclero.org So you'd like to learn more about scleroderma? an Amazon guide by Shelley Ensz, ISN President Our site menu requires pop-ups and javascript enabled. About the ISN Join/Donate Languages Medical Scleroderma Experts Symptoms Newsroom Message Board Support Stories Support Groups SWA Sites to Surf! Hope on Horizon ISN Gift Shop Email ISN ISN Medical

32. Scleroderma Foundation Chicago, Illinois Chapter - Home Page Supports patients and families of this chronic, autoimmune disease of the connective tissue. Includes overview of programs and events, donations, links, and contacts. http://www.scleroderma.org/chapter/illinois/

SF Home Page Sign Up for SF's Free Email Newsletter! Get Connected! Post Items to the SF Message Board. What is scleroderma? Welcome to the Scleroderma Foundation, Greater Chicago Chapter , based in Chicago, Illinois. We are here to serve you, so please feel free to contact us. News Tidbits October 8, "Shedding Light on Pulmonary Arterial Hypertension: The Journey Toward a Brighter Future." More October 22, Greater Chicago Chapter "Fall Educational Symposiums." More Greater Chicago Chapter Attempting to Build Email Database ~ The Greater Chicago Chapter is attempting to build an email database, so we can continue to keep our donors and supporters updated more regularly. If you would like to be added to our email registry, please forward your e-mail address to: SclerodermaChicago@hotmail.com

33. Http//www.srfcure.org/home/index.html http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

34. Brooklyn NY Scleroderma Page Profile, mission statement, medical background, contact information. http://members.aol.com/BklynScler/

The Brooklyn Area Scleroderma Support Group Scleroderma Foundation Mission Statement It's hard enough to face the debilitating physical and emotional effects of Scleroderma, but facing them alone can be devastating. The mission of the Scleroderma Foundation is to provide educational and emotional support for Scleroderma patients and their families. SF is committed to increasing awareness of this devastating disease and raising essential research dollars to determine its cause, enhance treatment and find a cure. What is Scleroderma? Scleroderma is a disease of the vascular and immune systems, as well as a severe connective tissue disorder. This disease can effect the skin, joints, blood vessels as well as other parts of the body. Scleroderma is a chronic disease. It can last for months, years or a lifetime. as of yet, there is no cure, but it can be treated. With early detection and proper management, many people with scleroderma can lead full, productive lives. This disease is not contagious, and it is rare for direct family members to also contract the disease. Scleroderma is a highly individualized disease that affects people in different ways. The following descriptions are intended to help you gain some knowledge about this disease.

35. Scleroderma - Arthritis And Arthritic Conditions, Medications, And scleroderma. What is scleroderma? How is scleroderma classified? scleroderma At A Glance What is scleroderma? http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

36. Girls With Scleroderma Look To Each Other CNN http://cnn.com/2002/HEALTH/conditions/07/22/life.with.scleroderma.ap/index.html

37. Kids Get Scleroderma Too!!! Organization that is working to provide educational programs about JSD, and to help children and their families to gain a better understanding. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

38. Mixed Connective Tissue Disorder An autoimmune process with symptoms of scleroderma, Systemic Lupus Erythematosus , Rheumatoid Arthritis and/or other autoimmune diseases. This page describes symptoms and treatments and has lists of useful links. http://hometown.aol.com/lindartc/index.htm

htmlAdWH('93212823', '728', '90'); Main NEW! Click here to join a group for spouses of people with Autoimmune Disease (Spousal Autoimmune Support Group). What is Mixed Connective Tissue Disorder? How do you know if you have Mixed Connective Tissue Disorder? ... VIVIENDO CON EMTC What is Mixed Connective Tissue Disorder? Mixed Connective Tissue Disorder is an autoimmune process with symptoms of Scleroderma, Myositis, Systemic Lupus Erythematosus , Rheumatoid Arthritis and/or other autoimmune diseases. It is a description of a group of symptoms occurring together. This is different from a diagnosis that describes the underlying process. It is a disorder of the immune system, which normally functions to protect the body against invading infections and cancers, and toxins. In Mixed Connective Tissue Disorder, as in other autoimmune diseases parts of the complex immune system is over-active and produces increased amounts of abnormal antibodies that attack the patient's own organs. Sometimes MCTD is called Overlap Syndrome or Undifferentiated Mix Connective Tissue Disorder. Some writers discriminate between them claiming that each of these are different. Some argue MCTD is not a distinct entity at all, and is just one of the forms of Lupus or Scleroderma. MCTD can affect many parts of the body, including the joints, skin, kidneys, lungs, heart, endocrine, digestive, and nervous system, blood vessels which all are made up of connective tissue. There are reports of psychiatric disturbances similar to those found in Lupus. The signs and symptoms of MCTD differ from person to person, with the symptoms of either Lupus, or Scleroderma, or Myositis or other autoimmune disease being most prevalent. Since its manifestations can vary it is often misdiagnosed. The disease can range from mild to life threatening. It can be mild for many years, and then after about 20 years of having the disease a medical crisis may occur. The lungs and kidneys are particularly at risk. Lungs and kidneys symptoms are particularly serious involvement and should be monitored vigilantly by both the doctor and the patient.

39. Scleroderma And Kidney Disease scleroderma and kidney disease. What is the problem and what is already known?scleroderma is an autoimmune disease that can cause changes in the skin, http://www.arthritis.org/research/ResearchUpdate/03Jan_Feb/Scleroderma.asp

Welcome! Log In Create Profile Search Arthritis.org Keyword advanced search Español Bulletin on the Rheumatic Diseases Research Update ... Mortality increased in older women with RA Scleroderma and kidney disease Progress in lupus genetics Contact Us Sign Up Archives Scleroderma and kidney disease What is the problem and what is already known? Scleroderma is an autoimmune disease that can cause changes in the skin, gastrointestinal tract, lungs, and kidneys. Kidney disease (called renal crisis ) is one of the most serious complications of scleroderma, and may be associated with high blood pressure and an increased risk of kidney failure and even death. Use of blood pressure medications called ACE-inhibitors and disease modifying drugs such as penicillamine appear to be improving the long-term outcome of people with scleroderma. This study was designed to provide additional data about what factors might help to predict renal crisis, and the effects of penicillamine and ACE-inhibitors. Researchers funded by the Arthritis Foundation involved in the study : Virginia Steen, MD, Georgetown University, Washington DC; Barbara White, MD, VA Maryland Health Care System, Baltimore; and Fredrick Wigley, MD, Johns Hopkins, Baltimore.

40. Scleroderma – Complete Medical Information Regarding This Autoimmune Disease An Explains arthritis conditions includes symptoms, causes, medications, and treatment.Written and reviewed by a Rheumatologist. http://www.medicinenet.com/scleroderma/article.htm

document.writeln(''); About Us MedicineNet Home Arthritis Home Page > Scleroderma search help Printer-Friendly Format FREE Newsletters Email to a Friend ... Next Scleroderma What is scleroderma? How is scleroderma classified? How is scleroderma diagnosed? How is scleroderma treated? ... Scleroderma At A Glance What is scleroderma? Scleroderma is an autoimmune disease of the connective tissue. Autoimmune diseases are illnesses which occur when the body's tissues are attacked by its own immune system. Scleroderma is characterized by the formation of scar tissue (fibrosis) in the skin and organs of the body. This leads to thickness and firmness of involved areas. Scleroderma is also referred to as systemic sclerosis. The cause of scleroderma is not known. Researchers have found some evidence that genes are important factors, but the environment seems to also play a role. The result is activation of the immune system causing injury to tissues that result in injury similar to scar tissue formation. The fact that genes seem to cause some predispositino to scleroderma means that inheritance at least play a partial role. It is not unusual to find other autoimmune diseases in families of scleroderma patients. Some evidence for the role genes may play in leading to the development of scleroderma comes from the study of Choctaw Native Americans who are the group with the highest reported prevalence of the disease. The disease is more frequent in females than in males.

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